DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-4 and Hspa14

DIOPT Version :9

Sequence 1:	NP_001262586.1	Gene:	Hsc70-4 / 41840	FlyBaseID:	FBgn0266599	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	NP_001004257.1	Gene:	Hspa14 / 307133	RGDID:	1303296	Length:	509	Species:	Rattus norvegicus

Alignment Length:	508	Identity:	173/508 - (34%)
Similarity:	288/508 - (56%)	Gaps:	15/508 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTQTIFDA 70
            |:|:.||.|.:||.|::.|:.:::|||.|:|.||:.||:::.|:::|.|||.....|.:.|:...
  Rat     3 AIGVHLGCTSACVAVYKDGRADVVANDAGDRVTPAVVAYSEREQVVGLAAKQSRIRNISSTVVKV 67

  Fly    71 KRLIGRKFDDAAVQSDMKHWPFEVVSADGKPKIEVTYKDEKKTFFPEEISSMVLTKMKETAEAYL 135
            |:::||...|...|..:......|:..:||.:.|:...:|.|...||:::.::.:||||||.:.|
  Rat    68 KQILGRSTADPQAQKYISESKCLVIEKNGKLQYEIDTGEETKLVSPEDVARLIFSKMKETAHSVL 132

  Fly   136 GKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKA-VGERNVLIFD 199
            |....:.|:|||..|.:.|:.|..:|...||.||||:|:||:||.:|||:.:.. .|:.|||:|.
  Rat   133 GSDANDVVVTVPFDFGEKQKSALGEAAGAAGFNVLRLIHEPSAALLAYGIGQDCPTGKSNVLVFK 197

  Fly   200 LGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNKRALRRLR 264
            |||.:..:||:.::.|::.|.||....::||..|.:.|..:...||:|..|.|:..:.||:.:|.
  Rat   198 LGGTSLSLSIMEVNSGMYRVLSTNTSDNIGGVHFTDSLAQYLASEFQRLFKHDVRGSARAMMKLM 262

  Fly   265 TACERAKRTLSSSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMDPVEKALRDAKLDKS 329
            .:.|.||.:||:...|:..:|||:||.||..:::|||||.|.:.||...::.|...|:.:.....
  Rat   263 NSAEVAKHSLSTLGSANCFVDSLYEGQDFDCNVSRARFELLCSPLFNKCIEAVRALLQQSGFTAD 327

  Fly   330 VIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQEVQDLLLL 394
            .|:.:||.|||:|||::|:|::|||...:|..||.|||.:..|||::|.||.|.:|....|.:|:
  Rat   328 DINKVVLCGGSSRIPRLQQLIKDLFPAGDLLNSIPPDEVIPIGAAIEAGILVGKESTSGDDSVLI 392

  Fly   395 DVTP---LSLGIETAG-GVMSVLIKRNTTIPTKQTQTFTTYSDNQPG----VLIQVYEGE-RAMT 450
            :.:.   |..|::.:| ...:||....|.:|.::..|.     ..||    |.:::||.| :...
  Rat   393 ECSARDILVKGVDESGANRFTVLFPSGTPLPARRQHTL-----QAPGSISSVCLELYESEGKNSV 452

  Fly   451 KDNNLLGKFELSGIPPAPRGVPQIEVTFDIDANGILNVTALERSTNKENKITI 503
            |:.....:..|..:.....|:..|.....:..:|.|.||..::.|.|...||:
  Rat   453 KEETKFAQVVLQDLDKKENGLRDILAVLTMKRDGSLQVTCTDQETGKCEAITV 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-4	NP_001262586.1	PTZ00009	1..612	CDD:240227	173/508 (34%)
Hsc70-4	NP_001262586.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	142/375 (38%)
Hspa14	NP_001004257.1	HSPA14-like_NBD	2..376	CDD:212680	140/372 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810