Protein Alignment Hsc70-4 and Hspa4l

DIOPT Version :9

• Sequence 1: NP_001262586.1
• Gene: Hsc70-4 / 41840
• FlyBaseID: FBgn0266599
• Length: 651
• Species: Drosophila melanogaster
• Sequence 2: NP_035150.3
• Gene: Hspa4l / 18415
• MGIID: 107422
• Length: 838
• Species: Mus musculus
• Alignment Length: 825
• Identity: 221/825 - (26%)
• Similarity: 350/825 - (42%)
• Gaps: 209/825 - (25%)

  Fly     7 VGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTQTIFDAK 71
            ||||||.....:.|.:.|.:|.|||:..:|.||:.::.....|.||:|||:|:..|...||...|
Mouse     4 VGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTNVRNTIHGFK 68

  Fly    72 RLIGRKFDDAAVQSDMKHWPFEVVS-ADGKPKIEVTYKDEKKTFFPEEISSMVLTKMKETAEAYL 135
            :|.||.|||..||::....|:|:.. .:|...::|.|.:|::.|..|:::.|:|.|:|||:|..|
Mouse    69 KLHGRSFDDPIVQTERIRLPYELQKMPNGSTGVKVRYLEEERPFAIEQVTGMLLAKLKETSENAL 133

  Fly   136 GKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYG--------LDKKAVGE 192
            .|.|.:.||::|::|.|::|::...|..:||||.||::||.||.|:|||        ||:|   .
Mouse   134 KKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALAYGIYKQDLPSLDEK---P 195

  Fly   193 RNVLIFDLGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNK 257
            |||:..|:|...:.||:.:.:.|..:|.:|..|.:|||.:||..||.:|..|||.|:|.::..|.
Mouse   196 RNVVFIDMGHSAYQVSVCAFNKGKLKVLATTFDPYLGGRNFDEALVDYFCDEFKTKYKINVKENS 260

  Fly   258 RALRRLRTACERAKRTLS-SSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMDPVEKAL 321
            |||.||...||:.|:.:| :::...:.|:......|..:.:.||:||:|.|.|......|::..:
Mouse   261 RALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSKMNRAQFEQLCASLLARVEPPLKSVM 325

  Fly   322 RDAKLDKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQ 386
            ..|.|.:..|:.|.:|||:||||.|:..:...|. |:::.::|.|||||.|.|:|.|||  ..:.
Mouse   326 DQANLQREDINSIEIVGGATRIPAVKEQVTRFFL-KDISTTLNADEAVARGCALQCAIL--SPAF 387

  Fly   387 EVQDLLLLDVTPLSL------GIETAGGVMSVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEG 445
            :|::..:.|:.|.|:      ..|...|...|..| |...|..:..||   ...:|..|...|..
Mouse   388 KVREFSITDLVPYSVTLRWKTSFEEGTGECEVFSK-NHPAPFSKVITF---HKKEPFELEAFYTN 448

  Fly   446 ERAMTKDNNLLGKFELSGIPPAPRG-VPQIEVTFDIDANGILNV-----------------TALE 492
            ...:...:..:|.|.:..:.|...| ..:::|...|:.:||.:|                 .|:|
Mouse   449 LHEVPYPDPRIGNFTIQNVFPQSDGDSSKVKVKVRINIHGIFSVASASVIEKQNLEGDHNDAAME 513

  Fly   493 RSTNK----------------------------ENKITITNDKGRLSKEDIERMVNEAEK----- 524
            ....|                            |.:|..|..|.:....|.:..:|:..|
Mouse   514 TEAPKSEGKEDVDKMQVDQEEGGHQKCHAEHTPEEEIDHTGAKAKAPPSDKQDRINQTIKKGKIK 578

  Fly   525 ----------YRN------------------EDEKQKETIAAKNGLESYCFNMKATL-------- 553
                      ||.                  :|:.:||...|||.:|.|.::.:..|
Mouse   579 SIDLPIQSSLYRQLTQDLLNSYIENEGKMIMQDKLEKERNDAKNAVEEYVYDFRDKLGTVYEKFI 643

  Fly   554 ---DEDNLKTKISDS-----------------DRTTILDKCNETI--KWLD-------ANQLADK 589
               |.:.|...:.|:                 ||...|.|..:.|  |:::       .|.|..|
Mouse   644 TPEDMNKLSAMLEDTENWLYEEGEDQPKQVYVDRLQELKKYGQPIQMKYVEHEERPKALNDLGKK 708

  Fly   590 ---------------EEYEH--------------------------------------------- 594
                           |.|:|
Mouse   709 IQLVLKVIEAHRNKDERYDHLDPAEMERVEKYISDSMNWLNSKMNAQNKLSLTQDPVVKVSEIVT 773

  Fly   595 RQKELEGVCNPIITKLYQGAGFP-----PGGMPGGPGGMPGAAGA 634
            :.|||:..||||:.|.......|     .|....||  |.|.:|:
Mouse   774 KSKELDNFCNPIVYKPKPKVEAPEDKAKTGSEHNGP--MDGQSGS 816

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-4	NP_001262586.1	PTZ00009	1..612	CDD:240227	214/796 (27%)
		HSPA1-2_6-8-like_NBD	6..381	CDD:212675	145/383 (38%)
Hspa4l	NP_035150.3	HSPA4L_NBD	2..384	CDD:212688	146/385 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	506..566		8/59 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	784..838		10/35 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910