DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-4 and LHS1

DIOPT Version :9

Sequence 1:	NP_001262586.1	Gene:	Hsc70-4 / 41840	FlyBaseID:	FBgn0266599	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	NP_012850.1	Gene:	LHS1 / 853789	SGDID:	S000001556	Length:	881	Species:	Saccharomyces cerevisiae

Alignment Length:	695	Identity:	168/695 - (24%)
Similarity:	306/695 - (44%)	Gaps:	105/695 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SKAPAVGIDLG-TTYSCVGVFQHGKVEIIANDQGNRTTPSYVAF-----------TDTERLIGDA 54
            |.|..:|:|.| .....:.|.....:|::...:..|...|.::.           ...||:.|.|
Yeast    18 SLAAVLGVDYGQQNIKAIVVSPQAPLELVLTPEAKRKEISGLSIKRLPGYGKDDPNGIERIYGSA 82

  Fly    55 AKNQVAMNPTQTIFDAKRLIGRKFDDAAVQS--DMKHWPFEVVSADGKPKIEVTYKDEKKTFFPE 117
            ..:.....|..|:...|.|:|:..:|....:  ..:|...|:||.:   :..:.:..:...:..|
Yeast    83 VGSLATRFPQNTLLHLKPLLGKSLEDETTVTLYSKQHPGLEMVSTN---RSTIAFLVDNVEYPLE 144

  Fly   118 EISSMVLTKMKETAEAYL----GKT---VTNAVITVPAYFNDSQRQATKDAGTI-AGLNVLRIIN 174
            |:.:|.:.::...|.:.|    .:|   |.....|:|.:|:..||:|..||.:| .|:....:::
Yeast   145 ELVAMNVQEIANRANSLLKDRDARTEDFVNKMSFTIPDFFDQHQRKALLDASSITTGIEETYLVS 209

  Fly   175 EPTAAAIAYGLDKKAV--GE-RNVLIFDLGGGTFDVSILSI---DDG----IFEVKSTAGDTHLG 229
            |..:.|:.:.|.::..  || ::.:::|:|.|:...|:.||   :|.    ..|.:....:.|||
Yeast   210 EGMSVAVNFVLKQRQFPPGEQQHYIVYDMGSGSIKASMFSILQPEDTTQPVTIEFEGYGYNPHLG 274

  Fly   230 GEDFDNRLVTHFVQEFKRKH----KKDLTTNKRALRRLRTACERAKRTLSSSTQASIEIDSLFEG 290
            |..|...:.:....:|...|    ..:|..|.:||.::..|.|:||..||::::|||.|:||...
Yeast   275 GAKFTMDIGSLIENKFLETHPAIRTDELHANPKALAKINQAAEKAKLILSANSEASINIESLIND 339

  Fly   291 TDFYTSITRARFEELNADLFRSTMDPVEKALR------DAKLDKSVIHDIVLVGGSTRIPKVQRL 349
            .||.|||||..|||..||.....:.|:..|:.      ...|.:  |:.::|.|||:|||.||..
Yeast   340 IDFRTSITRQEFEEFIADSLLDIVKPINDAVTKQFGGYGTNLPE--INGVILAGGSSRIPIVQDQ 402

  Fly   350 LQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDK---SQEVQDLLLLD--VTPLSLGIETAGGV 409
            |..|.:.:::.:::|.||     :||...::.|.|   |.:.:.|.::|  |...|..:.....:
Yeast   403 LIKLVSEEKVLRNVNADE-----SAVNGVVMRGIKLSNSFKTKPLNVVDRSVNTYSFKLSNESEL 462

  Fly   410 MSVLIKRNTTIPTKQTQTFTTYSDNQP----------GVLIQVYEGERAMTKDNNLLGKFELSGI 464
            ..| ..|.:..|.| |...|..:|:.|          |.|.:.........|::....|.. ||:
Yeast   463 YDV-FTRGSAYPNK-TSILTNTTDSIPNNFTIDLFENGKLFETITVNSGAIKNSYSSDKCS-SGV 524

  Fly   465 PPAPRGVPQIEVTFDIDANGILNVTALERSTNKENKI----TITNDKGRL--SKEDIE-RMVNEA 522
                    ...:|||:.::.:.::..:......||.|    .|.|...||  :.||:| :.::.:
Yeast   525 --------AYNITFDLSSDRLFSIQEVNCICQSENDIGNSKQIKNKGSRLAFTSEDVEIKRLSPS 581

  Fly   523 EKYRNE------DEKQKETIAAK---NGLESYCFNMKATLDEDNLKTKISDSDRTTILDKCNETI 578
            |:.|..      |::.||....:   |.|||..::.:..|.:|    ::..:...:.:::.:|.:
Yeast   582 ERSRLHEHIKLLDKQDKERFQFQENLNVLESNLYDARNLLMDD----EVMQNGPKSQVEELSEMV 642

  Fly   579 K----WL-DANQLADKEEYEHRQKELEGVCNPIITKLYQGAGFPP 618
            |    || ||:...|.|:...|.:|: |:....| :||..:...|
Yeast   643 KVYLDWLEDASFDTDPEDIVSRIREI-GILKKKI-ELYMDSAKEP 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-4	NP_001262586.1	PTZ00009	1..612	CDD:240227	166/687 (24%)
Hsc70-4	NP_001262586.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	106/416 (25%)
LHS1	NP_012850.1	HYOU1-like_NBD	23..430	CDD:212672	106/416 (25%)
LHS1	NP_012850.1	Smc	<581..737	CDD:224117	26/111 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19375
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910