DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-4 and pss1

DIOPT Version :9

Sequence 1:	NP_001262586.1	Gene:	Hsc70-4 / 41840	FlyBaseID:	FBgn0266599	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	NP_001342976.1	Gene:	pss1 / 3361514	PomBaseID:	SPAC110.04c	Length:	720	Species:	Schizosaccharomyces pombe

Alignment Length:	726	Identity:	219/726 - (30%)
Similarity:	341/726 - (46%)	Gaps:	93/726 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SKAPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTQT 66
            |:...||||.|.:.:.:.|.::..:::|.|:..||:|||.|::.:..|.:|:|||:..|.|...|
pombe     3 SRTNVVGIDFGNSKTVIAVARNRAIDVIVNEVSNRSTPSLVSYGERSRFLGEAAKSAEASNFRNT 67

  Fly    67 IFDAKRLIGRKFDDAAVQS-DMKHWPFEVVSADGKPKIEVTYKDEKKTFFPEEISSMVLTKMKET 130
            :...|||.||.:||..::. :......::...||....:|.|.:|:..|...::.:...||:|..
pombe    68 VGSLKRLAGRTYDDPEIKDIESNFISAKLTEVDGFVGAKVQYLNEETAFSNIQLIAAYFTKIKAI 132

  Fly   131 AEAYLGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKAVGE--- 192
            |||.|..:|::.||::||:|.|.||:|..:|..|||||.||::|:..|||:.||:.|..:.|
pombe   133 AEAELIGSVSDVVISIPAWFTDIQRRALLEAANIAGLNPLRLMNDNAAAALTYGITKTDLPEPES 197

  Fly   193 -RNVLIFDLGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTN 256
             |.|.|.|.|...:.|||:....|.|.:|||..|.:||..:.|..|:.:|..|||.|:|.|:.:|
pombe   198 PRRVAIVDFGHSNYSVSIVEFSRGQFHIKSTVCDRNLGSRNMDKALIDYFAAEFKEKYKIDVLSN 262

  Fly   257 KRALRRLRTACERAKRTLSSSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMDPVEKAL 321
            .:|..||.||.||.|:.||::..|.:.::.:....|..:.|.|:.||||...|......|:||||
pombe   263 PKATFRLATAVERLKKVLSANANAPLNVEMIMNDIDASSFIKRSDFEELIKPLLERLTPPIEKAL 327

  Fly   322 RDAKLDKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQ 386
            ..|.:.|..::.|.:|||.||:|.|:.::.:.| ||.|:.::|.|||||.|.|:..|||  ....
pombe   328 ELAGIKKEDLYSIEMVGGCTRVPIVKEVIANYF-GKGLSFTLNQDEAVARGCALSCAIL--SPVF 389

  Fly   387 EVQDLLLLDVT--PLSLGIE------TAGGVMSVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVY 443
            .|::..:.|||  |::...|      .....:.|..:.|   |...|:..|.|. ..|..|:..|
pombe   390 RVREFHVHDVTTYPITFSWEPIPENPEEDSSLEVFSEGN---PIPSTKILTFYR-KAPFKLLAAY 450

  Fly   444 EGERAM---TKDNNLLGKFELSGIPPAPRG-VPQIEVTFDIDANGILNV---------------- 488
            ..|..:   .|.|  :.::.::.:.|...| :..:::...:|.:|||.|
pombe   451 SKEAQLPGSIKQN--IAQYLINDVVPNKDGDLSIVKIKVRLDLHGILVVEQAYIVEEQEVEEPVE 513

  Fly   489 TALERSTNK--ENKITITNDKGRLSKEDIERMVNE-------AEKYRN-------EDEKQKETIA 537
            |:.|....|  :..:.:...|..:...|:...|.|       .||||.       .|:...||:.
pombe   514 TSPEEEAEKKTDEPVKMRKVKKLVKVADLSVSVQEDRLPTEVLEKYREAEHQMIATDKLVAETVD 578

  Fly   538 AKNGLESYCFNMKATLD---------EDNLK-----TKISD-----SDRTTILDKCNETIKWLDA 583
            .||.||.|.::.:|.||         |::.|     ||..|     .:.||   |...|.|..|.
pombe   579 RKNALEEYIYDTRAKLDDIYAPFTNEEESSKFKEMLTKAEDWLYEEGEDTT---KAVYTAKLEDL 640

  Fly   584 NQLA--------DKEEYEHRQKELEGVCNPIITKLYQGAGFPPGGMPGGPGGMPGAAGAAGAAGA 640
            .::.        |.||.:.::.:.|.......||.......|.|....|.||.     |.....|
pombe   641 MRVGGPIRQRYLDAEEAKRQKVQAEREAAKAATKSEAEKQKPSGKFEEGTGGR-----APPPPPA 700

  Fly   641 GGAGPTIEEVD 651
            ....|..|||:
pombe   701 EEVAPENEEVE 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-4	NP_001262586.1	PTZ00009	1..612	CDD:240227	208/685 (30%)
Hsc70-4	NP_001262586.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	142/379 (37%)
pss1	NP_001342976.1	HSPA4_like_NDB	7..386	CDD:212670	143/381 (38%)
pss1	NP_001342976.1	Neuromodulin_N	<517..681	CDD:331332	38/166 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810