Protein Alignment tefu and TEL1

DIOPT Version :9

• Sequence 1: NP_001036712.1
• Gene: tefu / 41839
• FlyBaseID: FBgn0045035
• Length: 2767
• Species: Drosophila melanogaster
• Sequence 2: NP_009465.2
• Gene: TEL1 / 852190
• SGDID: S000000184
• Length: 2787
• Species: Saccharomyces cerevisiae
• Alignment Length: 3243
• Identity: 685/3243 - (21%)
• Similarity: 1175/3243 - (36%)
• Gaps: 948/3243 - (29%)

  Fly     8 IQRILGDLQSGKAASRNKGIQQLDEKLSSCREDLDKLFLSKTSDISWTTIFEASKEALFKQAGNL 72
            |...|..|.|.|...||..   |||..:..:||.:::   .|..:|.|.  ||..|.|..:....
Yeast     6 IVETLNFLSSTKIKERNNA---LDELTTILKEDPERI---PTKALSTTA--EALVELLASEHTKY 62

  Fly    73 EDVNEKVFKTLAGKNYLYDNVLEKIT---QFNLEAGSQ-------------------TSGNGHFL 115
            .|:...:..:...|..|.:|.|..|:   :..:|...:                   ..|:...|
Yeast    63 CDLLRNLTVSTTNKLSLSENRLSTISYVLRLFVEKSCERFKVKTLKLLLAVVPELMVKDGSKSLL 127

  Fly   116 AKTSIFSAF-------EDGIKMRVVV-----------KYFGDRI-LSLLEKGIYSSVSYVRDL-- 159
            ...|:..:|       .|..|::.::           :||..:: ||:::|.:.:.:|.:.:|
Yeast   128 DAVSVHLSFALDALIKSDPFKLKFMIHQWISLVDKICEYFQSQMKLSMVDKTLTNFISILLNLLA 192

  Fly   160 ----KINEYSRILSY--LFELNVDMDEVLRTR---------ILKCITRTVSLAKDRVQLHVDLVE 209
                .|.:.:|.:::  :..|.:...|...||         ||||...:|          :|.:.
Yeast   193 LDTVGIFQVTRTITWTVIDFLRLSKKENGNTRLIMSLINQLILKCHCFSV----------IDTLM 247

  Fly   210 YLPELSSFALSAFGARKTEIVR----VYLIFASELAVNYNHQLNVHMQEILPKLCEYHDEDAFRD 270
            .:.|..|:.|: .|....|:|:    ::.:.:|||   .||:        ||.:.   .::.:.:
Yeast   248 LIKEAWSYNLT-IGCTSNELVQDQLSLFDVMSSEL---MNHK--------LPYMI---GQENYVE 297

  Fly   271 DTRNLFFQCVSKSLHSMYLKMDMCDFNTLGVPVHEKWPQTLLRLK-------TIVNVE---IR-- 323
            :.|       |:||.|:|.:                  ..||||.       |:.:||   ||
Yeast   298 ELR-------SESLVSLYRE------------------YILLRLSNYKPQLFTVNHVEFSYIRGS 337

  Fly   324 --KNSWARCKNALLSNNKFSDPFIKMSALAMYIVLWHLETKKADEN---------GEGDAPKKIP 377
              ||||....:..|.:......::|:..:...::.:....:| :||         .:.|.| .|.
Yeast   338 RDKNSWFALPDFRLRDRGGRSVWLKILGITKSLLTYFALNRK-NENYSLLFKRRKCDSDIP-SIL 400

  Fly   378 KPADKMET-IFSLIDKKENTFNDVWLAIFTEILQLSSVILNVANYQMALTTVAEIMQMYGNAKNL 441
            :.:|.|:| :..|::  ||:.::.      |:|.|                  ::...||   .|
Yeast   401 RISDDMDTFLIHLLE--ENSSHEF------EVLGL------------------QLCSFYG---TL 436

  Fly   442 RNLRLCLAHLLTKEQELLHSKS--------IREDFLGELWSQMANQLISETTTNSEEIKEKQLVL 498
            ::.....|..|   :|||.||.        :...|: .|.||...:|     :|.:..:..::.|
Yeast   437 QDFTKSFAEQL---KELLFSKFEKIQCFNWVCFSFI-PLLSQKECEL-----SNGDMARLFKVCL 492

  Fly   499 QMLIRHNKLNQKLSSTLLNNII--SNEMLKRNECLATIREIFIHADKCGQDKASADLEPIIAWAY 561
            . |::.|:..| ||..||.|.|  |.::|...:.:..|.:::..:|..|....:.  |..:.|.|
Yeast   493 P-LVKSNESCQ-LSCLLLANSIKFSKQLLSDEKTINQIYDLYELSDILGPILVTN--ESFMLWGY 553

  Fly   562 --------------GSADRFI--AAQMIHNIDSIDA-QLQADTFAISIINFLDVQQLRQISQSEH 609
                          .||||..  .....:.:...|| |.|...|...:.|..|.:......:.|.
Yeast   554 LQYVGKDFQSMNGISSADRIFEWLKSKWNQLRGTDAKQDQFCNFISWLGNKYDPENPFNDKKGEG 618

  Fly   610 IVP---------------STERN-LLAYKYNEQLICFDKDYATPFESITHIQSETKNCLIQSNYD 658
            ..|               ..:|. ||..|..|:..||:    |||.::..:..:    |.:.| :
Yeast   619 ANPVSLCWDESHKIWQHFQEQREFLLGVKPEEKSECFN----TPFFNLPKVSLD----LTRYN-E 674

  Fly   659 CLMRGL-NFEIAKENKPAAIIKNLNSLLKLICTMERLLHYKVFD----ADTYTGCPLIKRIGL-- 716
            .|.|.| |.|....:.|   ::....:.|||..::.|.....|.    |...|....|.::..
Yeast   675 ILYRLLENIESDAFSSP---LQKFTWVAKLIQIVDNLCGDSTFSEFIAAYKRTTLITIPQLSFDS 736

  Fly   717 ---YLSHIEFQLKANGAE----ILDKSDLPEILRLEIYVLDVFR-------TNLVLLDYLE---- 763
               |.|..|..|......    :|||.::.||      |.|..|       |....::|.|
Yeast   737 QNSYQSFFEEVLSIRTINVDHLVLDKINMKEI------VNDFIRMQKNKSQTGTSAINYFEASSE 795

  Fly   764 ---------------RQPIEMLVEFVGAALKLHSMQRERS------------VDAD-----HGTI 796
                           ::|:...::....|....|..:..|            |..|     .||:
Yeast   796 DTTQNNSPYTIGGRFQKPLHSTIDKAVRAYLWSSRNKSISERLVAILEFSDCVSTDVFISYLGTV 860

  Fly   797 TRLCLNILAGLCAYNSHRDEAFEHIVKVTMRWHPQDVLIVTKMLCSCQTISEASSSWLVSKLKTL 861
            .:.....:....:||...:|..|              ::..|:||:..:.|..:...|.|.::.:
Yeast   861 CQWLKQAIGEKSSYNKILEEFTE--------------VLGEKLLCNHYSSSNQAMLLLTSYIEAI 911

  Fly   862 FQQH--------HQDA-ELMDKVVQHMPTIFYFVRHKENHLDDMLMALN-SLLRIAIKKSY---- 912
            ..|.        :.|. :::|.::.         |.::|....:...:| |:|.:::.:::
Yeast   912 RPQWLSYPEQPLNSDCNDILDWIIS---------RFEDNSFTGVAPTVNLSMLLLSLLQNHDLSH 967

  Fly   913 ------TSNLTAKIVRCVGLIAQRCPDIYLLENFAVICKSTAKFITMPTLEVRFATLFTFTILL- 970
                  ...:.|..::|:..:..        .|...|..|.:.::...:.:.:....:....|.
Yeast   968 GSIRGGKQRVFATFIKCLQKLDS--------SNIINIMNSISSYMAQVSYKNQSIIFYEIKSLFG 1024

  Fly   971 -ESNCVTSDAIGHSRTHWDFCQELYESIEFKKLTYNNED-----AIQNSNALIVQMLIAIFLRSS 1029
             ....:...|.      :.....:...:.:..|.::.||     ...::.|.|.|.|..|.:...
Yeast  1025 PPQQSIEKSAF------YSLAMSMLSLVSYPSLVFSLEDMMTYSGFNHTRAFIQQALNKITVAFR 1083

  Fly  1030 FHQEIALKELLHHCALRRLTEREFISLQSMSSCHRQTVRDLIRPFAAILLHHWSS---------- 1084
            :..   |.||..:|..                       |||.        :|.:
Yeast  1084 YQN---LTELFEYCKF-----------------------DLIM--------YWFNRTKVPTSKLE 1114

  Fly  1085 KRWPISKFPYFLCYSTKSEFRKTHASEIMAYTFLYGKTEDIERCSKSISEELALPILASF----- 1144
            |.|.||.|.    ::...||...:..||.|..|           |:..:::..|.:|.:.
Yeast  1115 KEWDISLFG----FADIHEFLGRYFVEISAIYF-----------SQGFNQKWILDMLHAITGNGD 1164

  Fly  1145 -LLIKNS--SCSESEGQNFKEHLQLLSENLSYSQLNATDVDLDLDILCYVIS----MLHDPQEMM 1202
             .|:.||  .|..         |..:|..::         :|..|||..:..    ..|....::
Yeast  1165 AYLVDNSYYLCIP---------LAFISGGVN---------ELIFDILPQISGKTTVKYHKKYRLL 1211

  Fly  1203 RL--------FGSLAICNRTASWYSLSGESLFKCLNFHIDPEM--RPSMDSRIQ---------SM 1248
            .|        .|||.....|.       |.||.  ..::.|.:  ..|:..|.|         ..
Yeast  1212 MLKWIIRFTDLGSLTELRSTV-------EKLFP--TSYLSPYLFENSSVSMRYQYPLHIPLALGA 1267

  Fly  1249 TTLQTK--HSR------------VLVDIFGRLKTNCYSASF--SSQALHDFFLYCEVADAVYDAA 1297
            |.:||:  |.:            |:.|:   .||:.|....  :.:..:.|.||
Yeast  1268 TLVQTQFAHEKNNTHEFKLLFLSVITDL---EKTSTYIGKLRCARELKYLFVLY----------- 1318

  Fly  1298 RKNETIVTQCSFFVRDIWFFVVRLLIHTKFI---RVQMAALTFLELLLN---KHNFRLD-DYQNH 1355
               |.::.:.|    .:.|.::||   :||:   ::....:|....|||   |:.|.:: ...|.
Yeast  1319 ---ENVLVKSS----TLNFIIIRL---SKFLIDTQIHDEVITIFSSLLNLADKNTFEIEPSLPNL 1373

  Fly  1356 FGDI-------AKLLSNFQLCCEAKEVRE----KTMSIVMYILESKKGHINLNSFLEETTDCEFL 1409
            |..|       .:|..:||...:..|.|:    ||..   |.|::..|:|..:...|.|   |.|
Yeast  1374 FCKIFIYLRENKQLSPSFQQAIKLLEHRDLIKIKTWK---YCLDAIFGNIVQDDIYENT---ELL 1432

  Fly  1410 KPLREDCKSSQPNIDRADVANYLRSFLLSPTPERL-----RDLRTYIAEH---KDKVQEHEKLLF 1466
            .  ..||     .:|...:.:.|.|:...|...::     :.....|.:|   |:.:.::.||.|
Yeast  1433 D--ASDC-----GVDDVVLVSLLFSYARRPVASKIGCSLSKAAAINILKHHVPKEYLSKNFKLWF 1490

  Fly  1467 GVINKLIQMTRDAHNKTTSIDS---LKCLAQIGPLKISTVSYYFQTDFEAFEKSNGEPMEAFLGV 1528
            ..:::.|........::|:.::   ||                   :||...:...:|...:..:
Yeast  1491 AALSRRILQQEVQRERSTNFNNEVHLK-------------------NFEMVFRHPEQPHMIYQRI 1536

  Fly  1529 VCHSLDTSLFQFDPKTHEGLVS-------VAIQVVNSKP----GSNIMERYKNLRIFADKST--- 1579
            ...:.:..|:.   .|....:|       |...:.||:.    ..|||...|:.....||..
Yeast  1537 STFNKEAELYD---STEVFFISECILTYLVGYSIGNSESEFCFRDNIMNENKDKVAPLDKDVLNA 1598

  Fly  1580 --------------ASTFLHSNKQIRRIDWLSILKATKSLSYE------PWMCAFVSKVFQMC-G 1623
                          ..|:|..|:...  .|||  |..:||.::      |.:|     ::.:| |
Yeast  1599 IYPLANNFGMESFICDTYLSVNEPYN--CWLS--KFARSLIHQISFNIPPIVC-----LYPLCKG 1654

  Fly  1624 WLGFDKLAATSFAF------AKTCL------LPFIKLLLENSLEHVESLSQMLDYFFEGFTSSTA 1676
            ...|.:|..|...|      .|:||      ...|.:||     ||:.....|...|
Yeast  1655 STAFCELVLTDLFFLSTTYDPKSCLNWSNRIFTQIAMLL-----HVKDSEIKLKMLF-------- 1706

  Fly  1677 PNSQEIFRNKRAIKKFLHICEYIRIFNNWTIPINLSNVVMASNHCQAYFLSIMYLELWACSESPK 1741
             |..::.|.....|:  ..|  :||:::    ::|..:...|...:.:....:..|........:
Yeast  1707 -NVIKMIRMGSRCKE--RNC--LRIYSS----LDLQEICQISLKIKEFKFGYLLFEEMNMPNIRE 1762

  Fly  1742 SKADFLDN--ECFQDGAKKAYESIGCLDAIPGFVNPMRSRLD------FLGHGSNLS---TILLE 1795
            ...:.|..  ||..||...|  .:....:|.|.:|.: :|:|      ||.:.::..   |..||
Yeast  1763 MNINTLQKIYECINDGDFLA--GLPVPHSIEGVLNSI-NRIDSDTWKRFLFNNADFDANYTTSLE 1824

  Fly  1796 SDHLDRASGQLCIDIMKGNGLWSFAKLQQHQNIEPDYEIF-W--RLGQWDSLTDPKHQQN----- 1852
            .:.      :..|...:.:|.:....|.: ..:....::: |  .||.|..|| ||...:
Yeast  1825 EEK------ESLIKATEDSGFYGLTSLLE-SRLSGSSDVYKWNLELGDWKLLT-PKVVDSKAKGL 1881

  Fly  1853 --------QTVVRTSLDLEQEF-----KRHHFVALRSIGQREEENSLSAIEQAYSCVRDILMEIS 1904
                    |.|......||:..     .|.||     |.|.|..::|:|          |:..|.
Yeast  1882 YYAIKNLPQDVGFAEKSLEKSLLTIFDSRQHF-----ISQTEWMDTLNA----------IIEFIK 1931

  Fly  1905 VECL-QSVYKYLTWLCSLQQA--EDFCQIQFGTQLDPASTTK--------IFRKWQTELELKYGN 1958
            :..: |.|..:...|.|:.:|  |....|.|   .|..:|.|        :.|....|      |
Yeast  1932 IAAIPQDVTSFPQTLMSIMKADKERLNTIDF---YDHKTTLKSRHTLMNVLSRNSLDE------N 1987

  Fly  1959 FSCKEYV-------IAHQIALLKLAG------------TRASRRMSEFYQKDPISTYLMKGIEEC 2004
            ..|.:|:       :|:.:.|....|            ::..:.:::.|. ||.....::.:...
Yeast  1988 VKCSKYLRLGSIIQLANYVQLAIANGAPQDALRNATLMSKTVKNIAKLYD-DPSVVSQIEKLASF 2051

  Fly  2005 KSAGKLNLAAKYTA---TLREL-----PNIRESIKISVLLEDAEINLKMGNQQIAKAILDYVTNN 2061
            .||..|..:.:|.|   .:|:|     .||.|||    |.:|.::.:.:...||...::.:.:.:
Yeast  2052 TSANALWESREYKAPVMIMRDLLAQNEKNISESI----LYDDFKLLINVPMDQIKARLVKWSSES 2112

  Fly  2062 NEFVYCVQRVPALRMQGEFLL--DCNAETLSWVQSHKFNNSLKLIDDFVQHRQTLSEKYRDIFDW 2124
                   :..||..:..:.::  |.|      |:.|                    |...|:|
Yeast  2113 -------RLEPAAAIYEKIIVNWDIN------VEDH--------------------ESCSDVF-- 2142

  Fly  2125 HQLDAYASKQRTAAYATIAKYADREYQQLH-----DYRHSQEY---QTLK--DIIEQNRQTAEKV 2179
                           .|:..:.|.:.|:|.     :.|..:.|   .|||  ::|.:|    .|:
Yeast  2143 ---------------YTLGSFLDEQAQKLRSNGEIEDREHRSYTGKSTLKALELIYKN----TKL 2188

  Fly  2180 TQRENQD-----RRVISVQMKRYASLDEQQLNQIEEKLTEYLRLALTNYMAYCRLDSGFSSAAIY 2239
            .:.|.:|     .||: :|..|    |.:.|..:..:..::|..||..|:......:.:.:..|.
Yeast  2189 PENERKDAKRHYNRVL-LQYNR----DSEVLKALLLQKEKFLWHALHFYLNTLVFSNRYDNDIID 2248

  Fly  2240 RIISLWFTNATSKQCQECIKDEILTVPSYKFICAANQLTARLNSKNTSLLKGLTDLLVQCGKDHP 2304
            :...|||.|..:.:..:.:..||.|:||:||:...||:.::::.:.....|.|...:.:.....|
Yeast  2249 KFCGLWFENDDNSKINQLLYKEIGTIPSWKFLPWVNQIASKISMEENEFQKPLQLTMKRLLYKLP 2313

  Fly  2305 YHTFYQLYPLVFAHLDGENSNTERSGIARKIIA---MICEKNG-TAGECSKQLESLLP------- 2358
            |.:.|.:..::..    |..:.:.:.|::||.|   ::.|..| ..|..:|:.  |||
Yeast  2314 YDSLYSVMSILLY----EKQSNKDTNISQKIQAVKKILLELQGYDRGAFAKKY--LLPVQEFCEM 2372

  Fly  2359 ----ALITFANEGKTNDNRPVSDSVRNKQFDKVRRW---RNLNAVHCPTLELPVMPS------KE 2410
                |.:.|....||         :|.......:.|   .|:..:..||....|..|      :.
Yeast  2373 SVELANLKFVQNTKT---------LRLANLKIGQYWLKQLNMEKLPLPTSNFTVKSSADGRKARP 2428

  Fly  2411 YSIISVVKWTNETTQCGGLNAPVKIMCVCSDGKIRAQLVKG-KDDLRQDAVMQQVFGIVNELLNQ 2474
            | |:||.:....||.  ||:.|..:....|||..:..|:|| .|||||||:|:|||..||::|..
Yeast  2429 Y-IVSVNETVGITTT--GLSLPKIVTFNISDGTTQKALMKGSNDDLRQDAIMEQVFQQVNKVLQN 2490

  Fly  2475 DSEFIERKLKLRTYKVTPLSMRSGILEWCTNSVPVGHYLVVEGKGGAHARYRPNDWNNNKCRKLS 2539
            |.......|.:|||||.||..::||:|:..||..:...|         ::...||       |::
Yeast  2491 DKVLRNLDLGIRTYKVVPLGPKAGIIEFVANSTSLHQIL---------SKLHTND-------KIT 2539

  Fly  2540 SDHLK--------SPKETRYAIYKKICENIKPVFHYFLLEKFPIPGVWFERRLAYTNSVATTSMV 2596
            .|..:        ...|.|...|.||...|||....|..:.||.|..|||.:..||..||.:|:|
Yeast  2540 FDQARKGMKAVQTKSNEERLKAYLKITNEIKPQLRNFFFDSFPDPLDWFEAKKTYTKGVAASSIV 2604

  Fly  2597 GYVLGLGDRHTQNILVDQQTAEVIHIDFGIAFEQGKIQTTPETVPFRLTRDFVAPMGICGTKGVF 2661
            ||:|||||||..|||:|..|.|.||||.||||:|||:...||.||||||||.|...|:.|..|:|
Yeast  2605 GYILGLGDRHLNNILLDCSTGEPIHIDLGIAFDQGKLLPIPELVPFRLTRDIVDGFGVTGVDGLF 2669

  Fly  2662 AKSCEATMHILRRYKSVFTTILEVLLYDPLFIWGVLKKKQSPQQSGEE----------------- 2709
            .:|||....:||:.......:|.:|.:|||:.|.:...|:......||
Yeast  2670 RRSCERVYAVLRKDYVKVMCVLNILKWDPLYSWVMSPVKKYEHLFEEEHEITNFDNVSKFISNND 2734

  Fly  2710 -SVNLVAQRALLLVQNKLDGREAGTMGDS-NVEAQVERLINEATLPSNLCMLFPGWDP 2765
             :.|..:.|||..|:.||       ||:. :||:.|:.||.:||.||||.:::.||.|
Yeast  2735 RNENQESYRALKGVEEKL-------MGNGLSVESSVQDLIQQATDPSNLSVIYMGWSP 2785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tefu	NP_001036712.1	FAT	1829..2170	CDD:280429	78/411 (19%)
		PIKKc_ATM	2416..2696	CDD:270715	118/288 (41%)
		FATC	2739..2767	CDD:280430	14/27 (52%)
TEL1	NP_009465.2	TAN	6..157	CDD:402988	32/158 (20%)
		TEL1	292..2787	CDD:227365	621/2924 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346295
Domainoid	1	1.000	193	1.000	Domainoid score	I621
eggNOG	1	0.900	-	-		E1_KOG0892
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5823
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003948
OrthoInspector	1	1.000	-	-		oto99478
orthoMCL	1	0.900	-	-		OOG6_102827
Panther	1	1.100	-	-	LDO	PTHR11139
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2040
SonicParanoid	1	1.000	-	-		X3248
TreeFam	0	0.000	Not matched by this tool.
	12	11.720