DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-4 and Hsph1

DIOPT Version :9

Sequence 1:	NP_001262586.1	Gene:	Hsc70-4 / 41840	FlyBaseID:	FBgn0266599	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	NP_001011901.1	Gene:	Hsph1 / 288444	RGDID:	1311609	Length:	858	Species:	Rattus norvegicus

Alignment Length:	850	Identity:	231/850 - (27%)
Similarity:	347/850 - (40%)	Gaps:	225/850 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTQTIFDAK 71
            ||:|:|:....:.|.:.|.:|.|||:..:|.|||.::|....|.||.|||||...:...|:...|
  Rat     4 VGLDVGSQSCYIAVARAGGIETIANEFSDRCTPSVISFGPKNRTIGVAAKNQQITHANNTVSSFK 68

  Fly    72 RLIGRKFDDAAVQSDMKHWPFEVV-SADGKPKIEVTYKDEKKTFFPEEISSMVLTKMKETAEAYL 135
            |..||.|:|..:|.:.::..:::| ..:|...|:|.|.||...|..|:|::|:|||:|||||..|
  Rat    69 RFHGRAFNDPFIQKEKENLSYDLVPMKNGGVGIKVMYMDEDHLFSVEQITAMLLTKLKETAENNL 133

  Fly   136 GKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKAVGE-----RNV 195
            .|.||:.||:||::|.|::|::..||..|.|||.||::|:.||.|:.||:.|:.:..     |.|
  Rat   134 KKPVTDCVISVPSFFTDAERRSVLDAAQIVGLNCLRLMNDMTAVALNYGIYKQDLPNADEKPRVV 198

  Fly   196 LIFDLGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNKRAL 260
            :..|:|..:|.||..:.:.|..:|..||.|..|||::||.:||.||..|||.|:|.|..:..|||
  Rat   199 VFVDMGHSSFQVSACAFNKGKLKVLGTAFDPFLGGKNFDEKLVEHFCAEFKTKYKLDAKSKIRAL 263

  Fly   261 RRLRTACERAKRTLSS-STQASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMDPVEKALRDA 324
            .||...||:.|:.:|| ||...:.|:......|....:.|::||||.|:|.:....|:...:...
  Rat   264 LRLHQECEKLKKLMSSNSTDLPLNIECFMNDKDVSAKMNRSQFEELCAELLQKIEVPLHLLMEQT 328

  Fly   325 KLDKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQEVQ 389
            .|....:..|.:|||:||||.|:..:...| ||:::.::|.|||||.|.|:|.|||  ..:.:|:
  Rat   329 HLKTEEVSAIEIVGGATRIPAVKERIARFF-GKDVSTTLNADEAVARGCALQCAIL--SPAFKVR 390

  Fly   390 DLLLLDVTPLSLGI------ETAGGVMSVLIKRNTTIPTKQTQTF---------TTYSDNQ---- 435
            :..:.|..|..:.:      |...||..| ..||...|..:..||         ..|||.|
  Rat   391 EFSVTDAVPFPISLVWNHDSEETEGVHEV-FSRNHAAPFSKVLTFLRRGPFELEAFYSDPQAVPY 454

  Fly   436 PGVLIQVY---------EGERAMTKDN---NLLGKFELS------GIPPAPRGVPQIEV------ 476
            |...|..:         :||::..|..   |..|.|.:|      .:|........:|.
  Rat   455 PEAKIGRFVVQNVSAQKDGEKSKVKVKVRVNTHGIFTISTASMVEKVPTEEEDGSSVEADMECPN 519

  Fly   477 -----TFDIDAN--------GI---LNVTALERS--------TNKENKITITNDKGRLSK----- 512
                 :.|:|.|        |.   :.....:.|        |::||||. ..||....|
  Rat   520 QKPAESSDVDKNIQQDNSEAGTQPQVQTDGQQTSQSPPSPELTSEENKIP-DADKANEKKVDQPP 583

  Fly   513 -------------------------EDIERMVNEAE-KYRNEDEKQKETIAAKNGLESYCFNMK- 550
                                     .|:..|..|.| |...:|:.:||...|||.:|...:..:
  Rat   584 EAKKPKIKVVNVELPVEANLVWQLGRDLLNMYIETEGKMIMQDKLEKERNDAKNAVEECVYEFRD 648

  Fly   551 ---------------------ATLDEDNLKTKISDSDRTTILDKCNETIKW-------------- 580
                                 .|..||.|..:..|..:...:||..|.:|.
  Rat   649 KLCGPYEKFICEQEHEKFLRLLTETEDWLYEEGEDQAKQAYIDKLEELMKMGTPVKVRFQEAEER 713

  Fly   581 ----------------LDANQLADKEEYEH----------------------------------- 594
                            :.|:.....|:|.|
  Rat   714 PRVLEELGQRLQHYAKIAADFRGKDEKYNHIDESEMKKVEKSVNEVMEWMNNVMNAQAKRSLHQD 778

  Fly   595 ----------RQKELEGVCNPIIT---------KLYQGAGFPPGGMPGGPGGMPGAAGAAGAAGA 640
                      :.|||..||.|::|         ||.:        .|.|| .|.......|.:..
  Rat   779 PVVRTHEISAKVKELNNVCEPVVTQPKPKIESPKLER--------TPNGP-NMDKKEDLEGKSNL 834

  Fly   641 GGAGP 645
            |...|
  Rat   835 GADAP 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-4	NP_001262586.1	PTZ00009	1..612	CDD:240227	224/815 (27%)
Hsc70-4	NP_001262586.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	149/380 (39%)
Hsph1	NP_001011901.1	HSPH1_NBD	2..384	CDD:212689	150/382 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..585		15/85 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	801..858		9/47 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810