Protein Alignment Hsc70-4 and HSPA1B

DIOPT Version :10

• Sequence 1: NP_524356.1
• Gene: Hsc70-4 / 41840
• FlyBaseID: FBgn0266599
• Length: 651
• Species: Drosophila melanogaster
• Sequence 2: NP_005337.2
• Gene: HSPA1B / 3304
• HGNCID: 5233
• Length: 641
• Species: Homo sapiens
• Alignment Length: 651
• Identity: 529/651 - (81%)
• Similarity: 584/651 - (89%)
• Gaps: 10/651 - (1%)

  Fly     1 MSKAPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTQ 65
            |:||.|:|||||||||||||||||||||||||||||||||||||||||||||||||||||:||..
Human     1 MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQN 65

  Fly    66 TIFDAKRLIGRKFDDAAVQSDMKHWPFEVVSADGKPKIEVTYKDEKKTFFPEEISSMVLTKMKET 130
            |:|||||||||||.|..||||||||||:|::...|||::|:||.|.|.|:||||||||||||||.
Human    66 TVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEI 130

  Fly   131 AEAYLGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKAVGERNV 195
            ||||||..||||||||||||||||||||||||.|||||||||||||||||||||||:...|||||
Human   131 AEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNV 195

  Fly   196 LIFDLGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNKRAL 260
            |||||||||||||||:|||||||||:|||||||||||||||||.|||:|||||||||::.||||:
Human   196 LIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAV 260

  Fly   261 RRLRTACERAKRTLSSSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMDPVEKALRDAK 325
            |||||||||||||||||||||:||||||||.||||||||||||||.:||||||::||||||||||
Human   261 RRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAK 325

  Fly   326 LDKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQEVQD 390
            |||:.|||:|||||||||||||:||||.|||::||||||||||||||||||||||.||||:.|||
Human   326 LDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQD 390

  Fly   391 LLLLDVTPLSLGIETAGGVMSVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNL 455
            ||||||.|||||:|||||||:.|||||:||||||||.||||||||||||||||||||||||||||
Human   391 LLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNL 455

  Fly   456 LGKFELSGIPPAPRGVPQIEVTFDIDANGILNVTALERSTNKENKITITNDKGRLSKEDIERMVN 520
            ||:||||||||||||||||||||||||||||||||.::||.|.|||||||||||||||:|||||.
Human   456 LGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQ 520

  Fly   521 EAEKYRNEDEKQKETIAAKNGLESYCFNMKATLDEDNLKTKISDSDRTTILDKCNETIKWLDANQ 585
            |||||:.|||.|:|.::|||.||||.||||:.::::.||.|||::|:..:||||.|.|.|||||.
Human   521 EAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANT 585

  Fly   586 LADKEEYEHRQKELEGVCNPIITKLYQGAGFPPGGMPGGPGGMPGAAGAAGAAGAGGAGPTIEEV 650
            ||:|:|:||::||||.||||||:.|||||        ||||  ||..||.|..|..|:|||||||
Human   586 LAEKDEFEHKRKELEQVCNPIISGLYQGA--------GGPG--PGGFGAQGPKGGSGSGPTIEEV 640

  Fly   651 D 651
            |
Human   641 D 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-4	NP_524356.1	PTZ00009	1..612	CDD:240227	506/610 (83%)
HSPA1B	NP_005337.2	PTZ00009	1..611	CDD:240227	505/609 (83%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	2..386		330/383 (86%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	394..509		102/114 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	614..641		18/36 (50%)