Protein Alignment Hsc70-4 and HSPA12A

DIOPT Version :9

• Sequence 1: NP_001262586.1
• Gene: Hsc70-4 / 41840
• FlyBaseID: FBgn0266599
• Length: 651
• Species: Drosophila melanogaster
• Sequence 2: NP_001317093.1
• Gene: HSPA12A / 259217
• HGNCID: 19022
• Length: 692
• Species: Homo sapiens
• Alignment Length: 668
• Identity: 144/668 - (21%)
• Similarity: 241/668 - (36%)
• Gaps: 227/668 - (33%)

  Fly     7 VGIDLGTTYS-----------CVGVFQHGKVEIIANDQG--NRTTPSYVAFTDTERL--IGDAAK 56
            |.:|.|||.|           |:.|.:..:    ..|.|  |:.||:.:..|...:.  .|.||:
Human    76 VAVDFGTTSSGYAYSFTKEPECIHVMRRWE----GGDPGVSNQKTPTTILLTPERKFHSFGYAAR 136

  Fly    57 N-QVAMNPTQTIFDAKR-LIGRKF-------DDAAVQSDMKHWPFEVVSADGKPKIEVTYKDEKK 112
            : ...::|.    :||: |...||       .|..:.:|:       .:|:|| |::..
Human   137 DFYHDLDPN----EAKQWLYLEKFKMKLHTTGDLTMDTDL-------TAANGK-KVKAL------ 183

  Fly   113 TFFPEEISSMVLTKMKETAEAYL----GKTVTNA----VITVPAYFNDSQRQATKDAGTIAGL-- 167
                 ||.:..|...||.|...|    |....|:    ||||||.:....:|..:.|...|||
Human   184 -----EIFAYALQYFKEQALKELSDQAGSEFENSDVRWVITVPAIWKQPAKQFMRQAAYQAGLAS 243

  Fly   168 ----NVLRIINEPTAAAI---------AYGLDKKAV----------------------------- 190
                ..|.|..||.||:|         ...|..||.
Human   244 PENSEQLIIALEPEAASIYCRKLRLHQMIELSSKAAVNGYSGSDTVGAGFTQAKEHIRRNRQSRT 308

  Fly   191 ----------------GERNVLIFDLGGGTFDVSI--LSIDDGIFE--VKSTAGDTHLGGEDFDN 235
                            |::.|:: |.||||.|:::  :.:.:|..:  .|:|.|.....|.|::.
Human   309 FLVENVIGEIWSELEEGDKYVVV-DSGGGTVDLTVHQIRLPEGHLKELYKATGGPYGSLGVDYEF 372

  Fly   236 RLVTH------FVQEFKRKHKKDLTTNKRALRRLRTACERAKRTLSSSTQASIEIDSLFEGTDFY 294
            ..:.:      |:::||.|       ...|...|..|.|..||..:......:.|...|...|:|
Human   373 EKLLYKIFGEDFIEQFKIK-------RPAAWVDLMIAFESRKRAAAPDRTNPLNITLPFSFIDYY 430

  Fly   295 ------------------------TSITRARFEELNADLFRSTMDPVEKALRD--AKLDKSVIHD 333
                                    ..:.|...:.:|| ||:.|:|.:.:.|||  .|.:.|.:..
Human   431 KKFRGHSVEHALRKSNVDFVKWSSQGMLRMSPDAMNA-LFKPTIDSIIEHLRDLFQKPEVSTVKF 494

  Fly   334 IVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQEVQDLLLLDV-- 396
            :.||||....|.:|:.:|..| |.:....|..|..:   ..::.|:|.|      .|..::.|
Human   495 LFLVGGFAEAPLLQQAVQAAF-GDQCRIIIPQDVGL---TILKGAVLFG------LDPAVIKVRR 549

  Fly   397 TPLSLGIETAGGVMS-----------VLIKRNTT---------IPTKQT--------QTFTTYSD 433
            :||:.|:    ||::           :|:|..|.         |...|:        :::|....
Human   550 SPLTYGV----GVLNRYVEGKHPPEKLLVKDGTRWCTDVFDKFISADQSVALGELVKRSYTPAKP 610

  Fly   434 NQPGVLIQVYEGER---------AMTKDNNLLGKFELSGIP----PAPRGVPQIEVTFDIDANGI 485
            :|..::|.:|..|.         .:.|...|  :.:|:|..    ||.|.:..:....|.:
Human   611 SQLVIVINIYSSEHDNVSFITDPGVKKCGTL--RLDLTGTSGTAVPARREIQTLMQFGDTE---- 669

  Fly   486 LNVTALERSTNKENKITI 503
            :..||::.:|:|..|:.|
Human   670 IKATAIDIATSKSVKVGI 687

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-4	NP_001262586.1	PTZ00009	1..612	CDD:240227	144/668 (22%)
		HSPA1-2_6-8-like_NBD	6..381	CDD:212675	111/501 (22%)
HSPA12A	NP_001317093.1	HSPA12A_like_NBD	74..540	CDD:212685	113/509 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810