DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Caf1-55 and WTM2

DIOPT Version :9

Sequence 1:	NP_524354.1	Gene:	Caf1-55 / 41836	FlyBaseID:	FBgn0263979	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_014872.1	Gene:	WTM2 / 854404	SGDID:	S000005755	Length:	467	Species:	Saccharomyces cerevisiae

Alignment Length:	440	Identity:	95/440 - (21%)
Similarity:	155/440 - (35%)	Gaps:	117/440 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 KKNTPFLYD----------------LVMTHALEWPSLTAQWLPDVTKQDGKDYSVHRLILGTHTS 77
            :|..|.||.                |..:..|.|.|   :.:||.:|             ||.|:
Yeast    15 RKPAPSLYQHISSFKPQFSTRVDDVLHFSKTLTWRS---EIIPDKSK-------------GTLTT 63

  Fly    78 ----DEQNHLLIASVQLP----SEDAQFDGSHYDNEKG------------EFG-GFGSVCGKIEI 121
                .:.:.:......||    .:|...|.:..|:|:|            |:| .|..|.|| .:
Yeast    64 SLLYSQGSDIYEIDTTLPLKTFYDDDDDDDNDDDDEEGNGKTKSAATPNPEYGDAFQDVEGK-PL 127

  Fly   122 EIKINHEGE-VNRARYM--PQNACVIATKTPSSDVLVFDYTKHPSK--PEPSGECQPDLRLRGHQ 181
            ..|..::|| |.:.:|:  ..::..||.....|.....|..|.|..  .|..|.......:....
Yeast   128 RPKWIYQGETVAKMQYLESSDDSTAIAMSKNGSLAWFRDEIKVPVHIVQEMMGPATRYSSIHSLT 192

  Fly   182 KEG------YGLSWNPNL------NGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVV 234
            :.|      :.:|.|.:.      |||    .:|..:.:.|.:..|.:    ..:.:....|.|.
Yeast   193 RPGSLAVSDFDVSTNMDTVVKSQSNGY----EEDSILKIIDNSDRPGD----ILRTVHVPGTNVA 249

  Fly   235 EDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTV-DAHTAEVNCLSFNPYSEFILATGSA 298
            ..|.:...|  ||.|.:||..|..||||  ...||..|: :.....:.....:..:|.:..||.:
Yeast   250 HSVRFFNNH--LFASCSDDNILRFWDTR--TADKPLWTLSEPKNGRLTSFDSSQVTENLFVTGFS 310

  Fly   299 DKTVALWDLRNLKL--------------------KLHSFESHKDEIFQVQWSPHNETILASSGTD 343
            ...:.|||.|.::|                    ||  |.|..|.:..:.:|..:.|...:.|..
Yeast   311 TGVIKLWDARAVQLATTDLTHRQNGEEPIQNEIAKL--FHSGGDSVVDILFSQTSATEFVTVGGT 373

  Fly   344 RRLHVWDLSKIGEEQSTEDAED-----GPPE-----LLFIHGGHTAKISD 383
            ..::.||: :....::.:|.||     .|.|     |.|.|.|.|.:.|:
Yeast   374 GNVYHWDM-EYSFSRNDDDNEDEVRVAAPEELQGQCLKFFHTGGTRRSSN 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Caf1-55	NP_524354.1	CAF1C_H4-bd	23..92	CDD:403473	16/86 (19%)
		WD40	127..408	CDD:421866	67/305 (22%)
		WD40 repeat	132..179	CDD:293791	9/50 (18%)
		WD40 repeat	184..228	CDD:293791	9/55 (16%)
		WD40 repeat	235..274	CDD:293791	15/39 (38%)
		WD40 repeat	280..318	CDD:293791	10/57 (18%)
		WD40 repeat	324..375	CDD:293791	12/60 (20%)
		WD40 repeat	381..406	CDD:293791	1/3 (33%)
WTM2	NP_014872.1	WD40	221..>383	CDD:421866	38/172 (22%)
		WD40 repeat	251..285	CDD:293791	15/37 (41%)
		WD40 repeat	292..343	CDD:293791	8/50 (16%)
		WD40 repeat	354..399	CDD:293791	8/45 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22850
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100