DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-4 and HSP70

DIOPT Version :9

Sequence 1:	NP_001262586.1	Gene:	Hsc70-4 / 41840	FlyBaseID:	FBgn0266599	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	NP_187864.1	Gene:	HSP70 / 820438	AraportID:	AT3G12580	Length:	650	Species:	Arabidopsis thaliana

Alignment Length:	654	Identity:	485/654 - (74%)
Similarity:	562/654 - (85%)	Gaps:	14/654 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KAPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTQTI 67
            :.||:|||||||||||||:||.:|||||||||||||||||||||:|||||||||||||||||.|:
plant     6 EGPAIGIDLGTTYSCVGVWQHDRVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPTNTV 70

  Fly    68 FDAKRLIGRKFDDAAVQSDMKHWPFEVVSADG-KPKIEVTYKDEKKTFFPEEISSMVLTKMKETA 131
            |||||||||::.|.:||:|..||||:|||..| ||.|.|.:|.|:|.|..||||||||.||:|.|
plant    71 FDAKRLIGRRYSDPSVQADKSHWPFKVVSGPGEKPMIVVNHKGEEKQFSAEEISSMVLIKMREIA 135

  Fly   132 EAYLGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKA--VGERN 194
            ||:||..|.|||:||||||||||||||||||.|:||||:|||||||||||||||||||  |||:|
plant   136 EAFLGSPVKNAVVTVPAYFNDSQRQATKDAGVISGLNVMRIINEPTAAAIAYGLDKKASSVGEKN 200

  Fly   195 VLIFDLGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNKRA 259
            ||||||||||||||:|:|::||||||:|||||||||||||||:|.|||||||||:|||:|.|.||
plant   201 VLIFDLGGGTFDVSLLTIEEGIFEVKATAGDTHLGGEDFDNRMVNHFVQEFKRKNKKDITGNPRA 265

  Fly   260 LRRLRTACERAKRTLSSSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMDPVEKALRDA 324
            |||||||||||||||||:.|.:|||||||||.||||:||||||||||.||||..|:||||.||||
plant   266 LRRLRTACERAKRTLSSTAQTTIEIDSLFEGIDFYTTITRARFEELNMDLFRKCMEPVEKCLRDA 330

  Fly   325 KLDKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQEVQ 389
            |:|||.:||:|||||||||||||:||||.||||||.||||||||||||||||||||.|:.:::||
plant   331 KMDKSSVHDVVLVGGSTRIPKVQQLLQDFFNGKELCKSINPDEAVAYGAAVQAAILSGEGNEKVQ 395

  Fly   390 DLLLLDVTPLSLGIETAGGVMSVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNN 454
            |||||||||||||:|||||||:|||.||||||||:.|.|:|||||||||||||||||||.|||||
plant   396 DLLLLDVTPLSLGLETAGGVMTVLIPRNTTIPTKKEQIFSTYSDNQPGVLIQVYEGERARTKDNN 460

  Fly   455 LLGKFELSGIPPAPRGVPQIEVTFDIDANGILNVTALERSTNKENKITITNDKGRLSKEDIERMV 519
            ||||||||||||||||||||.|.|||||||||||:|.:::|.::|||||||||||||||:||:||
plant   461 LLGKFELSGIPPAPRGVPQITVCFDIDANGILNVSAEDKTTGQKNKITITNDKGRLSKEEIEKMV 525

  Fly   520 NEAEKYRNEDEKQKETIAAKNGLESYCFNMKATLDEDNLKTKISDSDRTTILDKCNETIKWLDAN 584
            .|||||:.|||:.|:.:.|||.||:|.:||:.|:.::.:.:|:..:|:..|.|..::.|:|||.|
plant   526 QEAEKYKAEDEEHKKKVDAKNALENYAYNMRNTIKDEKIASKLDAADKKKIEDAIDQAIEWLDGN 590

  Fly   585 QLADKEEYEHRQKELEGVCNPIITKLYQGAGFPPGGMP--GGPGGMPGAAGAAGAAGAGGAGPTI 647
            |||:.:|:|.:.||||.:|||||.::|||||      |  ||.|||.   ....|.|:|||||.|
plant   591 QLAEADEFEDKMKELESLCNPIIARMYQGAG------PDMGGAGGMD---DDTPAGGSGGAGPKI 646

  Fly   648 EEVD 651
            ||||
plant   647 EEVD 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-4	NP_001262586.1	PTZ00009	1..612	CDD:240227	462/611 (76%)
Hsc70-4	NP_001262586.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	306/377 (81%)
HSP70	NP_187864.1	PTZ00009	5..630	CDD:240227	471/629 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	930	1.000	Domainoid score	I2
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	950	1.000	Inparanoid score	I50
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	1	1.000	-	-		mtm1041
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X148
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.740