Protein Alignment Hsc70-4 and HSPA12B

DIOPT Version :10

• Sequence 1: NP_524356.1
• Gene: Hsc70-4 / 41840
• FlyBaseID: FBgn0266599
• Length: 651
• Species: Drosophila melanogaster
• Sequence 2: NP_443202.3
• Gene: HSPA12B / 116835
• HGNCID: 16193
• Length: 686
• Species: Homo sapiens
• Alignment Length: 654
• Identity: 134/654 - (20%)
• Similarity: 230/654 - (35%)
• Gaps: 192/654 - (29%)

  Fly     7 VGIDLGTTYSCVGVFQHGKVEII-------ANDQG--NRTTPSYVAFTDTERL--IGDAAKNQV- 59
            |.||.|||.|..........|.|       ..|.|  ::.||:.:..|.....  .|..|::..
Human    63 VAIDFGTTSSGYAFSFASDPEAIHMMRKWEGGDPGVAHQKTPTCLLLTPEGAFHSFGYTARDYYH 127

  Fly    60 AMNPTQT----IFDAKRLIGRKFDDAAVQSDMKHWPFEVVSADGKPKIEVTYKDEKKTFFPEEIS 120
            .::|.:.    .|:..::......|..:::.:     |.|:....|.:||.  .....||.|.
Human   128 DLDPEEARDWLYFEKFKMKIHSATDLTLKTQL-----EAVNGKTMPALEVF--AHALRFFREH-- 183

  Fly   121 SMVLTKMKETAEAYLGKTVTNAVITVPAYFNDSQRQATKDAGTIAGL------NVLRIINEPTAA 179
              .|.:::|.:.:...|.....|:||||.:....:|..::|..:|||      ..|.|..||.||
Human   184 --ALQELREQSPSLPEKDTVRWVLTVPAIWKQPAKQFMREAAYLAGLVSRENAEQLLIALEPEAA 246

  Fly   180 AI----------------AYG------------------------------LDKKAVGE------ 192
            ::                |.|                              |.:..|||
Human   247 SVYCRKLRLHQLLDLSGRAPGGGRLGERRSIDSSFRQAREQLRRSRHSRTFLVESGVGELWAEMQ 311

  Fly   193 --RNVLIFDLGGGTFDVSILSIDD--GIFE--VKSTAGDTHLGGED--FDNRLVTHFVQEFKRKH 249
              ...::.|.||||.|:::..::.  |..:  .|::.|.....|.|  |:..|...|.::|
Human   312 AGDRYVVADCGGGTVDLTVHQLEQPHGTLKELYKASGGPYGAVGVDLAFEQLLCRIFGEDF---- 372

  Fly   250 KKDLTTNKR----ALRRLRTACERAKRTLSSSTQASIEIDSLFEGTDFY---------TSITRAR 301
               :.|.||    |...|..|.|..|||.......::.|...|...|||         |::.|:.
Human   373 ---IATFKRQRPAAWVDLTIAFEARKRTAGPHRAGALNISLPFSFIDFYRKQRGHNVETALRRSS 434

  Fly   302 F---------------EELNADLFRSTMDPVEKALRDAKLDKSVIHDI---VLVGGSTRIPKVQR 348
            .               |.:| :||:.|:..:.:.: :|.|.:..:..:   .||||......:|.
Human   435 VNFVKWSSQGMLRMSCEAMN-ELFQPTVSGIIQHI-EALLARPEVQGVKLLFLVGGFAESAVLQH 497

  Fly   349 LLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQEVQDLLLLDVTPLSLGIETAGGVMS-- 411
            .:|.....:.|...:..|..:   ..::.|:|.|    :...::.:..:||:.|:    ||::
Human   498 AVQAALGARGLRVVVPHDVGL---TILKGAVLFG----QAPGVVRVRRSPLTYGV----GVLNRF 551

  Fly   412 ---------VLIKRNTTIPTKQTQTFT--------------TYSDNQPG---VLIQVY----EGE 446
                     :|::......|...:.|.              :|...:||   |||.:|    |..
Human   552 VPGRHPPEKLLVRDGRRWCTDVFERFVAAEQSVALGEEVRRSYCPARPGQRRVLINLYCCAAEDA 616

  Fly   447 RAMTKDN-NLLGKFEL-----------SGIPPAPRGVPQIEVTFDIDANGILNVTALERSTNKEN 499
            |.:|... ...|...|           :|.||..|.:.......|.:    :.|||::.|||:..
Human   617 RFITDPGVRKCGALSLELEPADCGQDTAGAPPGRREIRAAMQFGDTE----IKVTAVDVSTNRSV 677

  Fly   500 KITI 503
            :.:|
Human   678 RASI 681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-4	NP_524356.1	PTZ00009	1..612	CDD:240227	134/654 (20%)
HSPA12B	NP_443202.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	12..53
		ASKHA_NBD_HSP70_HSPA12B	61..528	CDD:466842	101/487 (21%)