Protein Alignment Hsc70-4 and hyou1

DIOPT Version :10

• Sequence 1: NP_524356.1
• Gene: Hsc70-4 / 41840
• FlyBaseID: FBgn0266599
• Length: 651
• Species: Drosophila melanogaster
• Sequence 2: NP_997868.1
• Gene: hyou1 / 327133
• ZFINID: ZDB-GENE-030131-5344
• Length: 980
• Species: Danio rerio
• Alignment Length: 720
• Identity: 201/720 - (27%)
• Similarity: 333/720 - (46%)
• Gaps: 124/720 - (17%)

  Fly     7 VGIDLGTTYSCVGVFQHG-KVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTQTIFDA 70
            :.:|||:.:..|.:.:.| .:||:.|.:..|.||..|...:.|||.||.|......||.......
Zfish    28 MSVDLGSEWMKVAIVKPGVPMEIVLNKESRRKTPVAVCLKENERLFGDGALGVAVKNPKVVYRFL 92

  Fly    71 KRLIGRKFDDAAVQSDMKHWPFEVVSADGKPKIEVTYK-DEKKTFFPEEISSMVLTKMKETAEAY 134
            :.::|:..|:..|....||:|...:..|.| :..|.:| .|:..:.|||:..|:|...:..|:.:
Zfish    93 QSILGKTADNPQVAEYQKHFPEHQLQKDEK-RGTVYFKFSEEMQYTPEELLGMILNYSRTLAQDF 156

  Fly   135 LGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGL-DKKAVGE--RNVL 196
            ..:.:.:||||||||||.::|:|...|..||||.||::||:.||.|:.||: .:|.:..  :|::
Zfish   157 AEQPIKDAVITVPAYFNQAERRAVLQAAHIAGLKVLQLINDNTAVALNYGVFRRKDINSTAQNIM 221

  Fly   197 IFDLGGGTFDVSILSI------DDGI---FEVKSTAGDTHLGGEDFDNRLVTHFVQEF--KRKHK 250
            .:|:|.|:...:|::.      :.|.   .:::....|..|||.:.:.||..|..:.|  ::|.|
Zfish   222 FYDMGSGSTTATIVTYQTVKTKESGTQPQLQIRGVGFDRTLGGFEMELRLRDHLAKLFNEQKKSK 286

  Fly   251 KDLTTNKRALRRLRTACERAKRTLSSSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMD 315
            ||:..|.||:.:|....:|.|..||::.:.:.:|:.|.:..||...:||:.||.|..|||.....
Zfish   287 KDVRDNLRAMAKLLKEAQRLKTVLSANAEHTAQIEGLMDDIDFKAKVTRSEFEALCEDLFDRVPG 351

  Fly   316 PVEKALRDAKLDKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAIL 380
            ||::||..|::....|..::||||:||:||||.:|......:||:|:||.|||.|.||..|||.|
Zfish   352 PVKQALAAAEMSMDEIEQVILVGGATRVPKVQDVLLKSVGKEELSKNINADEAAAMGAVYQAAAL 416

  Fly   381 HGDKSQEVQDLLLLDVTPLSLGIETA------GGVMS------VLIKRNTTIPTKQTQTFTTYSD 433
              .|:.:|:..|:.|.....:.:|.:      .||.|      :|.:|....|.::..||..|.|
Zfish   417 --SKAFKVKPFLVRDAAVFPIQVEFSRETEEEDGVKSLKHNKRILFQRMAPYPQRKVITFNRYID 479

  Fly   434 NQPGVLIQVYEGERAMTKDNNL-------LGKFELSGIPPA--------PRGVPQIEVTFDIDAN 483
            :   .:..:..|:.:...:.::       |...:|||:..:        .:|   |:..|::|.:
Zfish   480 D---FVFYINYGDLSFLSEQDMKVFGSQNLTTVKLSGVGSSFKKHSDAESKG---IKAHFNMDES 538

  Fly   484 GILNVTALER-----STNKENKITITNDKGRLSK-----------------EDIERMVNEAEKYR 526
            |:|.:..:|.     ...||.:.|:|.....:|.                 .|.|.:..||.|.:
Zfish   539 GVLILDRVESVFETIVEEKEEESTLTKLGNTISSLFGGGSSEPSANVTEPVTDEEEVTPEAGKEQ 603

  Fly   527 NEDEKQKETIAAK----NGLES------------YCFNM------------KATLDED------- 556
            ::.|||:||:..|    .|.|:            ...|.            :.|.||:
Zfish   604 DQPEKQEETVQEKPETEEGKEAEPQAEEQKEDKEKAENQGETESEKTEKPEEKTTDEEKEADMKP 668

  Fly   557 --NLKTKIS-----DSDRTTILDKCNETIKWLDANQLAD-------KEEYEHRQKELEGVCNPII 607
              ..|:|||     :.:...:||...|.::. ...:|.|       |:|.|.....||.......
Zfish   669 KLQKKSKISADIAVELEVNDVLDPSAEDMEG-SKKKLQDLTDRDLEKQEREKTLNSLEAFIFETQ 732

  Fly   608 TKLYQ 612
            .||||
Zfish   733 DKLYQ 737

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-4	NP_524356.1	PTZ00009	1..612	CDD:240227	199/718 (28%)
hyou1	NP_997868.1	ASKHA_NBD_HSP70_HYOU1	26..414	CDD:466828	131/386 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	558..682		25/123 (20%)
		PTZ00121	<592..973	CDD:173412	34/147 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	894..980
		Prevents secretion from ER. /evidence=ECO:0000255	977..980