Protein Alignment Hsc70-4 and HSPA9

DIOPT Version :9

• Sequence 1: NP_001262586.1
• Gene: Hsc70-4 / 41840
• FlyBaseID: FBgn0266599
• Length: 651
• Species: Drosophila melanogaster
• Sequence 2: NP_004125.3
• Gene: HSPA9 / 3313
• HGNCID: 5244
• Length: 679
• Species: Homo sapiens
• Alignment Length: 605
• Identity: 321/605 - (53%)
• Similarity: 408/605 - (67%)
• Gaps: 43/605 - (7%)

  Fly     3 KAPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVAMNPTQT 66
            |...||||||||.|||.|.:..:.:::.|.:|.|||||.|||| |.|||:|..||.|...||..|
Human    52 KGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNT 116

  Fly    67 IFDAKRLIGRKFDDAAVQSDMKHWPFEVVSA-DGKPKIEVTYKDEKKTFFPEEISSMVLTKMKET 130
            .:..||||||::||..||.|:|:.||::|.| :|...:|.    ..|.:.|.:|.:.||.|||||
Human   117 FYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEA----HGKLYSPSQIGAFVLMKMKET 177

  Fly   131 AEAYLGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKAVGERNV 195
            ||.|||.|..||||||||||||||||||||||.|:||||||:||||||||:||||||..  ::.:
Human   178 AENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSE--DKVI 240

  Fly   196 LIFDLGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNKRAL 260
            .::||||||||:|||.|..|:||||||.|||.|||||||..|:.|.|:||||:...|||.:..||
Human   241 AVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMAL 305

  Fly   261 RRLRTACERAKRTLSSSTQASIEIDSLFEGTD----FYTSITRARFEELNADLFRSTMDPVEKAL 321
            :|:|.|.|:||..||||.|..|.:..|...:.    ....:|||:||.:..||.|.|:.|.:||:
Human   306 QRVREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAM 370

  Fly   322 RDAKLDKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQ 386
            :||::.||.|.:::||||.||:||||:.:|||| |:..:|::|||||||.|||:|..:|.||
Human   371 QDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLF-GRAPSKAVNPDEAVAIGAAIQGGVLAGD--- 431

  Fly   387 EVQDLLLLDVTPLSLGIETAGGVMSVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTK 451
             |.|:||||||||||||||.|||.:.||.||||||||::|.|:|.:|.|..|.|:|.:|||.|..
Human   432 -VTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAG 495

  Fly   452 DNNLLGKFELSGIPPAPRGVPQIEVTFDIDANGILNVTALERSTNKENKITITNDKGRLSKEDIE 516
            ||.|||:|.|.|||||||||||||||||||||||::|:|.::.|.:|.:|.| ...|.|||:|||
Human   496 DNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVI-QSSGGLSKDDIE 559

  Fly   517 RMVNEAEKYRNEDEKQKETIAAKNGLESYCFNMKATLDE--DNLKTKISDSDRTTILDKCNETIK 579
            .||..||||..||.::||.:.|.|..|....:.:..::|  |.|..           |:||:.
Human   560 NMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPA-----------DECNKL-- 611

  Fly   580 WLDANQLADKEEYEHRQKEL 599
                     |||.. :.:||
Human   612 ---------KEEIS-KMREL 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-4	NP_001262586.1	PTZ00009	1..612	CDD:240227	321/605 (53%)
		HSPA1-2_6-8-like_NBD	6..381	CDD:212675	209/380 (55%)
HSPA9	NP_004125.3	Interaction with NFS1. /evidence=ECO:0000269|PubMed:26702583	1..432		213/390 (55%)
		dnaK	52..673	CDD:234715	321/605 (53%)
		Interaction with FXN and ISCU. /evidence=ECO:0000269|PubMed:26702583	432..679		108/214 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	656..679

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820