DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tefu and atr

DIOPT Version :10

Sequence 1:NP_001036712.1 Gene:tefu / 41839 FlyBaseID:FBgn0045035 Length:2767 Species:Drosophila melanogaster
Sequence 2:XP_696163.5 Gene:atr / 567770 ZFINID:ZDB-GENE-070912-458 Length:2633 Species:Danio rerio


Alignment Length:2802 Identity:578/2802 - (20%)
Similarity:957/2802 - (34%) Gaps:891/2802 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   386 IFSLIDKKENTFNDVWLAIFTEILQLSSVI--LNVANYQMALTTVAEIMQM--------YGNAKN 440
            ||...:...:.|..|.|.:..|.|:...||  |.....:....|:.|:...        |..|..
Zfish   303 IFQHEEGAHSRFERVHLNMLMERLEKLVVIGALEHLKVKEVKATLCEVFCFILGFVPPGYECALQ 367

  Fly   441 LRNLR---LCLAHLL---TKEQELLHSKSIREDFLGELWSQMANQLI-------------SETTT 486
            :|..|   :|.|.:.   ||:|   |.:|:.    |.|::.:....|             ::...
Zfish   368 IRKERVAAICKALIKTIGTKDQ---HEQSLE----GYLYAALKTDAIAAMQDVQASVSDPADPRM 425

  Fly   487 NSEEI--KEKQLVLQMLIRHNKLNQ---------------------KLSSTLLNNIISNEMLKRN 528
            ..||:  |...|.|...:|.....|                     :|.:.:.|:.:|       
Zfish   426 YEEELPAKRPNLSLPTQLRSRDKTQPMQVDMKSRSEVWAAVDCRLEELLTQMRNHTVS------- 483

  Fly   529 ECLATIR---EIFIHADKCGQDKASADLEPIIAWAYGSADRFIAAQMIHNIDSIDAQLQADTFAI 590
            :|::.::   .||..|..|.:........     ...|::..:.||:|                 
Zfish   484 QCVSAVQGLAVIFHLAALCSEHSLKGPQR-----GEKSSESSVVAQLI----------------- 526

  Fly   591 SIINFLDVQQLRQISQSEHIVPSTERNLLAYKYNEQ----LICFDKDYATPFESITHIQSETKNC 651
                :|..|.|.|:.:|       .|.:||..|||:    |:          |.|..|.......
Zfish   527 ----WLKPQMLAQVVES-------CRTVLANNYNEEHLEHLV----------EGIVRILDAVLYL 570

  Fly   652 LIQSNYD-------CLMRGLNFEIAKENKPAAIIKNLNSLLKLICTMERLLHYKVFDADTYTGC- 708
            ...|..|       |.:  |:.....|:...::.:..:....||...::|.  .|::|.|...| 
Zfish   571 STNSESDKSFHRNICAL--LSVPWVLEHSSQSVYQTASFPASLIALSQKLA--PVYNAQTRAHCV 631

  Fly   709 ----PLIKRI-GLYLSHI---EFQLKANGAEILDKSDLPEILRLEIYVLDVFRTNLV---LLDYL 762
                ||.|.: |.:.|.:   ..|.|:...........|.:|    :.|.|...:|:   ||:.|
Zfish   632 FLLAPLSKSVCGDWRSSVYRWALQSKSEAERASAVRGFPILL----HQLGVKSNSLIHEALLNRL 692

  Fly   763 ERQPIEMLVEFVGAALKLHSMQRERSVDADHGTITRLCLNILAGLCAYNSHRDEAFEHIVKVTMR 827
            :....|:..|..|...:|                          .|..:......|         
Zfish   693 QDSSTEVKTELAGITGQL--------------------------ACCLSESSQLQF--------- 722

  Fly   828 WHPQDVLIVTKMLCSCQTISEASSSWLVS---KLKTLFQQHHQDAELMDKVVQHMPTIFYFVRHK 889
              ||:.:...::|||..:||:..||...|   .:.|.|.|..:..|.| ||.|   .....:||.
Zfish   723 --PQETMPSHQLLCSGLSISDFHSSQTSSIGTSILTPFLQLLKPVEDM-KVKQ---AFIKNIRHL 781

  Fly   890 ENHLD------DMLMALNSLLRI------AIKKSYTSNLTAKIVRCVG------LIAQRCPDIYL 936
            ..|:|      |....:|:|:.:      .::..:..|:...:....|      |:..|..:.|.
Zfish   782 FKHVDLGNTDPDTKALVNALVNLIEDPDQEVRIMFGQNIKNLLEFWNGNGFLKELLVSRLKEAYT 846

  Fly   937 ---------LENFAVICKSTAKFITMPTLEVRFATL-FTFTILLESNCVTSDAIGH--------- 982
                     |:|..::............| |.||.| ....:|.:||.|:..|...         
Zfish   847 NAKTSRNNELKNTLILTTGEIGRAAEGNL-VSFALLRLLHCLLSKSNPVSVAAYTEIQALATCRD 910

  Fly   983 -------SRTHWDFCQELYESIEFKKLTYNNEDAIQNSNALIVQMLIAIFLRSSFHQ-EIALKEL 1039
                   |:.....||.|.||:..:.:|.......|:|.||         ...:.|| |:|| ::
Zfish   911 LKLQSFFSQYRNPICQFLVESLHSRHVTALRCTPDQSSEAL---------QEEAAHQRELAL-DI 965

  Fly  1040 LHHCA-------LRRLTEREF-ISLQSMSSCHRQTVRDLIRPFAAILLHHWSSKRWPISKFPY-- 1094
            |.|.|       |.|...|.. :.|..:::....|...|||..|..|  :.:.:...|:.|.|  
Zfish   966 LSHVAHVFDFPDLNRFLNRTLQVLLPFLAAKASPTASALIRTIAKQL--NVNRREMLINNFKYIF 1028

  Fly  1095 --FLCYSTKSEFRKTHASEIMAYTFLYGKTEDIERCS------KSISEEL-------------AL 1138
              .:|..:|.|..:       |:.:|..:|| ||..|      :.:..||             .|
Zfish  1029 SHLVCSCSKEELER-------AFHYLKNETE-IELGSLLRQDFQGLHNELLLRLGEHYQQVFNGL 1085

  Fly  1139 PILASFLLIKNSSCSESEGQNFKE----------------------HLQLLSENLSYSQ-----L 1176
            .|||||      :.|:...|..:|                      ::||||.:....:     |
Zfish  1086 AILASF------ASSDDPYQGPREITTPGCMADYLQPKLLGILAFFNMQLLSSSAGEKEKKKMAL 1144

  Fly  1177 NATDVDLDLDILCYVISMLHDPQEMMRLFGSL-----------AICNRTASWYSLSGESLFKCLN 1230
            |:      |..|..::...|.....:::..:|           .:|.||  |     :...:|| 
Zfish  1145 NS------LMSLMKLMGPKHISSVRVKMMTTLRTGLRYKDDFPELCCRT--W-----DCFVRCL- 1195

  Fly  1231 FHIDPE-MRPSMDSRIQS---MTTLQTKHSRVLVDIFGRLKTNCYSASFSSQALHDFFLYCEVAD 1291
               ||. :.|.:...|.:   :.::|.|.:.|:                    :|  :|..|..:
Zfish  1196 ---DPSYLGPLLSHVIVALLPLISIQPKETAVI--------------------MH--YLIVENRE 1235

  Fly  1292 AVYDAARKNETIVTQCSFFVRDIWFFVVRLLIHTKFIRVQMAALTFLELLLNKHNFRLDDYQNHF 1356
            .|.|              |:.:|:|    |..|.:           |:::   |.. |.||:...
Zfish  1236 EVQD--------------FLHEIYF----LPDHPE-----------LKII---HKV-LQDYRKQT 1267

  Fly  1357 GDIAKLLSNFQLCCEAKEVREKTMSIVMYILESKKGHI--NLNSFLEETTDCEFLKPLREDCKSS 1419
            .....:.:..||...|  ::.:.:.:.::.|.|.|..|  |.::.|:...|.|.::|:       
Zfish  1268 SKSTDMQAALQLSMRA--IQHENVDVRIHALTSLKEMIYKNQDALLKHVLDSEMVEPV------- 1323

  Fly  1420 QPNIDRADVANYLRSFLLSPTPERLRDLRTYIAEHKDKVQEHEKLLFGVINKLIQMTRDAHNKTT 1484
                                    :..|.|.:......|....:||.|                 
Zfish  1324 ------------------------ISQLVTVLLRGCQDVNTEARLLCG----------------- 1347

  Fly  1485 SIDSLKCLAQIG---PLKISTVSYYFQTDFEAFEKSNGEPMEAFLGVVCHSLDTSLFQ-----FD 1541
                 :||.::|   |.::.......|.....|.....:|..|:      .|.|.|.:     .|
Zfish  1348 -----ECLGELGAIDPGRLDLSPADTQGTGSTFVSGIDDPNFAY------ELLTELTRAFLAYAD 1401

  Fly  1542 PKTHEGLVSVAIQVVNS----KPGSNIMERYKNLRIFADKSTASTFLHSNKQIRR----IDWLSI 1598
            ....:...:.|:|.:.|    :.|.......:..|.|.::.......|.|.:.:.    ::|..:
Zfish  1402 DVRAQDAAAYAMQELLSLFECREGRTDSSGRRLWRRFPEQVQEILEPHLNTRYKSSQKVVNWSKL 1466

  Fly  1599 LK----ATKSLSYEPWMCAF------------VSKVFQMCGWLGFDKLAATSFAFAKTCLLPFIK 1647
            .|    :::...:..|...:            ..|||..|.::.......|.:      |||.|.
Zfish  1467 KKPIYLSSRGSKFSDWSATWAGYLISKVRHELAGKVFNCCSFIIKHDYKVTIY------LLPHIL 1525

  Fly  1648 LL---------------------------LENSLEHVESLSQ--------MLDYFFEGFTSSTAP 1677
            :.                           |....|:..||||        |||:    .|..:..
Zfish  1526 VYVLIGCTQEEQREVTEEIMAVLKEGDPRLVRLQENASSLSQLSTQTVFSMLDH----LTQWSRH 1586

  Fly  1678 NSQEIFRNKRAIK--------------KFLHICEYIRIFNNWTIPINLSNVVMASNHCQAYFLSI 1728
            ..|.:..|||..|              ::..:..::.     :||.::  :..||...:||..::
Zfish  1587 KLQTLSTNKRTGKNAREQPPATGPENSEYQSVVAFLN-----SIPQDV--LAKASFRSRAYTRAV 1644

  Fly  1729 MYLELWACSESPKSKADFLDNECFQDGAKKAYESIGCLDAIPGFVNPMRS-----RLDFLGHGS- 1787
            |:.|    |...:.|.:..|:..|   .:..|.::...|.:.| ||.:|.     |...|.|.| 
Zfish  1645 MHFE----SFIREKKQNIQDHLSF---LQTLYAAMHEPDGVRG-VNALRKEEPSLREQILEHESI 1701

  Fly  1788 ---NLST------ILLESDHLDR---------ASGQLCIDIMKGNGL------WSFAKLQQHQNI 1828
               ..||      |.||.|.|..         ..|||...|.:.||:      |. :.|..::  
Zfish  1702 GLLRESTACYDRAIQLEPDQLAHYHGVMNSMLGLGQLSTVITQVNGVLASRPRWK-SDLNAYR-- 1763

  Fly  1829 EPDYEIFWRLGQWDSLTD---------------------PKHQQNQTVVRTSLDLEQEFKRHHFV 1872
               .|..|:|.:||.:.|                     .|.|.::.                |.
Zfish  1764 ---VEAAWKLSKWDLVEDYLASDCKSSTWGVRLGQMLLAAKKQDSEA----------------FY 1809

  Fly  1873 ALRSIGQREEENSLSAIEQAYSCVRDILMEISVEC--LQSVYKY---LTWLCSLQQAEDFCQIQ- 1931
            ....|.::|:...|||              .|.||  .|..|:|   |..||.|:..  |.::| 
Zfish  1810 EKLKIARKEQVVPLSA--------------ASFECGTYQRGYEYIVRLHMLCELEHV--FTELQK 1858

  Fly  1932 ----FGTQLDPASTTKIFRKWQTELELKYGNFSCKEYVIAHQIALLKLA-GTRASRRMSEFYQKD 1991
                .|....|....    .|...|.:...:|..||.|:|.:.|||.|: |:....::.|.:   
Zfish  1859 ESSEAGRSKKPEPKL----NWDAHLLMTQNSFRAKEPVLALRRALLSLSKGSSCEEQVGECW--- 1916

  Fly  1992 PISTYLMKGIEECKSAGKLNLAAKYTATLRELPNIRESIKISVLLEDAEINLKMGNQQIAKAILD 2056
                        .:||.....|..:......|.|...|....:.:|.|:.....|:...|..:|.
Zfish  1917 ------------LQSARVARRAGHHQTAFNALLNAENSHLSELFIEKAKWLWSKGDVHQALIVLQ 1969

  Fly  2057 YVTNNNEFVYCVQRVPALRMQGEFLLDCNAETLSWVQSHKF---NNSLKLIDDFVQ-----HRQT 2113
                                  :.:..|..:..:.....:.   .|::.|:..:::     ....
Zfish  1970 ----------------------KGVQQCFPDDQTLTDPKRIQVKGNAMLLVGRYMEETANFESNA 2012

  Fly  2114 LSEKYRDIF----DWHQLDAYASKQRTAAYATIAKYADREYQQLHDYRHSQE------------- 2161
            :.:.|:|:.    :|...:.|           :|||.|:....:.|.:..::             
Zfish  2013 IMKTYKDVTTLLPEWEDGNFY-----------LAKYYDKVMPMVTDNKLERQGNLIRYIVTYFGK 2066

  Fly  2162 ---------YQTLKDIIEQNRQTAEKVTQRE---NQDRRVISVQMKRYASLDEQQLNQIEEKLTE 2214
                     ||.:..::........||.:.|   ..||    |||:...:.....::.....|:.
Zfish  2067 ALQFGNQYIYQAMPRMLTLWLDFGAKVYEFEKAGRSDR----VQMRTELTKINSVISDHTSNLSP 2127

  Fly  2215 YLRLALTNYMAYCRLDSGF--SSAAIYRII--------------SLWFTNATSK--------QCQ 2255
            |..|.     |:.:|.|..  ||..::.::              ::|...|.||        :|:
Zfish  2128 YQFLT-----AFSQLISRICHSSNEVFAVLMEIVAKVFLAYPQQAMWMMTAVSKSSYPTRMNRCK 2187

  Fly  2256 ECIKDEILTVPSY-KFICAANQLTARLNSKNTSLLKGLTDLLVQCGKDHPYHTFYQLYPLVFAHL 2319
            |.:|..|....|: |||..||:               |||.|::.| :.|              :
Zfish  2188 EILKKAISLNDSFMKFIGDANR---------------LTDKLLELG-NKP--------------V 2222

  Fly  2320 DGENSNTERSGIARKIIAMICEKNGTAGECSKQLESLLPALITFANEGKTNDNRPVSDSVRNKQF 2384
            || ||:|....:..|::..:.|: .|..:....|:|:|  :.|..:.|..|   |..|:...   
Zfish  2223 DG-NSSTLSMSVHFKMLKKLVEE-PTFSQILIPLQSVL--IPTLPSTGGAN---PKHDAFPG--- 2277

  Fly  2385 DKVRRWRNLNAVHCPTLELPVMPSKEYSIISVVKWTNETTQCGGLNAPVKIMCVCSDGKIRAQLV 2449
                .|..|:... .|:|:                      ...|..|.||....||||....:.
Zfish  2278 ----HWVYLSGFD-DTVEI----------------------LASLQKPKKISLKGSDGKFYTMMC 2315

  Fly  2450 KGKDDLRQDAVMQQVFGIVNELLNQDSEFIERKLKLRTYKVTPLSMRSGILEWCTNSVPVGHYLV 2514
            |.|||||:|..:.:...::|:.|.:|:|...|.|::|||.|.||:...||:||...:..:.|.|.
Zfish  2316 KPKDDLRKDCRLMEFNCLINKSLRKDAESRRRDLRIRTYAVIPLNEECGIIEWVNKTAGLRHILT 2380

  Fly  2515 VEGKGGAHARYRPNDWNNNKCRKLSSDHLK-------SPKETRYAIYKKI-CENIKPVFHYFLLE 2571
            ...|              .|...:|...||       :|.:.:..::|.: |....||||.:.|.
Zfish  2381 KLYK--------------EKGIYVSGTELKKLILPKTAPFQEKLKLHKDVLCARHPPVFHEWFLR 2431

  Fly  2572 KFPIPGVWFERRLAYTNSVATTSMVGYVLGLGDRHTQNILVDQQTAEVIHIDFGIAFEQGKIQTT 2636
            .||.|..|:..|.||..|.|..|||||:|||||||.:|||.|..|.|.:|:||...|.:|:....
Zfish  2432 TFPDPTSWYNSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSFTGECVHVDFNCLFNKGETFDV 2496

  Fly  2637 PETVPFRLTRDFVAPMGICGTKGVFAKSCEATMHILRRYKSVFTTILEVLLYDPLFIWGVLKKKQ 2701
            ||.||||||::.|..||..||:|:|.::||..:.::|..:....::|:..|:|||..|....|..
Zfish  2497 PEVVPFRLTQNMVHAMGPMGTEGLFRQACEVILRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGF 2561

  Fly  2702 SPQQSGE--ESVNLVAQRALLLVQNKLDG---REAGTMG-DSNVEAQVERLINEATLPSNLCMLF 2760
            |..|..|  |.:|..|:..:|.::.:|.|   .....|| ..::|..|..||.|||..:.|||::
Zfish  2562 SKTQVNESGEILNEKAKTHVLDIEQRLQGVIKNRNKVMGLPLSIEGHVHYLIQEATDDNLLCMMY 2626

  Fly  2761 PGWDPHL 2767
            .||.|:|
Zfish  2627 LGWGPYL 2633

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tefuNP_001036712.1 FAT 1829..>2064 CDD:396714 52/266 (20%)
PIKKc_ATM 2416..2696 CDD:270715 102/287 (36%)
FATC 2739..2767 CDD:460514 13/27 (48%)
atrXP_696163.5 HEAT repeat 683..715 CDD:293787 9/57 (16%)
HEAT repeat 753..780 CDD:293787 8/30 (27%)
HEAT repeat 794..823 CDD:293787 3/28 (11%)
UME 1110..1216 CDD:214825 20/122 (16%)
FAT 1760..2084 CDD:396714 66/412 (16%)
TEL1 <2125..2633 CDD:227365 175/593 (30%)
PIKKc_ATR 2282..2556 CDD:270625 105/310 (34%)

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