DRSC/TRiP Functional Genomics Resources

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Protein Alignment tefu and Mtor

DIOPT Version :10

Sequence 1:NP_001036712.1 Gene:tefu / 41839 FlyBaseID:FBgn0045035 Length:2767 Species:Drosophila melanogaster
Sequence 2:NP_063971.1 Gene:Mtor / 56718 RGDID:68371 Length:2549 Species:Rattus norvegicus


Alignment Length:3011 Identity:615/3011 - (20%)
Similarity:1029/3011 - (34%) Gaps:933/3011 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   218 ALSAFGARKTEIVRVYLIFASEL-----------AVNYNHQLNVHMQEILPKLCEYHDEDAFRDD 271
            |.:..||..:..|.|...|||.|           |....|.:.:.::|:     ...:...|.|.
  Rat     7 ATATAGAATSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREM-----SQEESTRFYDQ 66

  Fly   272 TRNLFFQCVSKSLHSMYLKMDMCDFNTLGVPVHEKWPQTLLRLKTIVNVE----IRKNSWARCKN 332
            ..:..|:.||.|           |.|        :....:|.:.:::.||    .|...:|....
  Rat    67 LNHHIFELVSSS-----------DAN--------ERKGGILAIASLIGVEGGNSTRIGRFANYLR 112

  Fly   333 ALLSNNKFSDPFIKMSA------LAM--------YI---VLWHLETKKADENGEG---DAPKKIP 377
            .||.:   |||.:...|      |||        |:   |...||...||.| ||   .|...:.
  Rat   113 NLLPS---SDPVVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRN-EGRRHAAVLVLR 173

  Fly   378 KPADKMETIFSLIDKKENTFNDVWLAIFTEILQLSSVILNVANYQMALTTVAEIMQMYGNAKNLR 442
            :.|..:.|.|  ..:.:..|:::::|::.....:....:......:.|||..|..:|        
  Rat   174 ELAISVPTFF--FQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEM-------- 228

  Fly   443 NLRLCLAHLLTKEQELLHSKSIREDFLGELWSQMANQLISETTTNSEE-IKEKQLVLQMLIRHNK 506
                      .|.|...|:....|....|       .|..|...|.:: |....|:|..|:|   
  Rat   229 ----------QKPQWYRHTFEEAEKGFDE-------TLAKEKGMNRDDRIHGALLILNELVR--- 273

  Fly   507 LNQKLSSTLLNNIISNEMLKRNECLATIREIFIHADKCGQDKASADLEPIIAWAYGSADRFIAAQ 571
                :||      :..|.| |.|.....::..:|      ||...||     ..:|:..|.|.. 
  Rat   274 ----ISS------MEGERL-REEMEEITQQQLVH------DKYCKDL-----MGFGTKPRHITP- 315

  Fly   572 MIHNIDSIDAQLQADTFAISIINFLDVQQLRQISQSEHIVPSTERNLLAYKYNEQLICFDKDYAT 636
                                   |...|.: |..||..:|     .||.|..::.|:.|.   |:
  Rat   316 -----------------------FTSFQAV-QPQQSNALV-----GLLGYSSHQGLMGFG---AS 348

  Fly   637 PFESITHIQSETKNCLIQSNYDC---LMRGLNFEIAKENKPAAIIK---NLNSLLKLICTMERLL 695
            |        |.||:.|::|.  |   ||.....::.:     .::|   :.|||:::  |:..||
  Rat   349 P--------SPTKSTLVESR--CCRDLMEEKFDQVCQ-----WVLKCRSSKNSLIQM--TILNLL 396

  Fly   696 -HYKVFDADTYTGCPLIK-RIGLYLSHIEFQLKANGAEILDKSDLPEILRLEIYVLDVFRTNLVL 758
             ....|....:|....:: .:...||.::.:.:...|       ...:..|.:.|...|:.    
  Rat   397 PRLAAFRPSAFTDTQYLQDTMNHVLSCVKKEKERTAA-------FQALGLLSVAVRSEFKV---- 450

  Fly   759 LDYLERQPIEMLVEFVGAAL--KLHSMQRERSVDADHGTITRLCLNILAGLCAYNSHRD--EAFE 819
              ||.|     :::.:.|||  |..:.:|:::|..|....|  |:::||........:|  |..|
  Rat   451 --YLPR-----VLDIIRAALPPKDFAHKRQKTVQVDATVFT--CISMLARAMGPGIQQDIKELLE 506

  Fly   820 HIVKVTM------------RWHP------QDVLIVTKMLC------------------------S 842
            .::.|.:            |..|      ||.|:  |||.                        .
  Rat   507 PMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLL--KMLSLVLMHKPLRHPGMPKGLAHQLASPG 569

  Fly   843 CQTISEASS-SWLVSKLKTL----FQQHHQDAELMDKVVQHMPTIFYFVRHKENHLDDMLMALNS 902
            ..|:.|||. :.:...|:||    |:.|               ::..||||..:|.      |||
  Rat   570 LTTLPEASDVASITLALRTLGSFEFEGH---------------SLTQFVRHCADHF------LNS 613

  Fly   903 ---LLRIAIKKSYTSNLTAKIVRCVGLIAQRCPDIYLLENFAVICKSTA---------KF----I 951
               .:|:...::.:..||              |.|:|:...|.:...||         |.    |
  Rat   614 EHKEIRMEAARTCSRLLT--------------PSIHLISGHAHVVSQTAVQVVADVLSKLLVVGI 664

  Fly   952 TMPTLEVRFATLFTFTILLESNCVTSDAIGHSRTHWDFCQELYESI-----EFKKLTYNNEDAIQ 1011
            |.|..::|:..|.:.....:::...::.:          |.|:.::     |.::|.......:.
  Rat   665 TDPDPDIRYCVLASLDERFDAHLAQAENL----------QALFVALNDQVFEIRELAICTVGRLS 719

  Fly  1012 NSNALIVQMLIAIFLRSSFHQEIALKELLHHCALRRLTEREFISLQSMSSCHRQTVRDLIRPFAA 1076
            :.|...|..    |||....|  .|.| |.|..:.|:.|:....|..:.|    ....||||:..
  Rat   720 SMNPAFVMP----FLRKMLIQ--ILTE-LEHSGIGRIKEQSARMLGHLVS----NAPRLIRPYME 773

  Fly  1077 ILLHHWSSKRWPISKFPYFLCYSTKSEFRKTHASEIMAYTFLYGKTEDIERCSKSISEELALPIL 1141
                       ||.|...........:......:.::|......:...:|  .:...:||.:.|:
  Rat   774 -----------PILKALILKLKDPDPDPNPGVINNVLATIGELAQVSGLE--MRKWVDELFVIIM 825

  Fly  1142 ----ASFLLIKNSSCSESEGQNFKEHLQLLSENLSYSQLNATDVDLDLDILCYVISMLHDPQ--- 1199
                .|.||.|......:.||.......::.....|..|        |::|   ::.|...|   
  Rat   826 DMLQDSSLLAKRQVALWTLGQLVASTGYVVEPYRKYPTL--------LEVL---LNFLKTEQNQG 879

  Fly  1200 ---EMMRLFGSLAIC--------------NRTASWYSLS-------------GESLFKCLNFHID 1234
               |.:|:.|.|...              :|.||..|||             .|.|....|..:|
  Rat   880 TRREAIRVLGLLGALDPYKHKVNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLD 944

  Fly  1235 PEMRPSMDS-------RIQSMTTLQTKHSRVLVDIFGRLKTNCYSASFSSQALHDFFLYCEVADA 1292
             |..|::..       |.||::...|...:.:..||..|...|  ..|..|.:..|.....|.|.
  Rat   945 -EFYPAVSMVALMRIFRDQSLSHHHTMVVQAITFIFKSLGLKC--VQFLPQVMPTFLNVIRVCDG 1006

  Fly  1293 VYDAARK--------------------NETIVTQCSFFVRDIWFF------VVRLLIHTKFIRVQ 1331
               |.|:                    .:.|||    .:|:.|..      .:.|||....:.:.
  Rat  1007 ---AIREFLFQQLGMLVSFVKSHIRPYMDEIVT----LMREFWVMNTSIQSTIILLIEQIVVALG 1064

  Fly  1332 MAALTFLELLLNKHNFRLDDYQNHFGDIA--KLLSNFQLCCEAKEVREKTMSIVMYILESKKGHI 1394
            .....:|..|: .|..|:..:.|..|.|.  |||:..||.                       ..
  Rat  1065 GEFKLYLPQLI-PHMLRVFMHDNSQGRIVSIKLLAAIQLF-----------------------GA 1105

  Fly  1395 NLNSFLEETTDCEFLKPLREDCKSSQPNIDRADVANYLRSFLLSPTPERLRDLRTY--IAEHKDK 1457
            ||:.:|      ..|.|         |.:...|....       |.|.|...|.|.  :.|..|.
  Rat  1106 NLDDYL------HLLLP---------PIVKLFDAPEV-------PLPSRKAALETVDRLTESLDF 1148

  Fly  1458 VQEHEKLLFGVINKLIQMTRDAHNKTTSIDSLKCLA-QIG-------PLKISTVSYYFQTDFEAF 1514
            .....:::..::..|.|   ....::|::|:|..|. |:|       |: ::.|....:.:.:.:
  Rat  1149 TDYASRIIHPIVRTLDQ---SPELRSTAMDTLSSLVFQLGKKYQIFIPM-VNKVLVRHRINHQRY 1209

  Fly  1515 EKSNGEPMEAFLGVVCHSL----------DTSLFQFDPKTHEGLVSVAIQVVNSKP-GSNIMERY 1568
            :.           ::|..:          |..::|     |..|.|.....:.|.| .:..|::.
  Rat  1210 DV-----------LICRIVKGYTLADEEEDPLIYQ-----HRMLRSSQGDALASGPVETGPMKKL 1258

  Fly  1569 KNLRIFADKSTASTFLHSNKQIRRIDW--------LSILKATKSLSYEP-WMCAFVSKVFQMCGW 1624
            ....|...|:..:.     :::.:.||        |.:||.:.|.|... |..|           
  Rat  1259 HVSTINLQKAWGAA-----RRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALA----------- 1307

  Fly  1625 LGFDKLAATSFAFAKTCLLPFIKLLLENSLEHVESLSQMLDYFFEGFTSSTAPNSQEIFRNKRAI 1689
            ..::.:|...|..|      |:....|.:.:..:.|.:.::         .|..||:|   ....
  Rat  1308 QAYNPMARDLFNAA------FVSCWSELNEDQQDELIRSIE---------LALTSQDI---AEVT 1354

  Fly  1690 KKFLHICEYIRIFNNWTIPINLSN-VVMASNH---CQAYFLSIMYLELW-------ACSESPKSK 1743
            :..|::.|::...:...:|:...| :|:....   |:||..::.|.||.       |..||..| 
  Rat  1355 QTLLNLAEFMEHSDKGPLPLRDDNGIVLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLIS- 1418

  Fly  1744 ADFLDNECFQDGA-----KKAYESIGCLDAIPGFVNPMRSRLDFL-GHGSNLSTILLESDHLDRA 1802
               ::|:..|..|     :.|.:..|.|:....:...:....|.| .:...:.|   ..|..:..
  Rat  1419 ---INNKLQQPEAASGVLEYAMKHFGELEIQATWYEKLHEWEDALVAYDKKMDT---NKDDPELM 1477

  Fly  1803 SGQL-CIDIMKGNGLWSFAKLQQHQ---------NIEPDYEI-------FWRLGQWDSLTD---- 1846
            .|:: |::.:   |.|.    |.||         |.|...::       .|.||||||:.:    
  Rat  1478 LGRMRCLEAL---GEWG----QLHQQCCEKWTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCM 1535

  Fly  1847 -PK--------------HQQNQTVVRTSLDLEQEFKRHHFVAL------RSIGQREEENSLSAIE 1890
             |:              ||...::.:..:|..::.......|:      |:.|.....:.||.:|
  Rat  1536 IPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELE 1600

  Fly  1891 QA--YSCV---RDILMEISVECLQSVYKYLTWLCSLQQAEDFCQIQFGTQLDPASTTKIFRKWQT 1950
            :.  |..|   |:|:.:|..|.||...:.:         ||:.:|.....| ..|..:..|.|  
  Rat  1601 EVIQYKLVPERREIIRQIWWERLQGCQRIV---------EDWQKILMVRSL-VVSPHEDMRTW-- 1653

  Fly  1951 ELELKYGNFSCK--EYVIAHQIALLKLAGTRASRRMSE-FYQKDPISTY-LMKGIEECKSAGKLN 2011
               |||.:...|  ...:||: .|:.|.|...||::.. .....|..|| .||.:  .|||.|::
  Rat  1654 ---LKYASLCGKSGRLALAHK-TLVLLLGVDPSRQLDHPLPTVHPQVTYAYMKNM--WKSARKID 1712

  Fly  2012 LAAKYTATLRELPNIRESIKISVLLED-----------AEINLKMGNQQIAKAILDYVTNNNEFV 2065
               .:......:..:::..:.::..||           |...||:|..|                
  Rat  1713 ---AFQHMQHFVQTMQQQAQHAIATEDQQHKQELHKLMARCFLKLGEWQ---------------- 1758

  Fly  2066 YCVQRVPALRMQGEFLLDCNAETLSWVQSHKFNNSLKLIDDFVQHRQTLSEKYRDIFD-WHQLDA 2129
                    |.:||     .|..|:..|               :|:....:|..|..:. ||    
  Rat  1759 --------LNLQG-----INESTIPKV---------------LQYYSAATEHDRSWYKAWH---- 1791

  Fly  2130 YASKQRTAAYATIAKYADREYQQLHDYRHSQEYQTLKDIIEQ-------NRQT---------AEK 2178
                    |:|.:      .::.:..|:|..:.:..|..:..       |..|         |..
  Rat  1792 --------AWAVM------NFEAVLHYKHQNQARDEKKKLRHASGANITNATTTATTAASAAAAT 1842

  Fly  2179 VTQRENQDRRVISVQMKRYAS-LDEQQLNQIEEKLTEYLRLALTNYMAYCRLDSGFSSAAIYRII 2242
            .|:..|.:....|.:.....| |.::....:.:.|..|...|:..:.....|..|.:.....|::
  Rat  1843 STEGSNSESEAESNESSPTPSPLQKKVTEDLSKTLLLYTVPAVQGFFRSISLSRGNNLQDTLRVL 1907

  Fly  2243 SLWFTNATSKQCQECIKDEILTVPSYKFICAANQLTARLNSKNTSLLKGLTDLLVQCGKDHPYHT 2307
            :|||.........|.:.:.:..:....::....||.||:::....:.:.:..||...|:.||...
  Rat  1908 TLWFDYGHWPDVNEALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQAL 1972

  Fly  2308 FYQLYPLVFAHLDGENSNTERSGIARKIIAMICEKNGTA-------------------------- 2346
               :|||..|   .:::.|.|...|.||:..:||.:.|.                          
  Rat  1973 ---IYPLTVA---SKSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGL 2031

  Fly  2347 --------GECS-KQLESLLPALITFANEG-----KTNDNRPVSDSVRNKQ------------FD 2385
                    ||.: |.:..:|..|......|     :|:.|:.....:...|            .|
  Rat  2032 EEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKD 2096

  Fly  2386 KVRRW-------RNLNAVHCPTLELPVMPSKEYSIIS-----------VVKWTNETTQ------- 2425
            ..:.|       |.::.      :||.:.|.|...:|           .|..|.:..|       
  Rat  2097 LTQAWDLYYHVFRRISK------QLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQS 2155

  Fly  2426 -------CGGLNAPVKIMCVCSDGKIRAQLVKGKDDLRQDAVMQQVFGIVNELLNQDSEFIERKL 2483
                   ......|.|:..:.|:|.....|:||.:|||||..:.|:||:||.||..|...:.:.|
  Rat  2156 IAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNL 2220

  Fly  2484 KLRTYKVTPLSMRSGILEWCTNSVPVGHYLVVEGKGGAHARYRPNDWNNNKCRKLSSDH----LK 2544
            .::.|.|.|||..||::.|    ||....|        ||..|  |:...|...|:.:|    ..
  Rat  2221 SIQRYAVIPLSTNSGLIGW----VPHCDTL--------HALIR--DYREKKKILLNIEHRIMLRM 2271

  Fly  2545 SPKETRYAIYKKICENIKPVFHY------------FLLEKFPIPGVWFERRLAYTNSVATTSMVG 2597
            :|......:.:|:     .||.:            .|..|.|...|||:||..||.|:|..||||
  Rat  2272 APDYDHLTLMQKV-----EVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVG 2331

  Fly  2598 YVLGLGDRHTQNILVDQQTAEVIHIDFGIAFEQGKI-QTTPETVPFRLTRDFVAPMGICGTKGVF 2661
            |:|||||||..|:::|:.:.:::|||||..||.... :..||.:||||||.....|.:.|..|.:
  Rat  2332 YILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNY 2396

  Fly  2662 AKSCEATMHILRRYKSVFTTILEVLLYDPLFIWGVL-------KKKQSPQQS------------- 2706
            ..:|...|.:||.:|.....:||..:||||..|.::       |:.::...|             
  Rat  2397 RTTCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNAKGNKRSRTRTDSYSAGQSVEILDGV 2461

  Fly  2707 --GE-------------------------ESVNLVAQRALLLVQNKLDGREAGTMGDSNVEAQVE 2744
              ||                         |::|..|.:.:..|::||.||:.......:|..|||
  Rat  2462 ELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLDVPTQVE 2526

  Fly  2745 RLINEATLPSNLCMLFPGWDP 2765
            .||.:||...|||..:.||.|
  Rat  2527 LLIKQATSHENLCQCYIGWCP 2547

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tefuNP_001036712.1 FAT 1829..>2064 CDD:396714 60/286 (21%)
PIKKc_ATM 2416..2696 CDD:270715 102/310 (33%)
FATC 2739..2767 CDD:460514 14/27 (52%)
MtorNP_063971.1 Interaction with NBN. /evidence=ECO:0000250|UniProtKB:P42345 1..651 169/830 (20%)
TEL1 363..2549 CDD:227365 515/2532 (20%)
HEAT 16 637..683 9/45 (20%)
HEAT repeat 655..681 CDD:293787 6/25 (24%)
HEAT 17 686..724 5/47 (11%)
HEAT repeat 691..721 CDD:293787 4/39 (10%)
HEAT 18 727..766 12/49 (24%)
HEAT repeat 729..759 CDD:293787 11/32 (34%)
HEAT 19 769..811 6/52 (12%)
HEAT repeat 772..805 CDD:293787 4/43 (9%)
HEAT 20 814..853 9/38 (24%)
HEAT repeat 817..847 CDD:293787 8/29 (28%)
HEAT 21 857..893 10/46 (22%)
HEAT 22 894..942 9/47 (19%)
HEAT 23 943..988 11/47 (23%)
HEAT repeat 955..981 CDD:293787 6/25 (24%)
HEAT 24 989..1027 7/40 (18%)
HEAT repeat 993..1021 CDD:293787 5/30 (17%)
HEAT 25 1029..1068 8/42 (19%)
HEAT repeat 1033..1062 CDD:293787 8/32 (25%)
HEAT 26 1069..1105 12/59 (20%)
HEAT repeat 1073..1099 CDD:293787 9/26 (35%)
HEAT 27 1106..1144 12/59 (20%)
HEAT repeat 1111..1142 CDD:293787 10/52 (19%)
HEAT 28 1145..1188 9/45 (20%)
HEAT repeat 1154..1180 CDD:293787 5/28 (18%)
HEAT 29 1189..1225 3/47 (6%)
HEAT 30 1226..1273 10/56 (18%)
HEAT 31 1274..1311 9/47 (19%)
HEAT 32 1312..1345 6/47 (13%)
TPR 1 1346..1382 7/38 (18%)
TPR 2 1383..1408 6/24 (25%)
TPR 3 1409..1442 8/36 (22%)
TPR 4 1443..1473 4/32 (13%)
TPR 5 1474..1507 8/39 (21%)
TPR 6 1508..1541 8/32 (25%)
TPR 7 1542..1574 3/31 (10%)
TPR 8 1575..1614 9/38 (24%)
TPR 9 1615..1649 9/43 (21%)
TPR 10 1650..1693 13/48 (27%)
TPR 11 1694..1731 9/41 (22%)
TPR 12 1732..1786 16/97 (16%)
TPR 13 1787..1846 11/76 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1812..1867 9/54 (17%)
TPR 14 1898..1930 5/31 (16%)
TPR 15 1931..1970 8/38 (21%)
TPR 16 1971..2005 11/39 (28%)
Sufficient for interaction with the FKBP1A/rapamycin complex. /evidence=ECO:0000250|UniProtKB:Q9JLN9 2012..2144 18/137 (13%)
G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 2162..2168 0/5 (0%)
Interaction with MLST8. /evidence=ECO:0000250|UniProtKB:P42345 2258..2296 6/42 (14%)
Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 2335..2343 6/7 (86%)
Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 2355..2380 12/24 (50%)

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