Protein Alignment tefu and nonC

DIOPT Version :9

• Sequence 1: NP_001036712.1
• Gene: tefu / 41839
• FlyBaseID: FBgn0045035
• Length: 2767
• Species: Drosophila melanogaster
• Sequence 2: NP_001284967.1
• Gene: nonC / 31625
• FlyBaseID: FBgn0263968
• Length: 3218
• Species: Drosophila melanogaster
• Alignment Length: 2565
• Identity: 471/2565 - (18%)
• Similarity: 835/2565 - (32%)
• Gaps: 844/2565 - (32%)

  Fly   663 GLNFEIAKENKPAAIIKNLNSLL-KLICTMERLLHYKVFDADTYTGCPLIKRIGLYLSHIEFQL- 725
            |.:.::|:....|.:::|:|.:: |....::.  |.|.:.....|..|:.....|.||.|..:|
  Fly    77 GKSHDVAQAFANALLLRNMNHVVGKGQPVVQN--HRKAYQCKGDTINPMANGEDLRLSKIIRRLI 139

  Fly   726 -KANGAEILDK-SDLPEILRLEI----------YVLDVFRT---------------NLVLLDYLE 763
             :.|....|:. |.|.:.:|..|          ::||...|               .|.|:.::.
  Fly   140 NENNPTVSLELCSKLDQAVRTPINMGYMTCSFVWILDNMLTLYKQCPPPVLEECSKTLGLIGFIN 204

  Fly   764 RQPIEMLVEFVGAALKLHSMQRERSVDADHGTITRLCLNILAGLCAYNSHRDEAFEHIVKVTMRW 828
            |:...:..||:....|.....::..:.|...|::  |    ...|..:.:.|:....:.......
  Fly   205 RKSYPIYEEFIVKNYKSSKRMQKYMIMALRATLS--C----DTKCELHMYADKIMLLLKDFLENA 263

  Fly   829 HPQDVLIVTKMLCSCQTISEASSSWLVSKLKTLFQQHHQDAELMDKVV-----QHMPTIFYFVRH 888
            ...|:.||..     .|:.:.::|:..:     |:.|..|  ::|.|:     ...||      .
  Fly   264 ESADIFIVVS-----NTLVQFAASYAET-----FECHFTD--VVDIVIGWQLEAGQPT------D 310

  Fly   889 KENHLDDMLMALNSLLRIAIKKSYTSNLTAKIVRCVGLIAQRCPDIYLLEN-------------- 939
            .:.|...:|..|.......|..||            ||:.|...||..||.
  Fly   311 LKTHCAQVLEQLTPFFSKQIDFSY------------GLLDQFVEDITTLEEGEPANTAERVGAFV 363

  Fly   940 --FAVICKSTAK---FITMPTLEVRFATLFTFTILLESNCVTSDAIGHSRTHWDFCQELYESIEF 999
              |..:.|..|:   |:.|||.|                |:...|:.|             .|:.
  Fly   364 GAFNTLLKCLARMQIFVGMPTCE----------------CIVKMAVDH-------------LIKI 399

  Fly  1000 KKLTYNNEDAIQNSNALIVQMLIAIFLRSSFH--QEIALKELLHHCALR--RLTEREFISLQSMS 1060
            ....:.|.:|:.|.|.     ||.|.|.::|.  ..|.|:::|.....|  .|||.:..|:..:.
  Fly   400 MPTLHLNTEALVNINE-----LICICLLNNFTGLDPILLEQVLLDQVKRMISLTELQRQSVLYLL 459

  Fly  1061 SCHRQTVRDLIRPFAAILLHHWSSKRWPISKFPYFLCYSTKSEFRKTHASEIMAYTFLYGKTEDI 1125
            .|   |||.|.......|:|      :.....||.    ||...|..            |:|
  Fly   460 LC---TVRRLRARLTPSLVH------FIFQSNPYM----TKVRLRSP------------GET--- 496

  Fly  1126 ERCSKSISEELALPILASFLLIKNSSCSESEGQNFKEHLQLLSENLSYSQLNATDVDLDLDILCY 1190
                   |.:|.|......|||:|              :.||.:...|.   ..|:|..|:.|
  Fly   497 -------SYKLLLRTCQETLLIRN--------------VPLLQQAYKYL---VDDIDACLEKL-- 535

  Fly  1191 VISMLHDPQEMMRLFGSLAICNRTASWYSLSGESLFKCLNFHIDPEMRPSMDSRIQSMTTLQTKH 1255
               ::..|:...|....|.:                    ||            :.::..|..:.
  Fly   536 ---LITAPRSKARKASVLLV--------------------FH------------LSALAALAKQT 565

  Fly  1256 SRVL------VDIFGRLKTNCYSASFSSQALHDFFLYCEVADAVYDAARKNETIVTQCSFFVRDI 1314
            |.::      ..|...|.|||.:        |:...:.:     |.||:       |..|.:
  Fly   566 SSIIGMYACKPSILELLLTNCRA--------HELKFWSK-----YPAAQ-------QAIFGL--- 607

  Fly  1315 WFFVVRLLIHTKFIRVQMAALTFLELLLNKHNFRLDDYQNHFGDIAKLLSNFQLCCEAKEVREKT 1379
                  |::|.:                ..||||.:         :.||.:.:|..|.......:
  Fly   608 ------LVVHCQ----------------ANHNFRTN---------SSLLRDQELSAENTSPTANS 641

  Fly  1380 MSIVMYILESKKGHI------NLNSFLEETTDCEFLKPLREDCKSSQPNIDRADVANYLRSFL-- 1436
            .:.::..|:|..|..      ||...|      ::::.|..:|:      ::.|:.....:|.
  Fly   642 FASILRFLDSVLGQAHQLAPQNLRVLL------QWIQMLLRECR------EKIDLLMEQENFRGI 694

  Fly  1437 ---LSPTPERLRDL------RTYIAEHKDKVQEHEKLLFGVINKLIQMTRDAHNKTTSIDSLKCL 1492
               ::.|..:|..|      :|.:....::::::.|||.        :.||     |::..|:.|
  Fly   695 CRNIAATASKLVPLESAACIQTVLDYGLERLEKYPKLLI--------LYRD-----TALQQLQML 746

  Fly  1493 AQIGPLKISTVSYYFQTDFEAFEK-------SNGEPMEAFLGVVCHSLDTSLFQFDPKTHEGLVS 1550
            :          :.|....|:.:.:       :.||                      .:..|:.|
  Fly   747 S----------TNYHAPYFQIYAQLPLHLTLTGGE----------------------SSMPGMAS 779

  Fly  1551 VAIQVVNSKPGSNIMERYKNLR--IFAD------KSTASTFLHSNKQI------------RRIDW 1595
            ..:.|...:     :.:|..:|  :|.|      |....:.:|..:::            |:::.
  Fly   780 RRVSVWQQR-----ISQYSAVRDNVFRDFFDRVQKPEQDSLIHCLRELFVRSCQVAPQDERQMNL 839

  Fly  1596 LSILKATKSLSYEPWM-------C------AFVSKVFQMCGWLGFDKLAATSFAFAKTCLLPFIK 1647
            ....|..:.|:. .|:       |      ..|.|..:.  :|||:.:..........|.....:
  Fly   840 SQCTKRCQRLAI-AWLQFEAARYCVDQRLRTTVGKPQET--FLGFEAIIMRHARLLSGCAKEIER 901

  Fly  1648 LLLEN-SLEHVESLSQMLDYFFEGFTSSTAPNSQEIFRNKRAIKKFL------HICEYIRIFN-- 1703
            ..|:: |||.:.|:...|.... ||..:.    :::..|......|.      .:..:.|:.|
  Fly   902 SALDDLSLEELLSMQSNLSLLL-GFLDAL----EKLIYNAAEGSAFALRPPEKQVAAFFRLNNPT 961

  Fly  1704 --NWTIPINLSNVVMASNHCQAYFLSIMYLELWACSESPKSKADFLDNECFQDGAKK------AY 1760
              :|...|.:..|::|. |.|...|.|.|.:            ..|.|...||....      |:
  Fly   962 CQSWFNRIRIGVVIIAM-HVQQPELVIRYAQ------------QILVNSKTQDPTYSQAIVYMAW 1013

  Fly  1761 ESIGCLDAIPGFVNPMRSRLDFLGHGSNLSTILLESDHLDRASGQLCIDIMKGNGLWSFAKLQQH 1825
            ..:.|.:|     :.:|. |.....|.:..:........|:|:|:      :.:.|..:..:...
  Fly  1014 SLVSCQEA-----DSLRG-LRLWARGKSCKSYKWLKYAADQAAGK------RESALAGYRTILAE 1066

  Fly  1826 QNIEPDYEIFWR-------------LGQWDSLTDPKHQQ---------NQTVVRTSLDLEQEFKR 1868
            :.::.:.|...|             ||||..|.:.|.||         |..:.|:::::.
  Fly  1067 KELQSELEPHTRQFVVSQMMQCLQDLGQWSQLVELKQQQMTRPEDRELNPFLQRSNVEVN----- 1126

  Fly  1869 HHFVALRSIGQREEENSLSAIEQAYSCVRDILMEISVECLQSVYKYLT-----W-----LCSLQQ 1923
                ||..:..:.||          ||       .|::.|..|::.|:     |     ...|.:
  Fly  1127 ----ALERLLAKSEE----------SC-------SSMDALGGVFQQLSLWPSNWDESVSSSGLSE 1170

  Fly  1924 AEDFCQIQFGTQLDPASTTKIFR--------------KWQTE-LELKYGNFSCKEYVI------- 1966
            ...|..|....:.:.....|:..              :|:.. |...:...||||..:
  Fly  1171 RASFSSIHMRQRTEDIVLHKLLEDRCVPDQAKNLLDTQWRDSLLNPSFDQRSCKELTLLRHIVQG 1235

  Fly  1967 ---AHQIALLKLAGTRASRRMSEFYQKDPISTYLMKGI-------EECKSAGKLNLAAKYTATLR 2021
               ..:::||.::..|...| |:|..    |..||:.:       :.|.......|.....|..|
  Fly  1236 VSGGQELSLLPVSSGRCQNR-SKFIS----SAILMRCLAWTQLLRQHCAPGSWETLCLDAAAAAR 1295

  Fly  2022 ELPNIR--------------------ESIKISVLLEDAE-------------------------- 2040
            |..|::                    .|::..|..::.|
  Fly  1296 EEGNLQLAETLLTQFFGQPIGEIAALFSLEQGVQTDNPEMLRGYSELVKCLHLQQQQSQTHSGDL 1360

  Fly  2041 -----------INLKMGNQQIAKA------ILDYV---------TNNNE-FVYCVQRVPALRMQG 2078
                       :|::..|.|.|..      :.|::         ||.:. .:..:.::|
  Fly  1361 SSSIDVCAALCLNIQKSNNQPAAGADLLLNLADWIAVRTCNGLTTNQSPVLIQLLDQLP------ 1419

  Fly  2079 EFLLDC-NAETLSWVQSHKFNNSLKLIDDFVQHRQTLSEKYRDIFDWHQLDAYASKQRTAAYATI 2142
            |..|.| :::.|:..|:.:.  ..:|:...:|.|...:|......:|    .|...::.|....:
  Fly  1420 ECPLTCDSSQPLAIPQAERM--VARLVHSCLQQRPNYAEALIAYGNW----CYRWGKKVADSCCV 1478

  Fly  2143 AKYAD-REYQQLHDYRHSQEYQTLKDIIE---------------QNRQTAEKVTQRENQDRRVIS 2191
            ...|| ....|..|.....|.:.|.::::               .:...|......:|:.||:..
  Fly  1479 LTQADATAISQALDIPQPLESEKLDELLQALSTEQPPANCVEVCPDAARARDDEAAKNRLRRLTF 1543

  Fly  2192 VQMKRYASLDEQQLNQIEEKLT----EYLRLALTNYMAYCRLDSGFSS----------------- 2235
            :..|...:||  .:.||..:..    :|.:.|..:|..|....||...
  Fly  1544 LADKTPEALD--AILQIWRRAIANTYDYYKDAARSYFQYLSFKSGSGPEKPEGEGVVSQRERLHV 1606

  Fly  2236 ------AAIYRIISLWFTNATSKQCQECIKDEILTVPSYKFICAANQLTARLNSKNTSLLKGLTD 2294
                  ....|::.|...:|:.  .||.::..:.|.|...:.....||.:|||.....:.|.:.|
  Fly  1607 DDSNLVTTTLRLLRLIVKHASG--LQEVLEQGLHTTPIAPWKVIIPQLFSRLNHHEPYVRKSVCD 1669

  Fly  2295 LLVQCGKDHPYHTFYQLYPLVFAHLDGENSNTERSGIARKIIAMICEKNGTAGECSKQ------- 2352
            ||.:..|..|.   ..::|.|......:...|.....||......|......||.|||
  Fly  1670 LLCRLAKSRPQ---LVIFPAVVGANREQQDATAPPATARPTTEDACCYGYLLGELSKQAPEAVQH 1731

  Fly  2353 -------------------LESLLPALITFAN--EGKTNDNRPVSDSVRNKQFDKVRRWR----- 2391
                               :.||.....|:.:  .....|.||.....:|.:|:.   ||
  Fly  1732 VKLMVKELRRVCLLWDEYWIHSLAHIYNTYVSRVSALATDFRPDDHEGKNNRFNV---WRPQLLA 1793

  Fly  2392 NLNAVHCPT---------------LELPVMPSKE-----------------YSII--SVVKWTNE 2422
            :|.|:...|               .:.|:..:.:                 |.|:  ::::.:..
  Fly  1794 DLEALVAVTSRPPETTYERSFRKRFDAPIRLTVDALRHRRYPEAWDKLKQLYHILQSNMIRGSGS 1858

  Fly  2423 TTQ--------CG---------GLNA-------------------------PVKIMCVCSDGKIR 2445
            |.:        ||         ||:|                         |.|:....|:|:..
  Fly  1859 TLKMQSISPVLCGIGRMRISMPGLDAHGPDGDQVYIESVESSVCVLPTKTKPKKVAFYGSNGQRY 1923

  Fly  2446 AQLVKGKDDLRQDAVMQQVFGIVNELLNQDSEFIERK-LKLRTYKVTPLSMRSGILEWCTNSVPV 2509
            ..|.||.:||..|..:.|...|.|.::...|:..... .:...|.|.||..:||::.|.....||
  Fly  1924 TFLFKGMEDLHLDERIMQFLSISNAIMACRSDAPGNGCYRAHHYSVIPLGPQSGLISWVDGVTPV 1988

  Fly  2510 --------GHYLVVEGKGGAHA----RYRPNDWNNNKCRKLSSDHLKSPKETR----YAIYKKIC 2558
                    .....|.|..||.|    ..|..|...||...|.:.|.....:.|    .::..::.
  Fly  1989 FALYKKWQQRRSQVAGNAGAGAVANVPRRFTDLFYNKLSPLLAKHNMQVSDPRRQWPISVLLQVL 2053

  Fly  2559 ENIKPVFHYFLLEKFPIPGVWFE-----------RRLAYTNSVATTSMVGYVLGLGDRHTQNILV 2612
            :.:.......||.:    .:|.:           ||  :...::..||:|||:||||||..|:|:
  Fly  2054 DELSQETPNDLLAR----ELWCQAGNAAEWRQSVRR--FVRCMSVMSMIGYVIGLGDRHLDNVLI 2112

  Fly  2613 DQQTAEVIHIDFGIAFEQGKIQTTPETVPFRLTRDFVAPMGICGTKGVFAKSCEATMHILRRYKS 2677
            :..:.:::|||:.:.||:|:....||.||||||::.|..|||.|.:|.|...||..:.::|:.:.
  Fly  2113 NLGSGDIVHIDYNVCFEKGRTLRIPEKVPFRLTQNLVQAMGITGIEGPFRLGCEYVLKVMRKERE 2177

  Fly  2678 VFTTILEVLLYDPLFIWGVLKKKQSPQQSGEESVNLVAQRALLLVQNKLDGREAGTMG------- 2735
            ...|:||..:||||..|......|:.::|      |.|:     :|...||..||.:|
  Fly  2178 TLLTLLEAFVYDPLVDWTTNDDAQALRRS------LNAK-----LQESADGGGAGGLGVGDLKYH 2231

  Fly  2736 --DSNVEAQVERLINEATLPSNLCMLFPGW 2763
              |.|....::..:......|.|.||...|
  Fly  2232 KKDKNKGKPLDSDVKRQPFLSKLGMLQKYW 2261

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tefu	NP_001036712.1	FAT	1829..2170	CDD:280429	77/479 (16%)
		PIKKc_ATM	2416..2696	CDD:270715	91/349 (26%)
		FATC	2739..2767	CDD:280430	5/25 (20%)
nonC	NP_001284967.1	SMG1	571..1140	CDD:292413	120/743 (16%)
		Rapamycin_bind	1738..1845	CDD:285924	14/109 (13%)
		PIKKc_SMG1	1894..2196	CDD:270714	85/307 (28%)
		FATC	3189..3217	CDD:280430

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464451
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11139
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030