DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-4 and HSPA6

DIOPT Version :9

Sequence 1:	NP_001262586.1	Gene:	Hsc70-4 / 41840	FlyBaseID:	FBgn0266599	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	NP_002146.2	Gene:	HSPA6 / 3310	HGNCID:	5239	Length:	643	Species:	Homo sapiens

Alignment Length:	652	Identity:	502/652 - (76%)
Similarity:	569/652 - (87%)	Gaps:	13/652 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KAP---AVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPT 64
            :||   |||||||||||||||||.|:|||:|||||||||||||||||||||:|||||:|.|:||.
Human     2 QAPRELAVGIDLGTTYSCVGVFQQGRVEILANDQGNRTTPSYVAFTDTERLVGDAAKSQAALNPH 66

  Fly    65 QTIFDAKRLIGRKFDDAAVQSDMKHWPFEVVSADGKPKIEVTYKDEKKTFFPEEISSMVLTKMKE 129
            .|:|||||||||||.|..||||||||||.|||..||||:.|.|:.|.|||:|||||||||:||||
Human    67 NTVFDAKRLIGRKFADTTVQSDMKHWPFRVVSEGGKPKVRVCYRGEDKTFYPEEISSMVLSKMKE 131

  Fly   130 TAEAYLGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKAVGERN 194
            |||||||:.|.:|||||||||||||||||||||.|||||||||||||||||||||||::..||||
Human   132 TAEAYLGQPVKHAVITVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDRRGAGERN 196

  Fly   195 VLIFDLGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNKRA 259
            ||||||||||||||:||||.|:||||:|||||||||||||||||.||::||:|||.|||:.||||
Human   197 VLIFDLGGGTFDVSVLSIDAGVFEVKATAGDTHLGGEDFDNRLVNHFMEEFRRKHGKDLSGNKRA 261

  Fly   260 LRRLRTACERAKRTLSSSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMDPVEKALRDA 324
            |||||||||||||||||||||::||||||||.||||||||||||||.:||||||::|||||||||
Human   262 LRRLRTACERAKRTLSSSTQATLEIDSLFEGVDFYTSITRARFEELCSDLFRSTLEPVEKALRDA 326

  Fly   325 KLDKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQEVQ 389
            ||||:.|||:|||||||||||||:||||.|||||||||||||||||||||||||:|.|||.::||
Human   327 KLDKAQIHDVVLVGGSTRIPKVQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAVLMGDKCEKVQ 391

  Fly   390 DLLLLDVTPLSLGIETAGGVMSVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNN 454
            |||||||.|||||:|||||||:.||:||.||||||||||||||||||||.|||||||||||||||
Human   392 DLLLLDVAPLSLGLETAGGVMTTLIQRNATIPTKQTQTFTTYSDNQPGVFIQVYEGERAMTKDNN 456

  Fly   455 LLGKFELSGIPPAPRGVPQIEVTFDIDANGILNVTALERSTNKENKITITNDKGRLSKEDIERMV 519
            |||:||||||||||||||||||||||||||||:|||.:|||.|.|||||||||||||||::||||
Human   457 LLGRFELSGIPPAPRGVPQIEVTFDIDANGILSVTATDRSTGKANKITITNDKGRLSKEEVERMV 521

  Fly   520 NEAEKYRNEDEKQKETIAAKNGLESYCFNMKATLDEDNLKTKISDSDRTTILDKCNETIKWLDAN 584
            :|||:|:.|||.|::.:||||.||::.|::|.:|.|::|:.||.:.||..:.|||.|.:.||:.|
Human   522 HEAEQYKAEDEAQRDRVAAKNSLEAHVFHVKGSLQEESLRDKIPEEDRRKMQDKCREVLAWLEHN 586

  Fly   585 QLADKEEYEHRQKELEGVCNPIITKLYQGAGFPPGGMPGGPGGMPGAAGAAGAAGAGGAGPTIEE 649
            |||:||||||:::|||.:|.||.::||.|        ||.|||  .:.|.....|....||.|||
Human   587 QLAEKEEYEHQKRELEQICRPIFSRLYGG--------PGVPGG--SSCGTQARQGDPSTGPIIEE 641

  Fly   650 VD 651
            ||
Human   642 VD 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-4	NP_001262586.1	PTZ00009	1..612	CDD:240227	486/611 (80%)
Hsc70-4	NP_001262586.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	317/374 (85%)
HSPA6	NP_002146.2	Nucleotide-binding domain (NBD). /evidence=ECO:0000250\|UniProtKB:P11142	3..388		323/384 (84%)
		HSP70	8..643	CDD:331774	498/644 (77%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250\|UniProtKB:P11142	396..511		101/114 (89%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	616..643		12/28 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S49
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D180577at33208
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	1	1.000	-	-		otm41703
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X148
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.680