Protein Alignment Hsc70-4 and Hsph1

DIOPT Version :9

• Sequence 1: NP_001262586.1
• Gene: Hsc70-4 / 41840
• FlyBaseID: FBgn0266599
• Length: 651
• Species: Drosophila melanogaster
• Sequence 2: XP_006504979.1
• Gene: Hsph1 / 15505
• MGIID: 105053
• Length: 877
• Species: Mus musculus
• Alignment Length: 782
• Identity: 208/782 - (26%)
• Similarity: 317/782 - (40%)
• Gaps: 227/782 - (29%)

  Fly    40 SYVAFTDTERLIGDAAKNQVAMNPTQTIFDAKRLIGRKFDDAAVQSDMKHWPFEVV-SADGKPKI 103
            |.::|....|.||.|||||...:...|:...||..||.|:|..:|.:.::..:::| ..:|...|
Mouse    56 SVISFGSKNRTIGVAAKNQQITHANNTVSSFKRFHGRAFNDPFIQKEKENLSYDLVPMKNGGVGI 120

  Fly   104 EVTYKDEKKTFFPEEISSMVLTKMKETAEAYLGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLN 168
            :|.|.||:..|..|:|::|:|||:|||||..|.|.||:.||:||::|.|::|::..||..|.|||
Mouse   121 KVMYMDEEHFFSVEQITAMLLTKLKETAENNLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLN 185

  Fly   169 VLRIINEPTAAAIAYGLDKK----AVGERNVLIF-DLGGGTFDVSILSIDDGIFEVKSTAGDTHL 228
            .||::|:.||.|:.||:.|:    |..:..|::| |:|..:|.||..:.:.|..:|..||.|..|
Mouse   186 CLRLMNDMTAVALNYGIYKQDLPNAEEKPRVVVFVDMGHSSFQVSACAFNKGKLKVLGTAFDPFL 250

  Fly   229 GGEDFDNRLVTHFVQEFKRKHKKDLTTNKRALRRLRTACERAKRTLSS-STQASIEIDSLFEGTD 292
            ||::||.:||.||..|||.|:|.|..:..|||.||...||:.|:.:|| ||...:.|:......|
Mouse   251 GGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLHQECEKLKKLMSSNSTDLPLNIECFMNDKD 315

  Fly   293 FYTSITRARFEELNADLFRSTMDPVEKALRDAKLDKSVIHDIVLVGGSTRIPKVQRLLQDLFNGK 357
            ....:.|::||||.|:|.:....|:...:...:|....:..|.:|||:||||.|:..:...| ||
Mouse   316 VSGKMNRSQFEELCAELLQKIEVPLHSLMAQTQLKAEDVSAIEIVGGATRIPAVKERIAKFF-GK 379

  Fly   358 ELNKSINPDEAVAYGAAVQAAILHGDKSQEVQDLLLLDVTPLSLGI------ETAGGVMSVLIKR 416
            :::.::|.|||||.|.|:|.|||  ..:.:|::..:.|..|..:.:      |...||..| ..|
Mouse   380 DVSTTLNADEAVARGCALQCAIL--SPAFKVREFSVTDAVPFPISLVWNHDSEETEGVHEV-FSR 441

  Fly   417 NTTIPTKQTQTF---------TTYSDNQ----PGVLIQVY---------EGERAMTK-------- 451
            |...|..:..||         ..|||.|    |...|..:         :||::..|
Mouse   442 NHAAPFSKVLTFLRRGPFELEAFYSDPQGVPYPEAKIGRFVVQNVSAQKDGEKSRVKVKVRVNTH 506

  Fly   452 -----------------------------------------------DNNLLGK--------FEL 461
                                                           ||:..|.        .:.
Mouse   507 GIFTISTASMVEKVPTEEEDGSSLEADMECPNQRPTESSDVDKNIQQDNSEAGTQPQVQTDGQQT 571

  Fly   462 SGIPPAPRGVPQIEVTFDIDANGILNVTALERSTN-----KENKITITN-----------DKGRL 510
            |..||:|....:...|.|.|       .|.|:..:     |:.||.:.|           ..||
Mouse   572 SQSPPSPELTSEESKTPDAD-------KANEKKVDQPPEAKKPKIKVVNVELPVEANLVWQLGR- 628

  Fly   511 SKEDIERMVNEAE-KYRNEDEKQKETIAAKNGLESYCFNMKATL--------------------- 553
               |:..|..|.| |...:|:.:||...|||.:|...:..:..|
Mouse   629 ---DLLNMYIETEGKMIMQDKLEKERNDAKNAVEECVYEFRDKLCGPYEKFICEQEHEKFLRLLT 690

  Fly   554 ---------DEDNLK-------------------------------------------------- 559
                     .||..|
Mouse   691 ETEDWLYEEGEDQAKQAYIDKLEELMKMGTPVKVRFQEAEERPKVLEELGQRLQHYAKIAADFRG 755

  Fly   560 -----TKISDSDRTTILDKCNETIKW------------LDANQLADKEEYEHRQKELEGVCNPII 607
                 ..|.:|:...:....||.::|            ||.:.:....|...:.|||..||.|::
Mouse   756 KDEKYNHIDESEMKKVEKSVNEVMEWMNNVMNAQAKRSLDQDPVVRTHEIRAKVKELNNVCEPVV 820

  Fly   608 TK 609
            |:
Mouse   821 TQ 822

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-4	NP_001262586.1	PTZ00009	1..612	CDD:240227	208/782 (27%)
		HSPA1-2_6-8-like_NBD	6..381	CDD:212675	137/347 (39%)
Hsph1	XP_006504979.1	NBD_sugar-kinase_HSP70_actin	56..403	CDD:388382	138/349 (40%)
		FtsN	<537..>620	CDD:225629	16/89 (18%)
		DUF4127	<673..761	CDD:379257	3/87 (3%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810