DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-4 and Hsc70-5

DIOPT Version :9

Sequence 1:	NP_001262586.1	Gene:	Hsc70-4 / 41840	FlyBaseID:	FBgn0266599	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	NP_001286414.1	Gene:	Hsc70-5 / 36583	FlyBaseID:	FBgn0001220	Length:	686	Species:	Drosophila melanogaster

Alignment Length:	614	Identity:	309/614 - (50%)
Similarity:	406/614 - (66%)	Gaps:	39/614 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KAPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVAMNPTQT 66
            |...:|||||||.||:.|.:..:.::|.|.:|.|||||:|||| |.|||:|..||.|...|...|
  Fly    51 KGAVIGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANT 115

  Fly    67 IFDAKRLIGRKFDDAAVQSDMKHWPFEVVSA-DGKPKIEVTYKDEKKTFFPEEISSMVLTKMKET 130
            .:..||||||:|||..|:.|:.:..::||.| :|...:..|   :.|.:.|.:|.:.:|.|||||
  Fly   116 FYATKRLIGRRFDDPEVKKDITNLSYKVVKASNGDAWVSST---DGKVYSPSQIGAFILMKMKET 177

  Fly   131 AEAYLGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKAVGERNV 195
            |||||...|.|||:||||||||||||||||||.||||||||:||||||||:|||:||  ..::.:
  Fly   178 AEAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDK--TEDKII 240

  Fly   196 LIFDLGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNKRAL 260
            .::||||||||:|||.|..|:||||||.|||.||||||||.:|...|.|||:....|:..:..|:
  Fly   241 AVYDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNIAM 305

  Fly   261 RRLRTACERAKRTLSSSTQASIEIDSLFEGT----DFYTSITRARFEELNADLFRSTMDPVEKAL 321
            :||:.|.|:||..||||.|..|.:..|....    .....:||::.|.|..||.:.|:.|.:|||
  Fly   306 QRLKEAAEKAKCELSSSQQTDINLPYLTMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQPCQKAL 370

  Fly   322 RDAKLDKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQ 386
            .||::.||.|.:::||||.||:||||..:|:|| |::.::|:|||||||.|||||..:|.||
  Fly   371 SDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELF-GRQPSRSVNPDEAVAVGAAVQGGVLAGD--- 431

  Fly   387 EVQDLLLLDVTPLSLGIETAGGVMSVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTK 451
             |.|:||||||||||||||.|||.:.||.||||||||::|.|:|.||.|..|.|:|::|||.|..
  Fly   432 -VTDVLLLDVTPLSLGIETLGGVFTRLISRNTTIPTKKSQVFSTASDGQTQVEIKVHQGEREMAN 495

  Fly   452 DNNLLGKFELSGIPPAPRGVPQIEVTFDIDANGILNVTALERSTNKENKITITNDKGRLSKEDIE 516
            ||.|||.|.|.||||||||||||||.||||||||::|:|.::.|.||.:|.| ...|.|||::||
  Fly   496 DNKLLGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQIVI-QSSGGLSKDEIE 559

  Fly   517 RMVNEAEKYRNEDEKQKETIAAKNGLESYCFNMKATLDE----------DNLKTKISDSDRTTIL 571
            .|:.:||:|...|::::|.|...|..||...:.:..::|          :.||.:|:|. ||.:.
  Fly   560 NMIKKAEEYATADKQKRELIEIVNQGESIVHDTETKMEEFKSQLPAEECEKLKKEIADL-RTLLA 623

  Fly   572 DKCNETIKWLDANQLADKEEYEHRQKELE 600
            :|           :.||.||.......|:
  Fly   624 NK-----------ETADLEEVRKATSSLQ 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-4	NP_001262586.1	PTZ00009	1..612	CDD:240227	309/614 (50%)
Hsc70-4	NP_001262586.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	198/380 (52%)
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	309/614 (50%)
		HSPA9-like_NBD	51..428	CDD:212683	199/382 (52%)
		Syntaphilin	<566..>642	CDD:291936	21/88 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464210
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19375
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850