DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tefu and Nipped-A

DIOPT Version :9

Sequence 1:	NP_001036712.1	Gene:	tefu / 41839	FlyBaseID:	FBgn0045035	Length:	2767	Species:	Drosophila melanogaster
Sequence 2:	NP_001097192.2	Gene:	Nipped-A / 35483	FlyBaseID:	FBgn0053554	Length:	3790	Species:	Drosophila melanogaster

Alignment Length:	3504	Identity:	638/3504 - (18%)
Similarity:	1182/3504 - (33%)	Gaps:	1136/3504 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 FLSK--TSDISWTTIFEASKEALFKQAGNLEDVN--EKVFKTLAGKNYLY--DNV------LEKI 97
            ||:.  ||.:..|.:.|.....:.:...|||..|  .::||.:.|...|:  :|.      |.||
  Fly   642 FLANPTTSPLFATVLVEYLLNKMEEMGSNLERSNLYLRLFKLVFGSVSLFPVENEQMLRPHLHKI 706

  Fly    98 TQFNLEAG--SQTSGNGHFLAKTSIFSAFEDGIKMRVVVKYFGDRILSLLE------KGIYSSVS 154
            ...::|..  |:...| :||...::|.:...| ...::.:.|...:.:|||      .|.:.  .
  Fly   707 VNRSMELALISEEPYN-YFLLLRALFRSIGGG-SHDLLYQEFLPLLPNLLEGLNRLQSGFHK--Q 767

  Fly   155 YVRDLKIN-------EYSRILSYLFELNVDMDEVLRT-----RILKCITRTVSLAKDRVQL---- 203
            ::|||.:.       ..|.:|.||..|   ||.::..     .::....||:.|..|.:|.
  Fly   768 HMRDLFVELCLTVPVRLSSLLPYLPML---MDPLVSALNGSPTLISQGLRTLELCVDNLQPDFLY 829

  Fly   204 -HVD---------LVEYLPELSSFALSAF--------GARKTEIVRVYLIFASELAVNY--NHQL 248
             |:.         |.:.|....:.||.||        |.||        :.....|::|  |.:.
  Fly   830 DHIQPVRAALMQALWKTLRNQDNAALVAFRVLGKFGGGNRK--------MMVEPQALSYIINDKP 886

  Fly   249 NVHMQEILPKLCEYHDEDAFRDD--TRNLFFQCVSKSLHSMY-------LKMDMCDFNTLGVPVH 304
            .:   .|:....||.....|..|  .::.|....|.|....|       ::..:..|.:|....|
  Fly   887 TI---SIVTYFQEYETPIDFPVDEAIKSAFRALGSNSTDQFYRRQSWEVIRCFLAAFISLDDEKH 948

  Fly   305 EKWPQTLLRLKTIVN-VEIRKNSWARCKN-------------ALLSNNKFS-------------- 341
                 .||:|.|.|: ||.:..:|:..::             ||:.....|
  Fly   949 -----MLLKLFTHVDFVENKIMNWSTFQHKAGNETVRETHQTALIGMLVASATKDLRDSVCPVMA 1008

  Fly   342 -----------------------------DPFIKMSALAMYIVLWHLETKKADENGEGDAPKKIP 377
                                         ||.|.:.|||..:               |...|::.
  Fly  1009 AVVRHYTMVAIAQQAGPFPQKGYQATHGIDPMILIDALASCM---------------GHEEKELC 1058

  Fly   378 KP---------------------ADKMETIFSLIDKKEN-TFNDVW---------LAIFTEILQL 411
            ||                     |.|:..|..|.:|..: .::..|         :....:.:.|
  Fly  1059 KPGIACMGIILDTATNIMGNKDRACKLPIIQYLAEKMVSLCYDRPWYSKVGGCQAIQFLCKHMSL 1123

  Fly   412 SSVILNVANYQMALTTVAEIMQMYGNAKN---------LRN-LRLCLAHLLTKEQELLHSKSIRE 466
            .::..|:.|:..|...|  :|.:.|:..|         ::: |.:|    ||...|...:..::
  Fly  1124 RALFQNLFNFLKAFMFV--LMDLEGDVSNGAIEITKSYMKSMLEIC----LTPINECYKNIDLK- 1181

  Fly   467 DFLGELWSQMANQLISETTTNSEEIKEKQLVLQMLIRHNKLNQKLSSTLLNNIISNEMLKRNECL 531
            |...:...::.::|:...|:.:..::|:.:|   |::|       ..|:.:..:|..|....:.|
  Fly  1182 DLQAKATYEVIHELVRHITSPNTIVREESMV---LLKH-------IGTIQSKTVSEVMDPHKDVL 1236

  Fly   532 ATI----REIFIHADKCGQDKASADLEPIIAWAYGSADRFIAAQMIHNIDSIDAQLQADTFAISI 592
            |.|    :.:..|      ..|:|.:        |..|.          ::....|:...|.|.:
  Fly  1237 ADIIPPKKHLLRH------QPANAQI--------GLMDG----------NTFCTTLEPRLFTIDL 1277

  Fly   593 INF---LDVQQLRQISQSE--------------HIVP---STERNLLA------YKYNEQLICFD 631
            .|.   |...:|..:|::|              :::|   |..|.|.|      ..|.|::|
  Fly  1278 TNTYHKLFFHELLTLSEAEDATLAKLDCYKNVPNLIPLRTSALRALAACHYISDIGYKEKII--- 1339

  Fly   632 KDYATPFESITHIQSETKNCLIQSNYDCLMRGLNFEIAKENKPAAIIKNLNSLLKL-------IC 689
                   ..|..:....|:.|..:.:.|:...:.....::.|..:.::.|  ||||       |.
  Fly  1340 -------NIIFKVMESDKSELQTTAFHCMKHFITGVTLEKEKVQSAMRPL--LLKLGDHRNLSIP 1395

  Fly   690 TMERLLHY-KVF--------DADTYTGCPLIKRIGL--YLS---HIEFQLKANGAEILDKSDLPE 740
            .::||.:: ::|        .......|..|..|.:  |.|   ::.|...:.|.|...|  :..
  Fly  1396 AIKRLSYFTQIFPQMFNEKLSEQILQHCSKIMEIFVSEYKSTSPNVNFFASSKGGEYEQK--IVI 1458

  Fly   741 ILRLEIYVLD-----------VFRT--NLV----------LLDYLERQPIEMLVEFVGAALK--- 779
            ::.:..|:..           |.:|  ||:          |:.:|:|.|.|.:..|:..:|.
  Fly  1459 LIEMFFYISASVKYIEKLCQLVLKTEKNLMIEASSPYREALIKFLQRFPTETVDLFLTESLMIDP 1523

  Fly   780 ------LHSMQRERSVDADHGTITRLCLNILAGLCAYNSHRD--EAFEHIVKVTMRWHPQDVLIV 836
                  ::.::.|..|.......:....|::..|   |:|.:  ||.::.::     | |.|||:
  Fly  1524 QWNRLFIYLLKHETGVSFRAVIKSSRYNNLIHYL---NTHTEFPEALKYEIQ-----H-QAVLII 1579

  Fly   837 TKMLCSCQTISEASSSW------LVSKLKTLFQQHHQDAELMDKVVQHMPTIFYFVRHKENHLDD 895
            .       |:.|:...|      :|..||..:|             .::.|:     ..|:.|.|
  Fly  1580 F-------TLMESDDQWIPTRQDIVDALKNCWQ-------------NYLSTL-----SSEDVLCD 1619

  Fly   896 MLMALNSLLRIAIKKSYTSNLTAKIVRCVGLIAQRC----PDIYLL---------ENFAVICKST 947
            :...:..:|     ..|.||.|..|.....|:...|    ||:|.|         ::|.|..|..
  Fly  1620 LWHLIGKIL-----LHYFSNNTNDIELLFQLLRALCFRFIPDVYFLRDFLQHTVAQSFTVNWKRN 1679

  Fly   948 AKFITMPTLEVRF------ATLFTFTILLESNCVTSD------AIGHSRTHWDFCQELYESIEFK 1000
            |.|..:......|      |.:.| .:::....|:.|      .||...|.:...::...|:...
  Fly  1680 AFFYFVENFNNSFLSEELKAKIIT-AVIIPCFAVSFDKGEGNKLIGAPPTPYQEDEKNIVSVFIN 1743

  Fly  1001 KL---TYNNEDAIQNSNALIVQMLIAIFLRSSFH----------QEIALKE-------------- 1038
            |:   ....:||::   ..::|:...:..|:|.|          |...|:.
  Fly  1744 KVFDPDKQYDDAVR---IALLQLACLLVERASQHIHDGDANNKRQGNKLRRLMTFAWPCLLSKSS 1805

  Fly  1039 -----------LLHHCALRRLTEREFISLQ---SMSSCHRQTVRDLIRPFAAIL----------- 1078
                       ||.| .:.||...:.|.||   |:...|....|.:::....:|
  Fly  1806 VDPTARYHGHLLLSH-IIARLAIHKKIVLQVFHSLLKGHALEARSIVKQALDVLTPAMPLRMEDG 1869

  Fly  1079 ---LHHWSSK--------------------RWPISKFP-------YFLCYSTKSEFRKTHA---- 1109
               |.||:.|                    |.....||       :.:.|..:..|..|.:
  Fly  1870 NTMLTHWTKKIIVEEGHAMQQLFHILQLIIRHYKVYFPVRHQLVQHLINYMQRLGFPPTASIEHK 1934

  Fly  1110 ------SEIMAYTFLYGKTEDIERCSKSISEEL---------ALPIL----ASFLLIKNSSCSES 1155
                  :|::....|:...:|.|..:....|||         .:.::    .||.:|:.::. :.
  Fly  1935 KLAVDLAEVIIKWELHRIKDDRETKTDGTEEELIQESSVKRSGIDLVETRKKSFDIIRETTV-QG 1998

  Fly  1156 EGQNFKEHLQLLSENLSYSQLNATDVDLDLDILCYVISMLHDPQEMMRLFGSLAICNRTASWYSL 1220
            .|.:.|....|.|.:.||       .|..|:.|..:...::|||..:                 |
  Fly  1999 VGSHTKPDDILRSIDKSY-------CDTVLNFLIRLACQVNDPQAPI-----------------L 2039

  Fly  1221 S-GESLF-KC---LNFHIDPEMRPS-MDSRI----QSMTTLQTKHSRVLVDIFGRLKTNCYSASF 1275
            | ||||. :|   |...:.||:.|. .|.::    :.:.|::|.|.        .|...|....|
  Fly  2040 SPGESLSRRCVMLLKMAMRPEIWPQPFDIKLNWLDKVLATVETPHH--------NLNNICTGIDF 2096

  Fly  1276 SSQALHDFFLYCEVADAVYDAARKNETIVT--QCSFFVRDIWFFVVRLLIH--TKFIRVQMAALT 1336
            .:      ||               .||::  |....:|.:...:...:||  |:.:|:....||
  Fly  2097 LT------FL---------------TTILSPDQLVSIIRPVQRGLSLCIIHQNTRIVRLMHMFLT 2140

  Fly  1337 FLELLL-----NKHNFRLDDYQNHFGDIAKLLSNFQLCCEAKEVREKTMSIVMYILESKKGHINL 1396
            .:..:.     :||    :|....:..::|:::. .|....|..:....|:...::..|....|.
  Fly  2141 RIMAIFPPDTQHKH----EDLDLLYTAVSKMIAE-NLTSYEKSPQPNASSLFGTLMILKACTTNN 2200

  Fly  1397 NSFLEETTDCEFLKPL----REDCKSSQPN--IDRADVANYLRSFLLSPTPERLRDLRTYIAEHK 1455
            .|:::... .:|::.|    |:...:...|  |.::..:|.|...||..:.|.::: |.::..
  Fly  2201 ASYIDRIL-VQFIRVLNHLTRDHINTIGGNTVISQSPDSNALPLELLVLSLELIKN-RIFVMS-- 2261

  Fly  1456 DKVQEHEKLLFGVINKLIQMTRDAHNKTTSIDSLKCLAQIGPLKISTVSYYFQTDFEAF-EKSNG 1519
               .|..||..|.|  |:.:.    .|:|.:..:||:.::....|.|......|...:. |||
  Fly  2262 ---VEIRKLFIGTI--LVSLI----EKSTEVKIIKCIIKMLDEWIKTKEPNVMTQVPSIREKS-- 2315

  Fly  1520 EPMEAFLGVVCHSLDTSLFQFDPKTHEGLVSVAIQ---VVNSKPGSNIMER----------YKNL 1571
                        :|...|.|...|.....:.:.||   ::|......|:::          :.|.
  Fly  2316 ------------ALLVKLMQNVEKKFTDEIELNIQFLEIINFIYRDEILKQTELTNKLEGAFLNG 2368

  Fly  1572 RIFADKSTASTF---LHSNKQIR---RIDWLSILKATKSLSYEPWMCAFVSKVFQMCGWLGFDKL 1630
            ..|.:.:..|.|   |.|:.:.|   |:.::...:|..::....|:...:..:......:...:.
  Fly  2369 LRFQNPNVRSKFFEILDSSMRRRLHDRLLYIICSQAWDTIGSHYWIKQCIELLILTANTMMQIQC 2433

  Fly  1631 AATSFAFAK-TCLLP----------FIKLLLEN--SLEHVESLSQMLDYFFEGFTSSTAPNSQEI 1682
            :...|.... |.::|          |:..|..:  |.:.::::....|.:.....:....:.|:|
  Fly  2434 SNEQFKIPSITSVIPVNSSETQENSFVSFLSSHSESFDIIQTVDDKDDVYDIDLNADRKEDCQQI 2498

  Fly  1683 FRNKRA--IKKFLHICEYIRIFNNWTIPINLSNVVMASNH--------CQAYFLSIMYLELWA-- 1735
            ..|:|.  ::......|::....|    |....:::|::.        .|:.:|| |:..:|:
  Fly  2499 LPNRRVTLVELVYKQAEFLEANRN----IRTDQMLVATSQLCHIDTQLAQSVWLS-MFPRIWSIF 2558

  Fly  1736 -----CSESPKSKADFLDN-------ECFQDGAKKAYESI-GCLDAIPGFVNPMRSRLDFLGHGS 1787
                 |:.: |....||.:       :|.........||: .|  |.|.::.|  :.|.:||...
  Fly  2559 TEDQRCNIT-KELIPFLSSGTNVNQKDCHPSTLNTFVESLTKC--APPIYIPP--NLLAYLGKSH 2618

  Fly  1788 NL---STILLE---------SDHLDRASGQLC-IDIMKGN--------------------GLW-S 1818
            ||   :.::||         |..:|....|.. :|:.:.|                    ||| .
  Fly  2619 NLWHRAILVLEDMAVNQSMQSKDIDGGENQFSDLDVQQSNNIFDSLSKMYSSMHEEDLWAGLWLK 2683

  Fly  1819 FAKLQQHQNIEPDYEIFWRLGQWD--------SLTDPKHQQNQTVVRTSLDLEQEFKRHHFV-AL 1874
            ||...: .||...||   ::|.::        ::|..|...:..||.|.::.|.....:|:: ..
  Fly  2684 FAHYPE-TNIAVSYE---QMGFFEEAQGAYDLAMTKFKQDLSNGVVNTYVNSELLLWENHWMRCA 2744

  Fly  1875 RSIGQ----------REEENSLSAIEQAYSCVRDILMEISVECLQSVY---------KYLTWLCS 1920
            :.:.|          .:::|....:|.::......||:|::...:..|         .|..:|..
  Fly  2745 KELNQWDILLDYAQTNKDKNMFLILESSWRVPDWNLMKIALAKTEQCYLKHYGFKINLYKGYLSI 2809

  Fly  1921 LQQAEDFCQIQFGT---QLDPASTTKIFRKWQTELELKYGNFSCKEYVIAHQIALLKLAGTRASR 1982
            |.|.|.    |.|.   .::.||:..| |:|:     :..|      :::|    :.|...:||:
  Fly  2810 LHQEER----QTGNIERYVEIASSLCI-REWR-----RLPN------IVSH----IHLPYLQASQ 2854

  Fly  1983 RMSEFYQKDPISTYLMKGIEECKSAGKLNLAAKYTATLRELPNIRESIK------------ISVL 2035
            ::.|.::    ::.:.:|:.:.::....::.|........||.|.:.:.            ..::
  Fly  2855 QIMELHE----ASQIHQGLAQSRNNSLHDMKAIVKTWRNRLPIISDDLSHWSDIFTWRQHHYQII 2915

  Fly  2036 LEDAEINLKMGNQQI-----AKAILDY--VTNNNEF----------VYCVQRVP------ALRMQ 2077
            .:..|.....|:..:     |:||:.:  :...:..          :|.:..||      .:|.|
  Fly  2916 TQHLEQQSDQGSTMLGVHASAQAIISFGKIARKHNLTGVCQETLSRIYTIPSVPIVDCFQKIRQQ 2980

  Fly  2078 GEFLLDCNAETLSWVQSHKFNNSLKLIDDFVQHRQTLSEKYRDIFDWHQLDAYASKQRTAAYATI 2142
                :.|..:..|....::.|.:|::|:         |...:........:.||.|....|....
  Fly  2981 ----VKCYLQMPSTSGKNEINEALEVIE---------STNLKYFTGEMNAEFYALKGLLLAQIGR 3032

  Fly  2143 AKYADREYQ---QLHDYRHSQEYQTLKDIIEQNRQTAEKVTQRENQDRRVISVQMKRYASLDEQQ 2204
            ::.|.:.:.   |||| ..::.:....|.:||......|:|..  .|..:..:|..|
  Fly  3033 SEEAGKSFSVAAQLHD-GLTKAWAMWGDYMEQIFLKERKITLA--VDALICYLQASR-------- 3086

  Fly  2205 LNQIEEKLTEYLRLALTNYMAY-------------------------------CRLDSG------ 2232
             ||||.|..:|:...|. :::|                               |.|:..
  Fly  3087 -NQIESKTRKYIAKVLW-FLSYDNNTKILISTLEKHVAGIPPSYWLPWIPQLLCCLEQFEGDVIL 3149

  Fly  2233 ---------FSSAAIYRIISLWFT-----NATSKQCQECIKDEIL----------------TVPS 2267
                     :..|..:.|.:|:.|     ....|..::.:|....                .:||
  Fly  3150 NLLSQIGRLYPQAVYFPIRTLYLTLKIEQREKHKTAEQAVKSSCSNIDGTTLSFGRGASHGNIPS 3214

  Fly  2268 YKFICA---------ANQLTARLNSKNTSLLKGLTDLLVQCGKDHPYHTFYQL-------YPLVF 2316
            ...|.|         ..||...::....|.|:|:.|.:|...:........||       |.:.|
  Fly  3215 INPIKATPPMWRCSKVMQLQREVHPTILSSLEGIVDQMVWFRESWTEEVLRQLRQGLIKCYAIAF 3279

  Fly  2317 AHLDGENSNTERSGIARKIIAMICEKNGTAG--------------ECSKQLESLL-PALITFAN- 2365
            ...|    ..:.|.|....:..:.:...|.|              ..|...|||. .|.:||.:
  Fly  3280 EKRD----TVQHSTITPHTLHFVKKLGSTFGIGIENVPGSVTSSISNSAASESLARRAQVTFQDP 3340

  Fly  2366 ------EGKTND---NRPVSDSVRNKQFDKVRRWRNL---NAVHCPT------------------ 2400
                  |..|||   ::|.:..:.| ...|::.|..:   .....||
  Fly  3341 VFQKMKEQFTNDFDFSKPGAMKLHN-LISKLKTWIKVLETKVKKLPTSFLIEDKCRFLSNFSQKT 3404

  Fly  2401 --LELP---VMP-SKEYSI--------ISVVKWTNETTQCGGLNAPVKIMCVCSDGKIRAQLV-- 2449
              :|||   ::| |..|.:        :.:|:..|        .|..::....::|||...||
  Fly  3405 AEVELPGELLIPLSSHYYVRIARFMPRVEIVQKNN--------TAARRLYIRGTNGKIYPYLVVL 3461

  Fly  2450 -KGKDDLRQDAVMQQVFGIVNELLNQDSEFIERKLKLRTYKVTPLSMRSGILEWCTNSVPVGHYL 2513
             .|..|.|::..:.|:..::|..|.:..|...|.|.:...:|.|:|.:..:.|...||:.:
  Fly  3462 DSGLGDARREERVLQLKRMLNYYLEKQKETSRRFLNITVPRVVPISPQMRLAEDNPNSISL---- 3522

  Fly  2514 VVEGKGGAHARYRPNDWNNNKCRKLSSDHLKSPKETRYAIYKKICENIK---------------- 2562
                                         ||        |:||.|::::
  Fly  3523 -----------------------------LK--------IFKKCCQSMQVDYDMPIVKYYDRLSE 3550

  Fly  2563 ------PVFHYFLLEKFP------IP----------------GVWFERRLAYTNSVATTSMVGYV 2599
                  |..|..|.|.|.      :|                ..|..|:: .|..:|...:..:.
  Fly  3551 VQARGTPTTHTLLREIFSEIQWTMVPKTLLKHWALKTFLAATDFWHFRKM-LTLQLALAFLCEHA 3614

  Fly  2600 LGLGDRHTQNILVDQQTAEVIHID-FGIAFEQGKIQTTP-ETVPFRLT---RDFVAPMGICGTKG 2659
            |.| .|...:::...|.:.:::|. |.......|.|... ..||||||   .:|:...||.|...
  Fly  3615 LNL-TRLNADMMYLHQDSGLMNISYFKFDVNDDKCQLNQHRPVPFRLTPNVGEFITHFGITGPLS 3678

  Fly  2660 VFAKSCEATMHILRRYKSVFTTILEVLLYDPLFIWGVLKKK--------------QSPQQSGEES 2710
            . |....|...|...||  .::||:.:|.|.:.   .|:||              .|.....|.|
  Fly  3679 A-AIVATARCFIQPNYK--LSSILQTILRDEII---ALQKKGFRECKLIEGSEDRYSDGNCMEHS 3737

  Fly  2711 VNLVAQRALLLVQ--NKLDGREAGTMGDSNVEAQVERLINEATLPSNLCMLFPGWDPHL 2767
            ||:|.....:::.  ||:      :..||....::..|:..||...|||.:.|.|.|.|
  Fly  3738 VNIVNSAVDIIMTRFNKI------SYFDSIENKKISVLVQSATNIDNLCRMDPAWHPWL 3790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tefu	NP_001036712.1	FAT	1829..2170	CDD:280429	66/409 (16%)
		PIKKc_ATM	2416..2696	CDD:270715	66/331 (20%)
		FATC	2739..2767	CDD:280430	9/27 (33%)
Nipped-A	NP_001097192.2	FRB_dom	<2568..3790	CDD:331513	249/1347 (18%)
		FAT	2767..3102	CDD:308074	67/383 (17%)
		PIKK_TRRAP	3425..3712	CDD:270707	67/343 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464450
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11139
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940