DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Art3 and PRMT9

DIOPT Version :9

Sequence 1:	NP_650434.1	Gene:	Art3 / 41837	FlyBaseID:	FBgn0038306	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_612373.2	Gene:	PRMT9 / 90826	HGNCID:	25099	Length:	845	Species:	Homo sapiens

Alignment Length:	479	Identity:	126/479 - (26%)
Similarity:	200/479 - (41%)	Gaps:	95/479 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 KISAEQLLSAEHPLW-QD-----EKYLQPGEYEPWLCYD------YEVLKTDGAPTQPSVLELQQ 154
            ::.:..|.||||.|. ||     ..||......|.|.:|      |.:.:      ....|:...
Human    23 ELVSRSLQSAEHCLGVQDFGTAYAHYLLVLSLAPELKHDVKETFQYTLFR------WAEELDALS 81

  Fly   155 RIAEQSQLLQQANE---DMERMRNDYKALLQKVHADGEPKGSDQSVPRNNVCLDN--EYFKSYAH 214
            ||.:.....:||.|   |.|.:.|.....|.::....|..|......:.|....:  |.|...|:
Human    82 RIQDLLGCYEQALELFPDDEVICNSMGEHLFRMGFRDEAAGYFHKAVKLNPDFSDAKENFYRVAN 146

  Fly   215 FGI---HHEMLSDKVRTSTYRASLLQNEAVVRGKTVLDVGCGTGILSIFASKAGAARVVGIDNSD 276
            :.:   |..||:|..|.:.|.|: :|....:..|:|||:|.||||||:||.||||..|...:.|.
Human   147 WLVERWHFIMLNDTKRNTIYNAA-IQKAVCLGSKSVLDIGAGTGILSMFAKKAGAHSVYACELSK 210

  Fly   277 IVY-TAMDIIRKNKVE-NVELIKGRLEDTDLPE---TKYDIIISEWMGYFLLYESMLDSIIYARE 336
            .:| .|.|::..||:| .::|:..:..|.::|:   .:..::::|.:...|..|.:::|:|:|.|
Human   211 TMYELACDVVAANKMEAGIKLLHTKSLDIEIPKHIPERVSLVVTETVDAGLFGEGIVESLIHAWE 275

  Fly   337 N-HLNPN-----------GIILPSRCTLSLLGYGDDTLYAD-------------------EVEFW 370
            : .|.|.           |.::|:...:    :|.....|:                   .|:|.
Human   276 HLLLQPKTKGESANCEKYGKVIPASAVI----FGMAVECAEIRRHHRVGIKDIAGIHLPTNVKFQ 336

  Fly   371 SNVY-EVDMSDLRKQSIEEPLMQVVDAEFMLTEPEQIANFDIMTVDMNYPNFTHQFSLKVTKP-- 432
            |..| .||..:..:....|.:.:|......|||     .|:|||||.|  |.....||...||
Human   337 SPAYSSVDTEETIEPYTTEKMSRVPGGYLALTE-----CFEIMTVDFN--NLQELKSLATKKPDK 394

  Fly   433 --------GRLSAFVGYFETLFELPSPVMFSTSPSATPTHWKQTVFFIEN--PQVVKEGD----- 482
                    |.|.|.:.:|  :.:|......||||| ..|.|:|.|:.:::  ...:|.||
Human   395 IGIPVIKEGILDAIMVWF--VLQLDDEHSLSTSPS-EETCWEQAVYPVQDLADYWIKPGDHVMME 456

  Fly   483 VICGKITSRRHKEDVRGLSVDIEV 506
            |.|.....|.....|.||..:::|
Human   457 VSCQDCYLRIQSISVLGLECEMDV 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art3	NP_650434.1	Methyltransf_18	243..346	CDD:289607	38/119 (32%)
PRMT9	NP_612373.2	TPR 1	25..58		11/32 (34%)
		TPR	<39..144	CDD:223533	23/110 (21%)
		TPR 2	67..100		7/38 (18%)
		TPR repeat	68..95	CDD:276809	6/32 (19%)
		TPR repeat	100..130	CDD:276809	5/29 (17%)
		TPR 3	101..134		6/32 (19%)
		AdoMet_MTases	148..>303	CDD:327401	47/155 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810