DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Art3 and PRMT2

DIOPT Version :9

Sequence 1:	NP_650434.1	Gene:	Art3 / 41837	FlyBaseID:	FBgn0038306	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001526.2	Gene:	PRMT2 / 3275	HGNCID:	5186	Length:	433	Species:	Homo sapiens

Alignment Length:	405	Identity:	127/405 - (31%)
Similarity:	208/405 - (51%)	Gaps:	38/405 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 GEYEPWLCYDYEVLKTDGAPTQPSVLELQQRIAEQSQLLQQANEDMERMRNDYKALLQKVHAD-- 187
            || ||..|.:..:|: :|...:..|........:::||        ..:|.:...:|::..||
Human    14 GE-EPAECSEAGLLQ-EGVQPEEFVAIADYAATDETQL--------SFLRGEKILILRQTTADWW 68

  Fly   188 -GEPKGSDQSVPRNNV------------CLDNEYFKSYAHFGIHHEMLSDKVRTSTYRASLLQNE 239
             ||..|....:|.|:|            ..|.|||.||....:|.|||:|:.||:.|.:.:|||:
Human    69 WGERAGCCGYIPANHVGKHVDEYDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNK 133

  Fly   240 AVVRGKTVLDVGCGTGILSIFASKAGAARVV-GIDNSDIV-YTAMDIIRKNKVENVELIKGRLED 302
            ..:..|.:|||||||||:|:|.:.....|.| .::.|::. :|...:::....:.:.:.:.::||
Human   134 ESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLVLQNGFADIITVYQQKVED 198

  Fly   303 TDLPETKYDIIISEWMGYFLLYESMLDSIIYARENHLNPNGIILPSRCTLSLLGYGDDTLYADEV 367
            ..||| |.|:::|||||..||:|.|::||:|||:..|..:|:|.|:...|.|:....|..|..:|
Human   199 VVLPE-KVDVLVSEWMGTCLLFEFMIESILYARDAWLKEDGVIWPTMAALHLVPCSADKDYRSKV 262

  Fly   368 EFWSNVYEVDMSDLRKQSIEE-----PLMQVVDAEFMLTEPEQIANFDIMTVDM-NYPNFTHQFS 426
            .||.|.||.::|.|:..:::|     ....::..|..|:||..|...|:.||.: :......:..
Human   263 LFWDNAYEFNLSALKSLAVKEFFSKPKYNHILKPEDCLSEPCTILQLDMRTVQISDLETLRGELR 327

  Fly   427 LKVTKPGRLSAFVG----YFETLFELPSPVMFSTSPSATPTHWKQTVFFIENPQVVKEGDVICGK 487
            ..:.|.|.|..|..    :|::|.|...|.:.||.|....||||||:|.:::|..|..|||:.|.
Human   328 FDIRKAGTLHGFTAWFSVHFQSLQEGQPPQVLSTGPFHPTTHWKQTLFMMDDPVPVHTGDVVTGS 392

  Fly   488 ITSRRHKEDVRGLSV 502
            :..:|:....|.:||
Human   393 VVLQRNPVWRRHMSV 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art3	NP_650434.1	Methyltransf_18	243..346	CDD:289607	39/104 (38%)
PRMT2	NP_001526.2	Interaction with ESR1	1..277		89/273 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		4/6 (67%)
		SH3_PRMT2	34..86	CDD:212740	13/59 (22%)
		Interaction with RB1. /evidence=ECO:0000250	83..207		40/124 (32%)
		AdoMet_MTases	110..>169	CDD:302624	25/58 (43%)
		Interaction with ESR1	133..275		51/142 (36%)
		AdoMet_MTases	141..241	CDD:100107	38/100 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D840669at2759
OrthoFinder	1	1.000	-	-		FOG0000206
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920