DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-4 and ssa2

DIOPT Version :9

Sequence 1:	NP_001262586.1	Gene:	Hsc70-4 / 41840	FlyBaseID:	FBgn0266599	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	NP_588421.1	Gene:	ssa2 / 2539225	PomBaseID:	SPCC1739.13	Length:	647	Species:	Schizosaccharomyces pombe

Alignment Length:	652	Identity:	495/652 - (75%)
Similarity:	562/652 - (86%)	Gaps:	6/652 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSKAPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTQ 65
            |||  ::||||||||||||.|.:.:||||||||||||||||||||||||||||||||||||||..
pombe     1 MSK--SIGIDLGTTYSCVGHFSNNRVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPHN 63

  Fly    66 TIFDAKRLIGRKFDDAAVQSDMKHWPFEVVSADGKPKIEVTYKDEKKTFFPEEISSMVLTKMKET 130
            |||||||||||||||..||||||||||:|:|.||||.::|.||.|.|||.|||||||||.||:||
pombe    64 TIFDAKRLIGRKFDDPEVQSDMKHWPFKVISKDGKPVLQVEYKGETKTFTPEEISSMVLMKMRET 128

  Fly   131 AEAYLGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKAVGERNV 195
            ||||||..||:||:||||||||||||||||||.|||||||||||||||||||||||:...||.||
pombe   129 AEAYLGGKVTDAVVTVPAYFNDSQRQATKDAGLIAGLNVLRIINEPTAAAIAYGLDRSNQGESNV 193

  Fly   196 LIFDLGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNKRAL 260
            |||||||||||||:|:|::||||||:|||||||||||||:|||.||:||||||:|||:|.|.||:
pombe   194 LIFDLGGGTFDVSLLTIEEGIFEVKATAGDTHLGGEDFDSRLVNHFIQEFKRKNKKDITGNARAV 258

  Fly   261 RRLRTACERAKRTLSSSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMDPVEKALRDAK 325
            |||||||||||||||||.||||||||||||.||||||||||||||.|||||.||:|||:.|||:|
pombe   259 RRLRTACERAKRTLSSSAQASIEIDSLFEGIDFYTSITRARFEELCADLFRKTMEPVERVLRDSK 323

  Fly   326 LDKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQEVQD 390
            :||:.:::|||||||||||:||:|:.|.|||||..||||||||||||||||||:|.||.|::.||
pombe   324 VDKASVNEIVLVGGSTRIPRVQKLVSDFFNGKEPCKSINPDEAVAYGAAVQAAVLTGDTSEKTQD 388

  Fly   391 LLLLDVTPLSLGIETAGGVMSVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNL 455
            ||||||.|||:|||||||||:.|||||||||||:::.|:|||||||||||||:|||||.|||.||
pombe   389 LLLLDVAPLSMGIETAGGVMTPLIKRNTTIPTKKSEIFSTYSDNQPGVLIQVFEGERARTKDCNL 453

  Fly   456 LGKFELSGIPPAPRGVPQIEVTFDIDANGILNVTALERSTNKENKITITNDKGRLSKEDIERMVN 520
            ||||||||||||||||||||||||:||||||||:|||:.|.|..||||||||||||||:|:|||.
pombe   454 LGKFELSGIPPAPRGVPQIEVTFDVDANGILNVSALEKGTGKTQKITITNDKGRLSKEEIDRMVA 518

  Fly   521 EAEKYRNEDEKQKETIAAKNGLESYCFNMKATLDEDNLKTKISDSDRTTILDKCNETIKWLDANQ 585
            |||||:.|||.:...|.|||.||||.::::.:||:.|||.|:..||:.|:.....|||:|||:|.
pombe   519 EAEKYKAEDEAESGRIQAKNHLESYAYSLRNSLDDPNLKDKVDASDKETVDKAVKETIEWLDSNT 583

  Fly   586 LADKEEYEHRQKELEGVCNPIITKLYQGAGFPPGGMPG-GPGGMPGAAGAAGAAGAGGAGPTIEE 649
            .|.|:|:|.:|||||.|.|||:.|:|| ||..|||||| .||..|||  |.|||..|..||.:||
pombe   584 TAAKDEFEAKQKELESVANPIMAKIYQ-AGGAPGGMPGAAPGAAPGA--APGAAPGGDNGPEVEE 645

  Fly   650 VD 651
            ||
pombe   646 VD 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-4	NP_001262586.1	PTZ00009	1..612	CDD:240227	469/610 (77%)
Hsc70-4	NP_001262586.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	306/374 (82%)
ssa2	NP_588421.1	PTZ00009	4..647	CDD:240227	490/645 (76%)
ssa2	NP_588421.1	HSPA1-2_6-8-like_NBD	4..379	CDD:212675	306/374 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	824	1.000	Domainoid score	I2
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	964	1.000	Inparanoid score	I43
OMA	1	1.010	-	-		QHG53894
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	1	1.000	-	-		mtm9261
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	1	1.100	-	-	O	PTHR19375
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R573
SonicParanoid	1	1.000	-	-		X148
TreeFam	1	0.960	-	-
	13	12.860