DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tefu and TOR1

DIOPT Version :10

Sequence 1:NP_001036712.1 Gene:tefu / 41839 FlyBaseID:FBgn0045035 Length:2767 Species:Drosophila melanogaster
Sequence 2:NP_012600.1 Gene:TOR1 / 853529 SGDID:S000003827 Length:2470 Species:Saccharomyces cerevisiae


Alignment Length:3082 Identity:606/3082 - (19%)
Similarity:1051/3082 - (34%) Gaps:993/3082 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 ASRNKGIQQLDE-KLSSCREDLDKLFLSKTSDISWTTIFEASKEALFKQAGNLEDVNEKVFKTLA 84
            ||||.     || .|:|.|  .|.:.:....|:                  |.:.:.||:|:.|.
Yeast    43 ASRNG-----DEFGLTSSR--FDGVVIGSNGDV------------------NFKPILEKIFRELT 82

  Fly    85 GKNYLYDNVLEKITQFNLEAGSQTSGNGHFLAKTSIFSAFEDGIKMRVV----VKYFGDRILSLL 145
             .:|..:..|..|:.|:|....:     |.|: ...|.|..:.|..:::    .|....|:.::|
Yeast    83 -SDYKEERKLASISLFDLLVSLE-----HELS-IEEFQAVSNDINNKILELVHTKKTSTRVGAVL 140

  Fly   146 E-KGIYSSVSYVRDLKINEYSRILSYLFELNVDMDEVLRTRILKCITRTV--------SLAKDRV 201
            . ..:.|..:|...|. ||.||:..||..|....|    ..:::...:|:        :...|.|
Yeast   141 SIDTLISFYAYTERLP-NETSRLAGYLRGLIPSND----VEVMRLAAKTLGKLAVPGGTYTSDFV 200

  Fly   202 QLHV-DLVEYLPELSSFALSAFGARKTEIVR-VYLIFASELAVNYNHQLNVHMQEILPKLCEYHD 264
            :..: ..:|:|  .:|...::|.:.|.:..: ..|:..:.||.|..:.|..::..||..:..   
Yeast   201 EFEIKSCLEWL--TASTEKNSFSSSKPDHAKHAALLIITALAENCPYLLYQYLNSILDNIWR--- 260

  Fly   265 EDAFRDDTRNLFFQCVSKSLHSMYLKMDMCDFNTLGVPVHEKWPQTLLRLKTIVNVEIRKNSWAR 329
              |.||                                     |..::|:...:.:       |:
Yeast   261 --ALRD-------------------------------------PHLVIRIDASITL-------AK 279

  Fly   330 CKNALLSNNKFSDPFIKMSALAMYIVLWHLETKKADENGEGDAPKKIPKPADKMETIFSLIDKKE 394
            |    ||..:..||.:...        |                  :.:.|...|..|.:     
Yeast   280 C----LSTLRNRDPQLTSQ--------W------------------VQRLATSCEYGFQV----- 309

  Fly   395 NTFNDVW--LAIFTEILQLSSVILNVANYQMALTTVAEIMQMYGNAKNLRNLRLCLAHLLTKEQE 457
            ||...:.  |.::.|||.|....||....||.|..:|     |.|.|                  
Yeast   310 NTLECIHASLLVYKEILFLKDPFLNQVFDQMCLNCIA-----YENHK------------------ 351

  Fly   458 LLHSKSIREDFLGELWSQMANQLISETTTNSEEIKEKQLVLQMLIRHNKLNQKLSSTLLNNIISN 522
               :|.|||...     |:...|.|   .|.:....|.|       |..::..|.  :|.|..:|
Yeast   352 ---AKMIREKIY-----QIVPLLAS---FNPQLFAGKYL-------HQIMDNYLE--ILTNAPAN 396

  Fly   523 EM--LK--RNECLATIREIFIHADKCGQDKASADLEPIIAWAYGSADRFIAAQMIHNIDSIDAQL 583
            ::  ||  :.:.|.:|.:|   |.:.|.|                    ||..:...:|.|:..|
Yeast   397 KIPHLKDDKPQILISIGDI---AYEVGPD--------------------IAPYVKQILDYIEHDL 438

  Fly   584 QADTFAISIINFLDVQQLRQISQSEHIVPSTERNLLAYKY-----NEQLICFDKDYATPFESITH 643
            |.                                  .:|:     ||...|..: .|.|...:  
Yeast   439 QT----------------------------------KFKFRKKFENEIFYCIGR-LAVPLGPV-- 466

  Fly   644 IQSETKNCLIQSNYDCLMRGL---NFEIAKENKPAAIIKNLNSLLKLICTMERLLHYKVFDADTY 705
            :.......::...:.|.:...   .|:|..|..|:...|..:.||.|:|:             |.
Yeast   467 LGKLLNRNILDLMFKCPLSDYMQETFQILTERIPSLGPKINDELLNLVCS-------------TL 518

  Fly   706 TGCPLIKRIGLYLSHIEFQ------------LKANGAEILDKSDLPEILRLEIYVLDVFRTNLVL 758
            :|.|.|:. |..:....|.            |:..|....|.:|:.       .::..||   :|
Yeast   519 SGTPFIQP-GSPMEIPSFSRERAREWRNKNILQKTGESNDDNNDIK-------IIIQAFR---ML 572

  Fly   759 LDYLERQPIEMLVEFVGAALKLHSMQRERSVDADHGTITRLCLNILAGLCAYNS-HR----DEAF 818
            .:...|..:...|..|..:...|:..|.|.:.|    :|...:.:...:|...| |.    .|..
Yeast   573 KNIKSRFSLVEFVRIVALSYIEHTDPRVRKLAA----LTSCEIYVKDNICKQTSLHSLNTVSEVL 633

  Fly   819 EHIVKVTMRWHPQDV-LIVTKMLCSCQTISEASSSWLVSKLKTLFQQHHQDA--------ELMDK 874
            ..::.:|:....||: |.|.|.|..|.....|..    ..|:.||...|.::        ||:.:
Yeast   634 SKLLAITIADPLQDIRLEVLKNLNPCFDPQLAQP----DNLRLLFTALHDESFNIQSVAMELVGR 694

  Fly   875 VVQHMPTIFYFVRHKENHLDDMLMALNSLLRIAI---KKSYTSNLTAKIVRCVGLIAQRCPDIYL 936
            :....|.  |.:    ..:..:|:.|.:.|:.:.   :|..|::|...::|.             
Yeast   695 LSSVNPA--YVI----PSIRKILLELLTKLKFSTSSREKEETASLLCTLIRS------------- 740

  Fly   937 LENFAVICKSTAKFITMPTLEVRFATLFTFTILLESNCVTSDAIGHSRTHWDFCQELYESIEFKK 1001
                   .|..||....|.|.| ....|..|    |:.|.|.|:   ||..:..           
Yeast   741 -------SKDVAKPYIEPLLNV-LLPKFQDT----SSTVASTAL---RTIGELS----------- 779

  Fly  1002 LTYNNEDAIQNSNALIVQMLIAIFLR------SSFHQEIALKELLHHCALRRLTER--------- 1051
             ....||.     .:.::.|..:.::      :||.:|.|||      ||.:|...         
Yeast   780 -VVGGEDM-----KIYLKDLFPLIIKTFQDQSNSFKREAALK------ALGQLAASSGYVIDPLL 832

  Fly  1052 ----------EFISLQSMSSCHRQTVRDLIRPFAAILLHHWSSKRWPISKFPYFLCYSTKSEFRK 1106
                      ..:..::..:..|||| .||....||              .||           :
Yeast   833 DYPELLGILVNILKTENSQNIRRQTV-TLIGILGAI--------------DPY-----------R 871

  Fly  1107 THASEIMAYTFLYGKTEDIERCSKSISEELALPILASFLLIKNSSCSESEGQNFKEHLQLLSENL 1171
            ....|:.:.|              .||.|...|.:...||::..|.|..|               
Yeast   872 QKEREVTSTT--------------DISTEQNAPPIDIALLMQGMSPSNDE--------------- 907

  Fly  1172 SYSQLNATDVDLDLDILCYVISMLHDP----------QEMMRLFGSLAICNRTASWYSLSGESLF 1226
            .|:.:          ::..::.:|.||          |.:|.:|.:|.:                
Yeast   908 YYTTV----------VIHCLLKILKDPSLSSYHTAVIQAIMHIFQTLGL---------------- 946

  Fly  1227 KCLNFHIDPEMRPSMDSRIQSMTTLQTKHSRVLVDIFGRLKTNCYSASFSSQALHDFFL--YCEV 1289
            ||::|         :|..|.:           ::|:   ::| |      ||:|.:|:.  .|.:
Yeast   947 KCVSF---------LDQIIPT-----------ILDV---MRT-C------SQSLLEFYFQQLCSL 981

  Fly  1290 ADAVYDAARKNETIVTQCSFFVRDIWFFVVRLLIHTKFIRVQMAALTFLELLLNKHNFRLDDYQN 1354
            ...|....|.:...:.|.   ::|.          :...::|:..::.:|.              
Yeast   982 IIIVRQHIRPHVDSIFQA---IKDF----------SSVAKLQITLVSVIEA-------------- 1019

  Fly  1355 HFGDIAKLLSNFQLCCEAKEVREKTMSIVMYILESKKGHINLNSFLEETTDCEFLKPLREDCKSS 1419
                |:|.|..     |.|.:...|:::.:.|||:.|           ::|....:.:....:|.
Yeast  1020 ----ISKALEG-----EFKRLVPLTLTLFLVILENDK-----------SSDKVLSRRVLRLLESF 1064

  Fly  1420 QPNIDRADVANYLRSFLLSPTPERLRDLRT------------YIAEHKDKVQEHEKLLFGVINKL 1472
            .||::     .|  |.|::|...::.:..:            .:|:..|..:...:::..::..|
Yeast  1065 GPNLE-----GY--SHLITPKIVQMAEFTSGNLQRSAIITIGKLAKDVDLFEMSSRIVHSLLRVL 1122

  Fly  1473 IQMTRDAHNKTTSIDSLKCLAQIGPLKISTVSYYFQTDFEAFEKSNGEPMEAFLGVVCHSLDTSL 1537
            ...|.|..:|.........|.|:|                                      ||.
Yeast  1123 SSTTSDELSKVIMNTLSLLLIQMG--------------------------------------TSF 1149

  Fly  1538 FQFDPKTHEGLVSVAIQ-----------VVNSKPGSNIMER----YKN-----------LRIFAD 1576
            ..|.|..:|.|:...||           :.|....:.|:|.    ||.           .::..:
Yeast  1150 AIFIPVINEVLMKKHIQHTIYDDLTNRILNNDVLPTKILEANTTDYKPAEQMEAADAGVAKLPIN 1214

  Fly  1577 KSTASTFLHSNKQIRRIDW------LSILKATKSLSYEPWMCAFVSKVFQMCGWLGFDKLAATSF 1635
            :|...:..:|::|..:.||      |||....:|.|:....|:.::.::.        .||...|
Yeast  1215 QSVLKSAWNSSQQRTKEDWQEWSKRLSIQLLKESPSHALRACSNLASMYY--------PLAKELF 1271

  Fly  1636 AFAKTCLLPFIKLLLENSLEHVESLSQMLDYFFEGFTSSTAPNSQEIFRNKRAIKKFLHICEYIR 1700
            ..|..|:  :.:|..:...:.:.||...|         |:..|..||.:.      .|::.|::.
Yeast  1272 NTAFACV--WTELYSQYQEDLIGSLCIAL---------SSPLNPPEIHQT------LLNLVEFME 1319

  Fly  1701 IFNNWTIPINLSNVVMASNHCQAYFLSIMYLELWACSESPKSKADFL---DNECFQDGAKKAYES 1762
             .::..:||...::...:..|.||..::.|.|:....|...|..:.|   :|:..|..|     :
Yeast  1320 -HDDKALPIPTQSLGEYAERCHAYAKALHYKEIKFIKEPENSTIESLISINNQLNQTDA-----A 1378

  Fly  1763 IGCL-----------------------DAIPGF--------------VNPMRSRLDFLGHGSNLS 1790
            ||.|                       ||:..:              :..||| |..||....||
Yeast  1379 IGILKHAQQHHSLQLKETWFEKLERWEDALHAYNEREKAGDTSVSVTLGKMRS-LHALGEWEQLS 1442

  Fly  1791 TILLESDHLDRASGQLCIDIMKGNGLWSFAKLQQHQNIEP-DYEIFWRLGQWDSLTDPKHQQNQT 1854
            .:....                    |..:|||..:.|.| .....|.||:||.|     :|..:
Yeast  1443 QLAARK--------------------WKVSKLQTKKLIAPLAAGAAWGLGEWDML-----EQYIS 1482

  Fly  1855 VVRTSLDLEQEFKRHHFVALRSIGQREEENSLSAIEQAYSCVRDILM-EISVECLQSVYKYLTWL 1918
            |::.. ..::||    |.|:..:.:.:.:|:...|..|    ||:|: |||....:|..:..:.:
Yeast  1483 VMKPK-SPDKEF----FDAILYLHKNDYDNASKHILNA----RDLLVTEISALINESYNRAYSVI 1538

  Fly  1919 CSLQQAEDFCQIQFGTQLDPASTTKIFRK--WQTELELKYGNFSCKEYVIAHQIALLKLAGTRAS 1981
            ...|...:|.:|....||.|.|..|:..:  |...|      ..|::.|...| .:|::      
Yeast  1539 VRTQIITEFEEIIKYKQLPPNSEKKLHYQNLWTKRL------LGCQKNVDLWQ-RVLRV------ 1590

  Fly  1982 RRMSEFYQKDPISTYLMKGIEECKSAGKLNLAAKYTATLRELPNIRESIKISVLLE---DAEI-N 2042
             |......|..:..:: |....|:.:|::.||.|               .:::|||   |..: |
Yeast  1591 -RSLVIKPKQDLQIWI-KFANLCRKSGRMRLANK---------------ALNMLLEGGNDPSLPN 1638

  Fly  2043 LKMGNQQIAKAILDYVTNNNEFVYCVQRVPAL--RMQGEFLLDCN-----------AETLSWVQS 2094
            .......:..|.|.|:.....:...:..:...  |:..:..||.|           |.|..:|: 
Yeast  1639 TFKAPPPVVYAQLKYIWATGAYKEALNHLIGFTSRLAHDLGLDPNNMIAQSVKLSSASTAPYVE- 1702

  Fly  2095 HKFNNSLKLIDDFVQHRQTLSEKYRDIFDWHQLDAYASKQRTAAYATIAKYA-----DRE-YQQL 2153
                          ::.:.|:..:....:| ::....:.:.|...|.:..|.     |:. |:..
Yeast  1703 --------------EYTKLLARCFLKQGEW-RIATQPNWRNTNPDAILGSYLLATHFDKNWYKAW 1752

  Fly  2154 HDYRHSQEYQTLKDIIEQNRQTAEK-----VTQRENQDRRV---------ISVQMKRYASLDEQQ 2204
            |::..: .::.:..:.|:.:....|     .|...|.:.|:         :::...||      .
Yeast  1753 HNWALA-NFEVISMVQEETKLNGGKNDDDDDTAVNNDNVRIDGSILGSGSLTINGNRY------P 1810

  Fly  2205 LNQIEEKLTEYLR---LALTNYMAYCRLDSGFSSAAIYRIISLWFTNATSKQCQECIKDEILTVP 2266
            |..|:..:...::   .:::.....|..|:       .|:::|.|.....|:..:.:.:....:.
Yeast  1811 LELIQRHVVPAIKGFFHSISLLETSCLQDT-------LRLLTLLFNFGGIKEVSQAMYEGFNLMK 1868

  Fly  2267 SYKFICAANQLTARLNSKNTSLLKGLTDLLVQCGKDHPYHTFYQLYPLVFAHLDGENSNTERS-- 2329
            ...::....||.:|::..:.::...|..||...||.||...   :|||..| :..|:.:.:::  
Yeast  1869 IENWLEVLPQLISRIHQPDPTVSNSLLSLLSDLGKAHPQAL---VYPLTVA-IKSESVSRQKAAL 1929

  Fly  2330 GIARKI--------------------IAMICEKNGTAG------------ECSKQLESLLPALIT 2362
            .|..||                    :|::..:....|            ...|...:|.|....
Yeast  1930 SIIEKIRIHSPVLVNQAELVSHELIRVAVLWHELWYEGLEDASRQFFVEHNIEKMFSTLEPLHKH 1994

  Fly  2363 FANEGKT--------------ND------NRPVSDSVRN---------KQFDKVRRW-------- 2390
            ..||.:|              ||      |...|..:.|         ..|.|:.|.        
Yeast  1995 LGNEPQTLSEVSFQKSFGRDLNDAYEWLNNYKKSKDINNLNQAWDIYYNVFRKITRQIPQLQTLD 2059

  Fly  2391 -----RNLNAVHCPTLELPV----MPSKEYSIISVVKWTNETTQCGGLNAPVKIMCVCSDGKIRA 2446
                 ..|.|.|  .|||.|    .|.|  ..|.:.|:....:.......|.|.....||||...
Yeast  2060 LQHVSPQLLATH--DLELAVPGTYFPGK--PTIRIAKFEPLFSVISSKQRPRKFSIKGSDGKDYK 2120

  Fly  2447 QLVKGKDDLRQDAVMQQVFGIVNELLNQDSEFIERKLKLRTYKVTPLSMRSGILEWCTNSVPVGH 2511
            .::||.:|:|||:::.|:||:||.||..|||..:|.|.::.|...|||.:||:|.|..|| ...|
Yeast  2121 YVLKGHEDIRQDSLVMQLFGLVNTLLKNDSECFKRHLDIQQYPAIPLSPKSGLLGWVPNS-DTFH 2184

  Fly  2512 YLVVEGKGGAHARYRPNDWNNNKCRKLSSDHLKSPKETRYAIYKKICENIKPVFHYFLL-EKFPI 2575
            .|:.|.:...........|   ...:::.|:.......:..::....:|.|....|.:| .|...
Yeast  2185 VLIREHRDAKKIPLNIEHW---VMLQMAPDYENLTLLQKIEVFTYALDNTKGQDLYKILWLKSRS 2246

  Fly  2576 PGVWFERRLAYTNSVATTSMVGYVLGLGDRHTQNILVDQQTAEVIHIDFGIAFEQGKI-QTTPET 2639
            ...|.|||..||.|:|..||.||:|||||||..|:::|:.|.:|||||||..||...: :..||.
Yeast  2247 SETWLERRTTYTRSLAVMSMTGYILGLGDRHPSNLMLDRITGKVIHIDFGDCFEAAILREKYPEK 2311

  Fly  2640 VPFRLTRDFVAPMGICGTKGVFAKSCEATMHILRRYKSVFTTILEVLLYDPLFIWGV-LKKKQSP 2703
            |||||||.....|.:.|.:|.|..:||..|.:||..|.....|||....|||..||. |..::..
Yeast  2312 VPFRLTRMLTYAMEVSGIEGSFRITCENVMRVLRDNKESLMAILEAFALDPLIHWGFDLPPQKLT 2376

  Fly  2704 QQSG-------------------EESVNLVAQ--------RALLL---VQNKLDGREAGTMGDSN 2738
            :|:|                   ||:.|:.|:        ||:|:   :.:||.|.:.....:.:
Yeast  2377 EQTGIPLPLINPSELLRKGAITVEEAANMEAEQQNETKNARAMLVLRRITDKLTGNDIKRFNELD 2441

  Fly  2739 VEAQVERLINEATLPSNLCMLFPGWDP 2765
            |..||::||.:||....||..:.||.|
Yeast  2442 VPEQVDKLIQQATSIERLCQHYIGWCP 2468

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tefuNP_001036712.1 FAT 1829..>2064 CDD:396714 53/242 (22%)
PIKKc_ATM 2416..2696 CDD:270715 102/281 (36%)
FATC 2739..2767 CDD:460514 12/27 (44%)
TOR1NP_012600.1 HEAT_EZ 229..279 CDD:463906 12/98 (12%)
TEL1 279..2470 CDD:227365 545/2758 (20%)
HEAT repeat 588..620 CDD:293787 7/35 (20%)
HEAT repeat 632..658 CDD:293787 7/25 (28%)
HEAT repeat 668..698 CDD:293787 6/29 (21%)
HEAT repeat 706..736 CDD:293787 6/29 (21%)
HEAT repeat 749..778 CDD:293787 11/36 (31%)
HEAT repeat 792..827 CDD:293787 10/40 (25%)

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