Protein Alignment tefu and Atm

DIOPT Version :9

• Sequence 1: NP_001036712.1
• Gene: tefu / 41839
• FlyBaseID: FBgn0045035
• Length: 2767
• Species: Drosophila melanogaster
• Sequence 2: XP_038936996.1
• Gene: Atm / 300711
• RGDID: 1593265
• Length: 3096
• Species: Rattus norvegicus
• Alignment Length: 3380
• Identity: 797/3380 - (23%)
• Similarity: 1332/3380 - (39%)
• Gaps: 905/3380 - (26%)

  Fly     1 MSALLNEIQRILGDLQSGKAASRNKGIQQLDEKLSSCREDLDKL-FLSKTSD------ISWTTIF 58
            ||..||::......|:..:|..|.|.:    :|.....:|.:.: .|.:.||      ::|..:|
  Rat     1 MSLALNDLLICCRQLEHDRATERRKEV----DKFKRLIQDPETVQHLDRHSDSKQGKYLNWDAVF 61

  Fly    59 EASKEALFKQAGNLEDVNEKVFKTLAGKNYLYDNVLEKITQFNLEAGSQTSGNGHFLAKTSIFSA 123
            ...::.:.|:..:|                       :..:.|:.|.:|||........:|:...
  Rat    62 RFLQKYIQKETESL-----------------------RTAKSNVSASTQTSRQKKMQEISSLVRF 103

  Fly   124 F-------EDGIKMRVVVKY-------------FGDRILSLLEKGIYSSVSYVRDLKINEYSRIL 168
            |       ...:|.:.::.|             :|....::|.|.|.|...|..::...::..:.
  Rat   104 FIKCANKRAPRLKCQDLLNYVMDTVKDSSNGATYGADCSNILLKDILSVRKYWCEVSQQQWLELF 168

  Fly   169 SYLFEL----NVDMDEVLRTRILKCITR-----TVSLAKDRVQLHVDLVEYL-PELSSFALSAFG 223
            |....|    :.|::.||..||:..:||     |..|....:.|....::|. .|.||..||
  Rat   169 SLYIRLYLKPSQDINRVLVARIIHAVTRGCCSQTDGLPSKFLDLFSKAIQYARQEKSSPGLS--- 230

  Fly   224 ARKTEIVRVYLIFASELAVNYNHQLNVHMQEILPKLCEYHDEDAFRDDTRNLFFQCVSKSLHSMY 288
                .|:....||...||||:..::.....||||.|.....:....|..:.:..:.:...::..:
  Rat   231 ----HILAALNIFLKTLAVNFRKRVCEIGDEILPTLLYIWTQHRLNDSLKEVIIELIHLQIYIHH 291

  Fly   289 LKMDMCDFNTLGVPVHE-------KWPQTLLRLKTIVNVEIRKNSWARCKNALLSNN-KFSDPFI 345
            .:         |....|       ||.:.|..|..::..|| .:..:|.|.:..|.| ...:..|
  Rat   292 PQ---------GAKAPEEGAYESMKWKRILYNLYDLLVNEI-SHIGSRGKYSSGSRNIAVKENLI 346

  Fly   346 KMSALAMYIVLWHLETKKAD---------ENGEGDAPKKIPKPADKMETIFSLIDKKENTFNDV- 400
            .:.|...| .|::.:|:..:         |:.:...|.|..|.....|.|...:.|.:|.|:.|
  Rat   347 DLMADVCY-QLFNADTRSVEISQSYATQRESTDYSVPCKRRKIDIGWEVIKDYLQKSQNDFDLVP 410

  Fly   401 WLAIFTEIL----------QLSSVILNVANYQM------------ALTTVAEIMQMYGNAKNLRN 443
            ||.|.|.::          :||.:||.:  ||:            .|..:.|:....|...||.:
  Rat   411 WLQITTRLISKYPSSLPNCELSPLILIL--YQLLPQQRRGERIPHVLRCLTEVALCQGKKSNLES 473

  Fly   444 ------LRL-------------------------------------------------------- 446
                  |:|
  Rat   474 SQKSDLLKLWIKIWSITFRGISSEQTQTENFGLLGAIIQGSLVELDREFWKLFTGSACKPSSPSV 538

  Fly   447 -CLAHLLT-----------KEQELL---HSKSIREDFLGELWSQMANQLISETTTNSEEIKEKQL 496
             ||...|:           .||.:.   .|.|::|..:..|       |..:...:.|:..|...
  Rat   539 RCLTLALSMCVVPDAIKMGTEQSVCDANRSFSVKESIMRWL-------LFYQLEGDLEDSAEPPP 596

  Fly   497 VLQMLIRHNKLNQKLSSTLLNNIISNEMLKRNECLATIREIFIHADKCGQDKASADLEPIIAWAY 561
            :||....|..|.:.|.|..:.|  |...:|          .|..|.:|.|.....: ||    ::
  Rat   597 ILQSNFPHLILEKILVSLTMKN--SKAAMK----------FFQSAPECEQHCEDTE-EP----SF 644

  Fly   562 GSADRFIAAQMIHNIDSIDAQLQADTFA--ISIINFLDVQQLRQISQSEHIVPSTERNLLAYK-- 622
            ..|:..........:|.: ..::.||..  .|.:.|...|.|:: |...:::..:|:.|..|.
  Rat   645 SEAEELFLQTTFDKMDFL-TPVKEDTVEKFQSRVGFSVHQNLKE-SLDHYLLGLSEQLLSNYSSE 707

  Fly   623 --YNEQLI-------------CF------DKDYATPF------------ESITHIQSETK----- 649
              .:|.|:             |:      |:.|.:..            |||:..:::|.
  Rat   708 ITSSETLVRCSSLLVGVLGCYCYMGVITEDEAYKSELFQKAKSLMQCAGESISLFKNKTNEESRV 772

  Fly   650 ---NCLIQSNYDCLMRGLNFEIAK--------------ENKPAAIIKNLNSLLKLICTM------ 691
               ..:|.....||.|.....:.|              .|..|.|.|:|.|     ||.
  Rat   773 GSLRSVIHLCTSCLCRHTKHTLNKIASGFFLRLLTSKLMNDIADICKSLAS-----CTKKPFDYG 832

  Fly   692 ------------------ERLLHYK---------------VFDADTY-------------TGCPL 710
                              |.|:..:               |.||:.|             |...|
  Rat   833 EEHSLRDDDDDGDGGDGGESLMETQGSSSTDLFSDYSASTVSDANDYGENQNAVGAANPLTADWL 897

  Fly   711 IKRIGLYLSHIEF-----------QLKANGAEI-------LDKS--DLPEILRLEIYVLDVFRTN 755
            .::..|.|..:.|           .....||:|       ||.|  ||.:.|.|.:|
  Rat   898 SRQDHLLLDMLRFLCLSVTACQSRTASFRGADIRRKLLMLLDPSTLDLTKSLHLHMY-------- 954

  Fly   756 LVLLDYLERQ----PIEMLVEFVGAALKLHSMQRERSVDAD-----HGTITRLCLNILAGLCAYN 811
            ||||..|..:    |:|.:||.:.....:.|:.|.   |.|     ...:..:..|:..|.....
  Rat   955 LVLLKDLPGKEHLLPMEDVVELLQPLSLVCSLYRR---DQDVCKTILSNVLHIVTNLGQGSVDTE 1016

  Fly   812 SHRDEAFEHIVKVTMRWH----PQDVLIVTKMLCSC-QTISEAS--SSWLVSKLKTLFQQHHQDA 869
            |.|:...:.:..:...||    .:.:..|...|..| ||:.||.  |.|.:..:|      .||.
  Rat  1017 STRNAQGQFLTVMGAFWHLTKEKKCIFSVRMALVKCLQTLLEADPYSKWAILNVK------GQDF 1075

  Fly   870 ELMDKVVQHMPTIFYFVRHKENHLDDMLMA---------------LNSLLRIAIKKSYTSNLTAK 919
            .:.:...|.:....:.||        ||.|               ..||..:.:|...||..:|.
  Rat  1076 PVREAFPQFLADGHHHVR--------MLAAGSISRLFQDMRQGDSSRSLKALPLKFQQTSFNSAY 1132

  Fly   920 IVRCVGLIAQRC----PD----IY-----LLENFAV------ICKSTAKFITMPTLEVRFATLFT 965
            ::...|:....|    ||    ||     ||...||      ||:..|.|....:::........
  Rat  1133 MIAEAGIRELLCDSQNPDLLDEIYNRKSVLLTVIAVVLHCSPICEKQALFALCKSVKENGLEPHL 1197

  Fly   966 FTILLESNCVTSDAIGHSRTHWDFCQELYESIEFKKLTY-NNEDAIQNSNA----LIVQMLIAIF 1025
            ...:||.   .|::.| .|...||   :...:::..|.: |.:||..:.::    |:..|.:..|
  Rat  1198 VKKVLEK---VSESFG-CRCLEDF---MASHLDYLVLEWLNLQDAKYSLSSFPFTLLNYMSVEDF 1255

  Fly  1026 LRSSFHQEIALKELLHHCALRRLTEREFISLQSMSS----CHRQTVRDLIRPFAAILLHHWSSKR 1086
            .||.:      |.|:.|..:|    :.|..::|:::    |.:..   ||..|..:|:|
  Rat  1256 YRSCY------KILIPHLVIR----KHFDEVKSIANQIQRCWKSL---LIDCFPKMLVH------ 1301

  Fly  1087 WPISKFPYFLCYST---KSEFRKTHASEIMAYTFLYGKTEDIERCSKSISEELA--LP-ILASFL 1145
                ..|||.|..|   .|..::..|:|:  |..|.|  ||.  ..|.|.:...  || |:...|
  Rat  1302 ----ILPYFACEGTGDSSSAQKRETATEV--YDTLKG--EDF--LGKQIDQVFISNLPEIVVELL 1356

  Fly  1146 LIKNSSCSESEGQNFKEHLQLLSENLSYSQLNATDVDLDLDILCYVISMLHDPQEMMRLFGSLAI 1210
            :..:.:.....||         |.:|       .|...||           ||......|.|..|
  Rat  1357 MTLHETADSDSGQ---------SPDL-------CDFSGDL-----------DPAPNPPYFPSHVI 1394

  Fly  1211 CNRTASWYSLSGESLFKCLNFHIDPEMRPSMDSRIQSMTTLQTKHSRVLVDIFGRLKTNCYSASF 1275
             ..|.::.|...::.||               |.::.::.:...:.::|:.|
  Rat  1395 -KATFAYISSCHKTKFK---------------SILEILSKIPDSYQKILLAI------------- 1430

  Fly  1276 SSQALHDFFLYCEVADAVYDAARKNETIVTQ---CSFFVRDI-------WFFVVRLLIHT----- 1325
                       ||.|....:..:|:..:...   .|..::||       |.||:|.:|:|
  Rat  1431 -----------CEQAAETNNVFKKHRILKIYHLFVSLLLKDIQSGLGGAWAFVLRDVIYTLIHYI 1484

  Fly  1326 --KFIRVQMAALTFLELLLNKHNFR----LDDY-----QNHFGDIAKLLSNFQLCCEA------- 1372
              ...:...:::.|: |.::...:|    |.:|     .:||.|::  |.:|.|||:.
  Rat  1485 NKSCYQADSSSVIFV-LPVSNEAWRSLPALREYPTGVTSSHFTDVS--LRSFSLCCDLLSRVCRT 1546

  Fly  1373 --------------------------KEVREKTMSIVMYILESKKGHINL---NSFLEETTDCEF 1408
                                      :||:|:.:.::.|::...|.:.||   ...|:...|...
  Rat  1547 AVTHCKDALENHLHVIVGTLIPLVDYQEVQEQVLDLLKYLVIDNKDNKNLFVTIKLLDPFPDHVV 1611

  Fly  1409 LKPLR---EDCK-SSQPNIDRADVANYLRSFLLSPTP----ERLRDLRTYIAEHKDKVQE----- 1460
            .|.||   :..| |..|.....::.::|.....:|.|    |.|:|||..:.:|||::.:
  Rat  1612 FKDLRLTQQKIKYSGGPFTLLEEINHFLSVSAYNPLPLTRLEGLKDLRRQLEQHKDQMLDLVRAS 1676

  Fly  1461 ----HEKLLFGVINKLIQMTRDAHNKTTSIDSL----KCLAQIGPLKISTVSYYFQTDFEAFEKS 1517
                .:.::..::..|:|:::.|.|:|...:.|    :||.:||||..||::.....| ..:.|:
  Rat  1677 QDNPQDGIVVKLVVSLLQLSKMAVNQTGEREVLEAVGRCLGEIGPLDFSTIAVQHSKD-TPYTKA 1740

  Fly  1518 NGEPMEAFLG---VVCHSLDTSLFQFDPKTHEGLVSVAIQVVNSKPGSNIMERYKN--------L 1571
            .|.|.:..|.   ::..:|:.:|.:...|......:....::.:|.|....|.:|.        |
  Rat  1741 YGLPEDRELQWTLIMLTALNNTLVEDSVKIRSAAATCLKNILATKTGHIFWENHKTSADPMLTYL 1805

  Fly  1572 RIFADKSTASTFLHSNKQIRR-----IDWLSILKATKSLSYEPWM----CAFV------SKVFQ- 1620
            :.|  :::...||...:.::.     :|.:: |...:|.|::.|:    |||:      |::.|
  Rat  1806 QPF--RASRKKFLELPQFVKEDALEGLDDVN-LWVPQSESHDIWIKTLTCAFLDSGGIKSEILQL 1867

  Fly  1621 ---MCGWLGFDKLAATSFAFAKTCLLPFI--KLLLENSLEHVESLSQMLDYFFEGF--------- 1671
               ||.       ..|.|.   ..:||::  .:||:::  | ||...:|.....||
  Rat  1868 LKPMCE-------VKTDFC---QMVLPYLIHDVLLQDT--H-ESWRTLLSTHVRGFFTNCFKHSS 1919

  Fly  1672 ---TSSTAPNSQEIFRN-------KRAIKKFLHICEYIR---------IFNN--WTIPINLSNVV 1715
               .|:|..||.....|       |::.:..|.:.:|:|         .|.:  | :.:|...|.
  Rat  1920 QASRSATPANSDSESENFLRCCLDKKSQRTMLAVVDYLRRQKRPSSGTAFEDAFW-LDLNYLEVA 1983

  Fly  1716 MASNHCQAYFLSIMYLELWA------------------------CSESPKSKADFLDNECFQDGA 1756
            ..:..|.|:|.:::|.|:::                        .|.|.|||.:  .....||..
  Rat  1984 KVAQSCAAHFTALLYAEIYSDKKNMDEQEKRSPTFEEGSQGTTISSLSEKSKEE--TGISLQDLL 2046

  Fly  1757 KKAYESIGCLDAIPG-----FVNPMRSRLDFLGHGSNLSTILLESD------HLDRASGQLCIDI 1810
            .:.|.|||..|::.|     .:.|: :|:....|.:.....|:..|      ...|.||  .|..
  Rat  2047 LEIYRSIGEPDSLYGCGGGKVLQPL-TRIRTYEHEATWEKALVTYDLETTISSSTRQSG--IIQA 2108

  Fly  1811 MKGNGL-----------------WSFAKLQQHQNIEPDYEIFWRLGQWDSLTDPKHQQNQTVVRT 1858
            ::..||                 |. .:||     |..|:..||..|||..|....:...|....
  Rat  2109 LQNLGLSHILSIYLKGLDHERREWC-GELQ-----ELHYQAAWRNMQWDLCTSANQELEGTSYHE 2167

  Fly  1859 SLDLEQEFKRHHFVALRSIGQREEENSLSAIEQAYSCVRDI--LMEISVECLQSVYKYLTWLCSL 1921
            ||          :.||:.:..||......::..|.  |:::  |.:.|:|.:.|:|..|:.|.::
  Rat  2168 SL----------YNALQCLRNREFSTFYDSLRHAR--VKEVEELSKGSLESVYSLYPTLSRLQAV 2220

  Fly  1922 QQAEDFCQIQFGTQLDPASTTKIFRKWQTELE-LKYGNFSCKEYVIAHQIALLKLAGTRASRRMS 1985
            .:.|:..:: |...:.....::::.|||...: ||..:||.:|.::|.:..:|::...:......
  Rat  2221 GELENSGEL-FSRSVTDRERSEVYLKWQKHSQLLKDSDFSFQEPLMALRTVILEILVQKEMENSQ 2284

  Fly  1986 EFYQKDPISTYLMKGIEECKSAGKLNLAAKYTATLRELPNIRESIKISVL-----------LEDA 2039
            ....||.::.:|:          :.::.|: |....:||. |...||...           ||:|
  Rat  2285 GGCSKDILTKHLV----------EFSVLAR-TFKNTQLPE-RAIFKIKQYNPAICGISEWHLEEA 2337

  Fly  2040 EINLKMGNQQIAKAILDYVTNNNEFVYCVQRVPALRMQGEFLLDCNAETLSWVQSHKFNNSLKLI 2104
            ::......|.:|.:||..:....:..:.........:..|.|..|.    :|:......|...::
  Rat  2338 QVFWAKKEQSLALSILKQMIKKLDSSFRENEAGLKGLHAECLRVCG----NWLAETCLENPAVIM 2398

  Fly  2105 DDFVQHRQTLSEKYRDIFDWHQLDAYASKQRTA---AYATIAKYADREYQQLHDYRHSQEYQTLK 2166
            ..:::....::..|         |..:.:.|..   |:.::|:::|.:||::.:|..|.|::..:
  Rat  2399 QTYLEKAVKVAGSY---------DGDSRELRNGQMKAFLSLARFSDTQYQRIENYMKSSEFENKQ 2454

  Fly  2167 DIIEQNRQTAEKVTQRENQDRRVISVQMKRYASLDEQQLNQIEEKLTEYLRLALTNYMAYCRLDS 2231
            .::::.::....:.:.:.|..| .:::::|...|||..|..::|....:|..|:.||:: |.|..
  Rat  2455 ALLKRAKEEVGLIREHKIQTNR-YTIKVQRELELDECALRALKEDRKRFLCKAVENYIS-CLLSG 2517

  Fly  2232 GFSSAAIYRIISLWFTNATSKQCQECIKDEILTVPSYKFICAANQLTARLNSKNTSLL---KGLT 2293
            ......::|:.|||..|:...:....:|.:.:.:.||||:....||.||:.:|.|..|   :.|.
  Rat  2518 EEHDLWVFRLCSLWLENSGVSEVNGMMKRDGMKISSYKFLPLMYQLAARMGTKMTGGLGFHEVLN 2582

  Fly  2294 DLLVQCGKDHPYHTFYQLYPLVFAHLD-------------------GENS--NTERSGIARKIIA 2337
            :|:.:...|||:||.:.:..|..|:.|                   .|:|  :.:|:..|.:||.
  Rat  2583 NLISRISMDHPHHTLFIILALANANKDEFLSKPETARRGRITKNAPKESSQLDEDRAEAASRIIH 2647

  Fly  2338 MICEKNGTAGECSKQLESLLPALITFANEGKT---NDNRPVSDSVRNKQFDKVRRWRNLNAVHCP 2399
            .|.....|   ..|.:|:|..|.|..||...:   |..:.:|... |:...|:   :||..|..|
  Rat  2648 TIRSARRT---MVKDMEALCDAYIILANLDASQWRNQRKGISIPA-NQPITKL---KNLEDVVVP 2705

  Fly  2400 TLELPVMPSKEY-SIISVVKWTNETTQCGGLNAPVKIMCVCSDGKIRAQLVKGKDDLRQDAVMQQ 2463
            |:|:.|.|:.|| .::::..:..|....||||.|..|.||.||||.|.|||||:|||||||||||
  Rat  2706 TMEIKVDPTGEYEKLVTIKSFKTEFRLAGGLNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQ 2770

  Fly  2464 VFGIVNELLNQDSEFIERKLKLRTYKVTPLSMRSGILEWCTNSVPVGHYLVVEGKGGAHARYRPN 2528
            ||.:.|.||.:::|..:|||.:.||||.|||.|||:|||||.::|:|.|| |..:.|||.|||||
  Rat  2771 VFQMCNMLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTIPIGEYL-VNNEEGAHKRYRPN 2834

  Fly  2529 DWNNNKCRKLSSDHLKSPKETRYAIYKKICENIKPVFHYFLLEKFPIPGVWFERRLAYTNSVATT 2593
            |.:.|:|:|...:..|...|.:|..:..||:|.:|||.||.:|||..|.||||:|||||.||||:
  Rat  2835 DLSANQCQKKMMEVQKKSFEEKYETFMTICQNFEPVFRYFCMEKFLDPAVWFEKRLAYTRSVATS 2899

  Fly  2594 SMVGYVLGLGDRHTQNILVDQQTAEVIHIDFGIAFEQGKIQTTPETVPFRLTRDFVAPMGICGTK 2658
            |:|||:|||||||.||||:::|:||::|||.|:|||||||..|||||||||:||.|..|||.|.:
  Rat  2900 SIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLSRDIVDGMGITGVE 2964

  Fly  2659 GVFAKSCEATMHILRRYKSVFTTILEVLLYDPLFIWGV-----LKKKQSPQ-------------- 2704
            |||.:.||.||.::|..:....||:|||||||||.|.:     |..:|.|:
  Rat  2965 GVFRRCCEKTMEVMRSSQEALLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDETDLQSTPSADDQ 3029

  Fly  2705 ------QSGEESVNLVAQRALLLVQNKLDGREAGTMGDSNVEAQVERLINEATLPSNLCMLFPGW 2763
                  ...::|.|.||:|.|:.:|.||.|.|.||:  .:|..||..||.:|..|.||..|||||
  Rat  3030 ECKRSLSDTDQSFNKVAERVLMRLQEKLKGVEEGTV--LSVGGQVNLLIQQAMDPKNLSRLFPGW 3092

  Fly  2764  2763
              Rat  3093  3092

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tefu	NP_001036712.1	FAT	1829..2170	CDD:280429	69/357 (19%)
		PIKKc_ATM	2416..2696	CDD:270715	164/279 (59%)
		FATC	2739..2767	CDD:280430	14/25 (56%)
Atm	XP_038936996.1	TAN	8..165	CDD:402988	28/183 (15%)
		FAT	2137..2529	CDD:396714	85/436 (19%)
		PIKKc_ATM	2723..3002	CDD:270715	164/279 (59%)
		FATC	3066..3095	CDD:396715	14/27 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	312	1.000	Domainoid score	I1261
eggNOG	1	0.900	-	-		E1_KOG0892
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	564	1.000	Inparanoid score	I1039
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10493at33208
OrthoFinder	1	1.000	-	-		FOG0003948
OrthoInspector	1	1.000	-	-		oto96736
orthoMCL	1	0.900	-	-		OOG6_102827
Panther	1	1.100	-	-	LDO	PTHR11139
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3248
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.830