DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsc70-4 and Hspa8

DIOPT Version :9

Sequence 1:NP_001262586.1 Gene:Hsc70-4 / 41840 FlyBaseID:FBgn0266599 Length:651 Species:Drosophila melanogaster
Sequence 2:NP_077327.1 Gene:Hspa8 / 24468 RGDID:621725 Length:646 Species:Rattus norvegicus


Alignment Length:654 Identity:555/654 - (84%)
Similarity:600/654 - (91%) Gaps:11/654 - (1%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSKAPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTQ 65
            |||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.
  Rat     1 MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTN 65

  Fly    66 TIFDAKRLIGRKFDDAAVQSDMKHWPFEVVSADGKPKIEVTYKDEKKTFFPEEISSMVLTKMKET 130
            |:|||||||||:||||.||||||||||.||:..|:||::|.||.|.|:|:|||:||||||||||.
  Rat    66 TVFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEI 130

  Fly   131 AEAYLGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKAVGERNV 195
            |||||||||||||:||||||||||||||||||||||||||||||||||||||||||||...||||
  Rat   131 AEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNV 195

  Fly   196 LIFDLGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNKRAL 260
            |||||||||||||||:|:|||||||||||||||||||||||:|.||:.|||||||||::.||||:
  Rat   196 LIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAV 260

  Fly   261 RRLRTACERAKRTLSSSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMDPVEKALRDAK 325
            |||||||||||||||||||||||||||:||.||||||||||||||||||||.|:|||||||||||
  Rat   261 RRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAK 325

  Fly   326 LDKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQEVQD 390
            ||||.|||||||||||||||:|:||||.|||||||||||||||||||||||||||.||||:.|||
  Rat   326 LDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQD 390

  Fly   391 LLLLDVTPLSLGIETAGGVMSVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNL 455
            ||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||
  Rat   391 LLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNL 455

  Fly   456 LGKFELSGIPPAPRGVPQIEVTFDIDANGILNVTALERSTNKENKITITNDKGRLSKEDIERMVN 520
            ||||||:||||||||||||||||||||||||||:|:::||.|||||||||||||||||||||||.
  Rat   456 LGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQ 520

  Fly   521 EAEKYRNEDEKQKETIAAKNGLESYCFNMKATLDEDNLKTKISDSDRTTILDKCNETIKWLDANQ 585
            |||||:.|||||::.:::||.||||.||||||::::.|:.||:|.|:..|||||||.|.|||.||
  Rat   521 EAEKYKAEDEKQRDKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIISWLDKNQ 585

  Fly   586 LADKEEYEHRQKELEGVCNPIITKLYQGAGFPPGGMPGG-PGGMPGAAGAAGAAGAGGA--GPTI 647
            .|:|||:||:|||||.|||||||||||.||..||||||| |||        ||..:|||  ||||
  Rat   586 TAEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPGGFPGG--------GAPPSGGASSGPTI 642

  Fly   648 EEVD 651
            ||||
  Rat   643 EEVD 646

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsc70-4NP_001262586.1 PTZ00009 1..612 CDD:240227 528/610 (87%)
HSPA1-2_6-8-like_NBD 6..381 CDD:212675 334/374 (89%)
Hspa8NP_077327.1 PTZ00009 1..613 CDD:240227 529/611 (87%)
Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142 2..386 341/383 (89%)
Interaction with BAG1. /evidence=ECO:0000250 186..377 169/190 (89%)
Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142 394..509 107/114 (94%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 614..646 23/39 (59%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 1055 1.000 Domainoid score I23
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1101 1.000 Inparanoid score I218
OMA 1 1.010 - - QHG53894
OrthoDB 1 1.010 - - D180577at33208
OrthoFinder 1 1.000 - - FOG0000049
OrthoInspector 1 1.000 - - otm45832
orthoMCL 1 0.900 - - OOG6_100083
Panther 1 1.100 - - LDO PTHR19375
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X148
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1312.880

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