DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-4 and SPAC57A7.12

DIOPT Version :9

Sequence 1:	NP_001262586.1	Gene:	Hsc70-4 / 41840	FlyBaseID:	FBgn0266599	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	NP_593369.1	Gene:	SPAC57A7.12 / 2542131	PomBaseID:	SPAC57A7.12	Length:	566	Species:	Schizosaccharomyces pombe

Alignment Length:	534	Identity:	144/534 - (26%)
Similarity:	265/534 - (49%)	Gaps:	59/534 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTQTIFDAK 71
            :||..|...|.:...:.||.:::||::|||..||.:::...:...|..|:.|:..|...::.:.:
pombe    27 IGISFGNQNSSIAFNRDGKTDVLANEEGNRQIPSILSYHGDQEYHGVQARGQLVRNADNSVTNFR 91

  Fly    72 RLIGRKFDDAAVQSDMKHWPFEVVSADGKPKIEVTYKDE------KKTFFPEEISSMVLTKMKET 130
            .|:|:..|:..:..  .|:....|:.:|:...::|.:::      :|.....|.|...|.::.|:
pombe    92 DLLGKSHDELTLHH--CHYSANPVNVEGQIGFKITVQEDEESDPKEKILTAHEASVRHLRRLTES 154

  Fly   131 AEAYLGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKAVGERNV 195
            ||.:||..|...|::||.||.|:||:|.:.|...|||.||::|::|.|..:|....::.:.::.|
pombe   155 AEDFLGTKVNGCVMSVPVYFTDAQRKALESAANEAGLPVLQLIHDPAAVILALMYSEEVLIDKTV 219

  Fly   196 LIFDLGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNKRAL 260
            ::.:.|....:||::|:..|:..:.::..|.:||||...:.||..|.:||::|:..|...|.|:|
pombe   220 VVANFGATRSEVSVVSVKGGLMTILASVHDENLGGEQLTDVLVNFFAKEFEKKNGIDPRKNARSL 284

  Fly   261 RRLRTACERAKRTLSSSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMDPVEKALRDAK 325
            .:||..||..||.||:.|.||..:|||.:|.||::||.|.|::...:.......|.|.:|:..|.
pombe   285 AKLRAQCEITKRVLSNGTTASAAVDSLADGIDFHSSINRLRYDLAASATLNRMADLVTEAVEKAN 349

  Fly   326 LDKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKS--------INPDEAVAYGAAVQAAIL-H 381
            ::...|.:::|.||::..||:..|::.:|..:.:.:|        ::|.|..|.|:.|||::: |
pombe   350 MEPFDISEVILAGGASNTPKLTSLMESIFPEQTIIRSSSSVTPLQLDPSELTAIGSGVQASLIGH 414

  Fly   382 GDKSQ--EVQDLLLLDVTPLS--LGIETAGGVMSVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQV 442
            .|.:.  ...|..::||..|:  :||......::: ....|.:|.:  :|....:..:....|.:
pombe   415 FDAADIAASTDAQVVDVPHLTAPIGINEGENFVTI-FDIETALPAR--KTVEVIAPKEGAAFIPI 476

  Fly   443 YEGERA--MTK-----------------------------DNNLLGKFELSGIPPAPRGVPQIEV 476
            ||.||:  :||                             ...|:....|..:.|..:    ||:
pombe   477 YEAERSVKVTKVEPEPIDEEEAFSDDEEEEPEEIKERIAIPKTLIATITLPDVSPNAK----IEL 537

  Fly   477 TFDIDANGILNVTA 490
            ...|||.|.|..:|
pombe   538 VLQIDAEGKLTASA 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-4	NP_001262586.1	PTZ00009	1..612	CDD:240227	144/534 (27%)
Hsc70-4	NP_001262586.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	115/388 (30%)
SPAC57A7.12	NP_593369.1	DnaK	22..554	CDD:223520	144/534 (27%)
SPAC57A7.12	NP_593369.1	ScSsz1p_like_NBD	25..410	CDD:212674	114/384 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810