DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-4 and sks2

DIOPT Version :9

Sequence 1:	NP_001262586.1	Gene:	Hsc70-4 / 41840	FlyBaseID:	FBgn0266599	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	NP_595438.1	Gene:	sks2 / 2540199	PomBaseID:	SPBC1709.05	Length:	613	Species:	Schizosaccharomyces pombe

Alignment Length:	583	Identity:	359/583 - (61%)
Similarity:	445/583 - (76%)	Gaps:	4/583 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTQTIFDA 70
            |:|||||||||||.|::...||||.||||.|||||:||||:||||:|||||||.||||..|:|||
pombe     8 AIGIDLGTTYSCVAVWETANVEIIPNDQGARTTPSFVAFTETERLVGDAAKNQAAMNPRNTVFDA 72

  Fly    71 KRLIGRKFDDAAVQSDMKHWPFEVVSADGKPKIEVTYKDEKKTFFPEEISSMVLTKMKETAEAYL 135
            ||||||:::|...|.|:|||||:|:..:|.|.|||.|..|||.|..:|||:||||||||.:||.|
pombe    73 KRLIGRRYEDPETQKDIKHWPFKVIDNNGIPTIEVNYLGEKKQFTAQEISAMVLTKMKEISEAKL 137

  Fly   136 GKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKAVGERNVLIFDL 200
            .|.|..|||||||||:||||.||||||.|||||||||||||||||||||||.|:...:|||||||
pombe   138 NKRVEKAVITVPAYFSDSQRAATKDAGAIAGLNVLRIINEPTAAAIAYGLDAKSDKPKNVLIFDL 202

  Fly   201 GGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNKRALRRLRT 265
            ||||||||:|.|..|:|||.:||||||||||||||.||.||:||||||.|.|::.:.|||||||:
pombe   203 GGGTFDVSLLKIQGGVFEVLATAGDTHLGGEDFDNALVEHFIQEFKRKQKIDISDDPRALRRLRS 267

  Fly   266 ACERAKRTLSSSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMDPVEKALRDAKLDKSV 330
            |||||||.|||.||.::|:|||..|.||.:||||||||::||..|::|:|||.|.|:|:|:.|:.
pombe   268 ACERAKRALSSVTQTTVEVDSLSNGIDFSSSITRARFEDINATTFKATIDPVAKVLKDSKVPKAD 332

  Fly   331 IHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAIL-HGDKSQEVQDLLLL 394
            :||||||||||||||||||:.|.|:|:.||||||||||||||||||||:| :...|.:.||||||
pombe   333 VHDIVLVGGSTRIPKVQRLVSDFFDGRALNKSINPDEAVAYGAAVQAAVLTNKADSDKTQDLLLL 397

  Fly   395 DVTPLSLGIETAGGVMSVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKF 459
            ||.|||||:...|.|..|:..|||.|||.:.:||||.:|||..|...||:|||....:|..||:|
pombe   398 DVVPLSLGVAMEGNVFGVVCPRNTPIPTIKKRTFTTVADNQTTVTFPVYQGERVNCAENEPLGEF 462

  Fly   460 ELSGIPPAPRGVPQIEVTFDIDANGILNVTALERSTNKENKITITNDKGRLSKEDIERMVNEAEK 524
            :|:||||.|||..::|.||::||||||.|||:|::|.:...|.|||..|.||...|:.|:..|:|
pombe   463 QLTGIPPMPRGQAELEATFELDANGILKVTAVEKTTGRSAHIEITNSVGHLSSTKIQEMIENADK 527

  Fly   525 YRNEDEKQKETIAAKNGLESYCFNMKATLDEDNLKTKISDSDRTTI---LDKCNETIKWLDAN 584
            ::.:|:...:.:.||:.||||..|::.|:.|.|:..|:...|::.|   |.:|...::..|.|
pombe   528 FKQQDKDFAKKLEAKSQLESYISNIETTISEPNVMMKLKRGDKSKIEAQLAECMSQLELEDTN 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-4	NP_001262586.1	PTZ00009	1..612	CDD:240227	359/583 (62%)
Hsc70-4	NP_001262586.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	268/375 (71%)
sks2	NP_595438.1	HSP70	8..613	CDD:278441	359/583 (62%)
		HSPA1-2_6-8-like_NBD	8..383	CDD:212675	267/374 (71%)
		BAR	<503..>603	CDD:299863	29/88 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.670