DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Art3 and PRMT6

DIOPT Version :9

Sequence 1:	NP_650434.1	Gene:	Art3 / 41837	FlyBaseID:	FBgn0038306	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_060607.2	Gene:	PRMT6 / 55170	HGNCID:	18241	Length:	375	Species:	Homo sapiens

Alignment Length:	321	Identity:	114/321 - (35%)
Similarity:	174/321 - (54%)	Gaps:	32/321 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 DNEYFKSYAHFGIHHEMLSDKVRTSTYRASLLQNEAVVRGKTVLDVGCGTGILSIFASKAGAARV 269
            |..|::.|:...:|.||::|:|||..||..:|:|.|.:|||||||||.||||||||.::|||.||
Human    44 DQLYYECYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRV 108

  Fly   270 VGIDNSDIVYTAMDIIRKNKVEN-VELIKGRLEDTDLPETKYDIIISEWMGYFLLYESMLDSIIY 333
            ..::.|.|...|.:::|.|.:|: |.::.|.:|..:||| :.|.|:||||||.||:||||.|:::
Human   109 YAVEASAIWQQAREVVRFNGLEDRVHVLPGPVETVELPE-QVDAIVSEWMGYGLLHESMLSSVLH 172

  Fly   334 ARENHLNPNGIILPSRCTLSLLGYGDDTLYADEVEFWSNV---YEVDMSDLR------KQSIEEP 389
            ||...|...|::||:...|.:....|..| ...:.|||.|   |.||||.|.      .....|.
Human   173 ARTKWLKEGGLLLPASAELFIAPISDQML-EWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEI 236

  Fly   390 LMQVVDAEFMLTEPEQIANFDIMTVDMNYPNFTHQFSLKVTKPGR----------LSAFVGYFET 444
            ::|.:..|.:|..|::.|..::....:       :..|:....||          :..|..:|:.
Human   237 VVQGLSGEDVLARPQRFAQLELSRAGL-------EQELEAGVGGRFRCSCYGSAPMHGFAIWFQV 294

  Fly   445 LF---ELPSPVMFSTSPSATPTHWKQTVFFIENPQVVKEGDVICGKITSRRHKEDVRGLSV 502
            .|   |...|::.||||....|||||.:.::..|..|::...:.|:||....:::.|.|.|
Human   295 TFPGGESEKPLVLSTSPFHPATHWKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRV 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art3	NP_650434.1	Methyltransf_18	243..346	CDD:289607	53/103 (51%)
PRMT6	NP_060607.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38
PRMT6	NP_060607.2	AdoMet_MTases	67..>200	CDD:418430	63/133 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D840669at2759
OrthoFinder	1	1.000	-	-		FOG0000206
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820