Protein Alignment Hsc70-4 and HSPA1L

DIOPT Version :9

• Sequence 1: NP_001262586.1
• Gene: Hsc70-4 / 41840
• FlyBaseID: FBgn0266599
• Length: 651
• Species: Drosophila melanogaster
• Sequence 2: NP_005518.3
• Gene: HSPA1L / 3305
• HGNCID: 5234
• Length: 641
• Species: Homo sapiens
• Alignment Length: 650
• Identity: 517/650 - (79%)
• Similarity: 576/650 - (88%)
• Gaps: 12/650 - (1%)

  Fly     2 SKAPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTQT 66
            :|..|:||||||||||||||||||||||||||||||||||||||||||||||||||||||||..|
Human     4 AKGIAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPQNT 68

  Fly    67 IFDAKRLIGRKFDDAAVQSDMKHWPFEVVSADGKPKIEVTYKDEKKTFFPEEISSMVLTKMKETA 131
            :|||||||||||:|..||:|||.|||:|::..||||:.|:||.|.|.|:|||||||||||:||||
Human    69 VFDAKRLIGRKFNDPVVQADMKLWPFQVINEGGKPKVLVSYKGENKAFYPEEISSMVLTKLKETA 133

  Fly   132 EAYLGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKAVGERNVL 196
            ||:||..||||||||||||||||||||||||.||||||||||||||||||||||||...|||:||
Human   134 EAFLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKGGQGERHVL 198

  Fly   197 IFDLGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNKRALR 261
            ||||||||||||||:|||||||||:|||||||||||||||||:|||:|||||||||::.||||:|
Human   199 IFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVR 263

  Fly   262 RLRTACERAKRTLSSSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMDPVEKALRDAKL 326
            |||||||||||||||||||::|||||:||.||||||||||||||.|||||.|::||||||||||:
Human   264 RLRTACERAKRTLSSSTQANLEIDSLYEGIDFYTSITRARFEELCADLFRGTLEPVEKALRDAKM 328

  Fly   327 DKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQEVQDL 391
            ||:.||||||||||||||||||||||.|||::||||||||||||||||||||||.||||::||||
Human   329 DKAKIHDIVLVGGSTRIPKVQRLLQDYFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSEKVQDL 393

  Fly   392 LLLDVTPLSLGIETAGGVMSVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLL 456
            |||||.|||||:|||||||:.|||||:||||||||.|||||||||||||||||||||||||||||
Human   394 LLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLL 458

  Fly   457 GKFELSGIPPAPRGVPQIEVTFDIDANGILNVTALERSTNKENKITITNDKGRLSKEDIERMVNE 521
            |:|:|:||||||||||||||||||||||||||||.::||.|.|||||||||||||||:|||||.:
Human   459 GRFDLTGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKVNKITITNDKGRLSKEEIERMVLD 523

  Fly   522 AEKYRNEDEKQKETIAAKNGLESYCFNMKATLDEDNLKTKISDSDRTTILDKCNETIKWLDANQL 586
            ||||:.|||.|:|.|||||.||||.||||:.:.::.||.|||:||:..|||||||.:.||:.|||
Human   524 AEKYKAEDEVQREKIAAKNALESYAFNMKSVVSDEGLKGKISESDKNKILDKCNELLSWLEVNQL 588

  Fly   587 ADKEEYEHRQKELEGVCNPIITKLYQGAGFPPGGMPGGPGGMPGAAGAAGAAGAGGAGPTIEEVD 651
            |:|:|::|::||||.:|||||||||||....|            |.|.....|....||||||||
Human   589 AEKDEFDHKRKELEQMCNPIITKLYQGGCTGP------------ACGTGYVPGRPATGPTIEEVD 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-4	NP_001262586.1	PTZ00009	1..612	CDD:240227	502/609 (82%)
		HSPA1-2_6-8-like_NBD	6..381	CDD:212675	322/374 (86%)
HSPA1L	NP_005518.3	Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	3..388		327/383 (85%)
		HSP70	4..641	CDD:331774	515/648 (79%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	396..511		100/114 (88%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D180577at33208
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	1	1.000	-	-		otm41703
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X148
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.730