DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tefu and atr

DIOPT Version :9

Sequence 1:NP_001036712.1 Gene:tefu / 41839 FlyBaseID:FBgn0045035 Length:2767 Species:Drosophila melanogaster
Sequence 2:XP_696163.5 Gene:atr / 567770 ZFINID:ZDB-GENE-070912-458 Length:2633 Species:Danio rerio


Alignment Length:2802 Identity:578/2802 - (20%)
Similarity:957/2802 - (34%) Gaps:891/2802 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   386 IFSLIDKKENTFNDVWLAIFTEILQLSSVI--LNVANYQMALTTVAEIMQM--------YGNAKN 440
            ||...:...:.|..|.|.:..|.|:...||  |.....:....|:.|:...        |..|..
Zfish   303 IFQHEEGAHSRFERVHLNMLMERLEKLVVIGALEHLKVKEVKATLCEVFCFILGFVPPGYECALQ 367

  Fly   441 LRNLR---LCLAHLL---TKEQELLHSKSIREDFLGELWSQMANQLI-------------SETTT 486
            :|..|   :|.|.:.   ||:|   |.:|:.    |.|::.:....|             ::...
Zfish   368 IRKERVAAICKALIKTIGTKDQ---HEQSLE----GYLYAALKTDAIAAMQDVQASVSDPADPRM 425

  Fly   487 NSEEI--KEKQLVLQMLIRHNKLNQ---------------------KLSSTLLNNIISNEMLKRN 528
            ..||:  |...|.|...:|.....|                     :|.:.:.|:.:|       
Zfish   426 YEEELPAKRPNLSLPTQLRSRDKTQPMQVDMKSRSEVWAAVDCRLEELLTQMRNHTVS------- 483

  Fly   529 ECLATIR---EIFIHADKCGQDKASADLEPIIAWAYGSADRFIAAQMIHNIDSIDAQLQADTFAI 590
            :|::.::   .||..|..|.:........     ...|::..:.||:|                 
Zfish   484 QCVSAVQGLAVIFHLAALCSEHSLKGPQR-----GEKSSESSVVAQLI----------------- 526

  Fly   591 SIINFLDVQQLRQISQSEHIVPSTERNLLAYKYNEQ----LICFDKDYATPFESITHIQSETKNC 651
                :|..|.|.|:.:|       .|.:||..|||:    |:          |.|..|.......
Zfish   527 ----WLKPQMLAQVVES-------CRTVLANNYNEEHLEHLV----------EGIVRILDAVLYL 570

  Fly   652 LIQSNYD-------CLMRGLNFEIAKENKPAAIIKNLNSLLKLICTMERLLHYKVFDADTYTGC- 708
            ...|..|       |.:  |:.....|:...::.:..:....||...::|.  .|::|.|...| 
Zfish   571 STNSESDKSFHRNICAL--LSVPWVLEHSSQSVYQTASFPASLIALSQKLA--PVYNAQTRAHCV 631

  Fly   709 ----PLIKRI-GLYLSHI---EFQLKANGAEILDKSDLPEILRLEIYVLDVFRTNLV---LLDYL 762
                ||.|.: |.:.|.:   ..|.|:...........|.:|    :.|.|...:|:   ||:.|
Zfish   632 FLLAPLSKSVCGDWRSSVYRWALQSKSEAERASAVRGFPILL----HQLGVKSNSLIHEALLNRL 692

  Fly   763 ERQPIEMLVEFVGAALKLHSMQRERSVDADHGTITRLCLNILAGLCAYNSHRDEAFEHIVKVTMR 827
            :....|:..|..|...:|                          .|..:......|         
Zfish   693 QDSSTEVKTELAGITGQL--------------------------ACCLSESSQLQF--------- 722

  Fly   828 WHPQDVLIVTKMLCSCQTISEASSSWLVS---KLKTLFQQHHQDAELMDKVVQHMPTIFYFVRHK 889
              ||:.:...::|||..:||:..||...|   .:.|.|.|..:..|.| ||.|   .....:||.
Zfish   723 --PQETMPSHQLLCSGLSISDFHSSQTSSIGTSILTPFLQLLKPVEDM-KVKQ---AFIKNIRHL 781

  Fly   890 ENHLD------DMLMALNSLLRI------AIKKSYTSNLTAKIVRCVG------LIAQRCPDIYL 936
            ..|:|      |....:|:|:.:      .::..:..|:...:....|      |:..|..:.|.
Zfish   782 FKHVDLGNTDPDTKALVNALVNLIEDPDQEVRIMFGQNIKNLLEFWNGNGFLKELLVSRLKEAYT 846

  Fly   937 ---------LENFAVICKSTAKFITMPTLEVRFATL-FTFTILLESNCVTSDAIGH--------- 982
                     |:|..::............| |.||.| ....:|.:||.|:..|...         
Zfish   847 NAKTSRNNELKNTLILTTGEIGRAAEGNL-VSFALLRLLHCLLSKSNPVSVAAYTEIQALATCRD 910

  Fly   983 -------SRTHWDFCQELYESIEFKKLTYNNEDAIQNSNALIVQMLIAIFLRSSFHQ-EIALKEL 1039
                   |:.....||.|.||:..:.:|.......|:|.||         ...:.|| |:|| ::
Zfish   911 LKLQSFFSQYRNPICQFLVESLHSRHVTALRCTPDQSSEAL---------QEEAAHQRELAL-DI 965

  Fly  1040 LHHCA-------LRRLTEREF-ISLQSMSSCHRQTVRDLIRPFAAILLHHWSSKRWPISKFPY-- 1094
            |.|.|       |.|...|.. :.|..:::....|...|||..|..|  :.:.:...|:.|.|  
Zfish   966 LSHVAHVFDFPDLNRFLNRTLQVLLPFLAAKASPTASALIRTIAKQL--NVNRREMLINNFKYIF 1028

  Fly  1095 --FLCYSTKSEFRKTHASEIMAYTFLYGKTEDIERCS------KSISEEL-------------AL 1138
              .:|..:|.|..:       |:.:|..:|| ||..|      :.:..||             .|
Zfish  1029 SHLVCSCSKEELER-------AFHYLKNETE-IELGSLLRQDFQGLHNELLLRLGEHYQQVFNGL 1085

  Fly  1139 PILASFLLIKNSSCSESEGQNFKE----------------------HLQLLSENLSYSQ-----L 1176
            .|||||      :.|:...|..:|                      ::||||.:....:     |
Zfish  1086 AILASF------ASSDDPYQGPREITTPGCMADYLQPKLLGILAFFNMQLLSSSAGEKEKKKMAL 1144

  Fly  1177 NATDVDLDLDILCYVISMLHDPQEMMRLFGSL-----------AICNRTASWYSLSGESLFKCLN 1230
            |:      |..|..::...|.....:::..:|           .:|.||  |     :...:|| 
Zfish  1145 NS------LMSLMKLMGPKHISSVRVKMMTTLRTGLRYKDDFPELCCRT--W-----DCFVRCL- 1195

  Fly  1231 FHIDPE-MRPSMDSRIQS---MTTLQTKHSRVLVDIFGRLKTNCYSASFSSQALHDFFLYCEVAD 1291
               ||. :.|.:...|.:   :.::|.|.:.|:                    :|  :|..|..:
Zfish  1196 ---DPSYLGPLLSHVIVALLPLISIQPKETAVI--------------------MH--YLIVENRE 1235

  Fly  1292 AVYDAARKNETIVTQCSFFVRDIWFFVVRLLIHTKFIRVQMAALTFLELLLNKHNFRLDDYQNHF 1356
            .|.|              |:.:|:|    |..|.:           |:::   |.. |.||:...
Zfish  1236 EVQD--------------FLHEIYF----LPDHPE-----------LKII---HKV-LQDYRKQT 1267

  Fly  1357 GDIAKLLSNFQLCCEAKEVREKTMSIVMYILESKKGHI--NLNSFLEETTDCEFLKPLREDCKSS 1419
            .....:.:..||...|  ::.:.:.:.::.|.|.|..|  |.::.|:...|.|.::|:       
Zfish  1268 SKSTDMQAALQLSMRA--IQHENVDVRIHALTSLKEMIYKNQDALLKHVLDSEMVEPV------- 1323

  Fly  1420 QPNIDRADVANYLRSFLLSPTPERLRDLRTYIAEHKDKVQEHEKLLFGVINKLIQMTRDAHNKTT 1484
                                    :..|.|.:......|....:||.|                 
Zfish  1324 ------------------------ISQLVTVLLRGCQDVNTEARLLCG----------------- 1347

  Fly  1485 SIDSLKCLAQIG---PLKISTVSYYFQTDFEAFEKSNGEPMEAFLGVVCHSLDTSLFQ-----FD 1541
                 :||.::|   |.::.......|.....|.....:|..|:      .|.|.|.:     .|
Zfish  1348 -----ECLGELGAIDPGRLDLSPADTQGTGSTFVSGIDDPNFAY------ELLTELTRAFLAYAD 1401

  Fly  1542 PKTHEGLVSVAIQVVNS----KPGSNIMERYKNLRIFADKSTASTFLHSNKQIRR----IDWLSI 1598
            ....:...:.|:|.:.|    :.|.......:..|.|.::.......|.|.:.:.    ::|..:
Zfish  1402 DVRAQDAAAYAMQELLSLFECREGRTDSSGRRLWRRFPEQVQEILEPHLNTRYKSSQKVVNWSKL 1466

  Fly  1599 LK----ATKSLSYEPWMCAF------------VSKVFQMCGWLGFDKLAATSFAFAKTCLLPFIK 1647
            .|    :::...:..|...:            ..|||..|.::.......|.:      |||.|.
Zfish  1467 KKPIYLSSRGSKFSDWSATWAGYLISKVRHELAGKVFNCCSFIIKHDYKVTIY------LLPHIL 1525

  Fly  1648 LL---------------------------LENSLEHVESLSQ--------MLDYFFEGFTSSTAP 1677
            :.                           |....|:..||||        |||:    .|..:..
Zfish  1526 VYVLIGCTQEEQREVTEEIMAVLKEGDPRLVRLQENASSLSQLSTQTVFSMLDH----LTQWSRH 1586

  Fly  1678 NSQEIFRNKRAIK--------------KFLHICEYIRIFNNWTIPINLSNVVMASNHCQAYFLSI 1728
            ..|.:..|||..|              ::..:..::.     :||.::  :..||...:||..::
Zfish  1587 KLQTLSTNKRTGKNAREQPPATGPENSEYQSVVAFLN-----SIPQDV--LAKASFRSRAYTRAV 1644

  Fly  1729 MYLELWACSESPKSKADFLDNECFQDGAKKAYESIGCLDAIPGFVNPMRS-----RLDFLGHGS- 1787
            |:.|    |...:.|.:..|:..|   .:..|.::...|.:.| ||.:|.     |...|.|.| 
Zfish  1645 MHFE----SFIREKKQNIQDHLSF---LQTLYAAMHEPDGVRG-VNALRKEEPSLREQILEHESI 1701

  Fly  1788 ---NLST------ILLESDHLDR---------ASGQLCIDIMKGNGL------WSFAKLQQHQNI 1828
               ..||      |.||.|.|..         ..|||...|.:.||:      |. :.|..::  
Zfish  1702 GLLRESTACYDRAIQLEPDQLAHYHGVMNSMLGLGQLSTVITQVNGVLASRPRWK-SDLNAYR-- 1763

  Fly  1829 EPDYEIFWRLGQWDSLTD---------------------PKHQQNQTVVRTSLDLEQEFKRHHFV 1872
               .|..|:|.:||.:.|                     .|.|.::.                |.
Zfish  1764 ---VEAAWKLSKWDLVEDYLASDCKSSTWGVRLGQMLLAAKKQDSEA----------------FY 1809

  Fly  1873 ALRSIGQREEENSLSAIEQAYSCVRDILMEISVEC--LQSVYKY---LTWLCSLQQAEDFCQIQ- 1931
            ....|.::|:...|||              .|.||  .|..|:|   |..||.|:..  |.::| 
Zfish  1810 EKLKIARKEQVVPLSA--------------ASFECGTYQRGYEYIVRLHMLCELEHV--FTELQK 1858

  Fly  1932 ----FGTQLDPASTTKIFRKWQTELELKYGNFSCKEYVIAHQIALLKLA-GTRASRRMSEFYQKD 1991
                .|....|....    .|...|.:...:|..||.|:|.:.|||.|: |:....::.|.:   
Zfish  1859 ESSEAGRSKKPEPKL----NWDAHLLMTQNSFRAKEPVLALRRALLSLSKGSSCEEQVGECW--- 1916

  Fly  1992 PISTYLMKGIEECKSAGKLNLAAKYTATLRELPNIRESIKISVLLEDAEINLKMGNQQIAKAILD 2056
                        .:||.....|..:......|.|...|....:.:|.|:.....|:...|..:|.
Zfish  1917 ------------LQSARVARRAGHHQTAFNALLNAENSHLSELFIEKAKWLWSKGDVHQALIVLQ 1969

  Fly  2057 YVTNNNEFVYCVQRVPALRMQGEFLLDCNAETLSWVQSHKF---NNSLKLIDDFVQ-----HRQT 2113
                                  :.:..|..:..:.....:.   .|::.|:..:::     ....
Zfish  1970 ----------------------KGVQQCFPDDQTLTDPKRIQVKGNAMLLVGRYMEETANFESNA 2012

  Fly  2114 LSEKYRDIF----DWHQLDAYASKQRTAAYATIAKYADREYQQLHDYRHSQE------------- 2161
            :.:.|:|:.    :|...:.|           :|||.|:....:.|.:..::             
Zfish  2013 IMKTYKDVTTLLPEWEDGNFY-----------LAKYYDKVMPMVTDNKLERQGNLIRYIVTYFGK 2066

  Fly  2162 ---------YQTLKDIIEQNRQTAEKVTQRE---NQDRRVISVQMKRYASLDEQQLNQIEEKLTE 2214
                     ||.:..::........||.:.|   ..||    |||:...:.....::.....|:.
Zfish  2067 ALQFGNQYIYQAMPRMLTLWLDFGAKVYEFEKAGRSDR----VQMRTELTKINSVISDHTSNLSP 2127

  Fly  2215 YLRLALTNYMAYCRLDSGF--SSAAIYRII--------------SLWFTNATSK--------QCQ 2255
            |..|.     |:.:|.|..  ||..::.::              ::|...|.||        :|:
Zfish  2128 YQFLT-----AFSQLISRICHSSNEVFAVLMEIVAKVFLAYPQQAMWMMTAVSKSSYPTRMNRCK 2187

  Fly  2256 ECIKDEILTVPSY-KFICAANQLTARLNSKNTSLLKGLTDLLVQCGKDHPYHTFYQLYPLVFAHL 2319
            |.:|..|....|: |||..||:               |||.|::.| :.|              :
Zfish  2188 EILKKAISLNDSFMKFIGDANR---------------LTDKLLELG-NKP--------------V 2222

  Fly  2320 DGENSNTERSGIARKIIAMICEKNGTAGECSKQLESLLPALITFANEGKTNDNRPVSDSVRNKQF 2384
            || ||:|....:..|::..:.|: .|..:....|:|:|  :.|..:.|..|   |..|:...   
Zfish  2223 DG-NSSTLSMSVHFKMLKKLVEE-PTFSQILIPLQSVL--IPTLPSTGGAN---PKHDAFPG--- 2277

  Fly  2385 DKVRRWRNLNAVHCPTLELPVMPSKEYSIISVVKWTNETTQCGGLNAPVKIMCVCSDGKIRAQLV 2449
                .|..|:... .|:|:                      ...|..|.||....||||....:.
Zfish  2278 ----HWVYLSGFD-DTVEI----------------------LASLQKPKKISLKGSDGKFYTMMC 2315

  Fly  2450 KGKDDLRQDAVMQQVFGIVNELLNQDSEFIERKLKLRTYKVTPLSMRSGILEWCTNSVPVGHYLV 2514
            |.|||||:|..:.:...::|:.|.:|:|...|.|::|||.|.||:...||:||...:..:.|.|.
Zfish  2316 KPKDDLRKDCRLMEFNCLINKSLRKDAESRRRDLRIRTYAVIPLNEECGIIEWVNKTAGLRHILT 2380

  Fly  2515 VEGKGGAHARYRPNDWNNNKCRKLSSDHLK-------SPKETRYAIYKKI-CENIKPVFHYFLLE 2571
            ...|              .|...:|...||       :|.:.:..::|.: |....||||.:.|.
Zfish  2381 KLYK--------------EKGIYVSGTELKKLILPKTAPFQEKLKLHKDVLCARHPPVFHEWFLR 2431

  Fly  2572 KFPIPGVWFERRLAYTNSVATTSMVGYVLGLGDRHTQNILVDQQTAEVIHIDFGIAFEQGKIQTT 2636
            .||.|..|:..|.||..|.|..|||||:|||||||.:|||.|..|.|.:|:||...|.:|:....
Zfish  2432 TFPDPTSWYNSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSFTGECVHVDFNCLFNKGETFDV 2496

  Fly  2637 PETVPFRLTRDFVAPMGICGTKGVFAKSCEATMHILRRYKSVFTTILEVLLYDPLFIWGVLKKKQ 2701
            ||.||||||::.|..||..||:|:|.::||..:.::|..:....::|:..|:|||..|....|..
Zfish  2497 PEVVPFRLTQNMVHAMGPMGTEGLFRQACEVILRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGF 2561

  Fly  2702 SPQQSGE--ESVNLVAQRALLLVQNKLDG---REAGTMG-DSNVEAQVERLINEATLPSNLCMLF 2760
            |..|..|  |.:|..|:..:|.::.:|.|   .....|| ..::|..|..||.|||..:.|||::
Zfish  2562 SKTQVNESGEILNEKAKTHVLDIEQRLQGVIKNRNKVMGLPLSIEGHVHYLIQEATDDNLLCMMY 2626

  Fly  2761 PGWDPHL 2767
            .||.|:|
Zfish  2627 LGWGPYL 2633

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tefuNP_001036712.1 FAT 1829..2170 CDD:280429 66/406 (16%)
PIKKc_ATM 2416..2696 CDD:270715 102/287 (36%)
FATC 2739..2767 CDD:280430 13/27 (48%)
atrXP_696163.5 HEAT repeat 683..715 CDD:293787 9/57 (16%)
HEAT repeat 753..780 CDD:293787 8/30 (27%)
HEAT repeat 794..823 CDD:293787 3/28 (11%)
UME 1110..1216 CDD:214825 20/122 (16%)
HEAT repeat 1275..1301 CDD:293787 5/27 (19%)
HEAT repeat 1324..1353 CDD:293787 8/50 (16%)
FAT 1760..2084 CDD:280429 66/412 (16%)
TEL1 <2125..2633 CDD:227365 175/593 (30%)
PIKKc_ATR 2282..2556 CDD:270625 105/310 (34%)
FATC 2602..2633 CDD:280430 13/30 (43%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D10493at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.920

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