DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-4 and Hsc70-3

DIOPT Version :9

Sequence 1:	NP_001262586.1	Gene:	Hsc70-4 / 41840	FlyBaseID:	FBgn0266599	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	NP_001285139.1	Gene:	Hsc70-3 / 32133	FlyBaseID:	FBgn0001218	Length:	656	Species:	Drosophila melanogaster

Alignment Length:	623	Identity:	393/623 - (63%)
Similarity:	495/623 - (79%)	Gaps:	9/623 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVAMNPTQTIFDA 70
            :|||||||||||||:::|:|||||||||||.|||||||| |.|||||||||||:..||..|:|||
  Fly    32 IGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTVFDA 96

  Fly    71 KRLIGRKFDDAAVQSDMKHWPFEVVSADGKPKIEVTYKDEKKTFFPEEISSMVLTKMKETAEAYL 135
            ||||||::.|..||.|:|.:||:||..:.||.|.|......|.|.|||||:|||.||||||||||
  Fly    97 KRLIGREWSDTNVQHDIKFFPFKVVEKNSKPHISVDTSQGAKVFAPEEISAMVLGKMKETAEAYL 161

  Fly   136 GKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKAVGERNVLIFDL 200
            ||.||:||:||||||||:|||||||||.||||.|:||||||||||||||||||. ||:|||:|||
  Fly   162 GKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYGLDKKE-GEKNVLVFDL 225

  Fly   201 GGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNKRALRRLRT 265
            ||||||||:|:||:|:|||.:|.|||||||||||.|::.||::.:|:|..||:..:.||:::||.
  Fly   226 GGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKLYKKKKGKDIRKDNRAVQKLRR 290

  Fly   266 ACERAKRTLSSSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMDPVEKALRDAKLDKSV 330
            ..|:|||.||.|.|..|||:|.|||.||..::|||:|||||.||||||:.||:|.|.||.::|..
  Fly   291 EVEKAKRALSGSHQVRIEIESFFEGDDFSETLTRAKFEELNLDLFRSTLKPVQKVLEDADMNKKD 355

  Fly   331 IHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQEVQDLLLLD 395
            :|:||||||||||||||:|::|.|.|||.::.|||||||||||||||.:|.|:  |:...::|||
  Fly   356 VHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAGVLSGE--QDTDAIVLLD 418

  Fly   396 VTPLSLGIETAGGVMSVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFE 460
            |.||::||||.||||:.||.|||.||||::|.|:|.||||..|.||||||||.|||||:|||||:
  Fly   419 VNPLTMGIETVGGVMTKLIPRNTVIPTKKSQVFSTASDNQHTVTIQVYEGERPMTKDNHLLGKFD 483

  Fly   461 LSGIPPAPRGVPQIEVTFDIDANGILNVTALERSTNKENKITITNDKGRLSKEDIERMVNEAEKY 525
            |:||||||||:|||||:|:|||||||.|:|.::.|..:.||.||||:.||:.|||:||:.:|||:
  Fly   484 LTGIPPAPRGIPQIEVSFEIDANGILQVSAEDKGTGNKEKIVITNDQNRLTPEDIDRMIRDAEKF 548

  Fly   526 RNEDEKQKETIAAKNGLESYCFNMKATL-DEDNLKTKISDSDRTTILDKCNETIKWLDANQLADK 589
            .:||:|.||.:.::|.||||.:::|..: |:|.|..|:||.::..:....:|:||||:.|..||.
  Fly   549 ADEDKKLKERVESRNELESYAYSLKNQIGDKDKLGAKLSDDEKNKLESAIDESIKWLEQNPDADP 613

  Fly   590 EEYEHRQKELEGVCNPIITKLYQGAGFPPGGMPGGPGG 627
            |||:.::|:||.:..|:|.||||||    ||.|...||
  Fly   614 EEYKKQKKDLEAIVQPVIAKLYQGA----GGAPPPEGG 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-4	NP_001262586.1	PTZ00009	1..612	CDD:240227	384/606 (63%)
Hsc70-4	NP_001262586.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	256/374 (68%)
Hsc70-3	NP_001285139.1	HSPA5-like_NBD	29..403	CDD:212681	255/371 (69%)
Hsc70-3	NP_001285139.1	PTZ00009	32..643	CDD:240227	390/617 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464232
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	1	1.100	-	-	P	PTHR19375
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.750