DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-4 and CG7182

DIOPT Version :9

Sequence 1:	NP_001262586.1	Gene:	Hsc70-4 / 41840	FlyBaseID:	FBgn0266599	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	NP_001286979.1	Gene:	CG7182 / 38944	FlyBaseID:	FBgn0035878	Length:	513	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	139/519 - (26%)
Similarity:	248/519 - (47%)	Gaps:	42/519 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PAVGIDLGTTYSCVG-VFQHGKVEIIANDQGNRTTPSYVAFTDTERL-IGDAAKNQVAMNPTQTI 67
            |..||.:|.:..|:. |...||.|:|||.||:|.:.:.:.:.....: .|..||.::|..|.|.:
  Fly     3 PRFGIKIGNSTLCIAHVRADGKAEVIANKQGDRVSQACLLWDGASEIECGLTAKQKMANRPRQAV 67

  Fly    68 FDAKRLIGRK--FDDAAVQSDMKHWPFEVVSADGKPKIEVTY----KDEKKTFFPEEISSMVLTK 126
            ..:.:|:..|  ..:..:.|.::..|.:....:...::|.|.    :|:......:::|:..:|.
  Fly    68 AHSFQLLQPKEELTEEKLSSALREIPCDFDKEELVFRMEHTVPSDREDQDDRVVTKDLSAYQVTV 132

  Fly   127 MKETAEAYL-------GKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYG 184
            ....||..|       |:....||:::|:|:..|..:...||...||.:|.:||.|||||.:.|.
  Fly   133 ELLRAELELAHQYHTDGEQAPIAVLSIPSYYPASAYKLLADAAQTAGFHVAQIITEPTAAVLGYS 197

  Fly   185 L-DKKAVGERNVLIFDLGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRK 248
            : :::....|:||....||...|::..|:.:|:|...:|.|...:||..|...||....:||:||
  Fly   198 IGEEQTEQRRHVLTIKCGGLYSDIAFYSVQNGLFVQLATFGPFPIGGRQFTEALVQFICEEFRRK 262

  Fly   249 HKKDLTTNKRALRRLRTACERAKRTLSSSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRST 313
            :|.|...::|::.::|||....|..|::.....:.||||.:|.|:...::|||||.|...:..:.
  Fly   263 YKLDPHESRRSVAKIRTAAANCKHILTTMPSTQLYIDSLMDGVDYNAQMSRARFESLIQPVINNL 327

  Fly   314 MDPVEKALRDAKLDK---SVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAV 375
            :..:.:.:..|:.:.   |.|.||||:|.:.:|||:|..:...|...:|:.|.:.||.||.|.|.
  Fly   328 IQQLGECVEQAQKEHPGLSKIDDIVLLGATMQIPKLQAAVGARFPDAKLHNSHSADEVVAIGCAR 392

  Fly   376 QAAILHGDKSQEV----------QDLLLLDVTPLSLGIETAGGVMSVLIKRNTTIPTKQTQTFTT 430
            ||..|.....|::          .||.:..      |.:.:..  .:::.|.:.:|.|...:...
  Fly   393 QAVCLIDPLEQQLHKEEDCVVAEDDLFIWH------GNDESNA--KLVLGRGSVLPAKIRISLPQ 449

  Fly   431 YSDNQPGVLIQVYEGERAMTKDNNLLGKFELSGIPPAPRGVPQIEVTFDI-DANGILNVTALER 493
            ..:.:...:.:.....:..|.::.:|.:...|.||  ..|:.|:||..|: |.:|  ||..|.|
  Fly   450 SEEGKGDDVSKAAASFKLRTGESEILARLPDSTIP--EDGLYQLEVEVDVDDKDG--NVVPLVR 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-4	NP_001262586.1	PTZ00009	1..612	CDD:240227	139/519 (27%)
Hsc70-4	NP_001262586.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	114/393 (29%)
CG7182	NP_001286979.1	NBD_sugar-kinase_HSP70_actin	5..394	CDD:302596	112/388 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464185
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19375
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840