Protein Alignment Hsc70-4 and Hspa1l

DIOPT Version :9

• Sequence 1: NP_001262586.1
• Gene: Hsc70-4 / 41840
• FlyBaseID: FBgn0266599
• Length: 651
• Species: Drosophila melanogaster
• Sequence 2: NP_038586.2
• Gene: Hspa1l / 15482
• MGIID: 96231
• Length: 641
• Species: Mus musculus
• Alignment Length: 653
• Identity: 521/653 - (79%)
• Similarity: 583/653 - (89%)
• Gaps: 18/653 - (2%)

  Fly     2 SKAPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTQT 66
            :|..|:||||||||||||||||||||||||||||||||||||||||||||||||||||||||..|
Mouse     4 NKGMAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPQNT 68

  Fly    67 IFDAKRLIGRKFDDAAVQSDMKHWPFEVVSADGKPKIEVTYKDEKKTFFPEEISSMVLTKMKETA 131
            :|||||||||||:|..||||||.|||:|::..||||:.|:||.|||.|:||||||||||||||||
Mouse    69 VFDAKRLIGRKFNDPVVQSDMKLWPFQVINEAGKPKVMVSYKGEKKAFYPEEISSMVLTKMKETA 133

  Fly   132 EAYLGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKAVGERNVL 196
            ||:||..||||||||||||||||||||||||.||||||||||||||||||||||||.:.|||:||
Mouse   134 EAFLGHNVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKGSHGERHVL 198

  Fly   197 IFDLGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNKRALR 261
            ||||||||||||||:|||||||||:|||||||||||||||||:|||:|||||||||::.||||:|
Mouse   199 IFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVR 263

  Fly   262 RLRTACERAKRTLSSSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMDPVEKALRDAKL 326
            |||||||||||||||||||::|||||:||.||||||||||||||.|||||.|::||||:|||||:
Mouse   264 RLRTACERAKRTLSSSTQANLEIDSLYEGIDFYTSITRARFEELCADLFRGTLEPVEKSLRDAKM 328

  Fly   327 DKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQEVQDL 391
            ||:.|||||||||||||||||:||||.|||::||||||||||||||||||||||.||||::||||
Mouse   329 DKAKIHDIVLVGGSTRIPKVQKLLQDYFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSEKVQDL 393

  Fly   392 LLLDVTPLSLGIETAGGVMSVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLL 456
            |||||.|||||:|||||||:||||||:||||||||.|||||||||||||||||||||||:|||||
Mouse   394 LLLDVAPLSLGLETAGGVMTVLIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTRDNNLL 458

  Fly   457 GKFELSGIPPAPRGVPQIEVTFDIDANGILNVTALERSTNKENKITITNDKGRLSKEDIERMVNE 521
            |:|:|:||||||||||||||||||||||||||||:::||.|.|||||||||||||||:|||||.|
Mouse   459 GRFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAMDKSTGKANKITITNDKGRLSKEEIERMVQE 523

  Fly   522 AEKYRNEDEKQKETIAAKNGLESYCFNMKATLDEDNLKTKISDSDRTTILDKCNETIKWLDANQL 586
            ||:|:.|||.|:|.|||||.||||.||||:.:.::.||.|||:||:..|||||||.:.||:||||
Mouse   524 AERYKAEDEGQREKIAAKNALESYAFNMKSAVGDEGLKDKISESDKKKILDKCNEVLSWLEANQL 588

  Fly   587 ADKEEYEHRQKELEGVCNPIITKLYQGAGFPPGGMPG---GPGGMPGAAGAAGAAGAGGAGPTIE 648
            |:|:|::|::||||.:||||||||||      .|..|   .||..||.|         ..|||||
Mouse   589 AEKDEFDHKRKELENMCNPIITKLYQ------SGCTGPTCTPGYTPGRA---------ATGPTIE 638

  Fly   649 EVD 651
            |||
Mouse   639 EVD 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-4	NP_001262586.1	PTZ00009	1..612	CDD:240227	504/609 (83%)
		HSPA1-2_6-8-like_NBD	6..381	CDD:212675	323/374 (86%)
Hspa1l	NP_038586.2	HSP70	3..641	CDD:331774	519/651 (80%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	3..388		328/383 (86%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	396..511		100/114 (88%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D180577at33208
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	1	1.000	-	-		otm43752
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X148
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.730