DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-4 and hyou1

DIOPT Version :9

Sequence 1:	NP_001262586.1	Gene:	Hsc70-4 / 41840	FlyBaseID:	FBgn0266599	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	NP_997868.1	Gene:	hyou1 / 327133	ZFINID:	ZDB-GENE-030131-5344	Length:	980	Species:	Danio rerio

Alignment Length:	720	Identity:	201/720 - (27%)
Similarity:	333/720 - (46%)	Gaps:	124/720 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VGIDLGTTYSCVGVFQHG-KVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTQTIFDA 70
            :.:|||:.:..|.:.:.| .:||:.|.:..|.||..|...:.|||.||.|......||.......
Zfish    28 MSVDLGSEWMKVAIVKPGVPMEIVLNKESRRKTPVAVCLKENERLFGDGALGVAVKNPKVVYRFL 92

  Fly    71 KRLIGRKFDDAAVQSDMKHWPFEVVSADGKPKIEVTYK-DEKKTFFPEEISSMVLTKMKETAEAY 134
            :.::|:..|:..|....||:|...:..|.| :..|.:| .|:..:.|||:..|:|...:..|:.:
Zfish    93 QSILGKTADNPQVAEYQKHFPEHQLQKDEK-RGTVYFKFSEEMQYTPEELLGMILNYSRTLAQDF 156

  Fly   135 LGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGL-DKKAVGE--RNVL 196
            ..:.:.:||||||||||.::|:|...|..||||.||::||:.||.|:.||: .:|.:..  :|::
Zfish   157 AEQPIKDAVITVPAYFNQAERRAVLQAAHIAGLKVLQLINDNTAVALNYGVFRRKDINSTAQNIM 221

  Fly   197 IFDLGGGTFDVSILSI------DDGI---FEVKSTAGDTHLGGEDFDNRLVTHFVQEF--KRKHK 250
            .:|:|.|:...:|::.      :.|.   .:::....|..|||.:.:.||..|..:.|  ::|.|
Zfish   222 FYDMGSGSTTATIVTYQTVKTKESGTQPQLQIRGVGFDRTLGGFEMELRLRDHLAKLFNEQKKSK 286

  Fly   251 KDLTTNKRALRRLRTACERAKRTLSSSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMD 315
            ||:..|.||:.:|....:|.|..||::.:.:.:|:.|.:..||...:||:.||.|..|||.....
Zfish   287 KDVRDNLRAMAKLLKEAQRLKTVLSANAEHTAQIEGLMDDIDFKAKVTRSEFEALCEDLFDRVPG 351

  Fly   316 PVEKALRDAKLDKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAIL 380
            ||::||..|::....|..::||||:||:||||.:|......:||:|:||.|||.|.||..|||.|
Zfish   352 PVKQALAAAEMSMDEIEQVILVGGATRVPKVQDVLLKSVGKEELSKNINADEAAAMGAVYQAAAL 416

  Fly   381 HGDKSQEVQDLLLLDVTPLSLGIETA------GGVMS------VLIKRNTTIPTKQTQTFTTYSD 433
              .|:.:|:..|:.|.....:.:|.:      .||.|      :|.:|....|.::..||..|.|
Zfish   417 --SKAFKVKPFLVRDAAVFPIQVEFSRETEEEDGVKSLKHNKRILFQRMAPYPQRKVITFNRYID 479

  Fly   434 NQPGVLIQVYEGERAMTKDNNL-------LGKFELSGIPPA--------PRGVPQIEVTFDIDAN 483
            :   .:..:..|:.:...:.::       |...:|||:..:        .:|   |:..|::|.:
Zfish   480 D---FVFYINYGDLSFLSEQDMKVFGSQNLTTVKLSGVGSSFKKHSDAESKG---IKAHFNMDES 538

  Fly   484 GILNVTALER-----STNKENKITITNDKGRLSK-----------------EDIERMVNEAEKYR 526
            |:|.:..:|.     ...||.:.|:|.....:|.                 .|.|.:..||.|.:
Zfish   539 GVLILDRVESVFETIVEEKEEESTLTKLGNTISSLFGGGSSEPSANVTEPVTDEEEVTPEAGKEQ 603

  Fly   527 NEDEKQKETIAAK----NGLES------------YCFNM------------KATLDED------- 556
            ::.|||:||:..|    .|.|:            ...|.            :.|.||:
Zfish   604 DQPEKQEETVQEKPETEEGKEAEPQAEEQKEDKEKAENQGETESEKTEKPEEKTTDEEKEADMKP 668

  Fly   557 --NLKTKIS-----DSDRTTILDKCNETIKWLDANQLAD-------KEEYEHRQKELEGVCNPII 607
              ..|:|||     :.:...:||...|.::. ...:|.|       |:|.|.....||.......
Zfish   669 KLQKKSKISADIAVELEVNDVLDPSAEDMEG-SKKKLQDLTDRDLEKQEREKTLNSLEAFIFETQ 732

  Fly   608 TKLYQ 612
            .||||
Zfish   733 DKLYQ 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-4	NP_001262586.1	PTZ00009	1..612	CDD:240227	199/718 (28%)
Hsc70-4	NP_001262586.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	133/389 (34%)
hyou1	NP_997868.1	HSP70	27..705	CDD:278441	190/686 (28%)
		HYOU1-like_NBD	28..414	CDD:212672	131/386 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	558..682		25/123 (20%)
		PTPRCAP	<598..>648	CDD:292341	12/49 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	894..980
		Prevents secretion from ER. /evidence=ECO:0000255	977..980
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810