DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-4 and HSPA2

DIOPT Version :9

Sequence 1:	NP_001262586.1	Gene:	Hsc70-4 / 41840	FlyBaseID:	FBgn0266599	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	NP_001374860.1	Gene:	HSPA2 / 3306	HGNCID:	5235	Length:	639	Species:	Homo sapiens

Alignment Length:	652	Identity:	531/652 - (81%)
Similarity:	583/652 - (89%)	Gaps:	17/652 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SKAPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTQT 66
            ::.||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|
Human     3 ARGPAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNT 67

  Fly    67 IFDAKRLIGRKFDDAAVQSDMKHWPFEVVSADGKPKIEVTYKDEKKTFFPEEISSMVLTKMKETA 131
            ||||||||||||:||.||||||||||.|||..||||::|.||.|.||||||||||||||||||.|
Human    68 IFDAKRLIGRKFEDATVQSDMKHWPFRVVSEGGKPKVQVEYKGETKTFFPEEISSMVLTKMKEIA 132

  Fly   132 EAYLGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKK--AVGERN 194
            |||||..|.:|||||||||||||||||||||||.|||||||||||||||||||||||  |.||:|
Human   133 EAYLGGKVHSAVITVPAYFNDSQRQATKDAGTITGLNVLRIINEPTAAAIAYGLDKKGCAGGEKN 197

  Fly   195 VLIFDLGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNKRA 259
            ||||||||||||||||:|:|||||||||||||||||||||||:|:|..:|||||||||:..||||
Human   198 VLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVSHLAEEFKRKHKKDIGPNKRA 262

  Fly   260 LRRLRTACERAKRTLSSSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMDPVEKALRDA 324
            :|||||||||||||||||||||||||||:||.||||||||||||||||||||.|::|||||||||
Human   263 VRRLRTACERAKRTLSSSTQASIEIDSLYEGVDFYTSITRARFEELNADLFRGTLEPVEKALRDA 327

  Fly   325 KLDKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQEVQ 389
            ||||..|.:||||||||||||:|:||||.|||||||||||||||||||||||||||.||||:.||
Human   328 KLDKGQIQEIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILIGDKSENVQ 392

  Fly   390 DLLLLDVTPLSLGIETAGGVMSVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNN 454
            |||||||||||||||||||||:.|||||||||||||||||||||||..||:||||||||||||||
Human   393 DLLLLDVTPLSLGIETAGGVMTPLIKRNTTIPTKQTQTFTTYSDNQSSVLVQVYEGERAMTKDNN 457

  Fly   455 LLGKFELSGIPPAPRGVPQIEVTFDIDANGILNVTALERSTNKENKITITNDKGRLSKEDIERMV 519
            |||||:|:||||||||||||||||||||||||||||.::||.||||||||||||||||:||:|||
Human   458 LLGKFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAADKSTGKENKITITNDKGRLSKDDIDRMV 522

  Fly   520 NEAEKYRNEDEKQKETIAAKNGLESYCFNMKATLDEDNLKTKISDSDRTTILDKCNETIKWLDAN 584
            .|||:|::|||..::.:||||.||||.:|:|.|::::.|:.|||:.|:..|||||.|.|.|||.|
Human   523 QEAERYKSEDEANRDRVAAKNALESYTYNIKQTVEDEKLRGKISEQDKNKILDKCQEVINWLDRN 587

  Fly   585 QLADKEEYEHRQKELEGVCNPIITKLYQGAGFPPGGMPGGPGGMPGAAGAAGAAGAGGAGPTIEE 649
            |:|:|:||||:|||||.||||||:||||          |||||  |:.|  |.:||.| ||||||
Human   588 QMAEKDEYEHKQKELERVCNPIISKLYQ----------GGPGG--GSGG--GGSGASG-GPTIEE 637

  Fly   650 VD 651
            ||
Human   638 VD 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-4	NP_001262586.1	PTZ00009	1..612	CDD:240227	510/611 (83%)
Hsc70-4	NP_001262586.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	331/376 (88%)
HSPA2	NP_001374860.1	PTZ00009	2..615	CDD:240227	510/611 (83%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250\|UniProtKB:P11142	2..389		336/385 (87%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250\|UniProtKB:P11142	397..512		103/114 (90%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	613..639		20/40 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142563
Domainoid	1	1.000	1030	1.000	Domainoid score	I26
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D180577at33208
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	1	1.000	-	-		otm41703
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	1	1.100	-	-	O	PTHR19375
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X148
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.760