DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsc70-4 and Hspa5

DIOPT Version :10

Sequence 1:NP_524356.1 Gene:Hsc70-4 / 41840 FlyBaseID:FBgn0266599 Length:651 Species:Drosophila melanogaster
Sequence 2:NP_037215.1 Gene:Hspa5 / 25617 RGDID:2843 Length:654 Species:Rattus norvegicus


Alignment Length:617 Identity:401/617 - (64%)
Similarity:499/617 - (80%) Gaps:6/617 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 VGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVAMNPTQTIFDA 70
            |||||||||||||||::|:|||||||||||.|||||||| :.|||||||||||:..||..|:|||
  Rat    31 VGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDA 95

  Fly    71 KRLIGRKFDDAAVQSDMKHWPFEVVSADGKPKIEVTY-KDEKKTFFPEEISSMVLTKMKETAEAY 134
            ||||||.::|.:||.|:|..||:||....||.|:|.. ..:.|||.|||||:|||||||||||||
  Rat    96 KRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAY 160

  Fly   135 LGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKAVGERNVLIFD 199
            |||.||:||:||||||||:||||||||||||||||:|||||||||||||||||:. ||:|:|:||
  Rat   161 LGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKRE-GEKNILVFD 224

  Fly   200 LGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNKRALRRLR 264
            |||||||||:|:||:|:|||.:|.|||||||||||.|::.||::.:|:|..||:..:.||:::||
  Rat   225 LGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKLR 289

  Fly   265 TACERAKRTLSSSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMDPVEKALRDAKLDKS 329
            ...|:|||.|||..||.|||:|.|||.||..::|||:|||||.|||||||.||:|.|.|:.|.||
  Rat   290 REVEKAKRALSSQHQARIEIESFFEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKKS 354

  Fly   330 VIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQEVQDLLLL 394
            .|.:||||||||||||:|:|:::.|||||.::.|||||||||||||||.:|.||  |:..||:||
  Rat   355 DIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGD--QDTGDLVLL 417

  Fly   395 DVTPLSLGIETAGGVMSVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKF 459
            ||.||:|||||.||||:.||.|||.:|||::|.|:|.|||||.|.|:||||||.:||||:|||.|
  Rat   418 DVCPLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLGTF 482

  Fly   460 ELSGIPPAPRGVPQIEVTFDIDANGILNVTALERSTNKENKITITNDKGRLSKEDIERMVNEAEK 524
            :|:||||||||||||||||:||.||||.|||.::.|..:||||||||:.||:.|:||||||:|||
  Rat   483 DLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIERMVNDAEK 547

  Fly   525 YRNEDEKQKETIAAKNGLESYCFNMKATL-DEDNLKTKISDSDRTTILDKCNETIKWLDANQLAD 588
            :..||:|.||.|..:|.||||.:::|..: |::.|..|:|..|:.|:.....|.|:||:::|.||
  Rat   548 FAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSPEDKETMEKAVEEKIEWLESHQDAD 612

  Fly   589 KEEYEHRQKELEGVCNPIITKLYQGAGFPPGG 620
            .|:::.::||||.:..|||:|||...|.||.|
  Rat   613 IEDFKAKKKELEEIVQPIISKLYGSGGPPPTG 644

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsc70-4NP_524356.1 PTZ00009 1..612 CDD:240227 396/607 (65%)
Hspa5NP_037215.1 Required for interaction with ELAPOR1. /evidence=ECO:0000250|UniProtKB:P11021 1..80 41/48 (85%)
HSP70 30..635 CDD:394970 395/606 (65%)
Nucleotide-binding (NBD). /evidence=ECO:0000250|UniProtKB:P11021 125..280 114/155 (74%)
Interdomain linker. /evidence=ECO:0000250|UniProtKB:G3I8R9 409..419 5/9 (56%)
Substrate-binding (SBD). /evidence=ECO:0000250|UniProtKB:P11021 420..500 57/79 (72%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 631..654 8/14 (57%)
Prevents secretion from ER 651..654
Blue background indicates that the domain is not in the aligned region.

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