Protein Alignment Hsc70-4 and HSPA4L

DIOPT Version :10

• Sequence 1: NP_524356.1
• Gene: Hsc70-4 / 41840
• FlyBaseID: FBgn0266599
• Length: 651
• Species: Drosophila melanogaster
• Sequence 2: NP_001304310.1
• Gene: HSPA4L / 22824
• HGNCID: 17041
• Length: 870
• Species: Homo sapiens
• Alignment Length: 822
• Identity: 215/822 - (26%)
• Similarity: 351/822 - (42%)
• Gaps: 205/822 - (24%)

  Fly     7 VGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTQTIFDAK 71
            ||||||.....:.|.:.|.:|.|||:..:|.||:.::.....|.||:|||:|:..|...||...|
Human    35 VGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTNVRNTIHGFK 99

  Fly    72 RLIGRKFDDAAVQSDMKHWPFEVVS-ADGKPKIEVTYKDEKKTFFPEEISSMVLTKMKETAEAYL 135
            :|.||.|||..||::....|:|:.. .:|...::|.|.:|::.|..|:::.|:|.|:|||:|..|
Human   100 KLHGRSFDDPIVQTERIRLPYELQKMPNGSAGVKVRYLEEERPFAIEQVTGMLLAKLKETSENAL 164

  Fly   136 GKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYG--------LDKKAVGE 192
            .|.|.:.||::|::|.|::|::...|..:||||.||::||.||.|:|||        ||:|   .
Human   165 KKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALAYGIYKQDLPPLDEK---P 226

  Fly   193 RNVLIFDLGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNK 257
            |||:..|:|...:.|.:.:.:.|..:|.:|..|.:|||.:||..||.:|..|||.|:|.::..|.
Human   227 RNVVFIDMGHSAYQVLVCAFNKGKLKVLATTFDPYLGGRNFDEALVDYFCDEFKTKYKINVKENS 291

  Fly   258 RALRRLRTACERAKRTLS-SSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMDPVEKAL 321
            |||.||...||:.|:.:| :::...:.|:......|..:.:.||:||:|.|.|......|::..:
Human   292 RALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSKMNRAQFEQLCASLLARVEPPLKAVM 356

  Fly   322 RDAKLDKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQ 386
            ..|.|.:..|..|.:|||:||||.|:..:...|. |:::.::|.|||||.|.|:|.|||  ..:.
Human   357 EQANLQREDISSIEIVGGATRIPAVKEQITKFFL-KDISTTLNADEAVARGCALQCAIL--SPAF 418

  Fly   387 EVQDLLLLDVTPLSL------GIETAGGVMSVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEG 445
            :|::..:.|:.|.|:      ..|...|...|..| |...|..:..||   ...:|..|...|..
Human   419 KVREFSITDLVPYSITLRWKTSFEDGSGECEVFCK-NHPAPFSKVITF---HKKEPFELEAFYTN 479

  Fly   446 ERAMTKDNNLLGKFELSGIPPAPRG-VPQIEVTFDIDANGILNVTA--------LE--------- 492
            ...:...:..:|.|.:..:.|...| ..:::|...::.:||.:|.:        ||
Human   480 LHEVPYPDARIGSFTIQNVFPQSDGDSSKVKVKVRVNIHGIFSVASASVIEKQNLEGDHSDAPME 544

  Fly   493 -----RSTNKEN--KITITNDKG------------------------------------------ 508
                 ::.||:|  |:.:..::|
Human   545 TETSFKNENKDNMDKMQVDQEEGHQKCHAEHTPEEEIDHTGAKTKSAVSDKQDRLNQTLKKGKVK 609

  Fly   509 ------------RLSKEDIERMVNEAEKYRNEDEKQKETIAAKNGLESYCFNMKATL-------- 553
                        :|.::.:...:....|...:|:.:||...|||.:|.|.::.:..|
Human   610 SIDLPIQSSLCRQLGQDLLNSYIENEGKMIMQDKLEKERNDAKNAVEEYVYDFRDRLGTVYEKFI 674

  Fly   554 ---DEDNLKTKISDSD-----------RTTILDKCNE--------TIKWLD-------ANQLADK 589
               |...|...:.|::           :...:||..|        .:|:::       .|.|..|
Human   675 TPEDLSKLSAVLEDTENWLYEDGEDQPKQVYVDKLQELKKYGQPIQMKYMEHEERPKALNDLGKK 739

  Fly   590 ---------------EEYEH--------------------------------------------- 594
                           |.|:|
Human   740 IQLVMKVIEAYRNKDERYDHLDPTEMEKVEKCISDAMSWLNSKMNAQNKLSLTQDPVVKVSEIVA 804

  Fly   595 RQKELEGVCNPIITKLYQGAGFP---PGGMPGGPGGMPGAAG 633
            :.|||:..|||||.|....|..|   |.......|.|.|.:|
Human   805 KSKELDNFCNPIIYKPKPKAEVPEDKPKANSEHNGPMDGQSG 846

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-4	NP_524356.1	PTZ00009	1..612	CDD:240227	208/796 (26%)
HSPA4L	NP_001304310.1	ASKHA_NBD_HSP70_HSPA4L	33..415	CDD:466844	145/385 (38%)