DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tefu and MEC1

DIOPT Version :10

Sequence 1:NP_001036712.1 Gene:tefu / 41839 FlyBaseID:FBgn0045035 Length:2767 Species:Drosophila melanogaster
Sequence 2:NP_009694.3 Gene:MEC1 / 852433 SGDID:S000000340 Length:2368 Species:Saccharomyces cerevisiae


Alignment Length:2839 Identity:577/2839 - (20%)
Similarity:1001/2839 - (35%) Gaps:877/2839 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   301 VPVHEKWPQTLLRLKTIVNVEIRKNSWARCKNALLSNNKFSDPFIKMSALAMYIVLWHLETKKAD 365
            ||......|...:...|:|..||.....|..|.:.::..||.   .:||||:.:..........|
Yeast    31 VPTDPSSSQEYAKSLKILNTLIRNLKDQRRNNIMKNDTIFSK---TVSALALLLEYNPFLLVMKD 92

  Fly   366 ENGEGDAPKKIPKPADKMETIFSLIDKKENTFNDVWL-------------------AIFTEILQL 411
            .||..:..:.|       :...::.....:.::.:|.                   |.|    ||
Yeast    93 SNGNFEIQRLI-------DDFLNISVLNYDNYHRIWFMRRKLGSWCKACVEFYGKPAKF----QL 146

  Fly   412 SSVILNVAN-YQMALTTV----AEIMQMYGNAKNLRNLRLCLAHLLTKEQELL-HSKSIREDFLG 470
            ::...|..| |:.|||.|    .|:::.|...|.|    ..|.:..|.|.... :|.:..:..||
Yeast   147 TAHFENTMNLYEQALTEVLLGKTELLKFYDTLKGL----YILLYWFTSEYSTFGNSIAFLDSSLG 207

  Fly   471 ----ELWSQMANQLISETTTNSE----EIKEKQLVLQMLIRHNKLNQKLSSTL-LNNIISNEMLK 526
                :...|...:::.....:.|    |..|.||....|:.....|:.:|:.| ...::..|.||
Yeast   208 FTKFDFNFQRLIRIVLYVFDSCELAALEYAEIQLKYISLVVDYVCNRTISTALDAPALVCCEQLK 272

  Fly   527 RNECLATIREIFIHADKCGQDKASADLEPIIAWAYGSADRFIAAQMIHNIDSIDAQLQAD----- 586
                                                    |:...|.|.:|:....|..|     
Yeast   273 ----------------------------------------FVLTTMHHFLDNKYGLLDNDPTMAK 297

  Fly   587 ----TFAISIIN-----FLD---VQQLRQISQSEHIVPSTERNLLAYKYNEQLICFD-KDYATPF 638
                .:::.|.|     |:|   :.|....|||||. |.|:....|.    .::.|| |..:.|.
Yeast   298 GILRLYSLCISNDFSKCFVDHFPIDQWADFSQSEHF-PFTQLTNKAL----SIVYFDLKRRSLPV 357

  Fly   639 ESITHIQSETKNCLIQSNYDCLMRGLNFEI-AKENKPAAIIKNLNS--------LLKLICTMERL 694
            |::              .||     ..|.| ..:::|.:.:||:.|        |.||     ||
Yeast   358 EAL--------------KYD-----NKFNIWVYQSEPDSSLKNVTSPFDDRYKQLEKL-----RL 398

  Fly   695 LHYKVFDADTYTGCPLIKRIGLYLSHIEFQLKANGAEILDKSDLPEILRLEIYVLDVFRTNLVLL 759
            |..|.|: .|..|..|..|:. .||...||...|..:::       :....:.:...|:||    
Yeast   399 LVLKKFN-KTERGTLLKYRVN-QLSPGFFQRAGNDFKLI-------LNEASVSIQTCFKTN---- 450

  Fly   760 DYLERQPIEMLVEFVGAALKLHSMQRER--------SVDADHGTITRLCLNILAG--LCAYNSHR 814
                  .|..|..:.....:|..::.|:        :.|.|:..:..||.....|  ....|.:|
Yeast   451 ------NITRLTSWTVILGRLACLESEKFSGTLPNSTKDMDNWYVCHLCDIEKTGNPFVRINPNR 509

  Fly   815 DEA-----FEHIVKVTMRWHPQDVLIVTKMLCSCQTISEASSSWLVSKLKTLFQQHHQDAELMD- 873
            .||     ...|:......||           :....||:..|.::..|..:| .|.|..:|.| 
Yeast   510 PEAAGKSEIFRILHSNFLSHP-----------NIDEFSESLLSGILFSLHRIF-SHFQPPKLTDG 562

  Fly   874 --------KVVQ--------------------------------HMPTIFYFVRH------KENH 892
                    |:||                                |..|:..|::.      ||| 
Yeast   563 NGQINKSFKLVQKCFMNSNRYLRLLSTRIIPLFNISDSHNSEDEHTATLIKFLQSQKLPVVKEN- 626

  Fly   893 LDDMLMALNSLLRIAIKKSYTSNLTAKIVRCVGLIAQRCPDIY-------------LLENFAVIC 944
                |:...:.|.:.........|..|::           ||:             .::|.|.|.
Yeast   627 ----LVIAWTQLTLTTSNDVFDTLLLKLI-----------DIFNSDDYSLRIMMTLQIKNMAKIL 676

  Fly   945 KSTAKFITMPTLEVRFATL--------FTFTILLESNCVTSDAIGH-SRTHWDFCQEL---YESI 997
            |.|...:..|.|.|....|        ..|..|:|       .:|: |:|..|..|..   |..|
Yeast   677 KKTPYQLLSPILPVLLRQLGKNLVERKVGFQNLIE-------LLGYSSKTILDIFQRYIIPYAII 734

  Fly   998 EFKK--LTYNNEDAIQNSNALIVQMLIAIFLRSSFHQEIALKELLHHCALRRLTEREFISLQSMS 1060
            ::|.  |:...:.......:||.||.:.:..::|  ::|....|:.| .|..|...|.:.|....
Yeast   735 QYKSDVLSEIAKIMCDGDTSLINQMKVNLLKKNS--RQIFAVALVKH-GLFSLDILETLFLNRAP 796

  Fly  1061 SCHRQTVRDLIRPFAAILLHHWSSKRWPISKFPYFLCYSTKSEFRKTHASEIMAYTFLYGKTEDI 1125
            :..:..:.                        .|...|.|.:|..|.:.:.:         |:| 
Yeast   797 TFDKGYIT------------------------AYLPDYKTLAEITKLYKNSV---------TKD- 827

  Fly  1126 ERCSKSISEELALPILASFLLIKN--------------SSCSESEGQNFKEHLQLLSEN-LSYSQ 1175
                .|.||...:.:.:...||.|              ::.::.:.|.|::.||   :| |...|
Yeast   828 ----ASDSENANMILCSLRFLITNFEKDKRHGSKYKNINNWTDDQEQAFQKKLQ---DNILGIFQ 885

  Fly  1176 LNATDV-DLDLDILCY----VIS-----MLHDPQE-MMRLFGSLAICNRTASWYSLSGESLFKCL 1229
            :.::|: |::.....|    ||:     :::.|:: ::.....::||.:|...........|:|.
Yeast   886 VFSSDIHDVEGRTTYYEKLRVINGISFLIIYAPKKSIISALAQISICLQTGLGLKEVRYEAFRCW 950

  Fly  1230 NF---HI-DPEMRPSMDSRIQSMTTLQTKHSRVLVDIFGRLKTNCYSASFSSQALHDFFLYCEVA 1290
            :.   |: |.|:...:||.|..:  || |.|    :..|:|:...||..                
Yeast   951 HLLVRHLNDEELSTVIDSLIAFI--LQ-KWS----EFNGKLRNIVYSIL---------------- 992

  Fly  1291 DAVYDAARKNETIVTQCSFFVRDIWFFVVRLLIHTKFIRVQMAALTFLELLLNKHNFRLDDYQNH 1355
                      :|::.:.|    |:   :::|..:|....|....|..|.               .
Yeast   993 ----------DTLIKEKS----DL---ILKLKPYTTLALVGKPELGILA---------------R 1025

  Fly  1356 FGDIAKLLSNFQLCCEAKEVREKTMSIVMY---ILESKKGHINLNSFLEETTDCEFLKPLREDCK 1417
            .|..|::::         ::|..|..|.::   :..|.|..||.|     ..|.|..  ||.  |
Yeast  1026 DGQFARMVN---------KIRSTTDLIPIFANNLKSSNKYVINQN-----LDDIEVY--LRR--K 1072

  Fly  1418 SSQPNID--------RADVANYLRSFLLSPTPERLRDLRTYIAEHKDKVQEHEKL--LFGVINKL 1472
            .::.:||        .:|:...|.:.|  .|..:.|:|      .||..::..|.  :.||::  
Yeast  1073 QTERSIDFTPKKVGQTSDITLVLGALL--DTSHKFRNL------DKDLCEKCAKCISMIGVLD-- 1127

  Fly  1473 IQMTRDAHNKTT-----------SIDSLKCLAQI-------------GPLKISTVSYYFQTDF-- 1511
              :|:....:||           |:.::|.|..:             .|.|...|:...|...  
Yeast  1128 --VTKHEFKRTTYSENEVYDLNDSVQTIKFLIWVINDILVPAFWQSENPSKQLFVALVIQESLKY 1190

  Fly  1512 -----EAFEKSNGE--PMEAFLGVVCHSLD-TSLFQFDPKTHEGLVSVAI-----QVVNSK-PGS 1562
                 |:::.::.|  |.||.|....:|:. |:::..       |.|:.:     :.|..| |.:
Yeast  1191 CGLSSESWDMNHKELYPNEAKLWEKFNSVSKTTIYPL-------LSSLYLAQSWKEYVPLKYPSN 1248

  Fly  1563 NIMERYK-------------------NLRIFA-----DKSTASTFLHSNKQIRRIDWLS---ILK 1600
            |..|.||                   .|.:|:     |..:.|.||        :.::|   |:|
Yeast  1249 NFKEGYKIWVKRFTLDLLKTGTTENHPLHVFSSLIREDDGSLSNFL--------LPYISLDIIIK 1305

  Fly  1601 ATKSLSYEPWMCAFVSKVFQMCGWLGFDKLAATSFAFAKTCLLPFIKLLLENSLEH-VESLSQML 1664
            |.|...|...:...:         :.||.:.        ||.|..:..|..:||.. .||:.::.
Yeast  1306 AEKGTPYADILNGII---------IEFDSIF--------TCNLEGMNNLQVDSLRMCYESIFRVF 1353

  Fly  1665 DY-------FFEGFTSSTAPNSQEIFRNKRAIKKFLHICEYIRIFNNWTIPINLSNVVMASNHCQ 1722
            :|       |.:.::..   :...|.::.:.....|.|.|::|     |.|.:|  :...|....
Yeast  1354 EYCKKWATEFKQNYSKL---HGTFIIKDTKTTNMLLRIDEFLR-----TTPSDL--LAQRSLETD 1408

  Fly  1723 AYFLSIMYLELWAC-SESPKSK---ADFLDNECFQDGAKKAYESIGCLDAIPGFVNPMRSRLDFL 1783
            ::..|.:|||  .| .::|..|   ...|.|      .:..||.||.:|::.|.:....:     
Yeast  1409 SFERSALYLE--QCYRQNPHDKNQNGQLLKN------LQITYEEIGDIDSLDGVLRTFAT----- 1460

  Fly  1784 GHGSNLSTILLESDHLDRASGQLCIDIMKGNGLWSFAKLQQHQNIEPDYEIFWRLGQWDSLTDPK 1848
                                         ||.:....:||..:|.:...:.|..||::..  |||
Yeast  1461 -----------------------------GNLVSKIEELQYSENWKLAQDCFNVLGKFSD--DPK 1494

  Fly  1849 -----------HQQNQTVVRTS--------LDLEQEFKRHHFVALRSIGQREEENSLSAIEQAYS 1894
                       ||....::..|        :.|..:.|..:.:.|.:..                
Yeast  1495 TTTRMLKSMYDHQLYSQIISNSSFHSSDGKISLSPDVKEWYSIGLEAAN---------------- 1543

  Fly  1895 CVRDILMEISVECLQSVYKYLTWLCSLQQAEDFCQIQFGTQL------DPASTTKIFRKWQTELE 1953
                  :|.:|:.|::..:.:..|.::...|...|......|      ||..|.|..   .....
Yeast  1544 ------LEGNVQTLKNWVEQIESLRNIDDREVLLQYNIAKALIAISNEDPLRTQKYI---HNSFR 1599

  Fly  1954 LKYGNF--SCKE-YVIAHQIALLK------LAGTRASRRMSEFYQKDPISTYLMKGIEECKSAGK 2009
            |...||  |.|| .::..|..|:|      |:...:::...|:.....|..|.|:          
Yeast  1600 LIGTNFITSSKETTLLKKQNLLMKLHSLYDLSFLSSAKDKFEYKSNTTILDYRME---------- 1654

  Fly  2010 LNLAAKYTATLRELPN-----IRESIKISVLLEDAEINLKMGN-----QQIAK--AILDYVTNNN 2062
             .:.|.:      :||     :|:|.....:.|.|:.:|  |.     .|:|:  |.||..:.: 
Yeast  1655 -RIGADF------VPNHYILSMRKSFDQLKMNEQADADL--GKTFFTLAQLARNNARLDIASES- 1709

  Fly  2063 EFVYCVQ-RVPALRMQGEFLLDCNAETLSWVQSHKFNNSLKLIDDFVQHRQTLSEKYRDIFDWHQ 2126
             .::|:: |:|...:  ||     ||.| |.|... :.:||::       |.:.|||:      :
Yeast  1710 -LMHCLERRLPQAEL--EF-----AEIL-WKQGEN-DRALKIV-------QEIHEKYQ------E 1751

  Fly  2127 LDAYASKQRTAAYATIAKYADREYQQLHDYRHSQEYQTLKDIIEQNRQTAEKVTQRENQDRRVIS 2191
            ..:..::.|.|......::.|.                      .|...:|::.::.....::.|
Yeast  1752 NSSVNARDRAAVLLKFTEWLDL----------------------SNNSASEQIIKQYQDIFQIDS 1794

  Fly  2192 VQMKRYASLDEQQLNQIEEKLTE-YLRLALTNYMA--YCRLDSGFSSAAIY----RIISLW---- 2245
            ...|.|.|:.......:|.|..| |:......|.|  |..|....::|.:.    ::|:.|    
Yeast  1795 KWDKPYYSIGLYYSRLLERKKAEGYITNGRFEYRAISYFLLAFEKNTAKVRENLPKVITFWLDIA 1859

  Fly  2246 --------------FTNATSKQCQECIKDEILTVPSYKFICAANQLTARLNSKNTSLLKGLTDLL 2296
                          .:.||...|.. :::.:...|:|.:.....||.:||...:.|..:.:..:|
Yeast  1860 AASISEAPGNRKEMLSKATEDICSH-VEEALQHCPTYIWYFVLTQLLSRLLHSHQSSAQIIMHIL 1923

  Fly  2297 VQCGKDHPYHTFYQLYPLVFAHLDGENSNTERSGIARKIIAMICEKNGTAGECSKQLES----LL 2357
            :....::|.|..:.:..||       |||:.:..:..|   .|.||.....:....|.|    |.
Yeast  1924 LSLAVEYPSHILWYITALV-------NSNSSKRVLRGK---HILEKYRQHSQNPHDLVSSALDLT 1978

  Fly  2358 PALITFA-NEGKTNDNRPVSDSVRNKQFD----------KVRRWRNLNAVHCPTLE-------LP 2404
            .||.... .:.|:..:|......::.:||          .||  :||:.:  ..||       .|
Yeast  1979 KALTRVCLQDVKSITSRSGKSLEKDFKFDMNVAPSAMVVPVR--KNLDII--SPLESNSMRGYQP 2039

  Fly  2405 VMPSKEYSIISVVKWTNETTQCGGLNAPVKIMCVCSDGKIRAQLVKGKDDLRQDAVMQQVFGIVN 2469
            ..|     ::|::::.:.......|..|.::..:.|||.|...:.| |:|:|||....|....::
Yeast  2040 FRP-----VVSIIRFGSSYKVFSSLKKPKQLNIIGSDGNIYGIMCK-KEDVRQDNQYMQFATTMD 2098

  Fly  2470 ELLNQDSEFIERKLKLRTYKVTPLSMRSGILEWCTNSVPVGHYLVVEGKG--------GAHARYR 2526
            .||::|....:|.|.:..|.|..|....||||...|.|.:...|..:.:.        ..|.|  
Yeast  2099 FLLSKDIASRKRSLGINIYSVLSLREDCGILEMVPNVVTLRSILSTKYESLKIKYSLKSLHDR-- 2161

  Fly  2527 PNDWNNNKCRKLSSDHLKSPKETRYAIYKKICENIKPVFHYFLLEKFPIPGVWFERRLAYTNSVA 2591
               |.:            :..:.:...|.:..:...|:.:.:.||.||.|..||..|..|..|.|
Yeast  2162 ---WQH------------TAVDGKLEFYMEQVDKFPPILYQWFLENFPDPINWFNARNTYARSYA 2211

  Fly  2592 TTSMVGYVLGLGDRHTQNILVDQQTAEVIHIDFGIAFEQGKIQTTPETVPFRLTRDFVAPMGICG 2656
            ..:|||::|||||||.:|||:|.||.:|:|:||...||:||....||.||||||.:.:..:||.|
Yeast  2212 VMAMVGHILGLGDRHCENILLDIQTGKVLHVDFDCLFEKGKRLPVPEIVPFRLTPNLLDALGIIG 2276

  Fly  2657 TKGVFAKSCEATMHILRRYKSVFTTILEVLLYDPLFIWGVLKKKQSPQQSGEESVNLVAQRALLL 2721
            |:|.|.||.|.|:.::|:.:.....::|.::||               ::.:.|:    |:||.:
Yeast  2277 TEGTFKKSSEVTLALMRKNEVALMNVIETIMYD---------------RNMDHSI----QKALKV 2322

  Fly  2722 VQNKLDGREAGTMGDSNVEAQVERLINEATLPSNLCMLFPGWDP 2765
            ::||:.|.:.......:|..|.|.||.|||...||..::.||.|
Yeast  2323 LRNKIRGIDPQDGLVLSVAGQTETLIQEATSEDNLSKMYIGWLP 2366

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tefuNP_001036712.1 FAT 1829..>2064 CDD:396714 51/280 (18%)
PIKKc_ATM 2416..2696 CDD:270715 90/287 (31%)
FATC 2739..2767 CDD:460514 13/27 (48%)
MEC1NP_009694.3 TEL1 194..2368 CDD:227365 539/2658 (20%)

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