DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-4 and Hsp70-2

DIOPT Version :9

Sequence 1:	NP_001262586.1	Gene:	Hsc70-4 / 41840	FlyBaseID:	FBgn0266599	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	NP_195869.1	Gene:	Hsp70-2 / 831856	AraportID:	AT5G02490	Length:	653	Species:	Arabidopsis thaliana

Alignment Length:	655	Identity:	479/655 - (73%)
Similarity:	554/655 - (84%)	Gaps:	13/655 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KAPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTQTI 67
            :.||:|||||||||||||:||.:|||||||||||||||||||||:||||||||||||||||..|:
plant     6 EGPAIGIDLGTTYSCVGVWQHDRVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPVNTV 70

  Fly    68 FDAKRLIGRKFDDAAVQSDMKHWPFEVVSADG-KPKIEVTYKDEKKTFFPEEISSMVLTKMKETA 131
            |||||||||:|.||:||||.:.|||.::|... ||.|.|.||.|:|.|..||||||||.||:|.|
plant    71 FDAKRLIGRRFSDASVQSDRQLWPFTIISGTAEKPMIVVEYKGEEKQFAAEEISSMVLIKMREIA 135

  Fly   132 EAYLGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKA--VGERN 194
            ||:||.||.|||:||||||||||||||||||.||||||||||||||||||||||||||  |||:|
plant   136 EAFLGTTVKNAVVTVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKKATSVGEKN 200

  Fly   195 VLIFDLGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNKRA 259
            ||||||||||||||:|:|::||||||:|||||||||||||||:|.|||||||||:|:|:|...||
plant   201 VLIFDLGGGTFDVSLLTIEEGIFEVKATAGDTHLGGEDFDNRMVNHFVQEFKRKNKQDITGQPRA 265

  Fly   260 LRRLRTACERAKRTLSSSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMDPVEKALRDA 324
            |||||||||||||||||:.|.:||||||:.|.|||:.||||||||:|.||||..|:||||.||||
plant   266 LRRLRTACERAKRTLSSTAQTTIEIDSLYGGADFYSPITRARFEEMNMDLFRKCMEPVEKCLRDA 330

  Fly   325 KLDKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQEVQ 389
            |:|||.:|:||||||||||||||:||||.||||||.||||||||||||||||||||.|:.:::||
plant   331 KMDKSTVHEIVLVGGSTRIPKVQQLLQDFFNGKELCKSINPDEAVAYGAAVQAAILSGEGNEKVQ 395

  Fly   390 DLLLLDVTPLSLGIETAGGVMSVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNN 454
            |||||||||||||:|||||||:.||:||||||||:.|.|:|||||||||||||:|||||.|||||
plant   396 DLLLLDVTPLSLGLETAGGVMTTLIQRNTTIPTKKEQVFSTYSDNQPGVLIQVFEGERARTKDNN 460

  Fly   455 LLGKFELSGIPPAPRGVPQIEVTFDIDANGILNVTALERSTNKENKITITNDKGRLSKEDIERMV 519
            ||||||||||||||||||||.|.|||||||||||:|.:::|.|:||||||||||||||||||:||
plant   461 LLGKFELSGIPPAPRGVPQITVCFDIDANGILNVSAEDKTTGKKNKITITNDKGRLSKEDIEKMV 525

  Fly   520 NEAEKYRNEDEKQKETIAAKNGLESYCFNMKATLDEDNLKTKISDSDRTTILDKCNETIKWLDAN 584
            .|||||::|||:.|:.:.|||.||:|.:||:.|:.::.:..|:..:|:..:.|...|.|:|||.|
plant   526 QEAEKYKSEDEEHKKKVEAKNALENYAYNMRNTIRDEKIGEKLPAADKKKVEDSIEEAIQWLDGN 590

  Fly   585 QLADKEEYEHRQKELEGVCNPIITKLYQGAGFPPGGMPGGPGGMPGAAGA---AGAAGAGGAGPT 646
            ||.:.:|:|.:.||||.||||||.|:|||..       ||..|.|||:|.   .....:|||||.
plant   591 QLGEADEFEDKMKELESVCNPIIAKMYQGGA-------GGEAGGPGASGMDEDEAPPASGGAGPK 648

  Fly   647 IEEVD 651
            |||||
plant   649 IEEVD 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-4	NP_001262586.1	PTZ00009	1..612	CDD:240227	459/611 (75%)
Hsc70-4	NP_001262586.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	302/377 (80%)
Hsp70-2	NP_195869.1	PTZ00009	5..653	CDD:240227	477/653 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	930	1.000	Domainoid score	I2
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	950	1.000	Inparanoid score	I50
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	1	1.000	-	-		mtm1041
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	1	1.100	-	-	O	PTHR19375
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X148
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840