DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-4 and HSPA12B

DIOPT Version :9

Sequence 1:	NP_001262586.1	Gene:	Hsc70-4 / 41840	FlyBaseID:	FBgn0266599	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	NP_443202.3	Gene:	HSPA12B / 116835	HGNCID:	16193	Length:	686	Species:	Homo sapiens

Alignment Length:	654	Identity:	134/654 - (20%)
Similarity:	230/654 - (35%)	Gaps:	192/654 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VGIDLGTTYSCVGVFQHGKVEII-------ANDQG--NRTTPSYVAFTDTERL--IGDAAKNQV- 59
            |.||.|||.|..........|.|       ..|.|  ::.||:.:..|.....  .|..|::..
Human    63 VAIDFGTTSSGYAFSFASDPEAIHMMRKWEGGDPGVAHQKTPTCLLLTPEGAFHSFGYTARDYYH 127

  Fly    60 AMNPTQT----IFDAKRLIGRKFDDAAVQSDMKHWPFEVVSADGKPKIEVTYKDEKKTFFPEEIS 120
            .::|.:.    .|:..::......|..:::.:     |.|:....|.:||.  .....||.|.
Human   128 DLDPEEARDWLYFEKFKMKIHSATDLTLKTQL-----EAVNGKTMPALEVF--AHALRFFREH-- 183

  Fly   121 SMVLTKMKETAEAYLGKTVTNAVITVPAYFNDSQRQATKDAGTIAGL------NVLRIINEPTAA 179
              .|.:::|.:.:...|.....|:||||.:....:|..::|..:|||      ..|.|..||.||
Human   184 --ALQELREQSPSLPEKDTVRWVLTVPAIWKQPAKQFMREAAYLAGLVSRENAEQLLIALEPEAA 246

  Fly   180 AI----------------AYG------------------------------LDKKAVGE------ 192
            ::                |.|                              |.:..|||
Human   247 SVYCRKLRLHQLLDLSGRAPGGGRLGERRSIDSSFRQAREQLRRSRHSRTFLVESGVGELWAEMQ 311

  Fly   193 --RNVLIFDLGGGTFDVSILSIDD--GIFE--VKSTAGDTHLGGED--FDNRLVTHFVQEFKRKH 249
              ...::.|.||||.|:::..::.  |..:  .|::.|.....|.|  |:..|...|.::|
Human   312 AGDRYVVADCGGGTVDLTVHQLEQPHGTLKELYKASGGPYGAVGVDLAFEQLLCRIFGEDF---- 372

  Fly   250 KKDLTTNKR----ALRRLRTACERAKRTLSSSTQASIEIDSLFEGTDFY---------TSITRAR 301
               :.|.||    |...|..|.|..|||.......::.|...|...|||         |::.|:.
Human   373 ---IATFKRQRPAAWVDLTIAFEARKRTAGPHRAGALNISLPFSFIDFYRKQRGHNVETALRRSS 434

  Fly   302 F---------------EELNADLFRSTMDPVEKALRDAKLDKSVIHDI---VLVGGSTRIPKVQR 348
            .               |.:| :||:.|:..:.:.: :|.|.:..:..:   .||||......:|.
Human   435 VNFVKWSSQGMLRMSCEAMN-ELFQPTVSGIIQHI-EALLARPEVQGVKLLFLVGGFAESAVLQH 497

  Fly   349 LLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQEVQDLLLLDVTPLSLGIETAGGVMS-- 411
            .:|.....:.|...:..|..:   ..::.|:|.|    :...::.:..:||:.|:    ||::
Human   498 AVQAALGARGLRVVVPHDVGL---TILKGAVLFG----QAPGVVRVRRSPLTYGV----GVLNRF 551

  Fly   412 ---------VLIKRNTTIPTKQTQTFT--------------TYSDNQPG---VLIQVY----EGE 446
                     :|::......|...:.|.              :|...:||   |||.:|    |..
Human   552 VPGRHPPEKLLVRDGRRWCTDVFERFVAAEQSVALGEEVRRSYCPARPGQRRVLINLYCCAAEDA 616

  Fly   447 RAMTKDN-NLLGKFEL-----------SGIPPAPRGVPQIEVTFDIDANGILNVTALERSTNKEN 499
            |.:|... ...|...|           :|.||..|.:.......|.:    :.|||::.|||:..
Human   617 RFITDPGVRKCGALSLELEPADCGQDTAGAPPGRREIRAAMQFGDTE----IKVTAVDVSTNRSV 677

  Fly   500 KITI 503
            :.:|
Human   678 RASI 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-4	NP_001262586.1	PTZ00009	1..612	CDD:240227	134/654 (20%)
Hsc70-4	NP_001262586.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	100/486 (21%)
HSPA12B	NP_443202.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	12..53
HSPA12B	NP_443202.3	NBD_sugar-kinase_HSP70_actin	61..529	CDD:327376	102/492 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810