DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tefu and Atr

DIOPT Version :9

Sequence 1:NP_001036712.1 Gene:tefu / 41839 FlyBaseID:FBgn0045035 Length:2767 Species:Drosophila melanogaster
Sequence 2:XP_003750609.1 Gene:Atr / 685055 RGDID:1305796 Length:2636 Species:Rattus norvegicus


Alignment Length:3143 Identity:615/3143 - (19%)
Similarity:1105/3143 - (35%) Gaps:1021/3143 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   138 GDRILSLLEKGIYSSVSYVRDL---KINEYSRIL--------SYLFELNVDMDEVLRTRILKCIT 191
            ||..|.|.     |.:..:|:|   ...||:.::        .::..:..|::.|....:.|..|
  Rat     2 GDHGLELA-----SMIPALRELGSATPEEYNTVVQKPRQILCQFIDRILTDVNVVALELVKKTDT 61

  Fly   192 RTVSLAKDRVQLHVDLVEYLPELSSFA-LSAFGAR-KTEIVRVYLIFASELAVNYNHQL------ 248
            :..|:      :.:|.::::.:.|... ::..|:: :.|        |.:..:.::|.:      
  Rat    62 QPTSV------MLLDFIQHIMKSSPLMFVNVNGSQGQNE--------AKDSCIEFSHWIITRLLR 112

  Fly   249 -----NVHMQEILPKLCEYHDEDAFRDDTRN-LFFQCVSKSLHSMYLKMDMCDFNTLGVPVHEK- 306
                 :.||  :..|:||......|...::| ..|..:::.|  :||..|:       :.:|:: 
  Rat   113 IAATPSCHM--LHKKICEVICSLLFLFKSKNPAIFGVLTREL--LYLFEDL-------IYLHKRN 166

  Fly   307 -------WPQTLLRLKTIVNVEIRKNSWARCKN--ALLSNNKFSDPFIKMSALAMYIVLWHLETK 362
                   ||..:.|..:      |.:....|..  .|...|..:..||:::.|   :||.|:   
  Rat   167 AVGDVMEWPVVVSRFLS------RLDEHMGCLQPAPLQFMNMQNVEFIEVTLL---MVLIHI--- 219

  Fly   363 KADENGEGDAPKKIPKPADKMETIF-------------SLIDKKENTFNDVWLAIFTEILQLSSV 414
                         :|       |:|             :|::........:.:::.||:.:|..:
  Rat   220 -------------VP-------TVFFRRQELLLWQIGCALLEHGSPKIRSLAISLLTELFELGGL 264

  Fly   415 ILNVANYQMALTTVAEIMQMYGNAKNLRNLRLCLAHLLTKEQELLHSKSIREDFLGELWSQMANQ 479
            ....|:...:|  ..|::|                ||:..:.:.|           :|:.:..::
  Rat   265 PAQPASTFFSL--FLELLQ----------------HLIGMDADQL-----------KLYEEPLSK 300

  Fly   480 LI-------SETTTNSEEIKEKQLVLQMLIR-HNKLNQKLSSTLLNNIISNEMLK--------RN 528
            |:       :|...|.|.:....|:.::.:. .:::..:|.|.||...:.: :|:        ..
  Rat   301 LVKTLFPFEAEAYRNIEPVYLNVLLEKLRVMFEDRVLMRLKSDLLKAALCH-LLQYFLTFVPAGY 364

  Fly   529 ECLATIREIFIHADKCGQDKASAD---LEPIIAWAYGSADRFIAAQMIHNIDSID-AQLQADTFA 589
            |....:|:::: .|.|   :|..|   ::..:.:..|.   |.||..:.:.:.|: .|.||    
  Rat   365 ESALQVRKVYV-TDIC---RALVDVLGVQTHVGYLLGP---FYAALKMESTEIIERIQCQA---- 418

  Fly   590 ISIINFLDVQQLRQISQSEHIVPSTER---NLLAYKYNEQLICFDKDYATPFESITHIQSETKNC 651
                     ||......::.:.|...|   :|.:||...:          ..|.|.|:..:.|:.
  Rat   419 ---------QQENLRGSNDGVSPKRRRLSSSLSSYKRPSR----------QSEEINHVDMDKKSI 464

  Fly   652 L---IQSNYDCLMRGLNFEIAKENKPAAIIKNLNSLLKL--ICTMERLLHYKVFDADTYTGCPLI 711
            |   ::...:.|...|.....| |..|..::.:..:|:|  :||    :|....|.|.:      
  Rat   465 LWNVLKQKAESLQISLECGTLK-NSVAEALEGITIVLQLTALCT----VHCSHQDMDGH------ 518

  Fly   712 KRIGLYLSHIEFQLKANGAEILDKSDLPEI---LRLEIYVLDVFRTNLVLLDYLERQPIEMLVEF 773
                          .|...:...|...|.:   :.|:.|. .|.::...||:.:::..:|::::.
  Rat   519 --------------NAKDCQHKYKKKPPVVITWMSLDFYT-KVLKSCKSLLESVQKHELELVIDS 568

  Fly   774 VGAALKLHSMQRERSVDADHGTITRLC-LNILAGLCAYNSHRDEAFEHIVKVTMRWHPQDVLIVT 837
            |..........:.:|...|| .:..|| :..|..:.:|:.      ::.:|:|        ...|
  Rat   569 VVRIYDALMYIQVKSSFQDH-VLEELCGMLSLPWIYSYSD------DNSLKMT--------TFAT 618

  Fly   838 KMLCSCQTISEASSSWLVSK---LKTLFQQHHQDAELMDKVVQHMPTIFYFVRHKENH------- 892
            .:|...|.:.|:.|....|:   |.|||.:         ::.....|..|....|.:|       
  Rat   619 NLLRLSQRVWESYSPQAQSQCVFLLTLFPK---------RIFLDWRTTVYNWALKSSHEVIRTSC 674

  Fly   893 ---LDDMLMALNSLLRI-------------AIKKSYTSNLTAKIVRCVGLIAQRCPDIYL----- 936
               ...:|...||..:|             .:||.:.|.|...:....|:       .||     
  Rat   675 VKGFFILLQQENSCNQIPKMLIDRVKDDSHVVKKEFASVLGQLVCTLHGM-------FYLTSSSV 732

  Fly   937 ------LENFAVICKSTAKFITMPTLEVRFATLFTFTILLESNCVTS------DAIGHSRTHWDF 989
                  ::.|....|:|::. ...:.:|:.:....|..||..|..:.      |.:.|...|.||
  Rat   733 EPFFGPVDLFCKNLKATSQH-ECSSSQVKASVCKPFLFLLTKNTPSPVKLAFIDNLHHLCKHLDF 796

  Fly   990 CQELYE-------------------------SIEFKKLTYNNEDAIQNSNALIVQMLIAIFLRSS 1029
            .::..|                         :|::...:.|:||.               |::..
  Rat   797 QEDETEVKAVLGTLLNLMEDPDKDVRIAFSGNIKYILESLNSEDG---------------FIKEL 846

  Fly  1030 FHQEIALKELLHHCALRRLTEREFISLQSMSSCHRQTVRDLIRPFAAI-LLHHWSSKRWPISKFP 1093
            |  .:.:||...|..:.|..|.:...:.:.....|....||| |||.: |||...||...:|...
  Rat   847 F--VLRMKEAYTHAQISRSNELKDTLILTTGDIGRAAKGDLI-PFALLHLLHCLLSKSASVSGAA 908

  Fly  1094 Y------FLCYSTK-----SEFRK---------THASEIMAYTFLYGKTEDIERCSKSISEELAL 1138
            |      ....|.|     |:::|         .|:|::.|......:|.::.:...:...|:||
  Rat   909 YTEIRALVAAKSVKLQNFFSQYKKPICQFLVESLHSSQMTALPSTPCQTAEMRKQHVAHHREMAL 973

  Fly  1139 PILASFLLIKNSSCSESEGQNFKEHLQLLSENLSY--------------SQLNATDVDLDLDILC 1189
            ..|:.   |.|........:.....||:|..:|:.              .|||....::.::...
  Rat   974 NTLSE---IANVFDFPDLNRFLTRTLQVLLPDLAAKASPAASALIRTLGKQLNVNRREILINNFK 1035

  Fly  1190 YVISMLHDPQEMMRLFGSLAICNRTASWYSLSGESLFKCLNFHIDPEMRPSMDSRIQSMTTLQTK 1254
            |:.|.|              :|       |.|.:.|.:.|:: :..|....:.|.::.  ..|..
  Rat  1036 YIFSHL--------------VC-------SCSKDELERALHY-LKNETEIELGSLLRQ--DFQGL 1076

  Fly  1255 HSRVLV-------DIFGRLKTNCYSASFSSQALHDFFLYCEVADAVYDAARKNETIVTQCSF--- 1309
            |:.:|:       .:|..|.   ..|||:|            :|..|...|...:......:   
  Rat  1077 HNELLLRIGEHYQQVFNGLS---ILASFAS------------SDDPYQGPRDITSPELMADYLQP 1126

  Fly  1310 -FVRDIWFFVVRLLIHTKFIRVQMAALTFLELLLN----KH----------------NFRLDDYQ 1353
             .:..:.||.::||..:..|..:..|||.|..|:.    ||                .|: ||:.
  Rat  1127 KLLGILAFFNMQLLSSSVGIEDKKMALTSLMSLMKLMGPKHVSSVRVKMMTTLRTGLRFK-DDFP 1190

  Fly  1354 NHFGDIAKLLSNFQLCCEAKE--VR--------------------------EKTMSIVMYIL--- 1387
                         :|||.|.:  ||                          ::|.:|..|::   
  Rat  1191 -------------ELCCRAWDCFVRCLDHAYLGPLLSHVIVALLPLIQMQPKETAAIFHYLIIEN 1242

  Fly  1388 ------------------ESKKGHINLNSFLEETTDCEFLK-PLREDCKSSQ-PNIDRADVANYL 1432
                              |.:|....|..:.:||::...|: .|:...|:.| .|:|       :
  Rat  1243 RVAVQDFLHEIYFLPDHPELEKIKAVLQEYRKETSESTDLQTTLQLSMKAIQHENVD-------V 1300

  Fly  1433 RSFLLSPTPERLRDLRTYIAEHKDKVQEHEKLLFGVINKLIQMTRDAHNKTTSIDSLKCLAQIGP 1497
            |...|:...|.|...:..:.::....:..|.::..::..:::..:||:::...:.. :||.::|.
  Rat  1301 RIHALTSLKETLYKNQEKLIKYATDSETVEPVISQLVTVILKGCQDANSQARLLCG-ECLGELGA 1364

  Fly  1498 -----LKISTV-----SYYFQTDFEAFEKSNGEPME---AFLGVVCHS--LDTSLFQFDPKTHEG 1547
                 |..||.     .:.|.|..|....:.|..||   |:|....:|  .|::.:..     :.
  Rat  1365 IDPGRLDFSTTETQGKDFTFVTGVEDLSFAYGLLMELTRAYLAYADNSRAQDSAAYAI-----QE 1424

  Fly  1548 LVSV--AIQVVNSKPGSNIMERY-KNLRIFADKSTASTFLHSNKQIRRIDWLSILK----ATKSL 1605
            |:|:  ..::.::.||..:.:|: :::|...:....:.:..|.|.   .||..:.|    :....
  Rat  1425 LLSIYDCREMQSNGPGHQLWKRFPEHVREILEPHLNTRYKSSQKS---TDWSGVTKPIYLSKLGN 1486

  Fly  1606 SYEPWMCAFVSKVFQMCGWLGF------DKLAATSFAFAKTC--------------LLPFIKL-- 1648
            ::..|..:          |.|:      |.||:..|    ||              |||.|.:  
  Rat  1487 NFAEWSSS----------WAGYLITKVRDNLASKIF----TCCSIMMKHDFKVTIYLLPHILVYV 1537

  Fly  1649 ------------------LLENSLEH---------------VESLSQMLDYFFEGFTSS-TAPNS 1679
                              :|::..:|               .:::..|||:..:..... .|.|:
  Rat  1538 LLGCSQEDQQEVYAEIMAVLKHDDQHAISTQDSASDLCQLSTQTVFSMLDHLTQWARHKFQALNA 1602

  Fly  1680 QEIFRNK------------RAIKKFLHICEYIRIFNNWTIPINLSNVVMASNHCQAYFLSIMYLE 1732
            :::.:||            :::.:||.:             |....:.:||...:||..::|:.|
  Rat  1603 EKLAQNKPKGVSSVNFEDYQSVTRFLDL-------------IPQDTLAVASFRSKAYTRAVMHFE 1654

  Fly  1733 -------------------LWACSESPKSKADFLDNECFQDGAKKA----------YESIGCL-D 1767
                               |:|....|       |........:||          :||||.| |
  Rat  1655 SFITEKKQNIQKHLGFLQKLYAAMHEP-------DGVAGVSAIRKAEPSLKEQILEHESIGLLRD 1712

  Fly  1768 AIPGFVNPMRSRLDFLGHGSNLSTILLESDHLDRASGQLCIDIMKGNGL------WSFAKLQQHQ 1826
            |...:...::...|.:.|...:...:|       ..|||...|.:.||:      |: .:|..::
  Rat  1713 ATACYDRAIQLEPDQIIHYHGVVKSML-------GLGQLSTVITQVNGVHANRSEWT-DELNTYR 1769

  Fly  1827 NIEPDYEIFWRLGQWDSLTDPKHQQNQTV---VRTSLDLEQEFKRHHFVALRSIGQREEENSLSA 1888
                 .|..|:|.|||.:.:......::.   ||                   :||.    .|||
  Rat  1770 -----VEAAWKLSQWDLVENYLAADGKSTTWSVR-------------------LGQL----LLSA 1806

  Fly  1889 IEQAYSCVRDILMEISVECL-------------QSVYKY---LTWLCSLQQAEDFCQIQFGTQLD 1937
            .::..:...|.|..:..|.:             |..|::   |..||.|:.:           |.
  Rat  1807 KKRDTTAFYDTLKLVRAEQIVPLSAASFERGSYQRGYEFIVRLHMLCELEHS-----------LK 1860

  Fly  1938 PASTTKIFRK------------WQTELELKYGNFSCKEYVIAHQIALLKLAGTRASRRMSEFYQK 1990
            |     :|.|            |...||:...::..||.::|.:.|||.|             .|
  Rat  1861 P-----LFHKFPGDSCNEDSLNWAARLEMTQNSYRAKEPILALRRALLSL-------------NK 1907

  Fly  1991 DPISTYLMKGIEEC--KSAGKLNLAAKYTATLRELPNIRESIKISVLLEDAEINLKMGNQQIAKA 2053
            .|....:   :.||  :||.....|..:......|.|..||....:.:|.|:.....|:...|..
  Rat  1908 RPDYNEM---VGECWLQSARVARKAGHHQTAYNALLNAGESRLAELYVERAKWLWSKGDVHQALI 1969

  Fly  2054 ILDYVTNNNEFVYCVQRVPALRMQGEFLLDCNAETLSWVQSHKFNNSLKLIDDFVQ-----HRQT 2113
            :|.   ...|..:...:.|.   :.:.:|.....||             |:..|::     ....
  Rat  1970 VLQ---KGVELCFPENKSPT---ESKHMLIHGRATL-------------LVGRFMEETANFESNA 2015

  Fly  2114 LSEKYRDIF----DWHQLDAYASKQRTAAYATIAKYADR-----------------EYQQLH--- 2154
            :.:||:|:.    :|.....|           :|||.|:                 .|..||   
  Rat  2016 IMKKYKDVTLFLPEWEDGHFY-----------LAKYYDKLMPMVTDNKMEKQGDLIRYIVLHFGR 2069

  Fly  2155 --DYRHSQEYQTLKDIIEQNRQTAEKVTQRE---NQDRRVISVQMKRYASLDEQQLNQIEEKLTE 2214
              .|.:...||::..::........|..:.|   ..||    :||:       ..|.:|...|||
  Rat  2070 SLQYGNQFIYQSMPRMLSLWLDFGAKAYEWEKGGRSDR----LQMR-------NDLAKINSVLTE 2123

  Fly  2215 YLRLALTNYMAYCRLDSGFSS-------------AAIYRII----------SLWFTNATSK---- 2252
            :     ||.:|..:..:.||.             ..:..||          ::|...|.||    
  Rat  2124 H-----TNRLAPYQFLTAFSQLISRICHSHDEVFVVLMEIIAKVFLAYPQQAMWMMTAVSKSSYP 2183

  Fly  2253 ----QCQECIKDEILTVPSY-KFICAANQLTARLNSKNTSLLKGLTDLLVQCGKDHPYHTFYQLY 2312
                :|:|.:...|....|. ||:..|.:||.:              ||..|.|.          
  Rat  2184 MRVNRCKEILTKAIHMKKSLEKFVGDATRLTDK--------------LLELCNKS---------- 2224

  Fly  2313 PLVFAHLDGENSNTERS---GIARKIIAMICEKNGTAGECSKQLES-LLPALITFANEGKTNDNR 2373
                  :||.||....|   .:.:|::     ::.|..|....|:| ::|.|.:.......:|..
  Rat  2225 ------VDGSNSTLSMSTHFKMLKKLV-----EDPTFSEILIPLQSVMIPTLPSILGAHANHDPF 2278

  Fly  2374 PVSDSVRNKQFDKVRRWRNLNAVHCPTLELPVMPSKEYSIISVVKWTNETTQCGGLNAPVKIMCV 2438
            |             ..|..|....              .::.::         ..|..|.||...
  Rat  2279 P-------------GHWAYLAGFD--------------DVVEIL---------SSLQKPKKISLK 2307

  Fly  2439 CSDGKIRAQLVKGKDDLRQDAVMQQVFGIVNELLNQDSEFIERKLKLRTYKVTPLSMRSGILEWC 2503
            .||||....:.|.|||||:|..:.:...::|:.|.:|:|...|:|.:|||.|.||:...||:||.
  Rat  2308 GSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKSLRKDAESRRRELHIRTYAVIPLNDECGIIEWV 2372

  Fly  2504 TNSV---PVGHYLVVEGKG----GAHARYRPNDWNNNKCRKLSSDHLKSPKETRYAIYKKICENI 2561
            .|:.   |:...|..| ||    |...|         :|        ..||....:...|:.:.|
  Rat  2373 NNTAGLRPILTKLYKE-KGVYMTGKELR---------QC--------MLPKSAALSEKLKVFQEI 2419

  Fly  2562 -----KPVFHYFLLEKFPIPGVWFERRLAYTNSVATTSMVGYVLGLGDRHTQNILVDQQTAEVIH 2621
                 .||||.:.|..||.|..|:..|.||..|.|..|||||:|||||||.:|||.|..|.|.:|
  Rat  2420 LLPRHPPVFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSFTGECVH 2484

  Fly  2622 IDFGIAFEQGKIQTTPETVPFRLTRDFVAPMGICGTKGVFAKSCEATMHILRRYKSVFTTILEVL 2686
            :||...|.:|:....||.||||||.:.|..||..||:|:|.::||.|:.::|..:....::|:..
  Rat  2485 VDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTLRLMRDQREPLMSVLKTF 2549

  Fly  2687 LYDPLFIWGVLKK---KQSPQQSGEESVNLVAQRALLLVQNKLDG----REAGTMGDSNVEAQVE 2744
            |:|||..|....|   |..|.::| |.||..|:..:|.::.:|.|    |...|....::|..|.
  Rat  2550 LHDPLVEWSKPVKGHSKAPPNETG-EVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVH 2613

  Fly  2745 RLINEATLPSNLCMLFPGWDPHL 2767
            .||.|||..:.||.::.||.|::
  Rat  2614 YLIQEATDENLLCQMYLGWTPYM 2636

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tefuNP_001036712.1 FAT 1829..2170 CDD:280429 74/404 (18%)
PIKKc_ATM 2416..2696 CDD:270715 106/291 (36%)
FATC 2739..2767 CDD:280430 12/27 (44%)
AtrXP_003750609.1 UME 1120..1226 CDD:214825 21/119 (18%)
FAT 1766..2087 CDD:280429 74/410 (18%)
TEL1 <2118..2636 CDD:227365 174/612 (28%)
PIKKc_ATR 2285..2559 CDD:270625 107/314 (34%)
FATC 2605..2636 CDD:280430 12/30 (40%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D10493at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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