Protein Alignment Hsc70-4 and hspa4b

DIOPT Version :9

• Sequence 1: NP_001262586.1
• Gene: Hsc70-4 / 41840
• FlyBaseID: FBgn0266599
• Length: 651
• Species: Drosophila melanogaster
• Sequence 2: NP_956151.1
• Gene: hspa4b / 334086
• ZFINID: ZDB-GENE-030131-6018
• Length: 840
• Species: Danio rerio
• Alignment Length: 838
• Identity: 221/838 - (26%)
• Similarity: 354/838 - (42%)
• Gaps: 215/838 - (25%)

  Fly     7 VGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTQTIFDAK 71
            ||.|:|.....|.|.:.|.:|.:||:..:|.||:.|:|....|.||.|||:|:..|...|:...|
Zfish     4 VGFDVGFLNCYVAVARAGGIETVANEYSDRCTPACVSFGPRNRSIGAAAKSQMVTNCKNTVHGFK 68

  Fly    72 RLIGRKFDDAAVQS-------DMKHWPFEVVSADGKPKIEVTYKDEKKTFFPEEISSMVLTKMKE 129
            |..||.|.|..||:       |:...|      .|...::|.|.:|:|.|..|::::|:|||:||
Zfish    69 RFHGRAFSDPFVQNLKPSLVYDLAQMP------SGTTGLKVMYMEEEKVFSIEQVTAMLLTKLKE 127

  Fly   130 TAEAYLGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKAV---- 190
            |||:.|.|.|.:.||:||.::.|::|::..||..|||||.||::||.||.|:|||:.|:.:
Zfish   128 TAESALKKPVADCVISVPCFYTDAERRSVIDAAQIAGLNCLRLMNETTAVALAYGIYKQDLPAPE 192

  Fly   191 -GERNVLIFDLGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLT 254
             ..|||:..|:|...:.||:.:.:.|..::.:||.|..:||:.||.|||.:|.:||..|:|.|..
Zfish   193 EKPRNVVFVDIGHSGYQVSVCAFNKGKLKILATAFDPEMGGKYFDERLVKYFCEEFVVKYKLDAK 257

  Fly   255 TNKRALRRLRTACERAKRTLS-SSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMDPVE 318
            |..|||.||...||:.|:.:| :|:...:.|:......|..:.:.||:|||:.||:......|:.
Zfish   258 TKPRALIRLFQECEKLKKLMSANSSDLPLNIECFMNDVDVSSRLNRAQFEEMCADILARVEPPLR 322

  Fly   319 KALRDAKLDKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGD 383
            ..|..|.|.|..||.:.:|||::|:|.::..:...| |||.:.::|.|||||.|.|:|.|||  .
Zfish   323 SLLEQAHLKKDDIHAVEIVGGASRMPAIKERISKFF-GKEPSTTLNADEAVARGCALQCAIL--S 384

  Fly   384 KSQEVQDLLLLDVTPLSLGIE----TAGGVMSV-LIKRNTTIPTKQTQTFTTYSDNQPGVLIQVY 443
            .:.:|::..:.:|.|..:.::    ...||... :..:|...|..:..||..   .:|..|...|
Zfish   385 PAFKVREFSITEVVPFPISLKWNSAAEDGVSDCEVFPKNHAAPFSKVLTFYR---REPFTLDAYY 446

  Fly   444 EGERAMTKDNNLLGKFELSGIPPAPRG-VPQIEVTFDIDANGILNVTA----------------- 490
            ...:.:...:..:|::.:..:.|...| ..:::|...::.:||.:|::
Zfish   447 NSPKELPYPDPTIGQYVVQKVVPQASGESSKVKVKVRVNIHGIFSVSSASLVEVQKSEEEEESME 511

  Fly   491 LERSTNKEN-----------KITITNDKGRLSKEDIERMVNEAEKYRNE---------------- 528
            .|:||.|||           |...|..:....|...|.|...||:.:.|
Zfish   512 TEQSTEKENENKMQVDQEEQKTPETEQENGEKKPGTEEMETSAEEGKQEKKSDQPPQAKKPKVKT 576

  Fly   529 ---------------------------------DEKQKETIAAKNGLESYCFNMKATL------- 553
                                             |:.:||...|||.:|.|.:.|:..|
Zfish   577 KVLDLPIENNPQWQLANDMLNLFVESEGKMIMQDKLEKERNDAKNYVEEYVYEMRDKLHGIFEKF 641

  Fly   554 ----DEDNLKTKISDSD-----------RTTILDK------------------------------ 573
                |.|.|..|:.|::           :...:||
Zfish   642 VTESDRDVLSLKLEDTEVWLYEDGEDQPKQIYIDKLAELKNLGQPIQDRYREFEERPKAFEELGR 706

  Fly   574 ---------------------------------CNETIKWLDA--NQLADKE----------EYE 593
                                             .|:.:.|:::  ||.:.:.          |.:
Zfish   707 QLQQYMKIVEAYKTKEEQYDHLEEAEIQKVDKMVNDVMIWMNSKMNQQSKQSLAIEPVVKTTEIQ 771

  Fly   594 HRQKELEGVCNPIITKLYQGAGFPPGGMPGGPGG----------MPGAAGAAGAAGAG 641
            .:.:||...|||::||.......|....|..|.|          .||....|.|..||
Zfish   772 AKTRELFSTCNPVVTKPKPKVDLPKEENPSEPNGPVNTQENPEAQPGGTEPAAADSAG 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-4	NP_001262586.1	PTZ00009	1..612	CDD:240227	211/797 (26%)
		HSPA1-2_6-8-like_NBD	6..381	CDD:212675	148/386 (38%)
hspa4b	NP_956151.1	HSPA4_NBD	2..384	CDD:212687	149/388 (38%)
		HSP70	3..693	CDD:278441	199/700 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810