DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Art3 and Prmt9

DIOPT Version :9

Sequence 1:	NP_650434.1	Gene:	Art3 / 41837	FlyBaseID:	FBgn0038306	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001074709.1	Gene:	Prmt9 / 102182	MGIID:	2142651	Length:	846	Species:	Mus musculus

Alignment Length:	483	Identity:	120/483 - (24%)
Similarity:	197/483 - (40%)	Gaps:	116/483 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 KISAEQLLSAEHPLWQDEKYLQPGEYEPWLCYDYEVLKTDGAPTQPSVLELQQRIAE--QSQLLQ 164
            ::.|..|.||||.|         |:.:....|.:.:|....||      ||:..:.|  |..|.:
Mouse    23 RLVARSLQSAEHCL---------GDQDFGTAYAHYLLVLSLAP------ELKDDVKETFQYTLFK 72

  Fly   165 QANE----------------------DMERMRNDYKALLQKVHADGEPKGSDQSVPRNNVCLDN- 206
            .|.|                      |.|.:.|.....|.::....|..|......:.|...::
Mouse    73 WAEELHALSRIQDLLGCYEQALELFPDDEVICNSMGEHLFRMGFRDEAAGYFHKAVKLNPDFNDA 137

  Fly   207 -EYFKSYAHFGI---HHEMLSDKVRTSTYRASLLQNEAVVRGKTVLDVGCGTGILSIFASKAGAA 267
             |.|...|::.:   |..||:|..|...|.|: :|....:..:||||:|.||||||:||.||||.
Mouse   138 KENFYRVANWLVERWHFIMLNDTRRNMVYNAA-IQKAVCLGSRTVLDIGTGTGILSMFAKKAGAQ 201

  Fly   268 RVVGIDNSDIVY-TAMDIIRKNKVEN-VELIKGRLEDTDLPE---TKYDIIISEWMGYFLLYESM 327
            .|...:.|..:| .|.|::..||:|| ::|:..:..|.::|:   .:..::::|.:...:..|.:
Mouse   202 SVYACELSKTMYELACDVVAANKMENGIKLLHMKSLDIEIPKHIPERVSLVVTETVDAGVFGEGI 266

  Fly   328 LDSIIYARENHL--------NPN----GIILPSRCTLSLLGYGDDTLYAD--------------- 365
            ::|:|:|.|:.|        |.|    |.::|:...:    :|.....|:
Mouse   267 VESLIHAWEHLLLQPKTKEENGNCGKYGKVIPAGAVI----FGMAVECAEIRRHHRVGAKDIAGI 327

  Fly   366 ----EVEFWSNVY-EVDMSDLRKQSIEEPLMQVVDAEFMLTEPEQIANFDIMTVDMNYPNFTHQF 425
                .|:|.|..| .||..:..:....|.:..:......|||     .|.||.||.|  |.....
Mouse   328 HLPTNVKFQSPAYTSVDTEETVEPYTTEKMSGIPGGYLPLTE-----CFQIMKVDFN--NLQELK 385

  Fly   426 SLKVTKP----------GRLSAFVGYFETLFELPSPVMFSTSPSATPTHWKQTVFFIE--NPQVV 478
            ||...||          |.|.|.:.:|  :.:|......||||| ..|.|:|.|:.::  ....:
Mouse   386 SLATKKPHSLNVPAIKEGVLDAIMVWF--VLQLDDEYSLSTSPS-EETCWEQAVYPVQALEDYCI 447

  Fly   479 KEGDVICGKITSRRHKED----VRGLSV 502
            :.||    ::|......|    ::|:|:
Mouse   448 QPGD----RVTMEASCHDCYLRIQGISI 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art3	NP_650434.1	Methyltransf_18	243..346	CDD:289607	39/119 (33%)
Prmt9	NP_001074709.1	TPR 1	25..58		12/47 (26%)
		TPR 2	67..100		4/32 (13%)
		TPR_11	68..132	CDD:290150	9/63 (14%)
		TPR repeat	68..95	CDD:276809	3/26 (12%)
		TPR repeat	100..130	CDD:276809	5/29 (17%)
		TPR 3	101..134		6/32 (19%)
		AdoMet_MTases	148..>303	CDD:302624	48/155 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810