DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Art3 and carm1

DIOPT Version :9

Sequence 1:	NP_650434.1	Gene:	Art3 / 41837	FlyBaseID:	FBgn0038306	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001003645.1	Gene:	carm1 / 445251	ZFINID:	ZDB-GENE-040724-77	Length:	588	Species:	Danio rerio

Alignment Length:	459	Identity:	129/459 - (28%)
Similarity:	219/459 - (47%)	Gaps:	65/459 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 YSFIKLINYIRA----KKISAEQLLSAEHPLWQDEKYLQPGEYEPWLCYDYEVLKTDGAPTQPSV 149
            :|.::|::...|    ::.|.:|.|..|..:.||...:.....|....:...||:    .|:.|
Zfish     6 FSGVRLLSIGDANGDIQRHSEQQPLRLEIKMNQDAAQIILSNNEETCVFKCTVLR----ETECS- 65

  Fly   150 LELQQRIAEQ---------SQLLQQANEDMERMRNDYKALLQKVHADGEPKGSDQSV--PRNNVC 203
                 |:.:|         |.|||.|:.      .|:.:....:......|| |:||  .|....
Zfish    66 -----RVGKQSFIITLGCNSVLLQFASP------ADFSSFYNLLKICRGQKG-DRSVFSDRTEES 118

  Fly   204 LDNEYFKSYAHFGIHHEMLSDKVRTSTYRASLLQNEAVVRGKTVLDVGCGTGILSIFASKAGAAR 268
            ...:||:.|.:......|:.|.|||.||:.::|||....:.|.|||||||:||||.||::|||.:
Zfish   119 SAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKVVLDVGCGSGILSFFAAQAGARK 183

  Fly   269 VVGIDNSDIVYTAMDIIRKNKV-ENVELIKGRLEDTDLPETKYDIIISEWMGYFLLYESMLDSII 332
            |..::.|.:...|..::..|:: |.|.:|.|::|:..||| :.||||||.|||.|..|.||:|.:
Zfish   184 VYAVEASTMAQHAEVLVNSNRLSERVVVIPGKVEEVSLPE-QVDIIISEPMGYMLFNERMLESYL 247

  Fly   333 YARENHLNPNGIILPSRCTLSLLGYGDDTLYADE---VEFW--SNVYEVDMSDLRKQSIEE---- 388
            :|:: .|.|:|.:.|:...:.|..:.|:.||.::   ..||  .:.:.||:|.||..:::|
Zfish   248 HAKK-FLKPSGKMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQ 311

  Fly   389 PLMQVVDAEFMLTEP-EQIANF------DIMTVDMNYPNFTHQFSLKVTKPGRLSAFVGYFETLF 446
            |::...|...::.:. :...||      |:..:::       .|...:...|.:.....:|:..|
Zfish   312 PIVDTFDIRILMAKSVKYTVNFLEAKEEDLYKIEI-------PFKFHMMHSGLVHGLAFWFDVAF 369

  Fly   447 ELPS--PVMFSTSPSATPTHWKQTVFFIENPQVVKEGDVICGK---ITSRRHKEDVRGLSVDIEV 506
             :.|  .|..||:|:...|||.|....:::|...|.||.:.|.   |.::|...|: .:...::.
Zfish   370 -IGSVMTVWLSTAPTEPLTHWYQVRCLLQSPLFAKAGDTMSGTALLIANKRQSYDI-SIVAQVDQ 432

  Fly   507 FGKK 510
            .|.|
Zfish   433 TGSK 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art3	NP_650434.1	Methyltransf_18	243..346	CDD:289607	47/103 (46%)
carm1	NP_001003645.1	CARM1	8..112	CDD:288395	26/120 (22%)
		PRMT5	<146..409	CDD:282971	86/272 (32%)
		AdoMet_MTases	162..263	CDD:100107	47/102 (46%)
		Transactivation domain. /evidence=ECO:0000250	473..588
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D840669at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820