DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tefu and Atm

DIOPT Version :9

Sequence 1:	NP_001036712.1	Gene:	tefu / 41839	FlyBaseID:	FBgn0045035	Length:	2767	Species:	Drosophila melanogaster
Sequence 2:	XP_011240687.1	Gene:	Atm / 11920	MGIID:	107202	Length:	3077	Species:	Mus musculus

Alignment Length:	3374	Identity:	795/3374 - (23%)
Similarity:	1319/3374 - (39%)	Gaps:	912/3374 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSALLNEIQRILGDLQSGKAASRNKGIQQLDEKLSSCREDLDKL-FLSKTSD------ISWTTIF 58
            ||..||::......|:..:|..|.|.:    :|.....:|.:.: .|.:.||      ::|..:|
Mouse     1 MSLALNDLLICCRQLEHDRATERRKEV----DKFKRLIQDPETVQHLDRHSDSKQGKYLNWDAVF 61

  Fly    59 EASKEALFKQAGNLEDVNEKVFKTLAGKNYLYDNVLEKITQFNLEAGSQTSGNGHFLAKTSIFSA 123
            ...::.:.|:..:|......|..|...........:..:.::.::..::.:..   |....:.:.
Mouse    62 RFLQKYIQKEMESLRTAKSNVSATTQSSRQKKMQEISSLVRYFIKCANKRAPR---LKCQDLLNY 123

  Fly   124 FEDGIKMRVVVKYFGDRILSLLEKGIYSSVSYVRDLKINEYSRILSYLFEL----NVDMDEVLRT 184
            ..|.:|.......:|....::|.|.|.|...|..::...::..:.|..|.|    :.|::.||..
Mouse   124 VMDTVKDSSNGLTYGADCSNILLKDILSVRKYWCEVSQQQWLELFSLYFRLYLKPSQDINRVLVA 188

  Fly   185 RILKCITR-----TVSLAKDRVQLHVDLVEYL-PELSSFALSAFGARKTEIVRVYLIFASELAVN 243
            ||:..:||     |..|....:.|....::|. .|.||..||       .|:....||...||||
Mouse   189 RIIHAVTRGCCSQTDGLPSKFLDLFSKAIQYARQEKSSPGLS-------HILAALNIFLKSLAVN 246

  Fly   244 YNHQLNVHMQEILPKLCEYHDEDAFRDDTRNLFFQCVSKSLH------------SMYLKMDMCDF 296
            :..::.....||||.|.....:....|..:.:..:.:...::            ..|..|
Mouse   247 FRKRVCEAGDEILPTLLYIWTQHRLNDSLKEVIIELIQLQIYIHHPQGARAPEEGAYESM----- 306

  Fly   297 NTLGVPVHEKWPQTLLRLKTIVNVEIRKNSWARCKNALLSNN-KFSDPFIKMSALAMYIVLWHLE 360
                     ||...|..|..::..|| .:..:|.|.:..|.| ...:..|.:.|...| .|:..:
Mouse   307 ---------KWKSILYNLYDLLVNEI-SHIGSRGKYSSGSRNIAVKENLIDLMADICY-QLFDAD 360

  Fly   361 TKKAD---------ENGEGDAPKKIPKPADKMETIFSLIDKKENTFNDV-WLAIFTEIL------ 409
            |:..:         |:.:...|.|..|.....|.|...:.|.::.|:.| ||.|.|.::
Mouse   361 TRSVEISQSYVTQRESTDYSVPCKRRKIDVGWEVIKDYLQKSQSDFDLVPWLQITTRLISKYPSS 425

  Fly   410 ----QLSSVILNVANYQM------------ALTTVAEIMQMYGNAKNLRN------LRL------ 446
                :||.:||.:  ||:            .|..:.|:....|...||.:      |:|
Mouse   426 LPNCELSPLILIL--YQLLPQQRRGERIPYVLRCLKEVALCQGKKSNLESSQKSDLLKLWIKIWS 488

  Fly   447 ---------------------------------------------------CLAHLLT------- 453
                                                               ||...|:
Mouse   489 ITFRGISSGQTQTENFGLLEAIIQGSLVELDREFWKLFTGSACKPSSPSVCCLTLALSICVVPDA 553

  Fly   454 ----KEQ---ELLHSKSIREDFL-GELWSQMANQLISETTTNSEEIKEKQ----LVLQMLIRHNK 506
                .||   |...|.|::|..: ..|:.|:.:.|  |.:|....|.:..    :|.::|:....
Mouse   554 IKMGTEQSVCEANRSFSVKESIMRWLLFYQLEDDL--EDSTELPPILQSNFPHLVVEKILVSLTM 616

  Fly   507 LNQKLSSTLLNNIISNEML---KRNECLATIREIFIHA--DKCG-----QDKASADLEPIIAWAY 561
            .|.|.:.....::...|..   |.....:.:.|:|:..  ||..     ::.|....:..:.::.
Mouse   617 KNSKAAMKFFQSVPECEQHCEDKEEPSFSEVEELFLQTTFDKMDFLTTVKEYAVEKFQSSVGFSV 681

  Fly   562 -----GSADRF---IAAQMIHN----IDSIDAQLQADTFAISIIN---FLDV--------QQLRQ 603
                 .|.|.:   ::.|::.|    |.|.:..::..:..:.::.   ::.:        .:|.|
Mouse   682 QQNLKESLDHYLLGLSEQLLSNYSSEITSSETLVRCSSLLVGVLGCYCYMGIITEDEAHKSELFQ 746

  Fly   604 ISQSEHIVPSTERNLLAYKYNEQLICFDKDYATPFESITHIQSETKNCL----------IQSNYD 658
            .::|.........:|...|.||:         :...|:.::.....:||          |.|.:
Mouse   747 KAKSLMQCAGESISLFKNKTNEE---------SRIGSLRNVMHLCTSCLCIHTKHTPNKIASGF- 801

  Fly   659 CLMRGLNFEIAKENKPAAIIKNLNSLLKLICTMERLLH--------------------------- 696
             .:|.|..::.  |..|.|.|:|.|     ||.:.|.|
Mouse   802 -FLRLLTSKLM--NDIADICKSLAS-----CTKKPLDHGVHPGEDDEDGGGCDSLMEAEGPSSTG 858

  Fly   697 -------YKVFDADTY------TGC--PLI-----KRIGLYLSHIEF-----------QLKANGA 730
                   ..|.||:.|      .|.  ||.     |:..|.|..:.|           .:...||
Mouse   859 LSTAYPASSVSDANDYGENQNAVGAMSPLAADYLSKQDHLLLDMLRFLGRSVTASQSHTVSFRGA 923

  Fly   731 EI-------LDKS--DLPEILRLEIYVLDVFRTNLVLLDYL----ERQPIEMLVEFVGAALKLHS 782
            :|       ||.|  ||.:.|.|.:|        ||||..|    ...|:|.:||.:.....:.|
Mouse   924 DIRRKLLLLLDSSILDLMKPLHLHMY--------LVLLKDLPGNEHSLPMEDVVELLQPLSLVCS 980

  Fly   783 MQRERSVDADHGTITRLCLNILAGLCAYNSHRDEAFEHIV------KVTMR-------------- 827
            :.|.   |.|      :|..||:.:.           |||      .|.|.
Mouse   981 LHRR---DQD------VCKTILSNVL-----------HIVTNLGQGSVDMESTRIAQGHFLTVMG 1025

  Fly   828 --WH----PQDVLIVTKMLCSC-QTISEAS--SSWLVSKLK------------TLFQQHHQDAEL 871
              ||    .:.|..|...|..| ||:.||.  |.|.:..:|            .|...|||...|
Mouse  1026 AFWHLTKEKKCVFSVRMALVKCLQTLLEADPYSEWAILNVKGQDFPVNEAFSQFLADDHHQVRML 1090

  Fly   872 MDKVVQHMPTIFYFVRHKENHLDDMLMA--LNSLLRIAIKKSYTSNLTAKIVRCVGLIAQRC--- 931
            ....|..:             ..||...  ..||..:.:|...||...|......|:....|
Mouse  1091 AAGSVNRL-------------FQDMRQGDFSRSLKALPLKFQQTSFNNAYTTAEAGIRGLLCDSQ 1142

  Fly   932 -PD----IY-----LLENFAV------ICKSTAKFITMPTLEVRFATLFTFTILLESNCVTSDAI 980
             ||    ||     ||...||      :|:..|.|....:::...........:||.   .|::.
Mouse  1143 NPDLLDEIYNRKSVLLMMIAVVLHCSPVCEKQALFALCKSVKENRLEPHLVKKVLEK---VSESF 1204

  Fly   981 GHSRTHWDFCQELYESIEFKKLTY------NNEDAIQNSNALIVQML----IAIFLRSSFHQEIA 1035
            |        |:.| |......|.|      |.:|...:.::....:|    |..|.||.:
Mouse  1205 G--------CRSL-EDFMISHLDYLVLEWLNLQDTEYSLSSFPFMLLNYTSIEDFYRSCY----- 1255

  Fly  1036 LKELLHHCALR-RLTEREFISLQSMSSCHRQTVRDLIRPFAAILLHHWSSKRWPISKFPYFLCYS 1099
             |.|:.|..:| ...|.:.|:.| :..|.:..:.|.   |..||:|          ..|||....
Mouse  1256 -KILIPHLVIRSHFDEVKSIANQ-IQKCWKSLLVDC---FPKILVH----------ILPYFAYEG 1305

  Fly  1100 TKSEF---RKTHASEIMAYTFLYGKTEDIERCSKSISEELA--LPILASFLLIKNSSCSESEGQN 1159
            |:..:   ::..|:::  |..|.|  ||.  ..|.|.:...  ||.:...||:.....::|...:
Mouse  1306 TRDSYVSQKRETATKV--YDTLKG--EDF--LGKQIDQVFISNLPEIVVELLMTLHETADSADSD 1364

  Fly  1160 FKEHLQLLSE-----NLSYSQLNATDVDLDLDILCYVISMLHDPQEMMRLFGSLAICNRTASWYS 1219
            ..:....|.:     .|:..:|...|.||             ||......|.|..| ..|.::.|
Mouse  1365 ASQSATALCDFSGYAGLTLGELAVADGDL-------------DPAPNPPYFPSHVI-QATFAYIS 1415

  Fly  1220 LSGESLFKCLNFHIDPEMRPSMDSRIQSMTTLQTKHSRVLVDIFGRLKTNCYSASFSSQALHDFF 1284
            ...::.||               |.::.::.:...:.::|:.|
Mouse  1416 NCHKTKFK---------------SILEILSKIPDSYQKILLAI---------------------- 1443

  Fly  1285 LYCEVADAVYDAARKNETIVTQ---CSFFVRDI-------WFFVVRLLIHTKFIRVQMAALTFLE 1339
              ||.|....:..:|:..:...   .|..::||       |.||:|.:|:|            |.
Mouse  1444 --CEQAAETNNVFKKHRILKIYHLFVSLLLKDIQSGLGGAWAFVLRDVIYT------------LI 1494

  Fly  1340 LLLNKHNFRLDDYQNHFGDIAKLLSNFQLCCEA-------------------------------- 1372
            ..:||.:       :||.|::  |.:|.|||:.
Mouse  1495 HYINKRS-------SHFTDVS--LRSFSLCCDLLSRVCHTAVTQCKDALESHLHVIVGTLIPLVD 1550

  Fly  1373 -KEVREKTMSIVMYILESKKGHINLN---SFLEETTDCEFLKPLR---EDCK-SSQPNIDRADVA 1429
             :||:|:.:.::.|::...|.:.||:   ..|:...|....|.||   :..| |..|.....::.
Mouse  1551 YQEVQEQVLDLLKYLVIDNKDNKNLSVTIKLLDPFPDHVIFKDLRLTQQKIKYSGGPFSLLEEIN 1615

  Fly  1430 NYLRSFLLSPTP----ERLRDLRTYIAEHKDKVQE---------HEKLLFGVINKLIQMTRDAHN 1481
            ::|.....:|.|    |.|:|||..:.:|||::.:         .:.::..::..|:|:::.|.|
Mouse  1616 HFLSVSAYNPLPLTRLEGLKDLRRQLEQHKDQMLDLLRASQDNPQDGIVVKLVVSLLQLSKMAVN 1680

  Fly  1482 KTTSIDSL----KCLAQIGPLKISTVSYYFQTDFEAFEKSNGEPMEAFLG---VVCHSLDTSLFQ 1539
            :|...:.|    :||.:||||..||::.....|. ::.|:.|.|.:..|.   ::..:|:.:|.:
Mouse  1681 QTGEREVLEAVGRCLGEIGPLDFSTIAVQHNKDV-SYTKAYGLPEDRELQWTLIMLTALNNTLVE 1744

  Fly  1540 FDPKTHEGLVSVAIQVVNSKPGSNIMERYKN--------LRIFADKSTASTFLHSNKQIRRIDWL 1596
            ...|......:....::.:|.|....|.||.        |:.|  :::...||...:.::. |.|
Mouse  1745 DSVKIRSAAATCLKNILATKIGHIFWENYKTSADPMLTYLQPF--RTSRKKFLEVPRSVKE-DVL 1806

  Fly  1597 SILKAT-----KSLSYEPWM----CAFV------SKVFQ----MCGWLGFDKLAATSFAFAKTCL 1642
            ..|.|.     :|.|::.|:    |||:      |::.|    ||.       ..|.|.   ..|
Mouse  1807 EGLDAVNLWVPQSESHDIWIKTLTCAFLDSGGINSEILQLLKPMCE-------VKTDFC---QML 1861

  Fly  1643 LPFI--KLLLENSLEHVESLSQMLDYFFEGFTSSTAPNSQEIFR-------------------NK 1686
            ||::  .:||:::  | ||...:|.....||.:|...:|.:..|                   :|
Mouse  1862 LPYLIHDVLLQDT--H-ESWRTLLSAHVRGFFTSCFKHSSQASRSATPANSDSESENFLRCCLDK 1923

  Fly  1687 RAIKKFLHICEYIR---------IFNN--WTIPINLSNVVMASNHCQAYFLSIMYLELWA----- 1735
            ::.:..|.:.:|:|         .|::  | :.:|...|...:..|.|:|.:::|.|:::
Mouse  1924 KSQRTMLAVVDYLRRQKRPSSGTAFDDAFW-LDLNYLEVAKVAQSCSAHFTALLYAEIYSDKKST 1987

  Fly  1736 -------------------CSESPKSKADFLDNECFQDGAKKAYESIGCLDAIPG-----FVNPM 1776
                               .|.|.|||.:  .....||...:.|.|||..|::.|     .:.|:
Mouse  1988 DEQEKRSPTFEEGSQGTTISSLSEKSKEE--TGISLQDLLLEIYRSIGEPDSLYGCGGGKMLQPL 2050

  Fly  1777 RSRLDFLGHGSNLSTILLESD------HLDRASGQLCIDIMKGNGL-----------------WS 1818
             :|:....|.:.....|:..|      ...|.||  .|..::..||                 |.
Mouse  2051 -TRIRTYEHEATWEKALVTYDLETSISSSTRQSG--IIQALQNLGLSHILSVYLKGLDYERREWC 2112

  Fly  1819 FAKLQQHQNIEPDYEIFWRLGQWDSLTDPKHQQNQTVVRTSLDLEQEFKRHHFVALRSIGQREEE 1883
             |:||     |..|:..||..||........:...|....||          :.||:.:..||..
Mouse  2113 -AELQ-----ELRYQAAWRNMQWGLCASAGQEVEGTSYHESL----------YNALQCLRNREFS 2161

  Fly  1884 NSLSAIEQAYSCVRDI--LMEISVECLQSVYKYLTWLCSLQQAEDFCQIQFGTQLDPASTTKIFR 1946
            ....::.  |:.|:::  |.:.|:|.:.|:|..|:.|.::.:.|:..:: |...:.....::.:.
Mouse  2162 TFYESLR--YARVKEVEELSKGSLESVYSLYPTLSRLQAIGELENSGEL-FSRSVTDRERSEAYW 2223

  Fly  1947 KWQTELE-LKYGNFSCKEYVIAHQIALLKLAGTRASRRMSEFYQKDPISTYLMKGIEECKSAGKL 2010
            |||...: ||..:||.:|.::|.:..:|:....:...|......||.::.:|:          :.
Mouse  2224 KWQKHSQLLKDSDFSFQEPLMALRTVILETLVQKEMERSQGACSKDILTKHLV----------EF 2278

  Fly  2011 NLAAKYTATLRELPNIRESIKISVL-----------LEDAEINLKMGNQQIAKAIL--------- 2055
            ::.|: |....:||. |...||...           ||:|::......|.:|.:||
Mouse  2279 SVLAR-TFKNTQLPE-RAIFKIKQYNSAICGISEWHLEEAQVFWAKKEQSLALSILKQMIKKLDS 2341

  Fly  2056 DYVTNNNEFVYCVQRVPALRMQGEFLLDCNAETLSWVQSHKFNNSLKLIDDFVQHRQTLSEKYRD 2120
            .:....|:....|.....||:.|           ||:......|...::..:::....::..|
Mouse  2342 SFKDKENDAGLKVIYAECLRVCG-----------SWLAETCLENPAVIMQTYLEKAVKVAGSY-- 2393

  Fly  2121 IFDWHQLDAYASKQRTA---AYATIAKYADREYQQLHDYRHSQEYQTLKDIIEQNRQTAEKVTQR 2182
                   |..:.:.|..   |:.::|:::|.:||::.:|..|.|::..:.::::.::....:.:.
Mouse  2394 -------DGNSRELRNGQMKAFLSLARFSDTQYQRIENYMKSSEFENKQTLLKRAKEEVGLLREH 2451

  Fly  2183 ENQDRRVISVQMKRYASLDEQQLNQIEEKLTEYLRLALTNYMAYCRLDSGFSSAAIYRIISLWFT 2247
            :.|..| .:|:::|...|||..|..:.|....:|..|:.||: .|.|........::|:.|||..
Mouse  2452 KIQTNR-YTVKVQRELELDECALRALREDRKRFLCKAVENYI-NCLLSGEEHDLWVFRLCSLWLE 2514

  Fly  2248 NATSKQCQECIKDEILTVPSYKFICAANQLTARLNSKNTSLL---KGLTDLLVQCGKDHPYHTFY 2309
            |:...:....:|.:.:.:.||||:....||.||:.:|.|..|   :.|.:|:.:...|||:||.:
Mouse  2515 NSGVSEVNGMMKKDGMKISSYKFLPLMYQLAARMGTKMTGGLGFHEVLNNLISRISLDHPHHTLF 2579

  Fly  2310 QLYPLVFAHLD-------------------GENS--NTERSGIARKIIAMICEKNGTAGECS--K 2351
            .:..|..|:.|                   .|||  :.:|:..|.:||..|..|     .|.  |
Mouse  2580 IILALANANKDEFLSKPETTRRSRITKSTSKENSHLDEDRTEAATRIIHSIRSK-----RCKMVK 2639

  Fly  2352 QLESLLPALITFANEGKTN-----------DNRPVSDSVRNKQFDKVRRWRNLNAVHCPTLELPV 2405
            .:|:|..|.|..||...:.           .|:|::            :.:||..|..||:|:.|
Mouse  2640 DMEALCDAYIILANMDASQWRAQRKGINIPANQPIT------------KLKNLEDVVVPTMEIKV 2692

  Fly  2406 MPSKEY-SIISVVKWTNETTQCGGLNAPVKIMCVCSDGKIRAQLVKGKDDLRQDAVMQQVFGIVN 2469
            .|:.|| :::::..:..|....||||.|..|.||.||||.|.|||||:|||||||||||||.:.|
Mouse  2693 DPTGEYENLVTIKSFKTEFRLAGGLNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCN 2757

  Fly  2470 ELLNQDSEFIERKLKLRTYKVTPLSMRSGILEWCTNSVPVGHYLVVEGKGGAHARYRPNDWNNNK 2534
            .||.:::|..:|||.:.||||.|||.|||:|||||.:||:|.|| |..:.|||.||||||::.|:
Mouse  2758 TLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEYL-VNSEDGAHRRYRPNDFSANQ 2821

  Fly  2535 CRKLSSDHLKSPKETRYAIYKKICENIKPVFHYFLLEKFPIPGVWFERRLAYTNSVATTSMVGYV 2599
            |:|...:..|...|.:|..:..||:|.:|||.||.:|||..|.||||:|||||.||||:|:|||:
Mouse  2822 CQKKMMEVQKKSFEEKYDTFMTICQNFEPVFRYFCMEKFLDPAVWFEKRLAYTRSVATSSIVGYI 2886

  Fly  2600 LGLGDRHTQNILVDQQTAEVIHIDFGIAFEQGKIQTTPETVPFRLTRDFVAPMGICGTKGVFAKS 2664
            |||||||.||||:::|:||::|||.|:|||||||..|||||||||:||.|..|||.|.:|||.:.
Mouse  2887 LGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLSRDIVDGMGITGVEGVFRRC 2951

  Fly  2665 CEATMHILRRYKSVFTTILEVLLYDPLFIWGV-----LKKKQSPQQSG----------------- 2707
            ||.||.::|..:....||:|||||||||.|.:     |..:|.|:...
Mouse  2952 CEKTMEVMRSSQETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDESDLHSTPNADDQECKQSL 3016

  Fly  2708 ---EESVNLVAQRALLLVQNKLDGREAGTMGDSNVEAQVERLINEATLPSNLCMLFPGW 2763
               ::|.|.||:|.|:.:|.||.|.|.||:  .:|..||..||.:|..|.||..|||||
Mouse  3017 SDTDQSFNKVAERVLMRLQEKLKGVEEGTV--LSVGGQVNLLIQQAMDPKNLSRLFPGW 3073

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tefu	NP_001036712.1	FAT	1829..2170	CDD:280429	71/366 (19%)
		PIKKc_ATM	2416..2696	CDD:270715	165/279 (59%)
		FATC	2739..2767	CDD:280430	14/25 (56%)
Atm	XP_011240687.1	TAN	8..165	CDD:371644	24/163 (15%)
		FAT	2128..2510	CDD:367004	83/428 (19%)
		PIKKc_ATM	2704..2983	CDD:270715	165/279 (59%)
		FATC	3047..3076	CDD:367005	14/27 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	315	1.000	Domainoid score	I1285
eggNOG	1	0.900	-	-		E1_KOG0892
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	560	1.000	Inparanoid score	I1091
Isobase	1	0.950	-	0	Normalized mean entropy	S5823
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10493at33208
OrthoFinder	1	1.000	-	-		FOG0003948
OrthoInspector	1	1.000	-	-		oto93192
orthoMCL	1	0.900	-	-		OOG6_102827
Panther	1	1.100	-	-	LDO	PTHR11139
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2040
SonicParanoid	1	1.000	-	-		X3248
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.810