Protein Alignment Hsc70-4 and Hspa4

DIOPT Version :10

• Sequence 1: NP_524356.1
• Gene: Hsc70-4 / 41840
• FlyBaseID: FBgn0266599
• Length: 651
• Species: Drosophila melanogaster
• Sequence 2: NP_705893.1
• Gene: Hspa4 / 266759
• RGDID: 628878
• Length: 840
• Species: Rattus norvegicus
• Alignment Length: 846
• Identity: 224/846 - (26%)
• Similarity: 365/846 - (43%)
• Gaps: 212/846 - (25%)

  Fly     7 VGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTQTIFDAK 71
            ||||||.....|.|.:.|.:|.|||:..:|.||:.|:|....|.:|.|||:||..|...|:...|
  Rat     4 VGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACVSFGPKNRSVGAAAKSQVISNAKNTVQGFK 68

  Fly    72 RLIGRKFDDAAVQSDMKHWPFEVVS-ADGKPKIEVTYKDEKKTFFPEEISSMVLTKMKETAEAYL 135
            |..||.|.|..|:::..:..:::|. ..|...|:|||.:|::.|..|::::|:|:|:|||||:.|
  Rat    69 RFHGRAFSDPFVEAEKSNLAYDIVQLPTGLTGIKVTYMEEERNFTTEQVTAMLLSKLKETAESVL 133

  Fly   136 GKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGL---DKKAVGE--RNV 195
            .|.|.:.|::||:::.|::|::..||..|||||.||::||.||.|:|||:   |..|:.|  |||
  Rat   134 KKPVVDCVVSVPSFYTDAERRSVMDATQIAGLNCLRLMNETTAVALAYGIYKQDLPALEEKPRNV 198

  Fly   196 LIFDLGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNKRAL 260
            :..|:|...:.||:.:.:.|..:|.:||.||.|||..||..||.||.:||.:|:|.|:.:..|||
  Rat   199 VFVDMGHSAYQVSVCAFNRGKLKVLATAFDTTLGGRKFDEVLVNHFCEEFGKKYKLDIKSKVRAL 263

  Fly   261 RRLRTACERAKRTLS-SSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMDPVEKALRDA 324
            .||...||:.|:.:| :::...:.|:......|...::.|.:|.|:..||......|:...|..:
  Rat   264 LRLSQECEKLKKLMSANASDLPLSIECFMNDIDVSGTMNRGKFLEMCDDLLARVEPPLRSILDQS 328

  Fly   325 KLDKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQEVQ 389
            ||.|..|:.:.:|||:||||.|:..:...| ||||:.::|.||||..|.|:|.|||  ..:.:|:
  Rat   329 KLKKEDIYAVEIVGGATRIPAVKEKISKFF-GKELSTTLNADEAVTRGCALQCAIL--SPAFKVR 390

  Fly   390 DLLLLDVTPLSLGIE-----TAGGVMSVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAM 449
            :..:.||.|..:.:.     ..|.....:..:|...|..:..||..   .:|..|...|...:.:
  Rat   391 EFSITDVVPYPISLRWNSPAEEGSSDCEVFPKNHAAPFSKVLTFYR---KEPFTLEAYYSSPQDL 452

  Fly   450 TKDNNLLGKFELSGIPPAPRG-VPQIEVTFDIDANGILNVTA---LERSTNKENKITITNDKGRL 510
            ...:..:.:|.:..:.|...| ..:::|...::.:||.:|::   :|...::|::..:..|:.
  Rat   453 PYPDPAIAQFSVQKVTPQSDGSSSKVKVKVRVNVHGIFSVSSAALVEVHKSEESEEPMETDQN-- 515

  Fly   511 SKEDIERMVNEAEKYRNE----------------------------------------------- 528
            :||:.:..|::.|.:..|
  Rat   516 AKEEEKMQVDQEEPHTEEQQPQTPAENKAESEEMETSQAGSKDKKMDQPPQAKKAKVKTSTVDLP 580

  Fly   529 ---------------------------DEKQKETIAAKNGLESYCFNMKATL-----------DE 555
                                       |:.:||...|||.:|.|.:.|:..|           |.
  Rat   581 IESQLLWQLDREMLGLYTENEGKMIMQDKLEKERNDAKNAVEEYVYEMRDKLSGEYEKFVSEDDR 645

  Fly   556 DNLKTKISD-------------------------------------------------------- 564
            :|...|:.|
  Rat   646 NNFTLKLEDTENWLYEDGEDQPKQVYVDKLAELRTLGQPIKTRFQESEERPKLFEELGKQIQQYM 710

  Fly   565 ------------------SDRTTILDKCNETIKW------------LDANQLADKEEYEHRQKEL 599
                              :|.|.:....||.::|            |.|:.:...:|.|.:.|||
  Rat   711 KVISSFKNKEDQYEHLDAADMTKVEKSTNEAMEWMNSKLNLQNKQSLTADPVVKTKEIEAKIKEL 775

  Fly   600 EGVCNPIITKLYQGAGFPP---------GGMPGGPGGMPGAAGAAGAAGAGGAGPT-----IEEV 650
            ..:|:|||:|...... ||         .|...|.|..||.  .|...||..|.|:     :.|:
  Rat   776 TNICSPIISKPKPKVE-PPKEEPKHAEQNGPVDGQGDNPGT--QAAEHGADTAVPSDGDKKLPEM 837

  Fly   651 D 651
            |
  Rat   838 D 838

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-4	NP_524356.1	PTZ00009	1..612	CDD:240227	210/791 (27%)
Hspa4	NP_705893.1	ASKHA_NBD_HSP70_HSPA4	2..382	CDD:466843	149/378 (39%)
		PTZ00121	<499..743	CDD:173412	26/245 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	500..575		7/76 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	781..840		18/61 (30%)