DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-4 and elp2

DIOPT Version :9

Sequence 1:	NP_001262586.1	Gene:	Hsc70-4 / 41840	FlyBaseID:	FBgn0266599	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	XP_012820102.2	Gene:	elp2 / 548516	XenbaseID:	XB-GENE-5752362	Length:	832	Species:	Xenopus tropicalis

Alignment Length:	590	Identity:	111/590 - (18%)
Similarity:	206/590 - (34%)	Gaps:	149/590 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 HW--------PFEVVSADGKPKIEVTYKDEKKTFFPEEISSMVLTKMKETAEAYLGKTVTNAVIT 145
            ||        ..|:||. |..|..:.:..||             .|.::...|.....|.|||..
Frog    70 HWVQKNDCSAETELVSG-GSDKKVIIWAIEK-------------NKCEQPVAAEGHTEVVNAVHA 120

  Fly   146 VPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKAVGERNVLIFDLGGG-TFDVSI 209
            |  |...|:             |.|.|::..:...:...| ::.|....:.....|.| ..||.|
Frog   121 V--YTQRSE-------------NELLIVSAASDCTVRLWL-RRNVKTECLQTLSFGKGFVLDVCI 169

  Fly   210 LSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNKRALRRLRTACERAKRTL 274
            ..:...:..|.:...|        |:|:..:.:|..:.:..:.|..::..:|.:..|.......|
Frog   170 SFLPGSLVPVLACGAD--------DSRIHLYVLQNEQFEKTQVLHGHEDWIRGVEWAVTGQNLFL 226

  Fly   275 SSSTQ-ASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMDPVEKALRDAKLDKSVIHDIVLVG 338
            :|..| ..|.|..:|..|....|.|    |:.|:...:..:..|::  :|.:...:|..:.||.|
Frog   227 ASCAQDCLIRIWKIFRKTAKENSKT----EDENSIKLKENIFKVKE--KDTETSYAVTLETVLTG 285

  Fly   339 GSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKS------QEVQDLLLLDVT 397
            ....|..|           ....|.:.|.::....::.:|.:  ||:      .|...:.|..|.
Frog   286 HENSIYAV-----------HWQPSFSRDGSIVQPMSLLSASM--DKTMILWEPDEESGVWLEQVR 337

  Fly   398 PLSLGIETAG--GVMSVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEG-----ERAMTKDNNL 455
            ...:|..|.|  |..                    :|.::..:|...:.|     .||..|.|..
Frog   338 VGEVGGNTLGFLGCQ--------------------FSPDKSMILAHAFHGALHLWSRAPNKQNEW 382

  Fly   456 LGKFELSGIPPAPRGVPQIEVTFDIDANGILNVTALERST------NKENKITIT---NDKGRLS 511
            :....:||...:.:     ::.:|.|...::.|:| :::|      .|:.:..:|   ..:.::.
Frog   383 IPMVIISGHFDSVQ-----DMRWDPDGQFVITVSA-DQTTRLFGPWKKKGQSHVTWHEIARPQIH 441

  Fly   512 KEDIE--RMVNEAEKYRNEDEKQKETIAA-KNGLESY----CFNM-KATLDEDNLKTKISDSDRT 568
            ..|::  .|:...:.....|||.....|| :|.:|::    |.:: |..|:||   |.:.:....
Frog   442 GYDMQCLAMIGRFQFVSGADEKVLRVFAAPRNFIENFSNISCISVEKLLLNED---TNLPEGATV 503

  Fly   569 TILDKCNETI----KWLDANQLADK-----EEYEHRQKE-------------LEGVCNPIITKLY 611
            ..|...|:.:    ..:.:.|...|     |:|.....:             |:....|.:.|||
Frog   504 PALGLSNKAVFHGEILIQSTQEEGKYNSVSEQYSQPNFQPLNLTEPPTEDHLLQNTLWPEVQKLY 568

  Fly   612 QGAGF 616
             |.|:
Frog   569 -GHGY 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-4	NP_001262586.1	PTZ00009	1..612	CDD:240227	108/584 (18%)
Hsc70-4	NP_001262586.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	58/301 (19%)
elp2	XP_012820102.2	WD40 repeat	28..61	CDD:293791
		WD40	56..419	CDD:238121	81/431 (19%)
		WD40 repeat	67..110	CDD:293791	11/53 (21%)
		WD40 repeat	126..158	CDD:293791	6/45 (13%)
		WD40 repeat	164..206	CDD:293791	8/49 (16%)
		WD40 repeat	212..284	CDD:293791	17/77 (22%)
		WD40 repeat	290..323	CDD:293791	7/45 (16%)
		WD40 repeat	349..388	CDD:293791	8/58 (14%)
		WD40 repeat	395..419	CDD:293791	5/29 (17%)
		WD40 repeat	445..496	CDD:293791	13/53 (25%)
		WD40 repeat	504..548	CDD:293791	6/43 (14%)
		WD40	<563..826	CDD:421866	5/11 (45%)
		WD40 repeat	574..616	CDD:293791
		WD40 repeat	622..672	CDD:293791
		WD40 repeat	677..719	CDD:293791
		WD40 repeat	732..765	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900