DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Art3 and PRMT3

DIOPT Version :9

Sequence 1:	NP_650434.1	Gene:	Art3 / 41837	FlyBaseID:	FBgn0038306	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_005779.1	Gene:	PRMT3 / 10196	HGNCID:	30163	Length:	531	Species:	Homo sapiens

Alignment Length:	521	Identity:	205/521 - (39%)
Similarity:	307/521 - (58%)	Gaps:	25/521 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 EPVKEAPEVPANSSSDEDEYDDIDDDDEPMDEGDELTTCLFCTETSANISVAIDHLDARHKVNLS 78
            |..::.||:  :.|.||..::|.||.|.|  .|.:.|.||||.....:......|..:.|:.|:.
Human    16 ENEEDLPEL--SDSGDEAAWEDEDDADLP--HGKQQTPCLFCNRLFTSAEETFSHCKSEHQFNID 76

  Fly    79 QLQRKFEMDQYSFIKLINYIRAKKISAEQLLSAEHPL-WQDEKYLQPG-EYEPWLCYDYEVL--- 138
            .:..|..::.|.:|||||:||.|..:.|.:.|..:|: |:.|:||:|. |.:..|.:|.|.|
Human    77 SMVHKHGLEFYGYIKLINFIRLKNPTVEYMNSIYNPVPWEKEEYLKPVLEDDLLLQFDVEDLYEP 141

  Fly   139 ------KTDGAPTQPSVLE----LQQRIAEQSQLLQQANEDMERMRNDYKALLQKVHADGEPKGS 193
                  ..:|.....||:|    ::.|.......|.:|.||:::|:...:..:  :|.|.....|
Human   142 VSVPFSYPNGLSENTSVVEKLKHMEARALSAEAALARAREDLQKMKQFAQDFV--MHTDVRTCSS 204

  Fly   194 DQSVPRN-NVCLDNEYFKSYAHFGIHHEMLSDKVRTSTYRASLLQNEAVVRGKTVLDVGCGTGIL 257
            ..||..: ....|..||.||.|:|||.|||.||:||.:||..:.||..:.:.|.|||||||||||
Human   205 STSVIADLQEDEDGVYFSSYGHYGIHEEMLKDKIRTESYRDFIYQNPHIFKDKVVLDVGCGTGIL 269

  Fly   258 SIFASKAGAARVVGIDNSDIVYTAMDIIRKNKVEN-VELIKGRLEDTDLPETKYDIIISEWMGYF 321
            |:||:||||.:|:|:|.|:|:|.||||||.||:|: :.||||::|:..||..|.|:|||||||||
Human   270 SMFAAKAGAKKVLGVDQSEILYQAMDIIRLNKLEDTITLIKGKIEEVHLPVEKVDVIISEWMGYF 334

  Fly   322 LLYESMLDSIIYARENHLNPNGIILPSRCTLSLLGYGDDTLYADEVEFWSNVYEVDMSDLRKQSI 386
            ||:||||||::||:..:|...|.:.|..||:||:...|...:||.:.||.:||...||.::|..|
Human   335 LLFESMLDSVLYAKNKYLAKGGSVYPDICTISLVAVSDVNKHADRIAFWDDVYGFKMSCMKKAVI 399

  Fly   387 EEPLMQVVDAEFMLTEPEQIANFDIMTVDMNYPNFTHQFSLKVTKPGRLSAFVGYFETLFE--LP 449
            .|.:::|:|.:.:::||..|.:.|..|..::...|:..|:||:|:....:|..|||:..||  ..
Human   400 PEAVVEVLDPKTLISEPCGIKHIDCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNCH 464

  Fly   450 SPVMFSTSPSATPTHWKQTVFFIENPQVVKEGDVICGKITSRRHKEDVRGLSVDIEVFGKKHKYN 514
            :.|:|||.|.:|.||||||||.:|.|..||.|:.:.||:|..::|:|.|.|:|.:.:......|.
Human   465 NRVVFSTGPQSTKTHWKQTVFLLEKPFSVKAGEALKGKVTVHKNKKDPRSLTVTLTLNNSTQTYG 529

  Fly   515 V 515
            :
Human   530 L 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art3	NP_650434.1	Methyltransf_18	243..346	CDD:289607	64/103 (62%)
PRMT3	NP_005779.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43		11/30 (37%)
PRMT3	NP_005779.1	AdoMet_MTases	259..359	CDD:100107	63/99 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148159
Domainoid	1	1.000	166	1.000	Domainoid score	I3897
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H24255
Inparanoid	1	1.050	366	1.000	Inparanoid score	I2168
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59188
OrthoDB	1	1.010	-	-		D432852at33208
OrthoFinder	1	1.000	-	-		FOG0000206
OrthoInspector	1	1.000	-	-		oto90840
orthoMCL	1	0.900	-	-		OOG6_105227
Panther	1	1.100	-	-	LDO	PTHR11006
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6843
SonicParanoid	1	1.000	-	-		X5241
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800