DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-4 and SSC1

DIOPT Version :9

Sequence 1:	NP_001262586.1	Gene:	Hsc70-4 / 41840	FlyBaseID:	FBgn0266599	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	NP_012579.1	Gene:	SSC1 / 853503	SGDID:	S000003806	Length:	654	Species:	Saccharomyces cerevisiae

Alignment Length:	618	Identity:	314/618 - (50%)
Similarity:	428/618 - (69%)	Gaps:	29/618 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VGIDLGTTYSCVGVFQHGKV-EIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVAMNPTQTIFD 69
            :|||||||.|.|.:.: ||| :||.|.:|:|||||.|||| :.|||:|..||.|..:||..|:|.
Yeast    33 IGIDLGTTNSAVAIME-GKVPKIIENAEGSRTTPSVVAFTKEGERLVGIPAKRQAVVNPENTLFA 96

  Fly    70 AKRLIGRKFDDAAVQSDMKHWPFEVVS-ADGKPKIEVTYKDEKKTFFPEEISSMVLTKMKETAEA 133
            .||||||:|:||.||.|:|..|:::|. ::|...:|.    ..:|:.|.:|...||.||||||||
Yeast    97 TKRLIGRRFEDAEVQRDIKQVPYKIVKHSNGDAWVEA----RGQTYSPAQIGGFVLNKMKETAEA 157

  Fly   134 YLGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKAVGERNVLIF 198
            ||||.|.|||:||||||||||||||||||.|.||||||::|||||||:||||:|.  ..:.|.:|
Yeast   158 YLGKPVKNAVVTVPAYFNDSQRQATKDAGQIVGLNVLRVVNEPTAAALAYGLEKS--DSKVVAVF 220

  Fly   199 DLGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNKRALRRL 263
            ||||||||:|||.||:|:||||||.|||||||||||..|:...|..||.:...||..::.|::|:
Yeast   221 DLGGGTFDISILDIDNGVFEVKSTNGDTHLGGEDFDIYLLREIVSRFKTETGIDLENDRMAIQRI 285

  Fly   264 RTACERAKRTLSSSTQASIEIDSLFEGTD------FYTSITRARFEELNADLFRSTMDPVEKALR 322
            |.|.|:||..|||:  .|.||:..|...|      .....:||:||.|.|.|.:.|:|||:|||:
Yeast   286 REAAEKAKIELSST--VSTEINLPFITADASGPKHINMKFSRAQFETLTAPLVKRTVDPVKKALK 348

  Fly   323 DAKLDKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQE 387
            ||.|..|.|.:::||||.:|:|||...::.|| ||:.:|::|||||||.|||||.|:|.|    |
Yeast   349 DAGLSTSDISEVLLVGGMSRMPKVVETVKSLF-GKDPSKAVNPDEAVAIGAAVQGAVLSG----E 408

  Fly   388 VQDLLLLDVTPLSLGIETAGGVMSVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKD 452
            |.|:||||||||||||||.|||.:.||.||||||||::|.|:|.:..|..|.|:|::|||.:.:|
Yeast   409 VTDVLLLDVTPLSLGIETLGGVFTRLIPRNTTIPTKKSQIFSTAAAGQTSVEIRVFQGERELVRD 473

  Fly   453 NNLLGKFELSGIPPAPRGVPQIEVTFDIDANGILNVTALERSTNKENKITITNDKGRLSKEDIER 517
            |.|:|.|.|:||||||:|||||||||||||:||:||:|.:::|||::.||:....| ||:.:||:
Yeast   474 NKLIGNFTLAGIPPAPKGVPQIEVTFDIDADGIINVSARDKATNKDSSITVAGSSG-LSENEIEQ 537

  Fly   518 MVNEAEKYRNEDEKQKETIAAKNGLESYCFNMKATLDEDNLKTKISDSDRTTILDK---CNETIK 579
            |||:|||::::||.:|:.|...|..:....:.:.:|.|  .:.|:..::...:.|:   ..|.:.
Yeast   538 MVNDAEKFKSQDEARKQAIETANKADQLANDTENSLKE--FEGKVDKAEAQKVRDQITSLKELVA 600

  Fly   580 WLDANQLADKEEYEHRQKELEGVCNPIITKLYQ 612
            .:...:..:.||.:.:.:||:.....:..:||:
Yeast   601 RVQGGEEVNAEELKTKTEELQTSSMKLFEQLYK 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-4	NP_001262586.1	PTZ00009	1..612	CDD:240227	313/616 (51%)
Hsc70-4	NP_001262586.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	210/382 (55%)
SSC1	NP_012579.1	dnaK	30..633	CDD:234715	313/616 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810