Protein Alignment Hsc70-4 and HSPA14

DIOPT Version :9

• Sequence 1: NP_001262586.1
• Gene: Hsc70-4 / 41840
• FlyBaseID: FBgn0266599
• Length: 651
• Species: Drosophila melanogaster
• Sequence 2: NP_057383.2
• Gene: HSPA14 / 51182
• HGNCID: 29526
• Length: 509
• Species: Homo sapiens
• Alignment Length: 508
• Identity: 175/508 - (34%)
• Similarity: 288/508 - (56%)
• Gaps: 15/508 - (2%)

  Fly     6 AVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTQTIFDA 70
            |:|:.||.|.:||.|::.|:..::|||.|:|.||:.||:::.|.::|.|||.....|.:.|:...
Human     3 AIGVHLGCTSACVAVYKDGRAGVVANDAGDRVTPAVVAYSENEEIVGLAAKQSRIRNISNTVMKV 67

  Fly    71 KRLIGRKFDDAAVQSDMKHWPFEVVSADGKPKIEVTYKDEKKTFFPEEISSMVLTKMKETAEAYL 135
            |:::||...|...|..:......|:..:||.:.|:...:|.|...||:::.::.:||||||.:.|
Human    68 KQILGRSSSDPQAQKYIAESKCLVIEKNGKLRYEIDTGEETKFVNPEDVARLIFSKMKETAHSVL 132

  Fly   136 GKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKA-VGERNVLIFD 199
            |....:.|||||..|.:.|:.|..:|...||.||||:|:||:||.:|||:.:.: .|:.|:|:|.
Human   133 GSDANDVVITVPFDFGEKQKNALGEAARAAGFNVLRLIHEPSAALLAYGIGQDSPTGKSNILVFK 197

  Fly   200 LGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNKRALRRLR 264
            |||.:..:|::.::.||:.|.||..|.::||..|...|..:...||:|..|.|:..|.||:.:|.
Human   198 LGGTSLSLSVMEVNSGIYRVLSTNTDDNIGGAHFTETLAQYLASEFQRSFKHDVRGNARAMMKLT 262

  Fly   265 TACERAKRTLSSSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMDPVEKALRDAKLDKS 329
            .:.|.||.:||:...|:..:|||:||.||..:::|||||.|.:.||...::.:...|........
Human   263 NSAEVAKHSLSTLGSANCFLDSLYEGQDFDCNVSRARFELLCSPLFNKCIEAIRGLLDQNGFTAD 327

  Fly   330 VIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQEVQDLLLL 394
            .|:.:||.|||:||||:|:|::|||...||..||.|||.:..|||::|.||.|.::..|:|.|::
Human   328 DINKVVLCGGSSRIPKLQQLIKDLFPAVELLNSIPPDEVIPIGAAIEAGILIGKENLLVEDSLMI 392

  Fly   395 DVTP---LSLGIETAGGV-MSVLIKRNTTIPTKQTQTFTTYSDNQPG----VLIQVYEGE-RAMT 450
            :.:.   |..|::.:|.. .:||....|.:|.::..|.     ..||    |.:::||.: :...
Human   393 ECSARDILVKGVDESGASRFTVLFPSGTPLPARRQHTL-----QAPGSISSVCLELYESDGKNSA 452

  Fly   451 KDNNLLGKFELSGIPPAPRGVPQIEVTFDIDANGILNVTALERSTNKENKITI 503
            |:.....:..|..:.....|:..|.....:..:|.|:||..::.|.|...|:|
Human   453 KEETKFAQVVLQDLDKKENGLRDILAVLTMKRDGSLHVTCTDQETGKCEAISI 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-4	NP_001262586.1	PTZ00009	1..612	CDD:240227	175/508 (34%)
		HSPA1-2_6-8-like_NBD	6..381	CDD:212675	145/375 (39%)
HSPA14	NP_057383.2	HSPA14-like_NBD	2..376	CDD:212680	143/372 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810