DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Art3 and rmt3

DIOPT Version :9

Sequence 1:	NP_650434.1	Gene:	Art3 / 41837	FlyBaseID:	FBgn0038306	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_595572.1	Gene:	rmt3 / 2541248	PomBaseID:	SPBC8D2.10c	Length:	543	Species:	Schizosaccharomyces pombe

Alignment Length:	528	Identity:	176/528 - (33%)
Similarity:	266/528 - (50%)	Gaps:	61/528 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 SDEDEYDDIDDDDEPMDEGDELTTCLFCTETSANISVAIDHLDARHKVNLSQLQRKFEMDQYSFI 92
            |..|...|.|:::|..::......||||..|...:.....|....|..:..|::::..:|.|:.|
pombe    36 SHSDSEVDWDNEEEVWEDEVHEFCCLFCDSTFTCLKDLWSHCKEAHNFDFYQVKQQNNLDFYACI 100

  Fly    93 KLINYIRAKKISAEQLLSAEHP-LWQDEKYLQPGEYEPWLCYDYEVL-----KTDGAPTQPSVLE 151
            ||:||||:      |:...:.| |.:....|:..||...:..|..||     :.|......:.||
pombe   101 KLVNYIRS------QVKEGKTPDLDKLSDILRSDEYMISVLPDDSVLFSLGDELDSDFEDDNTLE 159

  Fly   152 LQ-------------QRIAEQSQLLQQANEDMERMRNDYKALLQKVHADG---EPKGSDQSVPRN 200
            ::             :::..|:|||   ...:|.:|.|....|.....|.   .||.:|.
pombe   160 IEVENPADVSKDAEIKKLKLQNQLL---ISQLEEIRKDKMNELTSQTTDQLSVTPKKADN----- 216

  Fly   201 NVCLDNEYFKSYAHFGIHHEMLSDKVRTSTYRASLLQNEAVVRGKTVLDVGCGTGILSIFASKAG 265
                |:.||:|||...||..||:|.|||..||..:..|:.:..|||||||||||||||:|.:|||
pombe   217 ----DSYYFESYAGNDIHFLMLNDSVRTEGYRDFVYHNKHIFAGKTVLDVGCGTGILSMFCAKAG 277

  Fly   266 AARVVGIDNSDIVYTAMDIIRKNKVEN-----VELIKGRLEDTDLPETKYDIIISEWMGYFLLYE 325
            |.:|..:|||||:..|:    .|..||     :..|:|::||..||..|.||||||||||.|.:|
pombe   278 AKKVYAVDNSDIIQMAI----SNAFENGLADQITFIRGKIEDISLPVGKVDIIISEWMGYALTFE 338

  Fly   326 SMLDSIIYARENHLNPNGIILPSRCTLSLLGYGDDTLYADEVEFWSNVYEVDMSDLRKQSIEEPL 390
            ||:||::.||:..|.|:||:.||...|.|....:..|..:.::|||:||...|:.::..|.:...
pombe   339 SMIDSVLVARDRFLAPSGIMAPSETRLVLTATTNTELLEEPIDFWSDVYGFKMNGMKDASYKGVS 403

  Fly   391 MQVVDAEFMLTEPEQIANFDIMTVDMNYPNFTHQFSLKVTKPGRLSAFVGYFETLF------ELP 449
            :|||...::..:|...|.|::.|..:...:||..|||.:...|.|.||..:|:|.|      .:|
pombe   404 VQVVPQTYVNAKPVVFARFNMHTCKVQDVSFTSPFSLIIDNEGPLCAFTLWFDTYFTTKRTQPIP 468

  Fly   450 SPV----MFSTSPSATPTHWKQTVFFIENPQVVKEGDVICGKITSRRHKEDVRGLSVDI--EVFG 508
            ..:    .|:|.|..|||||||.|..:.|...:::|..:.|.|:..::|::.|.|.:.:  .|.|
pombe   469 EAIDEACGFTTGPQGTPTHWKQCVLLLRNRPFLQKGTRVEGTISFSKNKKNNRDLDISVHWNVNG 533

  Fly   509 KKHKYNVV 516
            |....:.|
pombe   534 KADSQSYV 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art3	NP_650434.1	Methyltransf_18	243..346	CDD:289607	59/107 (55%)
rmt3	NP_595572.1	zf-C2H2_2	60..>113	CDD:289522	18/58 (31%)
rmt3	NP_595572.1	Methyltransf_18	255..369	CDD:289607	63/117 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	59	1.000	Domainoid score	I3051
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H24255
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59188
OrthoFinder	1	1.000	-	-		FOG0000206
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105227
Panther	1	1.100	-	-	LDO	PTHR11006
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5241
TreeFam	1	0.960	-	-
	11	10.780