DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hsc70-4 and HSPA5

DIOPT Version :10

Sequence 1:NP_524356.1 Gene:Hsc70-4 / 41840 FlyBaseID:FBgn0266599 Length:651 Species:Drosophila melanogaster
Sequence 2:NP_005338.1 Gene:HSPA5 / 3309 HGNCID:5238 Length:654 Species:Homo sapiens


Alignment Length:617 Identity:401/617 - (64%)
Similarity:500/617 - (81%) Gaps:6/617 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 VGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVAMNPTQTIFDA 70
            |||||||||||||||::|:|||||||||||.|||||||| :.|||||||||||:..||..|:|||
Human    31 VGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDA 95

  Fly    71 KRLIGRKFDDAAVQSDMKHWPFEVVSADGKPKIEVTY-KDEKKTFFPEEISSMVLTKMKETAEAY 134
            ||||||.::|.:||.|:|..||:||....||.|:|.. ..:.|||.|||||:|||||||||||||
Human    96 KRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAY 160

  Fly   135 LGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKAVGERNVLIFD 199
            |||.||:||:||||||||:||||||||||||||||:|||||||||||||||||:. ||:|:|:||
Human   161 LGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKRE-GEKNILVFD 224

  Fly   200 LGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNKRALRRLR 264
            |||||||||:|:||:|:|||.:|.|||||||||||.|::.||::.:|:|..||:..:.||:::||
Human   225 LGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKLR 289

  Fly   265 TACERAKRTLSSSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMDPVEKALRDAKLDKS 329
            ...|:|||.|||..||.|||:|.:||.||..::|||:|||||.|||||||.||:|.|.|:.|.||
Human   290 REVEKAKRALSSQHQARIEIESFYEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKKS 354

  Fly   330 VIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQEVQDLLLL 394
            .|.:||||||||||||:|:|:::.|||||.::.|||||||||||||||.:|.||  |:..||:||
Human   355 DIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGD--QDTGDLVLL 417

  Fly   395 DVTPLSLGIETAGGVMSVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKF 459
            ||.||:|||||.||||:.||.|||.:|||::|.|:|.|||||.|.|:||||||.:||||:|||.|
Human   418 DVCPLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLGTF 482

  Fly   460 ELSGIPPAPRGVPQIEVTFDIDANGILNVTALERSTNKENKITITNDKGRLSKEDIERMVNEAEK 524
            :|:||||||||||||||||:||.||||.|||.::.|..:||||||||:.||:.|:||||||:|||
Human   483 DLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIERMVNDAEK 547

  Fly   525 YRNEDEKQKETIAAKNGLESYCFNMKATL-DEDNLKTKISDSDRTTILDKCNETIKWLDANQLAD 588
            :..||:|.||.|..:|.||||.:::|..: |::.|..|:|..|:.|:.....|.|:||:::|.||
Human   548 FAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEEKIEWLESHQDAD 612

  Fly   589 KEEYEHRQKELEGVCNPIITKLYQGAGFPPGG 620
            .|:::.::||||.:..|||:|||..||.||.|
Human   613 IEDFKAKKKELEEIVQPIISKLYGSAGPPPTG 644

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsc70-4NP_524356.1 PTZ00009 1..612 CDD:240227 395/607 (65%)
HSPA5NP_005338.1 Required for interaction with ELAPOR1. /evidence=ECO:0000269|PubMed:26045166 1..80 41/48 (85%)
HSP70 30..635 CDD:394970 394/606 (65%)
Nucleotide-binding (NBD). /evidence=ECO:0000303|PubMed:28286085 125..280 114/155 (74%)
Interdomain linker. /evidence=ECO:0000250|UniProtKB:G3I8R9 409..419 5/9 (56%)
Substrate-binding (SBD). /evidence=ECO:0000303|PubMed:28286085 420..500 57/79 (72%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 633..654 8/12 (67%)
Prevents secretion from ER. /evidence=ECO:0000255 651..654
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.